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60239-18-1,MFCD00068657
Catalog No.:AA00E8RD

60239-18-1 | DOTA

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250mg
95%
in stock  
$6.00   $4.00
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1g
95%
in stock  
$16.00   $12.00
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5g
95%
in stock  
$22.00   $15.00
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10g
95%
in stock  
$37.00   $26.00
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25g
95%
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$55.00   $39.00
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100g
95%
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$218.00   $153.00
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  • Technical Information
  • Properties
  • Upstream Synthesis Route
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Upstream Synthesis Route
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA00E8RD
Chemical Name:
DOTA
CAS Number:
60239-18-1
Molecular Formula:
C16H28N4O8
Molecular Weight:
404.4155
MDL Number:
MFCD00068657
SMILES:
OC(=O)CN1CCN(CCN(CCN(CC1)CC(=O)O)CC(=O)O)CC(=O)O
NSC Number:
681107
Properties
Properties
 
Form:
Solid  
MP:
267 °C  
Storage:
Keep in dry area;Room Temperature;  

Computed Properties
 
Complexity:
447  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
28  
Hydrogen Bond Acceptor Count:
12  
Hydrogen Bond Donor Count:
4  
Rotatable Bond Count:
8  
XLogP3:
-10.6  

Upstream Synthesis Route

[1]JournalofLabelledCompoundsandRadiopharmaceuticals,2003,vol.46,#3,p.197-209

[2]DaltonTransactions,2016,vol.45,#23,p.9553-9564

[3]Patent:WO2014/114664,2014,A1,.Locationinpatent:Page/Pagecolumn28-29

[4]Patent:WO2015/117911,2015,A1,.Locationinpatent:Paragraph0081;0082;0083;0084

[5]Patent:CN104447598,2017,B,.Locationinpatent:Paragraph0096;0098;0099

[1]Patent:WO2013/76743,2013,A2,.Locationinpatent:Page/Pagecolumn4;5

[2]Patent:US2014/323719,2014,A1,.Locationinpatent:Paragraph0018

[3]Patent:WO2015/117911,2015,A1,.Locationinpatent:Paragraph0085;0086;0087

[1]Patent:WO2017/103258,2017,A1,.Locationinpatent:Page/Pagecolumn9;10;11

[1]TetrahedronLetters,2012,vol.53,#50,p.6810-6814

[1]TetrahedronLetters,2012,vol.53,#50,p.6810-6814

Downstream Synthesis Route
5\-CTACGCCACTAGCTCCA-3\phosphodiester 
  60239-18-1   
5\-DOTA-CTACGCCACTAGCTCCA-3\phosphodiester 

[1]EuropeanJournalofPharmaceuticalSciences,2005,vol.26,p.26-38

5\-CTACGCCACTAGCTCCA-3\phosphorothioate 
  60239-18-1   
5\-DOTA-CTACGCCACTAGCTCCA-3\phosphorothioate 

[1]EuropeanJournalofPharmaceuticalSciences,2005,vol.26,p.26-38

2\-O-methylphosphodiester5\-CUACGCCACUAGCUCCA-3\ 
  60239-18-1   
2\-O-methylphosphodiester5\-DOTA-CUACGCCACUAGCUCCA-3\ 

[1]EuropeanJournalofPharmaceuticalSciences,2005,vol.26,p.26-38

60239-18-1   
Ho-166-DOTA 

[1]Patent:WO2007/126730,2007,A1.Locationinpatent:Page/Pagecolumn10-11

[1]Journaloflabelledcompoundsandradiopharmaceuticals,2003,vol.46,p.197-209

Literature

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Title: Measurement of protein synthesis: in vitro comparison of (68)Ga-DOTA-puromycin, [ (3)H]tyrosine, and 2-fluoro-[ (3)H]tyrosine.

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Title: 64Cu-p-NH2-Bn-DOTA-hu14.18K322A, a PET radiotracer targeting neuroblastoma and melanoma.

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Title: Synthesis and in vivo pharmacokinetic evaluation of degradable shell cross-linked polymer nanoparticles with poly(carboxybetaine) versus poly(ethylene glycol) surface-grafted coatings.

