Home Fluorides 575-03-1
575-03-1,MFCD00037578
Catalog No.:AA00E8VV

575-03-1 | 7-Hydroxy-4-(trifluoromethyl)coumarin

Pack Size
Purity
Availability
Price(USD)
Quantity
  
250mg
98%
in stock  
$14.00   $10.00
- +
1g
95%
in stock  
$18.00   $13.00
- +
5g
98%
in stock  
$70.00   $49.00
- +
10g
98%
in stock  
$133.00   $93.00
- +
25g
98%
in stock  
$323.00   $226.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00E8VV
Chemical Name:
7-Hydroxy-4-(trifluoromethyl)coumarin
CAS Number:
575-03-1
Molecular Formula:
C10H5F3O3
Molecular Weight:
230.1401
MDL Number:
MFCD00037578
SMILES:
Oc1ccc2c(c1)oc(=O)cc2C(F)(F)F
NSC Number:
138174
Properties
Properties
 
BP:
311.4 °C at 760 mmHg  
Form:
Solid  
MP:
178-180 °C(lit.)  
Solubility:
DMF: soluble  
Storage:
Keep in dry area;Room Temperature;  

Computed Properties
 
Complexity:
335  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
16  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
1  
XLogP3:
2.4  

Literature

Title: Interactions of sesquiterpenes zederone and germacrone with the human cytochrome P450 system.

Journal: Toxicology in vitro : an international journal published in association with BIBRA 20130901

Title: Design, synthesis, and evaluation of coumarin-based molecular probes for imaging of myelination.

Journal: Journal of medicinal chemistry 20110414

Title: A new ultrafast and high-throughput mass spectrometric approach for the therapeutic drug monitoring of the multi-targeted anti-folate pemetrexed in plasma from lung cancer patients.

Journal: Analytical and bioanalytical chemistry 20101201

Title: Functional characterization of human and cynomolgus monkey UDP-glucuronosyltransferase 1A1 enzymes.

Journal: Life sciences 20100814

Title: Pazopanib-induced hyperbilirubinemia is associated with Gilbert's syndrome UGT1A1 polymorphism.

Journal: British journal of cancer 20100427

Title: Defining the in Vivo Role for cytochrome b5 in cytochrome P450 function through the conditional hepatic deletion of microsomal cytochrome b5.

Journal: The Journal of biological chemistry 20081114

Title: Amino acid positions 69-132 of UGT1A9 are involved in the C-glucuronidation of phenylbutazone.

Journal: Archives of biochemistry and biophysics 20081001

Title: Quantitative analysis of antiretroviral drugs in lysates of peripheral blood mononuclear cells using MALDI-triple quadrupole mass spectrometry.

Journal: Analytical chemistry 20080701

Title: Determination of CYP2B6 component of 7-ethoxy-4-trifluoromethylcoumarin O-deethylation activity in human liver microsomes.

Journal: Methods in molecular biology (Clifton, N.J.) 20060101

Title: The naturally occurring cytochrome P450 (P450) 2B6 K262R mutant of P450 2B6 exhibits alterations in substrate metabolism and inactivation.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20050601

Title: Identification of UGT2B9*2 and UGT2B33 isolated from female rhesus monkey liver.

Journal: Archives of biochemistry and biophysics 20040601

Title: Quaternary ammonium-linked glucuronidation of tamoxifen by human liver microsomes and UDP-glucuronosyltransferase 1A4.

Journal: Biochemical pharmacology 20040601

Title: Silybin inactivates cytochromes P450 3A4 and 2C9 and inhibits major hepatic glucuronosyltransferases.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20040601

Title: Identification of human UDP-glucuronosyltransferase enzyme(s) responsible for the glucuronidation of posaconazole (Noxafil).

Journal: Drug metabolism and disposition: the biological fate of chemicals 20040201

Title: Generation and validation of rapid computational filters for cyp2d6 and cyp3a4.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20030901

Title: Functional characterization of wild-type and variant (T202I and M59I) human UDP-glucuronosyltransferase 1A10.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20030501

Title: Retention of transporter activities in cryopreserved, isolated rat hepatocytes.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20030401

Title: Isolation and characterization of a UDP-glucuronosyltransferase (UGT1A01) cloned from female rhesus monkey.

Journal: Archives of biochemistry and biophysics 20020615

Title: Effects of plant-derived phenols on rat liver cytochrome P450 2B1 activity.

Journal: Anticancer research 20020101

Title: Evaluation of 7-benzyloxy-4-trifluoromethylcoumarin, some other 7-hydroxy-4-trifluoromethylcoumarin derivatives and 7-benzyloxyquinoline as fluorescent substrates for rat hepatic cytochrome P450 enzymes.

Journal: Xenobiotica; the fate of foreign compounds in biological systems 20011201

Title: Metabolism of 2,5-bis(trifluoromethyl)-7-benzyloxy-4-trifluoromethylcoumarin by human hepatic CYP isoforms: evidence for selectivity towards CYP3A4.

Journal: Xenobiotica; the fate of foreign compounds in biological systems 20010401

Title: Isolation and characterization of the fungal metabolite 3-O-methylviridicatin as an inhibitor of tumour necrosis factor alpha-induced human immunodeficiency virus replication.

Journal: Antiviral chemistry & chemotherapy 19980301

Title: Examination of purported probes of human CYP2B6.

Journal: Pharmacogenetics 19970601

Quotation Request
Company Name:
*
Contact Person:
*
Email:
*
Quantity Required:
*
Country:
Additional Info:
SDS
Tags:575-03-1 Molecular Formula|575-03-1 MDL|575-03-1 SMILES|575-03-1 7-Hydroxy-4-(trifluoromethyl)coumarin |Halogenated_Heterocycles