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556-67-2,MFCD00003269
Catalog No.:AA0035CO

556-67-2 | Octamethylcyclotetrasiloxane

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5g
98%(GC)
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25g
98%(GC)
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA0035CO
Chemical Name:
Octamethylcyclotetrasiloxane
CAS Number:
556-67-2
Molecular Formula:
C8H24O4Si4
Molecular Weight:
296.6158
MDL Number:
MFCD00003269
SMILES:
C[Si]1(C)O[Si](C)(C)O[Si](O[Si](O1)(C)C)(C)C
NSC Number:
345674
Properties
Properties
 
BP:
175.8°C  
Form:
Liquid  
MP:
17-18 °C(lit.)  
Refractive Index:
n20/D 1.396(lit.)  
Stability:
Moisture Sensitive  
Storage:
2-8℃;  

Computed Properties
 
Complexity:
197  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
16  
Hydrogen Bond Acceptor Count:
4  

Literature

Title: Agonistic effects of diverse xenobiotics on the constitutive androstane receptor as detected in a recombinant yeast-cell assay.

Journal: Toxicology in vitro : an international journal published in association with BIBRA 20180201

Title: Exposure to cyclic volatile methylsiloxanes (cVMS) causes anchorage-independent growth and reduction of BRCA1 in non-transformed human breast epithelial cells.

Journal: Journal of applied toxicology : JAT 20170401

Title: Environmental contaminants activate human and polar bear (Ursus maritimus) pregnane X receptors (PXR, NR1I2) differently.

Journal: Toxicology and applied pharmacology 20150401

Title: Prioritizing organic chemicals for long-term air monitoring by using empirical monitoring data--application to data from the Swedish screening program.

Journal: Environmental monitoring and assessment 20120801

Title: Determination of siloxanes in silicone products and potential migration to milk, formula and liquid simulants.

Journal: Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment 20120801

Title: High refractive index polysiloxane as injectable, in situ curable accommodating intraocular lens.

Journal: Biomaterials 20120801

Title: Food web accumulation of cyclic siloxanes in Lake Mjøsa, Norway.

Journal: Environmental science & technology 20120605

Title: Method for simultaneous determination of partition coefficients for cyclic volatile methylsiloxanes and dimethylsilanediol.

Journal: Analytical chemistry 20120221

Title: A surprise from 1954: siloxane equilibration is a simple, robust, and obvious polymer self-healing mechanism.

Journal: Journal of the American Chemical Society 20120201

Title: Quantitative force and dissipation measurements in liquids using piezo-excited atomic force microscopy: a unifying theory.

Journal: Nanotechnology 20111202

Title: Cyclic volatile methylsiloxane bioaccumulation in flounder and ragworm in the Humber Estuary.

Journal: Environmental science & technology 20110715

Title: Confinement-dependent damping in a layered liquid.

Journal: Journal of physics. Condensed matter : an Institute of Physics journal 20110323

Title: Survey of cyclic and linear siloxanes in sediment from the Songhua River and in sewage sludge from wastewater treatment plants, Northeastern China.

Journal: Archives of environmental contamination and toxicology 20110201

Title: Unraveling the properties of octamethylcyclotetrasiloxane under nanoscale confinement: atomistic view of the liquidlike state from molecular dynamics simulation.

Journal: The Journal of chemical physics 20110128

Title: Toward identifying the next generation of superfund and hazardous waste site contaminants.

Journal: Environmental health perspectives 20110101

Title: Physiologically based pharmacokinetic modeling: methodology, applications, and limitations with a focus on its role in pediatric drug development.

Journal: Journal of biomedicine & biotechnology 20110101

Title: Determination of cyclic volatile methylsiloxanes in biota with a purge and trap method.

Journal: Analytical chemistry 20101115

Title: Functionalised polysiloxanes as injectable, in situ curable accommodating intraocular lenses.

Journal: Biomaterials 20101101

Title: Volatile siloxanes in the European arctic: assessment of sources and spatial distribution.

Journal: Environmental science & technology 20101001

Title: Do epitaxy and temperature affect oscillatory solvation forces?

Journal: Langmuir : the ACS journal of surfaces and colloids 20100817

Title: Occurrence of cyclic and linear siloxanes in indoor dust from China, and implications for human exposures.

Journal: Environmental science & technology 20100815

Title: Dissipation and oscillatory solvation forces in confined liquids studied by small-amplitude atomic force spectroscopy.

Journal: Nanotechnology 20100813

Title: High-resolution friction force microscopy under electrochemical control.

Journal: The Review of scientific instruments 20100801

Title: Nonlinear rheology of a nanoconfined simple fluid.

