Home Amines 5579-84-0
5579-84-0,MFCD00012813
Catalog No.:AA00I9VK

5579-84-0 | methyl[2-(pyridin-2-yl)ethyl]amine dihydrochloride

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1g
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5g
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25g
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100g
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500g
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00I9VK
Chemical Name:
methyl[2-(pyridin-2-yl)ethyl]amine dihydrochloride
CAS Number:
5579-84-0
Molecular Formula:
C8H14Cl2N2
Molecular Weight:
209.1162
MDL Number:
MFCD00012813
SMILES:
CNCCc1ccccn1.Cl.Cl
Properties
Computed Properties
 
Complexity:
83.3  
Covalently-Bonded Unit Count:
3  
Heavy Atom Count:
12  
Hydrogen Bond Acceptor Count:
2  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
3  

Literature

Title: Histamine H4 receptor antagonists as potent modulators of mammalian vestibular primary neuron excitability.

Journal: British journal of pharmacology 20121001

Title: Reducing olanzapine-induced weight gain side effect by using betahistine: a study in the rat model.

Journal: Journal of psychopharmacology (Oxford, England) 20120901

Title: Involvement of histamine receptors in SAPK/JNK phosphorylation.

Journal: International immunopharmacology 20120601

Title: Comparison of the therapeutic efficacy of a fixed low-dose combination of cinnarizine and dimenhydrinate with betahistine in vestibular neuritis: a randomized, double-blind, non-inferiority study.

Journal: Clinical drug investigation 20120601

Title: Effect of transtympanic low-pressure therapy in patients with unilateral Menière's disease unresponsive to betahistine: a randomised, placebo-controlled, double-blinded, clinical trial.

Journal: The Journal of laryngology and otology 20120401

Title: Meniere's disease: an evidence based approach to assessment and management.

Journal: International journal of clinical practice 20120201

Title: Development of novel sustained release matrix pellets of betahistine dihydrochloride: effect of lipophilic surfactants and co-surfactants.

Journal: Pharmaceutical development and technology 20120101

Title: The effects of betahistine in addition to epley maneuver in posterior canal benign paroxysmal positional vertigo.

Journal: Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery 20120101

Title: Duplicate internal auditory canals with facial and vestibulocochlear nerve dysfunction.

Journal: The Journal of laryngology and otology 20120101

Title: Betahistine exerts a dose-dependent effect on cochlear stria vascularis blood flow in guinea pigs in vivo.

Journal: PloS one 20120101

Title: [Efficacy of vestibo in the treatment of vertebrobasilar insufficiency].

Journal: Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20120101

Title: Topical application of betahistine improves eustachian tube function in an animal model.

Journal: Acta oto-laryngologica 20111101

Title: High-dosage betahistine dihydrochloride between 288 and 480 mg/day in patients with severe Menière's disease: a case series.

Journal: European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery 20110801

Title: Betahistine treatment improves the recovery of static symptoms in patients with unilateral vestibular loss.

Journal: Journal of clinical pharmacology 20110401

Title: Development and optimization of a multiple-unit controlled release formulation of a freely water soluble drug for once-daily administration.

Journal: International journal of pharmaceutics 20110227

Title: Comparison of efficacy of different treatment methods in the treatment of idiopathic tinnitus.

Journal: Kulak burun bogaz ihtisas dergisi : KBB = Journal of ear, nose, and throat 20110101

Title: [Prospects for the use of histaminergic preparations for the purpose of noise otoprotection].

Journal: Vestnik otorinolaringologii 20110101

Title: Betahistine in the treatment of tinnitus in patients with vestibular disorders.

Journal: Brazilian journal of otorhinolaryngology 20110101

Title: [Betahistine in the treatment of vestibular and coordination disturbances in multiple sclerosis].

Journal: Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20110101

Title: A predictive ligand-based Bayesian model for human drug-induced liver injury.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20101201

Title: An elderly female patient with tardive oromandibular dystonia after prolonged use of the histamine analog betahistine.

Journal: Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 20101001

Title: Allergy and its relation to Meniere's disease.