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Journal: Cancer biotherapy & radiopharmaceuticals 20121001

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Journal: Bioconjugate chemistry 20120919

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Journal: Bioconjugate chemistry 20120815

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Journal: Inorganic chemistry 20120806

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Journal: Amino acids 20120801

Title: Cyclotron produced ⁴⁴gSc from natural calcium.

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Title: Synthesis and characterization of a hypoxia-sensitive MRI probe.

Journal: Chemistry (Weinheim an der Bergstrasse, Germany) 20120727

Title: In vivo targeting of HER2-positive tumor using 2-helix affibody molecules.

Journal: Amino acids 20120701

Title: DOTAGA-anhydride: a valuable building block for the preparation of DOTA-like chelating agents.

Journal: Chemistry (Weinheim an der Bergstrasse, Germany) 20120618

Title: Synthesis of PECAM-1-specific 64Cu PET imaging agent: evaluation of myocardial infarction caused by ischemia-reperfusion injury in mouse.

Journal: Bioorganic & medicinal chemistry letters 20120615

Title: Preclinical evaluation of radiolabeled DOTA-derivatized cyclic minigastrin analogs for targeting cholecystokinin receptor expressing malignancies.

Journal: Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging 20120601

Title: Dual-labeling strategies for nuclear and fluorescence molecular imaging: a review and analysis.

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Journal: Anti-cancer agents in medicinal chemistry 20120601

Title: Synthesis and characterization of folic acid modified water-soluble chitosan derivatives for folate-receptor-mediated targeting.

Journal: Bioorganic & medicinal chemistry letters 20120515

Title: 68Ga-labeling and in vivo evaluation of a uPAR binding DOTA- and NODAGA-conjugated peptide for PET imaging of invasive cancers.

Journal: Nuclear medicine and biology 20120501

Title: Potential of the gastric motility drug lorglumide in prostate cancer imaging.

Journal: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20120411

Title: Europium(III) DOTA-tetraamide complexes as redox-active MRI sensors.

Journal: Journal of the American Chemical Society 20120404

Title: Evaluation of (111)In-labeled macrocyclic chelator-amino acid derivatives for cancer imaging.

Journal: Nuclear medicine and biology 20120401

Title: Therapeutic efficacy and toxicity of 225Ac-labelled vs. 213Bi-labelled tumour-homing peptides in a preclinical mouse model of peritoneal carcinomatosis.

Journal: European journal of nuclear medicine and molecular imaging 20120401

Title: Design, recombinant expression and convenient A-chain N-terminal europium-labelling of a fully active human relaxin-3 analogue.

Journal: The FEBS journal 20120401

Title: Treatment with unlabeled mAb BR96 after radioimmunotherapy with 177Lu-DOTA-BR96 in a syngeneic rat colon carcinoma model.

Journal: Cancer biotherapy & radiopharmaceuticals 20120401

Title: Comparative evaluation of synthetic anti-HER2 Affibody molecules site-specifically labelled with 111In using N-terminal DOTA, NOTA and NODAGA chelators in mice bearing prostate cancer xenografts.

Journal: European journal of nuclear medicine and molecular imaging 20120301

Title: Novel gastrin receptor-directed contrast agents - potential in brain tumor magnetic resonance imaging.

Journal: Medicinal chemistry (Shariqah (United Arab Emirates)) 20120301

Title: Targeted catalytic inactivation of angiotensin converting enzyme by lisinopril-coupled transition-metal chelates.

Journal: Journal of the American Chemical Society 20120222

Title: Magnetic anisotropy in a dysprosium/DOTA single-molecule magnet: beyond simple magneto-structural correlations.

Journal: Angewandte Chemie (International ed. in English) 20120213

Title: Influence of formulation variables on the biodistribution of multifunctional block copolymer micelles.

Journal: Journal of controlled release : official journal of the Controlled Release Society 20120210

Title: Imaging prostate cancer lymph node metastases with a multimodality contrast agent.

Journal: The Prostate 20120201

Title: A novel lily-of-the-valley fragrance contrast agent for magnetic resonance and fluorescence imaging of prostate cancer cells.

