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58652-20-3,MFCD00941390
Catalog No.:AA01CBPO

58652-20-3 | 19-Norpregna-4,6-diene-3,20-dione, 17-(acetyloxy)-6-methyl-

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50mg
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200mg
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1g
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  • Technical Information
  • Properties
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Technical Information
Catalog Number:
AA01CBPO
Chemical Name:
19-Norpregna-4,6-diene-3,20-dione, 17-(acetyloxy)-6-methyl-
CAS Number:
58652-20-3
Molecular Formula:
C23H30O4
Molecular Weight:
370.4819
MDL Number:
MFCD00941390
SMILES:
CC(=O)O[C@@]1(CC[C@@H]2[C@]1(C)CC[C@H]1[C@H]2C=C(C2=CC(=O)CC[C@H]12)C)C(=O)C
Properties
Computed Properties
 
Complexity:
775  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
6  
Heavy Atom Count:
27  
Hydrogen Bond Acceptor Count:
4  
Rotatable Bond Count:
3  
XLogP3:
2.6  

Literature

Title: Nomegestrol acetate sequentially or continuously combined to estradiol did not negatively affect membrane-receptor associated progestogenic effects in human breast cancer cells.

Journal: Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 20121101

Title: Nomegestrol acetate/estradiol: in oral contraception.

Journal: Drugs 20121001

Title: Efficacy, safety, and tolerability of a monophasic oral contraceptive containing nomegestrol acetate and 17β-estradiol: a randomized controlled trial.

Journal: Obstetrics and gynecology 20120501

Title: [Oral combined hormonal contraception containing nomegestrol acetate and 17beta-oestradiol--the statement of Polish Gynecological Society Experts Group].

Journal: Ginekologia polska 20120401

Title: [Zoely, a combined oral contraceptive, monophasic pill containing estradiol and nomegestrol acetate].

Journal: Revue medicale de Liege 20120301

Title: Effects of a monophasic combined oral contraceptive containing nomegestrol acetate and 17β-oestradiol in comparison to one containing levonorgestrel and ethinylestradiol on markers of endocrine function.

Journal: The European journal of contraception & reproductive health care : the official journal of the European Society of Contraception 20111201

Title: Efficacy and tolerability of a monophasic combined oral contraceptive containing nomegestrol acetate and 17β-oestradiol in a 24/4 regimen, in comparison to an oral contraceptive containing ethinylestradiol and drospirenone in a 21/7 regimen.

Journal: The European journal of contraception & reproductive health care : the official journal of the European Society of Contraception 20111201

Title: Effects of a monophasic combined oral contraceptive containing nomegestrol acetate and 17β-oestradiol compared with one containing levonorgestrel and ethinylestradiol on haemostasis, lipids and carbohydrate metabolism.

Journal: The European journal of contraception & reproductive health care : the official journal of the European Society of Contraception 20111201

Title: Comparison of a 24-day and a 21-day pill regimen for the novel combined oral contraceptive, nomegestrol acetate and 17β-estradiol (NOMAC/E2): a double-blind, randomized study.

Journal: Human reproduction (Oxford, England) 20110601

Title: Nomegestrol acetate, a novel progestogen for oral contraception.

Journal: Steroids 20110501

Title: Inhibition of ovulation by NOMAC/E2, a novel monophasic oral contraceptive combining nomegestrol acetate and 17β-oestradiol: a double-blind, randomised, dose-finding pilot study.

Journal: The European journal of contraception & reproductive health care : the official journal of the European Society of Contraception 20110401

Title: Haemostatic effects of a new combined oral contraceptive, nomegestrol acetate/17β-estradiol, compared with those of levonorgestrel/ethinyl estradiol. A double-blind, randomised study.

Journal: Thrombosis and haemostasis 20110301

Title: Multiple sclerosis and progestins: a comment to POPART'MUS.

Journal: Journal of the neurological sciences 20110115

Title: The use of nomegestrol acetate in rapid preparation of endometrium before operative hysteroscopy in pre-menopausal women.

Journal: Steroids 20101201

Title: Effects of a monophasic combined oral contraceptive containing nomegestrol acetate and 17 beta-oestradiol on ovarian function in comparison to a monophasic combined oral contraceptive containing drospirenone and ethinylestradiol.

Journal: The European journal of contraception & reproductive health care : the official journal of the European Society of Contraception 20101001

Title: Nomegestrol acetate: pharmacology, safety profile and therapeutic efficacy.

Journal: Drugs 20100326

Title: [Nomegestrol acetate: clinical pharmacology].

Journal: Minerva ginecologica 20091001

Title: Certain progestins prevent the enhancing effect of 17beta-estradiol on NO-mediated inhibition of platelet aggregation by endothelial cells.

Journal: Arteriosclerosis, thrombosis, and vascular biology 20090401

Title: An open-label study of subdermal implants of estradiol-only versus subdermal implants of estradiol plus nomegestrol acetate: effects on symptom control, lipid profile and tolerability.

Journal: Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 20090401

Title: Effects of nomegestrol acetate administration on central and peripheral beta-endorphin and allopregnanolone in ovx rats.

Journal: The Journal of steroid biochemistry and molecular biology 20080501

Title: Letter by Micheletti and Chevallier regarding article, 'Hormone therapy and venous thromboembolism among postmenopausal women: impact of the route of estrogen administration and progestogens: the ESTHER Study'.

