Title: HCV NS5A replication complex inhibitors. Part 5: discovery of potent and pan-genotypic glycinamide cap derivatives.
Journal: Bioorganic & medicinal chemistry letters 20130801
Title: Pemetrexed alters folate phenotype and inflammatory profile in EA.hy 926 cells grown under low-folate conditions.
Journal: European journal of pharmacology 20121205
Title: Association between expression of thymidylate synthase, dihydrofolate reductase, and glycinamide ribonucleotide formyltransferase and efficacy of pemetrexed in advanced non-small cell lung cancer.
Journal: Anticancer research 20121001
Title: Preventing cleavage of Mer promotes efferocytosis and suppresses acute lung injury in bleomycin treated mice.
Journal: Toxicology and applied pharmacology 20120815
Title: Biomarker analysis in a phase III study of pemetrexed-carboplatin versus etoposide-carboplatin in chemonaive patients with extensive-stage small-cell lung cancer.
Journal: Annals of oncology : official journal of the European Society for Medical Oncology 20120701
Title: Imidazolopiperazines: lead optimization of the second-generation antimalarial agents.
Journal: Journal of medicinal chemistry 20120510
Title: Sjögren's syndrome autoantibodies provoke changes in gene expression profiles of inflammatory cytokines triggering a pathway involving TACE/NF-κB.
Journal: Laboratory investigation; a journal of technical methods and pathology 20120401
Title: Targeting of multidrug-resistant human ovarian carcinoma cells with anti-P-glycoprotein antibody conjugates.
Journal: Macromolecular bioscience 20120401
Title: 3-aminopiperidine-based peptide analogues as the first selective noncovalent inhibitors of the bacterial cysteine protease IdeS.
Journal: Journal of medicinal chemistry 20120322
Title: Conserved signal peptide recognition systems across the prokaryotic domains.
Journal: Biochemistry 20120227
Title: The crystal structure of Leishmania major N(5),N(10)-methylenetetrahydrofolate dehydrogenase/cyclohydrolase and assessment of a potential drug target.
Journal: Molecular and biochemical parasitology 20120201
Title: 2-Amino-N-[3-(2-chloro-benzo-yl)-5-ethyl-thio-phen-2-yl]acetamide.
Journal: Acta crystallographica. Section E, Structure reports online 20120201
Title: Oxidative Stress and Down Syndrome: A Route toward Alzheimer-Like Dementia.
Journal: Current gerontology and geriatrics research 20120101
Title: Mechanisms of action of (meth)acrylates in hemolytic activity, in vivo toxicity and dipalmitoylphosphatidylcholine (DPPC) liposomes determined using NMR spectroscopy.
Journal: International journal of molecular sciences 20120101
Title: Safety and efficacy of pemetrexed in maintenance therapy of non-small cell lung cancer.
Journal: Clinical Medicine Insights. Oncology 20120101
Title: The use of mouse models for understanding the biology of down syndrome and aging.
Journal: Current gerontology and geriatrics research 20120101
Title: Algorithms for optimizing cross-overs in DNA shuffling.
Journal: BMC bioinformatics 20120101
Title: Constitutive and treatment-induced CXCL8-signalling selectively modulates the efficacy of anti-metabolite therapeutics in metastatic prostate cancer.
Journal: PloS one 20120101
Title: Pemetrexed plus platinum as the first-line treatment option for advanced non-small cell lung cancer: a meta-analysis of randomized controlled trials.
Journal: PloS one 20120101
Title: Synthesis and properties of molecular probes for the rescue site on mutant cystic fibrosis transmembrane conductance regulator.
Journal: Journal of medicinal chemistry 20111222
Title: Therapeutic targeting of a novel 6-substituted pyrrolo [2,3-d]pyrimidine thienoyl antifolate to human solid tumors based on selective uptake by the proton-coupled folate transporter.
Journal: Molecular pharmacology 20111201
Title: 1,1-Diarylalkenes as anticancer agents: dual inhibitors of tubulin polymerization and phosphodiesterase 4.
Journal: Bioorganic & medicinal chemistry 20111101
Title: Design and pharmacological activity of glycinamide and N-methoxy amide derivatives of analogs and constitutional isomers of valproic acid.
Journal: Epilepsy & behavior : E&B 20111101
Title: Establishment of pemetrexed-resistant non-small cell lung cancer cell lines.
Journal: Cancer letters 20111028
Title: Redox-responsive self-healing materials formed from host-guest polymers.
Journal: Nature communications 20111025
Title: Acylglycinamides as inhibitors of glycine transporter type 1.
Journal: Bioorganic & medicinal chemistry letters 20111015
Title: N-Heteroaryl glycinamides and glycinamines as potent NPY5 antagonists.
Journal: Bioorganic & medicinal chemistry letters 20110915
Title: Quantitative shotgun proteomics using a uniform ¹⁵N-labeled standard to monitor proteome dynamics in time course experiments reveals new insights into the heat stress response of Chlamydomonas reinhardtii.
Journal: Molecular & cellular proteomics : MCP 20110901
Title: N-Acryloyl glycinamide.
Journal: Acta crystallographica. Section E, Structure reports online 20110801
Title: Thymidylate synthase as a determinant of pemetrexed sensitivity in non-small cell lung cancer.
Journal: British journal of cancer 20110510
Title: Gastroprotective effect and cytotoxicity of labdeneamides with amino acids.
Journal: Planta medica 20110301
Title: Glycine amide shielding on the aromatic surfaces of lysozyme: implication for suppression of protein aggregation.