Journal: Otolaryngologic clinics of North America 20101001

Title: Medical and noninvasive therapy for Meniere's disease.

Journal: Otolaryngologic clinics of North America 20101001

Title: Medical management of Ménière's disease: a 10-year case series and review of literature.

Journal: European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery 20100901

Title: Effects of betahistine at histamine H3 receptors: mixed inverse agonism/agonism in vitro and partial inverse agonism in vivo.

Journal: The Journal of pharmacology and experimental therapeutics 20100901

Title: Does betahistine treatment have additional benefits to vestibular rehabilitation?

Journal: European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery 20100801

Title: Comprehensive analysis of MHC class I genes from the U-, S-, and Z-lineages in Atlantic salmon.

Journal: BMC genomics 20100101

Title: Comparative bioavailability of betahistine tablet formulations administered in healthy subjects.

Journal: Arzneimittel-Forschung 20100101

Title: Organic functionalization of single-walled carbon nanotubes (SWCNTs) with some chemotherapeutic agents as a potential method for drug delivery.

Journal: International journal of nanomedicine 20100101

Title: Effects of betahistine on patient-reported outcomes in routine practice in patients with vestibular vertigo and appraisal of tolerability: experience in the OSVaLD study.

Journal: The international tinnitus journal 20100101

Title: Effect of treatment with betahistine dihydrochloride on the postural stability in patients with different duration of benign paroxysmal positional vertigo.

Journal: The international tinnitus journal 20100101

Title: Comparable efficacy and tolerability between twice daily and three times daily betahistine for Ménière's disease.

Journal: Acta oto-laryngologica 20090501

Title: Frequency of ill-founded off-label prescribing in Dutch general practice.

Journal: Pharmacoepidemiology and drug safety 20090101

Title: [Comparable efficacy between twice and three times daily for treatment of balance system disturbances].

Journal: Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego 20090101

Title: [Vestibular disorders in patients with otosclerosis: prevalence, diagnostic and therapeutic options].

Journal: Vestnik otorinolaringologii 20090101

Title: [Picrotoxin in the treatment of Menière's disease].

Journal: Laryngo- rhino- otologie 20081201

Title: Effect of histaminergic manipulation on weight in obese adults: a randomized placebo controlled trial.

Journal: International journal of obesity (2005) 20081001

Title: Management of Ménière's disease in general practice: adherence to the UK National Health Service 'Prodigy' guidelines.

Journal: The Journal of laryngology and otology 20080801

Title: Stress degradation studies on betahistine and development of a validated stability-indicating assay method.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20080615

Title: Efficacy of a home-based exercise program on benign paroxysmal positional vertigo compared with betahistine.

Journal: Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale 20080601

Title: Long-term prophylactic treatment of attacks of vertigo in Menière's disease--comparison of a high with a low dosage of betahistine in an open trial.

Journal: Acta oto-laryngologica 20080501

Title: Betahistine: what's new on the agenda?

Journal: Expert opinion on investigational drugs 20080501

Title: Prescribing practices for Betahistine.

Journal: British journal of clinical pharmacology 20080401

Title: Improving the quality of life in patients with vestibular disorders: the role of medical treatments and physical rehabilitation.

Journal: International journal of clinical practice 20080101

Title: Treatment of vertebrobasilar insufficiency--associated vertigo with a fixed combination of cinnarizine and dimenhydrinate.

Journal: The international tinnitus journal 20080101

Title: Multimodal therapy for chronic tinnitus.

Journal: The international tinnitus journal 20080101

Title: [Vestibo in the treatment of cochleovestibular disorders].

Journal: Vestnik otorinolaringologii 20080101

Title: Disability in patients with Menière's disease following the use of two different treatment modalities: betahistine and intratympanic gentamicin.

Journal: Revue de laryngologie - otologie - rhinologie 20080101

Title: [Diagnostic and treatment of the vestibular apparatus diseases in the climacteric patients].

