Home Quinolines 553-03-7
553-03-7,MFCD00016722
Catalog No.:AA003IEI

553-03-7 | 3,4-Dihydro-2(1H)-quinolinone

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5g
98%
in stock  
$15.00   $11.00
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10g
98%
in stock  
$21.00   $15.00
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25g
98%
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$36.00   $25.00
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100g
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  • Technical Information
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA003IEI
Chemical Name:
3,4-Dihydro-2(1H)-quinolinone
CAS Number:
553-03-7
Molecular Formula:
C9H9NO
Molecular Weight:
147.1739
MDL Number:
MFCD00016722
SMILES:
O=C1CCc2c(N1)cccc2
NSC Number:
49170
Properties
Properties
 
BP:
328.1°C at 760 mmHg  
Form:
Solid  
MP:
165-167 °C  
Refractive Index:
1.5200 (estimate)  
Stability:
Light Sensitive  
Storage:
Keep in dry area;Room Temperature;  

Computed Properties
 
Complexity:
167  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
11  
Hydrogen Bond Acceptor Count:
1  
Hydrogen Bond Donor Count:
1  
XLogP3:
1.1  

Literature

Title: 3-Eth-oxy-methyl-1,4-dihydro-quinolin-4-one.

Journal: Acta crystallographica. Section E, Structure reports online 20120701

Title: Aflaquinolones A-G: secondary metabolites from marine and fungicolous isolates of Aspergillus spp.

Journal: Journal of natural products 20120323

Title: Synthesis of tripeptide mimetics based on dihydroquinolinone and benzoxazinone scaffolds.

Journal: Chemistry (Weinheim an der Bergstrasse, Germany) 20111209

Title: Design, synthesis, and biological evaluation of 3,4-dihydroquinolin-2(1H)-one and 1,2,3,4-tetrahydroquinoline-based selective human neuronal nitric oxide synthase (nNOS) inhibitors.

Journal: Journal of medicinal chemistry 20110811

Title: 2-(2-Chloro-6,7-dimethyl-quinolin-3-yl)-2,3-dihydro-quinolin-4(1H)-one.

Journal: Acta crystallographica. Section E, Structure reports online 20110801

Title: Reactive spin state dependent enantiospecific photocyclization of axially chiral α-substituted acrylanilides.

Journal: Chemical communications (Cambridge, England) 20110307

Title: Discovery of novel positive allosteric modulators of the metabotropic glutamate receptor 5 (mGlu5).

Journal: Bioorganic & medicinal chemistry letters 20110301

Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Journal: Bioorganic & medicinal chemistry letters 20101101

Title: Potent dihydroquinolinone dopamine D2 partial agonist/serotonin reuptake inhibitors for the treatment of schizophrenia.

Journal: Bioorganic & medicinal chemistry letters 20100501

Title: Ethyl 6-chloro-2-oxo-4-phenyl-1,2-dihydro-quinoline-3-carboxyl-ate.

Journal: Acta crystallographica. Section E, Structure reports online 20091201

Title: Synthesis of highly enantioenriched 3,4-dihydroquinolin-2-ones by 6-exo-trig radical cyclizations of axially chiral alpha-halo-ortho-alkenyl anilides.

Journal: Journal of the American Chemical Society 20091028

Title: (RS)-3-Acetyl-2-methyl-4-(3-nitro-phen-yl)-1,4,5,6,7,8-hexa-hydro-quinolin-5-one.

Journal: Acta crystallographica. Section E, Structure reports online 20091001

Title: Novel approach to 3,4-dihydro-2(1H)-quinolinone derivatives via cyclopropane ring expansion.

Journal: Organic letters 20090305

Title: In vivo active aldosterone synthase inhibitors with improved selectivity: lead optimization providing a series of pyridine substituted 3,4-dihydro-1H-quinolin-2-one derivatives.

Journal: Journal of medicinal chemistry 20081225

Title: Comparison of the bioactivation potential of the antidepressant and hepatotoxin nefazodone with aripiprazole, a structural analog and marketed drug.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20080601

Title: Synthesis and biological activity of quinolinone and dihydroquinolinone p38 MAP kinase inhibitors.

Journal: Bioorganic & medicinal chemistry letters 20080315

Title: Quinoline and derivatives at a tar oil contaminated site: hydroxylated products as indicator for natural attenuation?

Journal: Environmental science & technology 20070801

Title: Synthesis, biological testing, and binding mode prediction of 6,9-diarylpurin-8-ones as p38 MAP kinase inhibitors.

Journal: Journal of medicinal chemistry 20070503

Title: Development of potent, orally active 1-substituted-3,4-dihydro-2-quinolone glycogen phosphorylase inhibitors.

Journal: Bioorganic & medicinal chemistry letters 20070115

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Title: Synthesis and SAR of highly potent and selective dopamine D(3)-receptor antagonists: Quinolin(di)one and benzazepin(di)one derivatives. [email protected].

Journal: Bioorganic & medicinal chemistry letters 20060201

Title: Synthesis of five-, six-, and seven-membered ring lactams by CpRh complex-catalyzed oxidative N-heterocyclization of amino alcohols.

Journal: Organic letters 20040805

Title: Novel 3,4-dihydroquinolin-2(1H)-one inhibitors of human glycogen phosphorylase a.

Journal: Bioorganic & medicinal chemistry letters 20031215

Title: Syntheses and binding affinities of 6-nitroquipazine analogues for serotonin transporter: Part 3. A potential 5-HT transporter imaging agent, 3-(3-[18F]fluoropropyl)-6-nitroquipazine.

Journal: Bioorganic & medicinal chemistry 20031117

Title: Radical ring closures of 4-isocyanato carbon-centered radicals.

Journal: The Journal of organic chemistry 20030404

Title: Synthesis of 3-methoxycarbonylmethyl derivatives of dihydroquinolone and dihydrochromenone.

Journal: The Journal of organic chemistry 20010323

Title: Synthesis and vasorelaxing evaluation of alpha-methylidene-gamma-butyrolactone bearing quinolin-2(1H)-one and 3,4-dihydroquinolin-2(1H)-one derivatives.

Journal: European journal of medicinal chemistry 20010101

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Tags:553-03-7 Molecular Formula|553-03-7 MDL|553-03-7 SMILES|553-03-7 3,4-Dihydro-2(1H)-quinolinone |Heterocyclic_Building_Blocks