Journal: FEBS letters 20110204
Title: Combination effects of platinum drugs and N1, N11 diethylnorspermine on spermidine/spermine N1-acetyltransferase, polyamines and growth inhibition in A2780 human ovarian carcinoma cells and their oxaliplatin and cisplatin-resistant variants.
Journal: Cancer chemotherapy and pharmacology 20110201
Title: Crystal structures of two aminoglycoside kinases bound with a eukaryotic protein kinase inhibitor.
Journal: PloS one 20110101
Title: MDM2 antagonist Nutlin-3a potentiates antitumour activity of cytotoxic drugs in sarcoma cell lines.
Journal: BMC cancer 20110101
Title: Thiadiazine derivatives as antiprotozoal new drugs.
Journal: The open medicinal chemistry journal 20110101
Title: 4D Flexible Atom-Pairs: An efficient probabilistic conformational space comparison for ligand-based virtual screening.
Journal: Journal of cheminformatics 20110101
Title: An integrated Drosophila model system reveals unique properties for F14512, a novel polyamine-containing anticancer drug that targets topoisomerase II.
Journal: PloS one 20110101
Title: Rationally designed interfacial peptides are efficient in vitro inhibitors of HIV-1 capsid assembly with antiviral activity.
Journal: PloS one 20110101
Title: Purine biosynthesis in archaea: variations on a theme.
Journal: Biology direct 20110101
Title: Mthfs is an Essential Gene in Mice and a Component of the Purinosome.
Journal: Frontiers in genetics 20110101
Title: Investigational approaches for mesothelioma.
Journal: Frontiers in oncology 20110101
Title: Modeling mechanisms of in vivo variability in methotrexate accumulation and folate pathway inhibition in acute lymphoblastic leukemia cells.
Journal: PLoS computational biology 20101201
Title: Piperidinium N-(ferrocenylcarbon-yl)glycinate.
Journal: Acta crystallographica. Section E, Structure reports online 20101201
Title: [Design, synthesis and in vitro activity of glycinamide-bearing compounds as DPP-IV inhibitors].
Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20101101
Title: Targeting the proton-coupled folate transporter for selective delivery of 6-substituted pyrrolo[2,3-d]pyrimidine antifolate inhibitors of de novo purine biosynthesis in the chemotherapy of solid tumors.
Journal: Molecular pharmacology 20101001
Title: Crystal structures of glycinamide ribonucleotide synthetase, PurD, from thermophilic eubacteria.
Journal: Journal of biochemistry 20101001
Title: TS, DHFR and GARFT expression in non-squamous cell carcinoma of NSCLC and malignant pleural mesothelioma patients treated with pemetrexed.
Journal: Anticancer research 20101001
Title: Palmitoylation of human FasL modulates its cell death-inducing function.
Journal: Cell death & disease 20101001
Title: Cellular and molecular mechanisms for the synergistic cytotoxicity elicited by oxaliplatin and pemetrexed in colon cancer cell lines.
Journal: Cancer chemotherapy and pharmacology 20100801
Title: Well-defined synthetic polymers with a protein-like gelation behavior in water.
Journal: Chemical communications (Cambridge, England) 20100707
Title: Human ROBO1 is cleaved by metalloproteinases and gamma-secretase and migrates to the nucleus in cancer cells.
Journal: FEBS letters 20100702
Title: Glycine amides as PPARalpha agonists.
Journal: Bioorganic & medicinal chemistry letters 20100601
Title: gamma-Lactams as glycinamide replacements in cyclohexane-based CC chemokine receptor 2 (CCR2) antagonists.
Journal: Bioorganic & medicinal chemistry letters 20100415
Title: Synthesis and antitumor activity of a novel series of 6-substituted pyrrolo[2,3-d]pyrimidine thienoyl antifolate inhibitors of purine biosynthesis with selectivity for high affinity folate receptors and the proton-coupled folate transporter over the reduced folate carrier for cellular entry.
Journal: Journal of medicinal chemistry 20100211
Title: The role of folate receptor alpha (FRalpha) in the response of malignant pleural mesothelioma to pemetrexed-containing chemotherapy.
Journal: British journal of cancer 20100202
Title: A phase II study of biweekly pemetrexed and gemcitabine in patients with metastatic breast cancer.
Journal: Cancer chemotherapy and pharmacology 20100201
Title: The role of pemetrexed in advanced non small-cell lung cancer: special focus on pharmacology and mechanism of action.
Journal: Current drug targets 20100101
Title: Effect of leucovorin (folinic acid) on the developmental quotient of children with Down's syndrome (trisomy 21) and influence of thyroid status.
Journal: PloS one 20100101
Title: GPG-NH2 acts via the metabolite alphaHGA to target HIV-1 Env to the ER-associated protein degradation pathway.
Journal: Retrovirology 20100101
Title: Phase II Study of Biweekly Pemetrexed Plus Irinotecan as Second-Line Therapy for Metastatic Colorectal Cancer.
Journal: Journal of oncology 20100101
Title: Pemetrexed plus cisplatin/carboplatin in previously treated locally advanced or metastatic non-small cell lung cancer patients.
Journal: Journal of experimental & clinical cancer research : CR 20100101
Title: Transcript profiling of common bean (Phaseolus vulgaris L.) using the GeneChip Soybean Genome Array: optimizing analysis by masking biased probes.
Journal: BMC plant biology 20100101
Title: Chitosan modification and pharmaceutical/biomedical applications.
Journal: Marine drugs 20100101
Title: In vitro study on the schedule-dependency of the interaction between pemetrexed, gemcitabine and irradiation in non-small cell lung cancer and head and neck cancer cells.