Journal: Current pharmaceutical biotechnology 20120201

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Journal: European journal of nuclear medicine and molecular imaging 20120201

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Journal: European journal of nuclear medicine and molecular imaging 20120201

Title: Preliminary evaluation of a microwave-assisted metal-labeling strategy for quantification of peptides via RPLC-ICP-MS and the method of standard additions.

Journal: Talanta 20120115

Title: 17O NMR and density functional theory study of the dynamics of the carboxylate groups in DOTA complexes of lanthanides in aqueous solution.

Journal: Inorganic chemistry 20120102

Title: Complexation of metal ions with TRAP (1,4,7-triazacyclononane phosphinic acid) ligands and 1,4,7-triazacyclononane-1,4,7-triacetic acid: phosphinate-containing ligands as unique chelators for trivalent gallium.

Journal: Inorganic chemistry 20120102

Title: Imaging of insulinlike growth factor type 1 receptor in prostate cancer xenografts using the affibody molecule 111In-DOTA-ZIGF1R:4551.

Journal: Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20120101

Title: Quantitative PET of human urokinase-type plasminogen activator receptor with 64Cu-DOTA-AE105: implications for visualizing cancer invasion.

Journal: Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20120101

Title: Simple method for quantification of gadolinium magnetic resonance imaging contrast agents using ESR spectroscopy.

Journal: Chemical & pharmaceutical bulletin 20120101

Title: (68)Ga-Labeling of RGD peptides and biodistribution.

Journal: International journal of clinical and experimental medicine 20120101

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Journal: Inorganic chemistry 20111219

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Title: Evaluation of 177Lu-DOTA-sst2 antagonist versus 177Lu-DOTA-sst2 agonist binding in human cancers in vitro.

Journal: Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20111201

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Journal: European journal of nuclear medicine and molecular imaging 20111101

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Journal: Nuclear medicine and biology 20111101

Title: The pH sensitivity of -NH exchange in LnDOTA-tetraamide complexes varies with amide substituent.

Journal: Contrast media & molecular imaging 20111101

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Journal: Bioconjugate chemistry 20111019

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Journal: Bioconjugate chemistry 20111019

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Journal: ChemMedChem 20111004

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Title: Radiolabelling of peptides for PET, SPECT and therapeutic applications using a fully automated disposable cassette system.

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Title: Influence of an aliphatic linker between DOTA and synthetic Z(HER2:342) Affibody molecule on targeting properties of the (111)In-labeled conjugate.

Journal: Nuclear medicine and biology 20110701

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Journal: Bioorganic & medicinal chemistry 20110615

Title: DNP by thermal mixing under optimized conditions yields >60,000-fold enhancement of 89Y NMR signal.

Journal: Journal of the American Chemical Society 20110608

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Journal: Organic & biomolecular chemistry 20110607

Title: The interaction of La(3+) complexes of DOTA/DTPA glycoconjugates with the RCA(120) lectin: a saturation transfer difference NMR spectroscopic study.

Journal: Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 20110601

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Title: Preclinical evaluation of a new bombesin analog for imaging of gastrin-releasing peptide receptors.

Journal: Cancer biotherapy & radiopharmaceuticals 20110601

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Journal: Angewandte Chemie (International ed. in English) 20110502

Title: Synthesis and in vivo evaluation of 201Tl(III)-DOTA complexes for applications in SPECT imaging.

Journal: Nuclear medicine and biology 20110501

Title: Highly improved metabolic stability and pharmacokinetics of indium-111-DOTA-gastrin conjugates for targeting of the gastrin receptor.

Journal: Journal of medicinal chemistry 20110428

Title: Site-specific conjugation of monodispersed DOTA-PEGn to a thiolated diabody reveals the effect of increasing peg size on kidney clearance and tumor uptake with improved 64-copper PET imaging.

Journal: Bioconjugate chemistry 20110420

Title: Biodistribution and clearance of small molecule hapten chelates for pretargeted radioimmunotherapy.

Journal: Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging 20110401

Title: Preliminary evaluation of (177)Lu-labeled knottin peptides for integrin receptor-targeted radionuclide therapy.