Journal: Akusherstvo i ginekologiia 20080101

Title: Patient baseline characteristics in an open-label multinational study of betahistine in recurrent peripheral vestibular vertigo: the OSVaLD study.

Journal: Current medical research and opinion 20071101

Title: Histaminergic ligands improve vestibular compensation in the cat: behavioural, neurochemical and molecular evidence.

Journal: European journal of pharmacology 20070730

Title: [Frequently occurring forms of dizziness and their treatment].

Journal: MMW Fortschritte der Medizin 20070521

Title: Optimizing the pharmacological component of integrated balance therapy.

Journal: Brazilian journal of otorhinolaryngology 20070101

Title: [Vestibular neuritis--a case description].

Journal: Otolaryngologia polska = The Polish otolaryngology 20070101

Title: [Current methods for diagnosis and treatment of iatrogenic ototoxicity].

Journal: Vestnik otorinolaringologii 20070101

Title: Reversible sensorineural hearing loss in a girl with Kawasaki disease.

Journal: The Turkish journal of pediatrics 20070101

Title: [Therapy of tinnitus in children].

Journal: Otolaryngologia polska = The Polish otolaryngology 20070101

Title: [Comparative assessment of results in cervical vertigo pharmacotherapy vs physiotherapy treatment].

Journal: Otolaryngologia polska = The Polish otolaryngology 20070101

Title: Efficacy of histaminergic drugs in experimental motion sickness.

Journal: Journal of vestibular research : equilibrium & orientation 20070101

Title: Menière's disease.

Journal: BMJ clinical evidence 20070101

Title: [Fluctuating deafness].

Journal: Annales d'oto-laryngologie et de chirurgie cervico faciale : bulletin de la Societe d'oto-laryngologie des hopitaux de Paris 20061201

Title: [Treatment costs of otogenic vertigo].

Journal: Medizinische Klinik (Munich, Germany : 1983) 20061115

Title: Betahistine in the treatment of vertiginous syndromes: a meta-analysis.

Journal: Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale 20060801

Title: Betahistine increases ACh release from the cortex, but not histamine release from the nucleus basalis magnocellularis of freely-moving rats. 2. Histaminergic mechanisms in the CNS.

Journal: Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20060401

Title: [Efficacy of Betahistine Mesilate combined with Flunarizine Hydrochloride for treating tinnitus].

Journal: Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery 20060401

Title: [Assessment of betahistine dihydrochloride effectiveness in the treatment of vertigo of a different aetiology based on videonystagmography test results].

Journal: Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego 20060301

Title: [Betaserc in the treatment of vestibular dysfunctions of different etiology].

Journal: Vestnik otorinolaringologii 20060101

Title: Betahistine: a retrospective synopsis of safety data.

Journal: Drug safety 20060101

Title: [Betaserk in therapy of cochleovestibular disordes].

Journal: Vestnik otorinolaringologii 20060101

Title: [Clinical effectiveness of betahistine in monotherapy of vertigo for different etiology].

Journal: Otolaryngologia polska = The Polish otolaryngology 20060101

Title: [Assessment of betahistine dihydrochloride effectiveness in the treatment of disturbance of balance system, based on analysis of doctors and patients questionnaires results].

Journal: Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego 20060101

Title: Histamine (H3) receptors modulate the excitatory amino acid receptor response of the vestibular afferents.

Journal: Brain research 20051207

Title: Menière's disease.

Journal: Clinical evidence 20051201

Title: [Vertigo attacks -- current therapy].

Journal: Laryngo- rhino- otologie 20051101

Title: Dose- and duration-dependent effects of betahistine dihydrochloride treatment on histamine turnover in the cat.

Journal: European journal of pharmacology 20051031

Title: [A clinical study on the effect of Yinxing Damo combined with betahistine hydrochloride injection on vertebral basilar artery ischemic vertigo].

Journal: Chinese journal of integrative medicine 20050901

Title: Effects of betahistine on the spatiotemporal response properties of vestibulospinal neurons to labyrinthine volleys.

Journal: European journal of pharmacology 20050516

Title: Benign paroxysmal positional vertigo: a study of two manoeuvres with and without betahistine.