Journal: BMC cancer 20100101
Title: Antibiotic optimization in the difficult-to-treat patient with complicated intra-abdominal or complicated skin and skin structure infections: focus on tigecycline.
Journal: Therapeutics and clinical risk management 20100101
Title: Combined effect of mutations in ADSL and GARS-AIRS-GART genes on IMP content in chickens.
Journal: British poultry science 20091101
Title: Distinct mechanistic activity profile of pralatrexate in comparison to other antifolates in in vitro and in vivo models of human cancers.
Journal: Cancer chemotherapy and pharmacology 20091001
Title: Serum vitamin B12 and folate status among patients with chemotherapy treatment for advanced colorectal cancer.
Journal: Upsala journal of medical sciences 20090901
Title: Inhibition of de novo purine synthesis in human prostate cells results in ATP depletion, AMPK activation and induces senescence.
Journal: The Prostate 20090801
Title: A mapping of drug space from the viewpoint of small molecule metabolism.
Journal: PLoS computational biology 20090801
Title: Protein preparation, crystallization and preliminary crystallographic studies of Bacillus subtilis glycinamide ribonucleotide transformylase.
Journal: Acta crystallographica. Section F, Structural biology and crystallization communications 20090701
Title: Structures of glycinamide ribonucleotide transformylase (PurN) from Mycobacterium tuberculosis reveal a novel dimer with relevance to drug discovery.
Journal: Journal of molecular biology 20090619
Title: Estimation on the intramolecular 10-membered ring N-H...O=C hydrogen-bonding energies in glycine and alanine peptides.
Journal: Journal of computational chemistry 20090601
Title: Synthesis and biological activity of a novel series of 6-substituted thieno[2,3-d]pyrimidine antifolate inhibitors of purine biosynthesis with selectivity for high affinity folate receptors over the reduced folate carrier and proton-coupled folate transporter for cellular entry.
Journal: Journal of medicinal chemistry 20090514
Title: Coupled growth and division of model protocell membranes.
Journal: Journal of the American Chemical Society 20090422
Title: Gene expression profiling of leukemia T-cells resistant to methotrexate and 7-hydroxymethotrexate reveals alterations that preserve intracellular levels of folate and nucleotide biosynthesis.
Journal: Biochemical pharmacology 20090415
Title: [In vitro activity of tigecycline against methicillin-resistant staphylococci].
Journal: Mikrobiyoloji bulteni 20090401
Title: Optimal alpha-chymotrypsin-catalyzed synthesis of N-Ac-Phe-Gly-NH(2).
Journal: Journal of agricultural and food chemistry 20090128
Title: 5,10-Methenyltetrahydrofolate synthetase activity is increased in tumors and modifies the efficacy of antipurine LY309887.
Journal: Archives of biochemistry and biophysics 20090115
Title: Activated human neutrophils rapidly release the chemotactically active D2D3 form of the urokinase-type plasminogen activator receptor (uPAR/CD87).
Journal: Molecular and cellular biochemistry 20090101
Title: Isolation and characterization of a small antiretroviral molecule affecting HIV-1 capsid morphology.
Journal: Retrovirology 20090101
Title: Genome-scale gene/reaction essentiality and synthetic lethality analysis.
Journal: Molecular systems biology 20090101
Title: Equilibrium and kinetic investigations of the interaction of model platinum(II) complex with DNA constituents in reference to the antitumour activity: complex-formation reactions of [Pd(N,N-diethylethylenediamine)(H2O)2]2+ with ligands of biological significance and displacement reactions of DNA constituents.
Journal: Bioinorganic chemistry and applications 20090101
Title: Novel approach for formation of platelet-like particles from mouse embryonic stem cells without using feeder cells.
Journal: The Kurume medical journal 20090101
Title: IRMPD spectroscopy shows that AGG forms an oxazolone b2+ ion.
Journal: Journal of the American Chemical Society 20081231
Title: Activity of the small modified amino acid alpha-hydroxy glycineamide on in vitro and in vivo human immunodeficiency virus type 1 capsid assembly and infectivity.
Journal: Antimicrobial agents and chemotherapy 20081001
Title: Asymmetric synthesis of inhibitors of glycinamide ribonucleotide transformylase.
Journal: Journal of medicinal chemistry 20080911
Title: Molecular pathways involved in the synergistic interaction of the PKC beta inhibitor enzastaurin with the antifolate pemetrexed in non-small cell lung cancer cells.
Journal: British journal of cancer 20080902
Title: Synthesis and discovery of high affinity folate receptor-specific glycinamide ribonucleotide formyltransferase inhibitors with antitumor activity.
Journal: Journal of medicinal chemistry 20080828
Title: Rapid cleavage of unactivated, unstrained amide bonds at neutral pH.
Journal: The Journal of organic chemistry 20080815
Title: Gamma-secretase and metalloproteinase activity regulate the distribution of endoplasmic reticulum to hippocampal neuron dendritic spines.
Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20080801
Title: The depletion of cellular ATP by AG2034 mediates cell death or cytostasis in a hypoxanthine-dependent manner in human prostate cancer cells.
Journal: Cancer chemotherapy and pharmacology 20080701
Title: [Pemetrexed].
Journal: Gan to kagaku ryoho. Cancer & chemotherapy 20080601
Title: Systemic treatments for mesothelioma: standard and novel.
Journal: Current treatment options in oncology 20080601
Title: Synthesis of glutamic acid analogs as potent inhibitors of leukotriene A4 hydrolase.