Journal: European journal of nuclear medicine and molecular imaging 20110401

Title: Synthesis of 68Ga-labeled DOTA-nitroimidazole derivatives and their feasibilities as hypoxia imaging PET tracers.

Journal: Bioorganic & medicinal chemistry 20110401

Title: Ga(III) chelates of amphiphilic DOTA-based ligands: synthetic route and in vitro and in vivo studies.

Journal: Nuclear medicine and biology 20110401

Title: Site-specific 68Ga-labeled Annexin A5 as a PET imaging agent for apoptosis.

Journal: Nuclear medicine and biology 20110401

Title: Spacer effects on in vivo properties of DOTA-conjugated dimeric [Tyr3]octreotate peptides synthesized by a 'Cu(I)-click' and 'sulfo-click' ligation method.

Journal: Chembiochem : a European journal of chemical biology 20110321

Title: Radiolabeled affibody-albumin bioconjugates for HER2-positive cancer targeting.

Journal: Bioconjugate chemistry 20110316

Title: Europium(III) DOTA-derivatives having ketone donor pendant arms display dramatically slower water exchange.

Journal: Inorganic chemistry 20110307

Title: A small MRI contrast agent library of gadolinium(III)-encapsulated supramolecular nanoparticles for improved relaxivity and sensitivity.

Journal: Biomaterials 20110301

Title: Biological stability evaluation of the α2β1 receptor imaging agents: diamsar and DOTA conjugated DGEA peptide.

Journal: Bioconjugate chemistry 20110216

Title: Synthesis and evaluation of new iRGD peptide analogs for tumor optical imaging.

Journal: Bioorganic & medicinal chemistry letters 20110215

Title: Challenges in optimizing a prostate carcinoma binding peptide, identified through the phage display technology.

Journal: Molecules (Basel, Switzerland) 20110214

Title: The cell labeling efficacy, cytotoxicity and relaxivity of copper-activated MRI/PET imaging contrast agents.

Journal: Biomaterials 20110201

Title: Macrocyclic complexes of scandium radionuclides as precursors for diagnostic and therapeutic radiopharmaceuticals.

Journal: Journal of inorganic biochemistry 20110201

Title: Influence of biological assay conditions on stability assessment of radiometal-labelled peptides exemplified using a 177Lu-DOTA-minigastrin derivative.

Journal: Nuclear medicine and biology 20110201

Title: Engineering an antibody with picomolar affinity to DOTA chelates of multiple radionuclides for pretargeted radioimmunotherapy and imaging.

Journal: Nuclear medicine and biology 20110201

Title: Gd-complexes of 1,4,7,10-tetraazacyclododecane-N,N',N'',N'''-1,4,7,10-tetraacetic acid (DOTA) conjugates of tranexamates as a new class of blood-pool magnetic resonance imaging contrast agents.

Journal: Journal of medicinal chemistry 20110113

Title: Development of a potent DOTA-conjugated bombesin antagonist for targeting GRPr-positive tumours.

Journal: European journal of nuclear medicine and molecular imaging 20110101

Title: Development of new folate-based PET radiotracers: preclinical evaluation of ⁶⁸Ga-DOTA-folate conjugates.

Journal: European journal of nuclear medicine and molecular imaging 20110101

Title: Imaging cancer using PET--the effect of the bifunctional chelator on the biodistribution of a (64)Cu-labeled antibody.

Journal: Nuclear medicine and biology 20110101

Title: In vivo testing of 177Lu-labelled anti-PSMA antibody as a new radioimmunotherapeutic agent against prostate cancer.

Journal: In vivo (Athens, Greece) 20110101

Title: Fluorescent and lanthanide labeling for ligand screens, assays, and imaging.

Journal: Methods in molecular biology (Clifton, N.J.) 20110101

Title: PET imaging of CXCR4 using copper-64 labeled peptide antagonist.

Journal: Theranostics 20110101

Title: Comparison of the in vivo distribution of four different annexin a5 adducts in rhesus monkeys.

Journal: International journal of molecular imaging 20110101

Title: The application of carbon nanotubes in target drug delivery systems for cancer therapies.

Journal: Nanoscale research letters 20110101

Title: Non-invasive imaging of cysteine cathepsin activity in solid tumors using a 64Cu-labeled activity-based probe.