Journal: Physical review letters 20100528

Title: Building a tiered approach to in vitro predictive toxicity screening: a focus on assays with in vivo relevance.

Journal: Combinatorial chemistry & high throughput screening 20100201

Title: Quantitative analysis of volatile methylsiloxanes in waste-to-energy landfill biogases using direct APCI-MS/MS.

Journal: Environmental science & technology 20100115

Title: Indoor air in beauty salons and occupational health exposure of cosmetologists to chemical substances.

Journal: International journal of environmental research and public health 20100101

Title: Assessment and validation of the CAESAR predictive model for bioconcentration factor (BCF) in fish.

Journal: Chemistry Central journal 20100101

Title: Molecular momentum transport at fluid-solid interfaces in MEMS/NEMS: a review.

Journal: International journal of molecular sciences 20091101

Title: Direct analysis of volatile methylsiloxanes in gaseous matrixes using atmospheric pressure chemical ionization-tandem mass spectrometry.

Journal: Analytical chemistry 20090901

Title: Siloxane treatment by adsorption into porous materials.

Journal: Environmental technology 20090901

Title: Low molecular weight cyclic volatile methylsiloxanes in cosmetic products sold in Canada: implication for dermal exposure.

Journal: Environment international 20090801

Title: Heats of mixing using an isothermal titration calorimeter: associated thermal effects.

Journal: International journal of molecular sciences 20090701

Title: Effect of ozone and relative humidity on the heterogeneous uptake of octamethylcyclotetrasiloxane and decamethylcyclopentasiloxane on model mineral dust aerosol components.

Journal: The journal of physical chemistry. A 20090625

Title: Temperature dependence of solvation forces as measured in atomic force microscopy.

Journal: The Journal of chemical physics 20090407

Title: A mechanistic study of cyclic siloxane pyrolyses at low pressures.

Journal: Physical chemistry chemical physics : PCCP 20081207

Title: Biological removal of siloxanes from landfill and digester gases: opportunities and challenges.

Journal: Environmental science & technology 20081115

Title: Inhalation dosimetry modeling with decamethylcyclopentasiloxane in rats and humans.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20081001

Title: Are highly lipophilic volatile compounds expected to bioaccumulate with repeated exposures?

Journal: Toxicology letters 20080630

Title: [Analysis of the volatile oils chemical constituents of roots of Actinidia deliciosa].

Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20080501

Title: Effect of tip size on force measurement in atomic force microscopy.

Journal: Langmuir : the ACS journal of surfaces and colloids 20080318

Title: In vitro and in vivo percutaneous absorption of 14C-octamethylcyclotetrasiloxane (14C-D4) and 14C-decamethylcyclopentasiloxane (14C-D5).

Journal: Regulatory toxicology and pharmacology : RTP 20080301

Title: Assessing kinetic determinants for metabolism and oral uptake of octamethylcyclotetrasiloxane (D4) from inhalation chamber studies.

Journal: Inhalation toxicology 20080201

Title: Physiologically based pharmacokinetic modeling of the disposition of octamethylcyclotetrasiloxane (D4) migration from implants in humans.

Journal: Journal of long-term effects of medical implants 20080101

Title: Freezing of fluids confined between mica surfaces.

Journal: The journal of physical chemistry. B 20071227

Title: Modeling of human dermal absorption of octamethylcyclotetrasiloxane (D(4)) and decamethylcyclopentasiloxane (D(5)).

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20071001

Title: Effects of octamethylcyclotetrasiloxane (D4) on the luteinizing hormone (LH) surge and levels of various reproductive hormones in female Sprague-Dawley rats.

Journal: Reproductive toxicology (Elmsford, N.Y.) 20070601

Title: Recent progress in the determination of solid surface tensions from contact angles.

Journal: Advances in colloid and interface science 20070328

Title: In vitro and in vivo evaluation of the estrogenic, androgenic, and progestagenic potential of two cyclic siloxanes.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20070301

Title: Surface melting of octamethylcyclotetrasiloxane confined in controlled pore glasses: curvature effects observed by 1H NMR.

Journal: The journal of physical chemistry. B 20070222

Title: A two-generation reproductive toxicity study of octamethylcyclotetrasiloxane (D4) in rats exposed by whole-body vapor inhalation.

Journal: Reproductive toxicology (Elmsford, N.Y.) 20070201

Title: An inhalation reproductive toxicity study of octamethylcyclotetrasiloxane (D4) in female rats using multiple and single day exposure regimens.

Journal: Reproductive toxicology (Elmsford, N.Y.) 20070201

Title: NMR cryoporometry with octamethylcyclotetrasiloxane as a probe liquid. Accessing large pores.