Journal: Bioorganic & medicinal chemistry 20080501
Title: Effect of amino acids and amino acid derivatives on crystallization of hemoglobin and ribonuclease A.
Journal: Journal of synchrotron radiation 20080501
Title: Hesr1 and Hesr2 may act as early effectors of Notch signaling in the developing cochlea.
Journal: Developmental biology 20080401
Title: In vivo response to methotrexate forecasts outcome of acute lymphoblastic leukemia and has a distinct gene expression profile.
Journal: PLoS medicine 20080401
Title: A semi-supervised method for predicting transcription factor-gene interactions in Escherichia coli.
Journal: PLoS computational biology 20080301
Title: Review of pemetrexed in combination with cisplatin for the treatment of malignant pleural mesothelioma.
Journal: Therapeutics and clinical risk management 20080201
Title: Evaluating the surface charge of C18 stationary phases.
Journal: Journal of chromatographic science 20080101
Title: A mathematical model of glutathione metabolism.
Journal: Theoretical biology & medical modelling 20080101
Title: Remodeling of the Streptococcus agalactiae transcriptome in response to growth temperature.
Journal: PloS one 20080101
Title: Pemetrexed single agent chemotherapy in previously treated patients with locally advanced or metastatic non-small cell lung cancer.
Journal: BMC cancer 20080101
Title: Protein functional surfaces: global shape matching and local spatial alignments of ligand binding sites.
Journal: BMC structural biology 20080101
Title: The integrated analysis of metabolic and protein interaction networks reveals novel molecular organizing principles.
Journal: BMC systems biology 20080101
Title: New data integrating multitargeted antifolates into treatment of first-line and relapsed non-small-cell lung cancer.
Journal: Clinical lung cancer 20080101
Title: Modifications of antiepileptic drugs for improved tolerability and efficacy.
Journal: Perspectives in medicinal chemistry 20080101
Title: Current and novel antibiotics against resistant Gram-positive bacteria.
Journal: Infection and drug resistance 20080101
Title: Pemetrexed pharmacokinetics and pharmacodynamics in a phase I/II study of doublet chemotherapy with vinorelbine: implications for further optimisation of pemetrexed schedules.
Journal: British journal of cancer 20071022
Title: In vitro chemosensitivity of freshly explanted tumor cells to pemetrexed is correlated with target gene expression.
Journal: Investigational new drugs 20071001
Title: Investigation of anion retention and cation exclusion effects for several C18 stationary phases.
Journal: Analytical chemistry 20070715
Title: Computational study of urea and its homologue glycinamide: conformations, rotational barriers, and relative interactions with sodium chloride.
Journal: Langmuir : the ACS journal of surfaces and colloids 20070508
Title: A preclinical evaluation of pemetrexed and irinotecan combination as second-line chemotherapy in pancreatic cancer.
Journal: British journal of cancer 20070507
Title: The rate enhancement produced by the ribosome: an improved model.
Journal: Biochemistry 20070403
Title: Preparation of guanine and diaminopurine from biuret. Part III.
Journal: Chemistry & biodiversity 20070401
Title: Molecular basis of antifolate resistance.
Journal: Cancer metastasis reviews 20070301
Title: Nanogold hollow balls with dendritic surface for hybridization of DNA.
Journal: Biosensors & bioelectronics 20070115
Title: Human glycinamide ribonucleotide transformylase: active site mutants as mechanistic probes.
Journal: Biochemistry 20070109
Title: Sequence-dependent administration of raloxifene and 5-fluorouracil/pemetrexed protects against pemetrexed cytotoxicity in human bone marrow.
Journal: Anticancer research 20070101
Title: [Pemetrexed: from preclinic to clinic].
Journal: Bulletin du cancer 20070101
Title: Covalent attachment of proteins to solid supports and surfaces via Sortase-mediated ligation.
Journal: PloS one 20070101
Title: Altering coenzyme specificity of Pichia stipitis xylose reductase by the semi-rational approach CASTing.
Journal: Microbial cell factories 20070101
Title: Oxytocin analogues with amide groups substituted by tetrazole groups in position 4, 5 or 9.
Journal: Acta biochimica Polonica 20070101
Title: Mass-spectrometrical analysis of proteins encoded on chromosome 21 in human fetal brain.
Journal: Amino acids 20061101
Title: Design and characterization of a noncompetitive antagonist of the transient receptor potential vanilloid subunit 1 channel with in vivo analgesic and anti-inflammatory activity.
Journal: The journal of pain : official journal of the American Pain Society 20061001
Title: The effect of a novel transition state inhibitor of methylthioadenosine phosphorylase on pemetrexed activity.
Journal: Molecular cancer therapeutics 20061001
Title: Role of adenosine salvage in wound-induced adenylate biosynthesis in potato tuber slices.
Journal: Plant physiology and biochemistry : PPB 20061001
Title: Molecular mechanisms underlying the enhanced sensitivity of thiopurine-resistant T-lymphoblastic cell lines to methyl mercaptopurineriboside.
Journal: Biochemical pharmacology 20060928
Title: A phase I study of pemetrexed (LY231514) supplemented with folate and vitamin B12 in Japanese patients with solid tumours.
Journal: British journal of cancer 20060918
Title: In vitro synergistic cytotoxicity of gemcitabine and pemetrexed and pharmacogenetic evaluation of response to gemcitabine in bladder cancer patients.
Journal: British journal of cancer 20060807
Title: Discovery of 3,5-bis(trifluoromethyl)benzyl L-arylglycinamide based potent CCR2 antagonists.