Journal: PloS one 20110101

Title: TmDOTA-tetraglycinate encapsulated liposomes as pH-sensitive LipoCEST agents.

Journal: PloS one 20110101

Title: Positron emission tomography imaging of CD105 expression with a 64Cu-labeled monoclonal antibody: NOTA is superior to DOTA.

Journal: PloS one 20110101

Title: Advances in drug design of radiometal-based imaging agents for bone disorders.

Journal: International journal of molecular imaging 20110101

Title: Microfluidic labeling of biomolecules with radiometals for use in nuclear medicine.

Journal: Lab on a chip 20101221

Title: Gallium(III) complexes of DOTA and DOTA-monoamide: kinetic and thermodynamic studies.

Journal: Inorganic chemistry 20101206

Title: Polymeric micelles in anticancer therapy: targeting, imaging and triggered release.

Journal: Pharmaceutical research 20101201

Title: Polyion complex micelle MRI contrast agents from poly(ethylene glycol)-b-poly(l-lysine) block copolymers having Gd-DOTA; preparations and their control of T(1)-relaxivities and blood circulation characteristics.

Journal: Journal of controlled release : official journal of the Controlled Release Society 20101201

Title: TETA analogue containing one methylenephosphonate pendant arm: Lanthanide complexes and biological evaluation of its 153Sm and 166Ho complexes.

Journal: European journal of medicinal chemistry 20101201

Title: Characterization of metal-labelled peptides by matrix-assisted laser desorption/ionization mass spectrometry and tandem mass spectrometry.

Journal: Rapid communications in mass spectrometry : RCM 20101130

Title: First bodipy-DOTA derivatives as probes for bimodal imaging.

Journal: Chemical communications (Cambridge, England) 20101121

Title: Surface modification of PLGA nanospheres with Gd-DTPA and Gd-DOTA for high-relaxivity MRI contrast agents.

Journal: Biomaterials 20101101

Title: Synthesis and evaluation of macrocyclic amino acid derivatives for tumor imaging by gallium-68 positron emission tomography.

Journal: Bioorganic & medicinal chemistry 20101101

Title: Radiolabeled bicyclic somatostatin-based analogs: a novel class of potential radiotracers for SPECT/PET of neuroendocrine tumors.

Journal: Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20101101

Title: Comparison of the stability of Y-90-, Lu-177- and Ga-68- labeled human serum albumin microspheres (DOTA-HSAM).

Journal: Nuclear medicine and biology 20101101

Title: Synthesis of novel 68Ga-labeled amino acid derivatives for positron emission tomography of cancer cells.

Journal: Nuclear medicine and biology 20101101

Title: PET imaging of inflammation and adenocarcinoma xenografts using vascular adhesion protein 1 targeting peptide 68Ga-DOTAVAP-P1: comparison with 18F-FDG.

Journal: European journal of nuclear medicine and molecular imaging 20101001

Title: Procedure guidelines for PET/CT tumour imaging with 68Ga-DOTA-conjugated peptides: 68Ga-DOTA-TOC, 68Ga-DOTA-NOC, 68Ga-DOTA-TATE.

Journal: European journal of nuclear medicine and molecular imaging 20101001

Title: Anti-EGFRvIII monoclonal antibody armed with 177Lu: in vivo comparison of macrocyclic and acyclic ligands.

Journal: Nuclear medicine and biology 20101001

Title: Design, synthesis, and evaluation of 1,4,7,10-tetraazacyclododecane-1,4,7-triacetic acid derived, redox-sensitive contrast agents for magnetic resonance imaging.

Journal: Journal of medicinal chemistry 20100923

Title: RGD-cyclam conjugate: synthesis and potential application for positron emission tomography.

Journal: Bioorganic & medicinal chemistry letters 20100915

Title: Matrix metalloproteinase 9 targeting peptides: syntheses, 68Ga-labeling, and preliminary evaluation in a rat melanoma xenograft model.

Journal: Bioconjugate chemistry 20100915

Title: Evaluation of copper-64 labeled AmBaSar conjugated cyclic RGD peptide for improved microPET imaging of integrin alphavbeta3 expression.