Journal: Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale 20050401

Title: The effect of betahistine, a histamine H1 receptor agonist/H3 antagonist, on olanzapine-induced weight gain in first-episode schizophrenia patients.

Journal: International clinical psychopharmacology 20050301

Title: A national survey amongst UK otolaryngologists regarding the treatment of Ménière's disease.

Journal: The Journal of laryngology and otology 20050201

Title: Treatment of vertigo with a homeopathic complex remedy compared with usual treatments: a meta-analysis of clinical trials.

Journal: Arzneimittel-Forschung 20050101

Title: [Betaserc and improvement of life quality in war veterans].

Journal: Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20050101

Title: [Betaserk in the treatment of aftereffects of craniocerebral injury and vascular events].

Journal: Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20050101

Title: [Epidemiology, clinical features and betaserc therapy of vertigo in initial and reversible cerebrovascular pathology].

Journal: Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20050101

Title: [Efficacy of betaserk in experimental motor disease].

Journal: Vestnik otorinolaringologii 20050101

Title: [Clinico-neurological and stabilometric analysis of betahistine (betaserc) efficacy in the patients with vertigo in the rehabilitation period of ischemic stroke].

Journal: Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20050101

Title: Meniere's disease.

Journal: Clinical evidence 20041201

Title: [Delirium in a 73-year-old man after many years of unwise use of betahistine].

Journal: Nederlands tijdschrift voor geneeskunde 20041120

Title: Menière's disease.

Journal: Clinical evidence 20040601

Title: [The role of betaserk in combined treatment of neurosensory hypoacusis and vestibulopathy in childhood].

Journal: Vestnik otorinolaringologii 20040101

Title: [Rehabilitation of patients with peripheral vestibular disorders].

Journal: Vestnik otorinolaringologii 20040101

Title: [Betaserc treatment of psychogenic vertigo].

Journal: Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20040101

Title: [Pharmacological correction of cochleovestibular impairments].

Journal: Vestnik otorinolaringologii 20040101

Title: [A use of betaserc in ataxic syndromes].

Journal: Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20040101

Title: Management of idiopathic sudden sensorineural hearing loss: experience in newly developing Qatar.

Journal: The international tinnitus journal 20040101

Title: Investigation of Betaserc in auditory and vestibular disturbances.

Journal: The international tinnitus journal 20040101

Title: Betahistine in vertebrobasilar insufficiency.

Journal: The international tinnitus journal 20040101

Title: [Cerebral hemodynamics and statokinetic functions in patients with vertebral basilar vascular insufficiency].

Journal: Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20040101

Title: LC-MS-MS analysis of 2-pyridylacetic acid, a major metabolite of betahistine: application to a pharmacokinetic study in healthy volunteers.

Journal: Xenobiotica; the fate of foreign compounds in biological systems 20031201

Title: Double-blind, randomized, multicenter study comparing the effect of betahistine and flunarizine on the dizziness handicap in patients with recurrent vestibular vertigo.

Journal: Acta oto-laryngologica 20030601

Title: Menière's disease.

Journal: Clinical evidence 20030601

Title: Homeopathic vs conventional treatment of vertigo.

Journal: Archives of otolaryngology--head & neck surgery 20030401

Title: Influence of 3 antivertiginous medications on the vigilance of healthy volunteers.

Journal: International journal of clinical pharmacology and therapeutics 20030401

Title: Evaluation of a sol-gel derived carbon composite electrode as an amperometric detector for capillary electrophoresis.

Journal: Journal of chromatography. A 20030328

Title: Betahistine dihydrochloride in the treatment of peripheral vestibular vertigo.

Journal: European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery 20030201

Title: [Vestibular migraine].

Journal: Likars'ka sprava 20030101

Title: [Comparative efficacy of betaserc and cinnarizine of vertigo in patients with migraine].

Journal: Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20030101

Title: Evaluation of betahistine for the prevention of seasickness: effect on vestibular function, psychomotor performance and efficacy at sea.