Journal: Bioorganic & medicinal chemistry letters 20060715
Title: Computer modelling of antifolate inhibition of folate metabolism using hybrid functional petri nets.
Journal: Journal of theoretical biology 20060621
Title: Metalloprotease inhibitors GM6001 and TAPI-0 inhibit the obligate intracellular human pathogen Chlamydia trachomatis by targeting peptide deformylase of the bacterium.
Journal: The Journal of biological chemistry 20060616
Title: Derivation and characterization of a monoclonal antibody against human glycinamide ribonucleotide formyltransferase.
Journal: Hybridoma (2005) 20060601
Title: Metalloprotease-dependent amphiregulin release mediates tumor necrosis factor-alpha-induced IL-8 secretion in the human airway epithelial cell line NCI-H292.
Journal: Life sciences 20060522
Title: Discovery of a potent, nonpolyglutamatable inhibitor of glycinamide ribonucleotide transformylase.
Journal: Journal of medicinal chemistry 20060518
Title: Synthesis and anticonvulsant activity of a class of 2-amino 3-hydroxypropanamide and 2-aminoacetamide derivatives.
Journal: Bioorganic & medicinal chemistry 20060515
Title: Synthesis of a precursor dipeptide of RGDS (Arg-Gly-Asp-Ser) catalysed by the industrial protease alcalase.
Journal: Biotechnology and applied biochemistry 20060501
Title: Clinical studies of pemetrexed and gemcitabine combinations.
Journal: Annals of oncology : official journal of the European Society for Medical Oncology 20060501
Title: A phase II trial of pemetrexed in advanced breast cancer: clinical response and association with molecular target expression.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20060201
Title: Clinical experience with pemetrexed in breast cancer.
Journal: Seminars in oncology 20060201
Title: The inverse relationship between reduced folate carrier function and pemetrexed activity in a human colon cancer cell line.
Journal: Molecular cancer therapeutics 20060201
Title: Linear and branched bicin linkers for releasable PEGylation of macromolecules: controlled release in vivo and in vitro from mono- and multi-PEGylated proteins.
Journal: Bioconjugate chemistry 20060101
Title: On systems and control approaches to therapeutic gain.
Journal: BMC cancer 20060101
Title: Analysis of folylpoly-gamma-glutamate synthetase gene expression in human B-precursor ALL and T-lineage ALL cells.
Journal: BMC cancer 20060101
Title: [New biological active derivatives of indomethacin and acetylsalicylic acid. Synthesis, physico-chemical characterisation and structure validation].
Journal: Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi 20060101
Title: Synthesis of (-)-quinocarcin by directed condensation of alpha-amino aldehydes.
Journal: Journal of the American Chemical Society 20051207
Title: A quantum chemical study on the mechanism of glycinamide ribonucleotide transformylase inhibitor: 10-Formyl-5,8,10-trideazafolic acid.
Journal: Biophysical chemistry 20051201
Title: Adenosine kinase inhibitors. 6. Synthesis, water solubility, and antinociceptive activity of 5-phenyl-7-(5-deoxy-beta-D-ribofuranosyl)pyrrolo[2,3-d]pyrimidines substituted at C4 with glycinamides and related compounds.
Journal: Journal of medicinal chemistry 20051201
Title: Application of Fourier transform infrared spectroscopy for monitoring hydrolysis and synthesis reactions catalyzed by a recombinant amidase.
Journal: Analytical biochemistry 20051101
Title: Synthesis of some derivatives of C-(1-deoxy-1-N-substituted-D-glucopyranosyl)formic acid (D-gluco-hept-2-ulopyranosonic acid) as potential inhibitors of glycogen phosphorylase.
Journal: Carbohydrate research 20051017
Title: Kinetic investigation of the effect of the amino acid side chains in the selective acidolysis of N-acyl-N,alpha,alpha-trialkyl glycine amides.
Journal: Journal of peptide science : an official publication of the European Peptide Society 20051001
Title: Transpeptidation reactions of a specific substrate catalyzed by the Streptomyces R61 DD-peptidase: the structural basis of acyl acceptor specificity.
Journal: Biochemistry 20050802
Title: The apo and ternary complex structures of a chemotherapeutic target: human glycinamide ribonucleotide transformylase.
Journal: Biochemistry 20050726
Title: Kinetic and mechanistic investigation of the selective acidolysis of the C-terminal amide bond of N-acyl-N,alpha,alpha-trialkyl glycine amides.
Journal: Journal of peptide science : an official publication of the European Peptide Society 20050701
Title: Cellular and pharmacogenetics foundation of synergistic interaction of pemetrexed and gemcitabine in human non-small-cell lung cancer cells.
Journal: Molecular pharmacology 20050701
Title: A potential prebiotic route to adenine from hypoxanthine.
Journal: Chemistry & biodiversity 20050701
Title: Synthesis of fenoprofen and gemfibrozil styrene-maleic acid copolymer conjugates.
Journal: Acta pharmaceutica (Zagreb, Croatia) 20050601
Title: Design, synthesis, and biological evaluation of 10-methanesulfonyl-DDACTHF, 10-methanesulfonyl-5-DACTHF, and 10-methylthio-DDACTHF as potent inhibitors of GAR Tfase and the de novo purine biosynthetic pathway.
Journal: Bioorganic & medicinal chemistry 20050516
Title: Synthesis and biological evaluation of N-[4-[5-(2,4-diamino-6-oxo-1,6-dihydropyrimidin-5-yl)-2-(2,2,2-trifluoroacetyl)pentyl]benzoyl]-L-glutamic acid as a potential inhibitor of GAR Tfase and the de novo purine biosynthetic pathway.