Journal: Journal of colloid and interface science 20070115

Title: Prediction of estrogen receptor agonists and characterization of associated molecular descriptors by statistical learning methods.

Journal: Journal of molecular graphics & modelling 20061101

Title: Diagnosing inborn errors of lipid metabolism with proton nuclear magnetic resonance spectroscopy.

Journal: Clinical chemistry 20060701

Title: Oscillatory dissipation of a simple confined liquid.

Journal: Physical review letters 20060303

Title: Interpretation of contact angle measurements on two different fluoropolymers for the determination of solid surface tension.

Journal: Journal of colloid and interface science 20051115

Title: Density functional theory calculation of (29)Si NMR chemical shifts of organosiloxanes.

Journal: The journal of physical chemistry. B 20050721

Title: Effects of age and pregnancy on cytochrome P450 induction by octamethyltetracyclosiloxane in female Sprague-Dawley rats.

Journal: Journal of biochemical and molecular toxicology 20050101

Title: How confined lubricants diffuse during shear.

Journal: Physical review letters 20041203

Title: Contact angle measurements with liquids consisting of bulky molecules.

Journal: Journal of colloid and interface science 20041115

Title: Octamethylcyclotetrasiloxane exhibits estrogenic activity in mice via ERalpha.

Journal: Toxicology and applied pharmacology 20031101

Title: PBPK modeling advances understanding of D4 pharmacokinetics.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20030301

Title: Physiological modeling of inhalation kinetics of octamethylcyclotetrasiloxane in humans during rest and exercise.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20030301

Title: Determination of siloxanes, silicon, and platinum in tissues of women with silicone gel-filled implants.

Journal: Analytical and bioanalytical chemistry 20030201

Title: Route-specific differences in distribution characteristics of octamethylcyclotetrasiloxane in rats: analysis using PBPK models.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20030101

Title: The measurement of conformational stability of proteins adsorbed on siloxanes.

Journal: Journal of biomaterials science. Polymer edition 20030101

Title: Bioavailability of D4 after inhalation and implantation exposure to silicones.

Journal: Environmental health perspectives 20020801

Title: Further comments on the bioavailability of D4.

Journal: Environmental health perspectives 20020801

Title: Dose-response modeling of cytochrome p450 induction in rats by octamethylcyclotetrasiloxane.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20020601

Title: Effect of interfacial liquid structuring on the coherence length in nanolubrication.

Journal: Physical review letters 20020415

Title: Study of the advancing and receding contact angles: liquid sorption as a cause of contact angle hysteresis.

Journal: Advances in colloid and interface science 20020225

Title: Inhalation toxicology of octamethylcyclotetrasiloxane (D4) following a 3-month nose-only exposure in Fischer 344 rats.

Journal: International journal of toxicology 20020101

Title: The effect of cyclic swelling (octamethylcyclotetrasiloxane) on the physical properties of silicone breast implant shells.

Journal: Journal of biomaterials science. Polymer edition 20020101

Title: Percutaneous absorption studies of octamethylcyclotetrasiloxane using the human skin/nude mouse model.

Journal: Skin pharmacology and applied skin physiology 20020101

Title: Bioavailability of octamethylcyclotetrasiloxane (D(4)) after exposure to silicones by inhalation and implantation.

Journal: Environmental health perspectives 20011101

Title: Potential estrogenic and antiestrogenic activity of the cyclic siloxane octamethylcyclotetrasiloxane (D4) and the linear siloxane hexamethyldisiloxane (HMDS) in immature rats using the uterotrophic assay.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20010901

Title: Repeated inhalation exposure to octamethylcyclotetrasiloxane produces hepatomegaly, transient hepatic hyperplasia, and sustained hypertrophy in female Fischer 344 rats in a manner similar to phenobarbital.

Journal: Toxicology and applied pharmacology 20010415

Title: Physiological modeling reveals novel pharmacokinetic behavior for inhaled octamethylcyclotetrasiloxane in rats.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20010401

Title: Determination of low molecular weight silicones in plasma and blood of women after exposure to silicone breast implants by GC/MS.

Journal: Analytical chemistry 20010201

Title: The transport of octamethylcyclotetrasiloxane (D4) and polydimethylsiloxane (PDMS) in lightly cross-linked silicone rubber.

Journal: Journal of biomaterials science. Polymer edition 20010101

Title: Microbial degradation of octamethylcyclotetrasiloxane.

Journal: Applied and environmental microbiology 19990501

Title: Cyclosiloxanes produce fatal liver and lung damage in mice.

Journal: Environmental health perspectives 19990201

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