Journal: Journal of vestibular research : equilibrium & orientation 20030101

Title: [Current approaches to the treatment of vertigo in children].

Journal: Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20030101

Title: Betahistine dihydrochloride interaction with the histaminergic system in the cat: neurochemical and molecular mechanisms.

Journal: European journal of pharmacology 20020620

Title: [Betaserc in symptomatic therapy of multiple sclerosis].

Journal: Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20020101

Title: [Betaserc treatment of acute disorders of cerebral circulation with vestibulo-ataxic and cochleo-vestibular syndromes].

Journal: Vestnik otorinolaringologii 20020101

Title: [A variant of monotherapy in vertigo and subjective noise in the ears].

Journal: Vestnik otorinolaringologii 20020101

Title: Fixed combination of cinnarizine and dimenhydrinate versus betahistine dimesylate in the treatment of Ménière's disease: a randomized, double-blind, parallel group clinical study.

Journal: The international tinnitus journal 20020101

Title: The effect of betahistine on vestibular habituation: comparison of rotatory and sway habituation training.

Journal: Acta oto-laryngologica 20010701

Title: Betahistine in the treatment of vertigo. History and clinical implications of recent pharmacological researches.

Journal: Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale 20010601

Title: The pharmacology of betahistine in the context of the vestibular system.

Journal: Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale 20010601

Title: Effects of betahistine and of its metabolites on vestibular sensory organs.

Journal: Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale 20010601

Title: Action mechanism of betahistine in the vestibular end organs.

Journal: Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale 20010601

Title: Binding affinity profile of betahistine and its metabolites for central histamine receptors of rodents.

Journal: Pharmacological research 20010401

Title: Betahistine for Menière's disease or syndrome.

Journal: The Cochrane database of systematic reviews 20010101

Title: Effect of positively and negatively charged liposomes on skin permeation of drugs.

Journal: Journal of drug targeting 20010101

Title: [Betaserk efficiency in cochlear and vestibular disorders in the regional surdocenter].

Journal: Vestnik otorinolaringologii 20010101

Title: Betahistine produces post-synaptic inhibition of the excitability of the primary afferent neurons in the vestibular endorgans.

Journal: Acta oto-laryngologica. Supplementum 20010101

Title: Histamine and betahistine in the treatment of vertigo: elucidation of mechanisms of action.

Journal: CNS drugs 20010101

Title: [Menière's disease. Current status].

Journal: Revue de laryngologie - otologie - rhinologie 20010101

Title: Betahistine inhibits food intake in rats.

Journal: Polish journal of pharmacology 20010101

Title: Laboral outcome after acute unilateral vestibulopathy.

Journal: Neurologia i neurochirurgia polska 20010101

Title: [Acute dystonia secondary to treatment with betahistine].

Journal: Neurologia (Barcelona, Spain) 20001101

Title: Postmarketing study of the use of flunarizine in vestibular vertigo and in migraine.

Journal: European journal of clinical pharmacology 19960101

Title: A study of the effect of betahistine on gastric acid secretion in man.

Journal: Current medical research and opinion 19740101

Title: Poyurovsky M, et al. The effect of betahistine, a histamine H1 receptor agonist/H3 antagonist, on olanzapine-induced weight gain in first-episode schizophrenia patients. Int Clin Psychopharmacol. 2005 Mar;20(2):101-3.

Title: Gbahou F, et al. Effects of betahistine at histamine H3 receptors: mixed inverse agonism/agonism in vitro and partial inverse agonism in vivo.J Pharmacol Exp Ther. 2010 Sep 1;334(3):945-54.

Title: Tang KT, et al. Betahistine attenuates murine collagen-induced arthritis by suppressing both inflammatory and Th17 cell responses.Int Immunopharmacol. 2016 Oct;39:236-245.

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Tags:5579-84-0 Molecular Formula|5579-84-0 MDL|5579-84-0 SMILES|5579-84-0 methyl[2-(pyridin-2-yl)ethyl]amine dihydrochloride |Heterocyclic_Building_Blocks