Journal: Bioorganic & medicinal chemistry 20050516
Title: Application of intramolecular 1,3-dipolar cyclic addition of azide and olefin; construction of (pyrrolidine-2-ylidene)glycinate and glycinamides.
Journal: Chemical & pharmaceutical bulletin 20050501
Title: Double proton transfer and one-electron oxidation behavior in double H-bonded glycinamide-glycine complex in the gas phase.
Journal: Journal of computational chemistry 20050430
Title: Arylamide dendrimers with flexible linkers via haloacyl halide method.
Journal: Organic letters 20050428
Title: Highly enantioselective phase-transfer-catalyzed alkylation of protected alpha-amino acid amides toward practical asymmetric synthesis of vicinal diamines, alpha-amino ketones, and alpha-amino alcohols.
Journal: Journal of the American Chemical Society 20050413
Title: Crystal structure and mechanism of the Escherichia coli ArnA (PmrI) transformylase domain. An enzyme for lipid A modification with 4-amino-4-deoxy-L-arabinose and polymyxin resistance.
Journal: Biochemistry 20050412
Title: Sister group relationship of turtles to the bird-crocodilian clade revealed by nuclear DNA-coded proteins.
Journal: Molecular biology and evolution 20050401
Title: Three emerging new drugs for NSCLC: pemetrexed, bortezomib, and cetuximab.
Journal: The oncologist 20050401
Title: Theoretical study of the effect of water in the process of proton transfer of glycinamide.
Journal: The journal of physical chemistry. B 20050331
Title: Molecular characterization and chromosomal assignment of the bovine glycinamide ribonucleotide formyltransferase (GART) gene on cattle chromosome 1q12.1-q12.2.
Journal: Gene 20050328
Title: Loss of reduced folate carrier function and folate depletion result in enhanced pemetrexed inhibition of purine synthesis.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20050201
Title: Chiral ion-exchange capillary electrochromatography of arylglycine amides with dextran sulfate as a pseudostationary phase.
Journal: Electrophoresis 20050201
Title: Specific inhibition and stabilization of aspergilloglutamic peptidase by the propeptide. Identification of critical sequences and residues in the propeptide.
Journal: The Journal of biological chemistry 20050114
Title: Glycine-amide is an active metabolite of the antiretroviral tripeptide glycyl-prolyl-glycine-amide.
Journal: Antimicrobial agents and chemotherapy 20050101
Title: Genome-wide screening for genes whose deletions confer sensitivity to mutagenic purine base analogs in yeast.
Journal: BMC genetics 20050101
Title: Folate system correlations in DNA microarray data.
Journal: BMC cancer 20050101
Title: Inhibition of glycinamide ribonucleotide formyltransferase results in selective inhibition of macrophage cytokine secretion in vitro and in vivo efficacy in rat adjuvant arthritis.
Journal: Clinical and experimental rheumatology 20050101
Title: CamTHP*OH: a camphor-derived delta-lactol auxiliary for the effective desymmetrization of attached glycinamide residues. Asymmetric synthesis of alpha-amino carbonyl compounds.
Journal: Organic letters 20041125
Title: Highly stereoselective Michael addition reactions of CamTHP*-desymmetrized glycinamide for the synthesis of functionally dense amino acid derivatives.
Journal: Organic letters 20041125
Title: Double proton transfer behavior and one-electron oxidation effect in double H-bonded glycinamide-formic acid complex.
Journal: The Journal of chemical physics 20041122
Title: Phase II clinical trial of capecitabine and gemcitabine chemotherapy in patients with metastatic renal carcinoma.
Journal: British journal of cancer 20041115
Title: Biochemical pharmacology of pemetrexed.
Journal: Oncology (Williston Park, N.Y.) 20041101
Title: Overview of phase I/II pemetrexed studies.
Journal: Oncology (Williston Park, N.Y.) 20041101
Title: Translational research with pemetrexed in breast cancer.
Journal: Oncology (Williston Park, N.Y.) 20041101
Title: Tumor necrosis factor-alpha-converting enzyme (ADAM17) mediates GPIbalpha shedding from platelets in vitro and in vivo.
Journal: Circulation research 20041001
Title: Tumor necrosis factor alpha stimulates MUC1 synthesis and ectodomain release in a human uterine epithelial cell line.
Journal: Endocrinology 20040901
Title: Construction, characterization, and use of small-insert gene banks of DNA isolated from soil and enrichment cultures for the recovery of novel amidases.
Journal: Environmental microbiology 20040901
Title: A quantum chemical study of the water-assisted mechanism in one-carbon unit transfer reaction catalyzed by glycinamide ribonucleotide transformylase.
Journal: Biophysical chemistry 20040801
Title: BMS-201620: a selective beta 3 agonist.
Journal: Bioorganic & medicinal chemistry letters 20040705
Title: A second-generation system for unbiased reading frame selection.
Journal: Protein engineering, design & selection : PEDS 20040701
Title: Pemetrexed (ALIMTA), a novel multitargeted antineoplastic agent.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20040615
Title: Analysis of antigen-specific T-cell responses with synthetic peptides--what kind of peptide for which purpose?
Journal: Human immunology 20040501
Title: The crystal structure of the hydrolase domain of 10-formyltetrahydrofolate dehydrogenase: mechanism of hydrolysis and its interplay with the dehydrogenase domain.
Journal: The Journal of biological chemistry 20040402
Title: Pharmacology and mechanism of action of pemetrexed.
Journal: Clinical lung cancer 20040401
Title: CHF 3381.