Journal: Circulation 20070925

Title: [Evaluation of the climacteric symptomatology modifications and clinical-instrumental parameters in women in physiological menopause treated with hormone replacement therapy with nomegestrol acetate and in surgical menopause treated with estrogen replacement therapy. Part I].

Journal: Minerva ginecologica 20070601

Title: Effects of a single Silastic contraceptive implant containing nomegestrol acetate (Uniplant) on endometrial morphology and ovarian function for 1 year.

Journal: Contraception 20061201

Title: Activation of nitric oxide synthesis in human endothelial cells using nomegestrol acetate.

Journal: Obstetrics and gynecology 20061001

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Title: Effects of estrogen, raloxifene, and hormone replacement therapy on serum C-reactive protein and homocysteine levels.

Journal: Maturitas 20060220

Title: New progestagens for contraceptive use.

Journal: Human reproduction update 20060101

Title: Cyclic progestin administration increases energy expenditure and decreases body fat mass in perimenopausal women.

Journal: Menopause (New York, N.Y.) 20060101

Title: Nomegestrol acetate may enhance the skeletal effects of estradiol on biochemical markers of bone turnover in menopausal women after a 12-week treatment period.

Journal: Climacteric : the journal of the International Menopause Society 20050601

Title: [Actions of a 19-norprogesterone derivative on mammary gland: nomegestrol acetate].

Journal: Journal de gynecologie, obstetrique et biologie de la reproduction 20050201

Title: Effect of nomegestrol acetate on estrogen biosynthesis and transformation in MCF-7 and T47-D breast cancer cells.

Journal: The Journal of steroid biochemistry and molecular biology 20050101

Title: Control of sulfatase activity by nomegestrol acetate in normal and cancerous human breast tissues.

Journal: Anticancer research 20050101

Title: Progestogens: effects on clinical and biochemical parameters in postmenopausal women.

Journal: Menopause (New York, N.Y.) 20050101

Title: Bleeding patterns during continuous estradiol with different sequential progestogens therapy.

Journal: Menopause (New York, N.Y.) 20050101

Title: A comparison of the central effects of different progestins used in hormone replacement therapy.

Journal: Maturitas 20040820

Title: Nomegestrol acetate: a progestin that deserves recognition.

Journal: Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20040401

Title: An overview of nomegestrol acetate selective receptor binding and lack of estrogenic action on hormone-dependent cancer cells.

Journal: The Journal of steroid biochemistry and molecular biology 20031101

Title: Effects of progestins of human proliferative endometrium: an in vitro model of potential clinical relevance.

Journal: International journal of molecular medicine 20031001

Title: [Effects of a 19-norprogesterone derivative, the fourth decade nomegestrol acetate, on lipids].

Journal: Annales d'endocrinologie 20030601

Title: [Comparison of changes in biochemical markers of bone turnover after 6 months of hormone replacement therapy with either transdermal 17 beta-estradiol or equine conjugated estrogen plus nomegestrol acetate].

Journal: Gynecologie, obstetrique & fertilite 20030501

Title: [Antigonadotropic effects of a 19-nor-progesterone derivative: the example of nomegestrol acetate].

Journal: Gynecologie, obstetrique & fertilite 20030101

Title: Effect of nomegestrol acetate on human estrogen sulfotransferase activity in the hormone-dependent MCF-7 and T-47D breast cancer cell lines.

Journal: Anticancer research 20030101

Title: [Reversal of nomegestrol acetate on multidrug resistance in drug-resistant human breast cancer cell line MCF7/ADR].

Journal: Zhonghua zhong liu za zhi [Chinese journal of oncology] 20020301

Title: Nonmenstrual adverse events during use of implantable contraceptives for women: data from clinical trials.

Journal: Contraception 20020101

Title: Serum immunoglobulins, total protein and albumin levels during UniplantR use by Nigerian women.

Journal: African journal of medicine and medical sciences 20011201

Title: Effects of different types of hormone replacement therapy on mammographic density.

Journal: Maturitas 20011130

Title: Effects of a short-term suspension of hormone replacement therapy on mammographic density.

Journal: Fertility and sterility 20010901

Title: Carbohydrate metabolism in sickle cell patients using a subdermal implant containing nomegestrol acetate (Uniplant).

Journal: Contraception 20010501

Title: Reversal effects of nomegestrol acetate on multidrug resistance in adriamycin-resistant MCF7 breast cancer cell line.

Journal: Breast cancer research : BCR 20010101

Title: Prevention of menstruation with leuprorelin (GnRH agonist) in women undergoing myelosuppressive chemotherapy or radiochemotherapy for hematological malignancies: a pilot study.

Journal: Leukemia & lymphoma 20010101

Title: Inhibitory effect of nomegestrol acetate on steroidogenesis of cultured granulosa cells from rat ovary in vitro.

Journal: Acta pharmacologica Sinica 20010101

Title: Mueck AO, et al. Nomegestrol acetate, a novel progestogen for oral contraception. Steroids. 2011 May;76(6):531-9.

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Tags:58652-20-3 Molecular Formula|58652-20-3 MDL|58652-20-3 SMILES|58652-20-3 19-Norpregna-4,6-diene-3,20-dione, 17-(acetyloxy)-6-methyl-