Journal: Drugs in R&D 20040101
Title: Basal jawed vertebrate phylogeny inferred from multiple nuclear DNA-coded genes.
Journal: BMC biology 20040101
Title: FDA drug approval summaries: pemetrexed (Alimta).
Journal: The oncologist 20040101
Title: One-step synthesis of hypoxanthine from glycinamide and diformylurea.
Journal: Chemistry & biodiversity 20040101
Title: Membrane topology of guinea pig cytochrome P450 17 alpha revealed by a combination of chemical modifications and mass spectrometry.
Journal: Biochemistry 20031216
Title: A defect in the p53 response pathway induced by de novo purine synthesis inhibition.
Journal: The Journal of biological chemistry 20031205
Title: Using a residue clash map to functionally characterize protein recombination hybrids.
Journal: Protein engineering 20031201
Title: Design, synthesis, and biological evaluation of simplified alpha-keto heterocycle, trifluoromethyl ketone, and formyl substituted folate analogues as potential inhibitors of GAR transformylase and AICAR transformylase.
Journal: Bioorganic & medicinal chemistry 20031001
Title: 10-(2-benzoxazolcarbonyl)-5,10-dideaza-acyclic-5,6,7,8-tetrahydrofolic acid: a potential inhibitor of GAR transformylase and AICAR transformylase.
Journal: Bioorganic & medicinal chemistry 20031001
Title: Design, synthesis and biological evaluation of 10-CF3CO-DDACTHF analogues and derivatives as inhibitors of GAR Tfase and the de novo purine biosynthetic pathway.
Journal: Bioorganic & medicinal chemistry 20031001
Title: On the structural and functional modularity of glycinamide ribonucleotide formyltransferases.
Journal: Protein science : a publication of the Protein Society 20031001
Title: Tomoregulin ectodomain shedding by proinflammatory cytokines.
Journal: Life sciences 20030815
Title: Thymidine and hypoxanthine protection patterns of the folic acid-enhanced synergies for combinations of trimetrexate plus a polyglutamylatable inhibitor of purine or thymidylate synthesis against human ileocecal HCT-8 cells.
Journal: International journal of oncology 20030801
Title: The role of Pemetrexed (Alimta , LY231514) in lung cancer therapy.
Journal: Clinical lung cancer 20030701
Title: Pemetrexed and its emerging role in the treatment of thoracic malignancies.
Journal: Expert opinion on investigational drugs 20030501
Title: Decreased expression of the reduced folate carrier and folypolyglutamate synthetase is the basis for acquired resistance to the pemetrexed antifolate (LY231514) in an L1210 murine leukemia cell line.
Journal: Biochemical pharmacology 20030401
Title: Pemetrexed (Alimta): a promising new agent for the treatment of breast cancer.
Journal: Seminars in oncology 20030401
Title: Pemetrexed (Alimta): a novel multitargeted antifolate agent.
Journal: Expert review of anticancer therapy 20030401
Title: Metal-catalyzed hydroxylaminolysis of unactivated amide and peptide bonds.
Journal: Organic & biomolecular chemistry 20030307
Title: Novel antifolate drugs.
Journal: Current oncology reports 20030301
Title: Loss of folylpoly-gamma-glutamate synthetase activity is a dominant mechanism of resistance to polyglutamylation-dependent novel antifolates in multiple human leukemia sublines.
Journal: International journal of cancer 20030220
Title: Antineoplastic agents. 487. Synthesis and biological evaluation of the antineoplastic agent 3,4-methylenedioxy-5,4'-dimethoxy-3'-amino-Z-stilbene and derived amino acid amides.
Journal: Journal of medicinal chemistry 20030213
Title: Fragmentation reactions of protonated peptides containing glutamine or glutamic acid.
Journal: Journal of mass spectrometry : JMS 20030201
Title: Deaza analogs of folic acid as antitumor agents.
Journal: Current pharmaceutical design 20030101
Title: Practical asymmetric synthesis of vicinal diamines through the catalytic highly enantioselective alkylation of glycine amide derivatives.
Journal: Angewandte Chemie (International ed. in English) 20030101
Title: Current data with pemetrexed (Alimta) in non-small-cell lung cancer.
Journal: Clinical lung cancer 20030101
Title: LY309887, antifolate via the folate receptor suppresses murine type II collagen-induced arthritis.
Journal: Clinical and experimental rheumatology 20030101
Title: Biochemical and structural characterization of the cross-linked complex of nitrogenase: comparison to the ADP-AlF4(-)-stabilized structure.
Journal: Biochemistry 20021231
Title: Crystal structures of human GAR Tfase at low and high pH and with substrate beta-GAR.
Journal: Biochemistry 20021203
Title: Molecular, biochemical, and cellular pharmacology of pemetrexed.
Journal: Seminars in oncology 20021201
Title: Pemetrexed safety and dosing strategy.
Journal: Seminars in oncology 20021201
Title: Preclinical and clinical studies with combinations of pemetrexed and gemcitabine.
Journal: Seminars in oncology 20021201
Title: Pemetrexed in pancreatic cancer.
Journal: Seminars in oncology 20021201
Title: Pemetrexed: an active new agent for breast cancer.
Journal: Seminars in oncology 20021201
Title: A universal, vector-based system for nucleic acid reading-frame selection.
Journal: Protein engineering 20021201
Title: Alimta (pemetrexed disodium): a multitargeted antifolate for the treatment of mesothelioma.
Journal: Lung cancer (Amsterdam, Netherlands) 20021101
Title: New 2H-tetrahydro-1, 3, 5-thiadiazine-2-thiones incorporating glycine and glycinamide as potential antifungal agents.
Journal: Archiv der Pharmazie 20021101
Title: Chemotactic agents induce IL-6Ralpha shedding from polymorphonuclear cells: involvement of a metalloproteinase of the TNF-alpha-converting enzyme (TACE) type.
Journal: European journal of immunology 20021001
Title: Endotoxin induces rapid metalloproteinase-mediated shedding followed by up-regulation of the monocyte hemoglobin scavenger receptor CD163.
Journal: Journal of leukocyte biology 20021001
Title: Chemically modified 'polar patch' mutants of subtilisin in peptide synthesis with remarkably broad substrate acceptance: designing combinatorial biocatalysts.
Journal: Chemistry (Weinheim an der Bergstrasse, Germany) 20020916
Title: Antifolates targeting purine synthesis allow entry of tumor cells into S phase regardless of p53 function.
Journal: Cancer research 20020915
Title: The pemetrexed/gemcitabine combination in pancreatic cancer.
Journal: Cancer 20020815
Title: 10-Formyl-5,10-dideaza-acyclic-5,6,7,8-tetrahydrofolic acid (10-formyl-DDACTHF): a potent cytotoxic agent acting by selective inhibition of human GAR Tfase and the de novo purine biosynthetic pathway.
Journal: Bioorganic & medicinal chemistry 20020801
Title: Pemetrexed disodium combined with oxaliplatin, SN38, or 5-fluorouracil, based on the quantitation of drug interactions in human HT29 colon cancer cells.
Journal: International journal of oncology 20020801
Title: Effect of short-term N(2) deficiency on expression of the ureide pathway in cowpea root nodules.
Journal: Plant physiology 20020701
Title: [Differentially expressed genes in vascular endothelial cell line ECV 304 induced by high density lipoprotein].
Journal: Zhonghua yi xue za zhi 20020701
Title: PurT-encoded glycinamide ribonucleotide transformylase. Accommodation of adenosine nucleotide analogs within the active site.
Journal: The Journal of biological chemistry 20020628
Title: New N(3)S donor ligand small peptide analogues of the N-mercaptoacetyl-glycylglycylglycine ligand in the clinically used Tc-99m renal imaging agent: evidence for unusual amide oxygen coordination by two new ligands.
Journal: Inorganic chemistry 20020603
Title: Incorporation of pemetrexed (Alimta) into the treatment of non-small cell lung cancer (thoracic tumors).
Journal: Seminars in oncology 20020601
Title: Pemetrexed: translational research in breast cancer.
Journal: Seminars in oncology 20020601
Title: Pemetrexed: a promising new treatment for breast cancer.
Journal: Seminars in oncology 20020401
Title: Pemetrexed in the treatment of selected solid tumors.
Journal: Seminars in oncology 20020401
Title: Nonpeptide alpha(v)beta(3) antagonists. Part 2: constrained glycyl amides derived from the RGD tripeptide.
Journal: Bioorganic & medicinal chemistry letters 20020107
Title: Synthesis of a new antischistosomally active and toxicologically tolerant C-12 monothione surrogate of the universal antihelmintic praziquantel.
Journal: Acta poloniae pharmaceutica 20020101
Title: Gemcitabine and pemetrexed disodium combinations in vitro and in vivo.
Journal: Lung cancer (Amsterdam, Netherlands) 20011201
Title: Unexpected formation of an epoxide-derived multisubstrate adduct inhibitor on the active site of GAR transformylase.
Journal: Biochemistry 20011113
Title: Proton transfer dynamics of GART: the pH-dependent catalytic mechanism examined by electrostatic calculations.
Journal: Protein science : a publication of the Protein Society 20011101
Title: Pemetrexed disodium (Eli Lilly).
Journal: Current opinion in investigational drugs (London, England : 2000) 20011101
Title: Pemetrexed disodium in recurrent locally advanced or metastatic squamous cell carcinoma of the head and neck.
Journal: British journal of cancer 20010901
Title: Site-directed mutagenesis of ATP binding residues of biotin carboxylase. Insight into the mechanism of catalysis.
Journal: The Journal of biological chemistry 20010706
Title: Synthesis and biological activity of 7-oxo substituted analogues of 5-deaza-5,6,7,8-tetrahydrofolic acid (5-DATHF) and 5,10-dideaza-5,6,7,8-tetrahydrofolic acid (DDATHF).
Journal: Journal of medicinal chemistry 20010705
Title: Involvement of a transformylase enzyme in siderophore synthesis in Pseudomonas aeruginosa.
Journal: Microbiology (Reading, England) 20010601
Title: A permissive role for tumor necrosis factor in vascular endothelial growth factor-induced vascular permeability.
Journal: Blood 20010301
Title: Increased shedding of angiotensin-converting enzyme by a mutation identified in the stalk region.
Journal: The Journal of biological chemistry 20010223
Title: Gemcitabine and Pemetrexed disodium in treating breast cancer.
Journal: Oncology (Williston Park, N.Y.) 20010201
Title: Synthetic Cu(II) and Ni(II) peptidases.
Journal: Metal ions in biological systems 20010101
Title: Pemetrexed disodium: a novel antifolate clinically active against multiple solid tumors.
Journal: The oncologist 20010101
Title: Preparation of Fab' from murine IgG2a for thiol reactive conjugation.
Journal: Journal of drug targeting 20010101
Title: Sequence dependence of Alimta (LY231514, MTA) combined with doxorubicin in ZR-75-1 human breast carcinoma cells.
Journal: Anticancer research 20010101