Journal: Bioconjugate chemistry 20100818

Title: A DOTA-peptide conjugate by copper-free click chemistry.

Journal: Bioorganic & medicinal chemistry letters 20100815

Title: dsDNA-triggered energy transfer and lanthanide sensitization processes. Luminescent probing of specific A/T sequences.

Journal: Chemical communications (Cambridge, England) 20100814

Title: Switch from antagonist to agonist after addition of a DOTA chelator to a somatostatin analog.

Journal: European journal of nuclear medicine and molecular imaging 20100801

Title: Synthesis, characterization and biological evaluation of In(III) complexes anchored by DOTA-like chelators bearing a quinazoline moiety.

Journal: Metallomics : integrated biometal science 20100801

Title: Studies on the biodistribution of dextrin nanoparticles.

Journal: Nanotechnology 20100723

Title: Hybrid PET/CT for noninvasive pharmacokinetic evaluation of dynamic PolyConjugates, a synthetic siRNA delivery system.

Journal: Bioconjugate chemistry 20100721

Title: Multimodality nuclear and fluorescence tumor imaging in mice using a streptavidin nanoparticle.

Journal: Bioconjugate chemistry 20100721

Title: Design and synthesis of bis-biotin-containing reagents for applications utilizing monoclonal antibody-based pretargeting systems with streptavidin mutants.

Journal: Bioconjugate chemistry 20100721

Title: 68Ga-labelled exendin-3, a new agent for the detection of insulinomas with PET.

Journal: European journal of nuclear medicine and molecular imaging 20100701

Title: A novel 177Lu-labeled porphyrin for possible use in targeted tumor therapy.

Journal: Nuclear medicine and biology 20100701

Title: Synthesis and characterization of dinuclear heterometallic lanthanide complexes exhibiting MRI and luminescence response.

Journal: Dalton transactions (Cambridge, England : 2003) 20100628

Title: Large relaxivity enhancement of paramagnetic lipid nanoparticles by restricting the local motions of the Gd(III) chelates.

Journal: Journal of the American Chemical Society 20100616

Title: Synthesis of DOTA-conjugated multimeric [Tyr3]octreotide peptides via a combination of Cu(I)-catalyzed 'click' cycloaddition and thio acid/sulfonyl azide 'sulfo-click' amidation and their in vivo evaluation.

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Title: Preclinical and clinical studies of peptide receptor radionuclide therapy.

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Title: Peptide modified nanocarriers for selective targeting of bombesin receptors.

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Title: Tumor targeting chitosan nanoparticles for dual-modality optical/MR cancer imaging.

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Title: In vivo evaluation of (64)Cu-labeled magnetic nanoparticles as a dual-modality PET/MR imaging agent.

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Title: PET/NIRF/MRI triple functional iron oxide nanoparticles.

Journal: Biomaterials 20100401

Title: Magnetic resonance imaging of human glioma cells by means of an interleukin-6 receptor-targeted contrast agent.

Journal: Chemical biology & drug design 20100401

Title: Imaging of EGFR expression in murine xenografts using site-specifically labelled anti-EGFR 111In-DOTA-Z EGFR:2377 Affibody molecule: aspect of the injected tracer amount.

Journal: European journal of nuclear medicine and molecular imaging 20100301

Title: Optimization of time-resolved fluorescence assay for detection of europium-tetraazacyclododecyltetraacetic acid-labeled ligand-receptor interactions.

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Title: Glycoconjugate probes and targets for molecular imaging using magnetic resonance.

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Title: Design, synthesis and in vitro characterization of Glucagon-Like Peptide-1 derivatives for pancreatic beta cell imaging by SPECT.

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Title: Controlled radio-frequency hyperthermia using an MR scanner and simultaneous monitoring of temperature and therapy response by (1)H, (23)Na and (31)P magnetic resonance spectroscopy in subcutaneously implanted 9L-gliosarcoma.

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Title: Evaluation of a (64)Cu-labeled cystine-knot peptide based on agouti-related protein for PET of tumors expressing alphavbeta3 integrin.

Journal: Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20100201

Title: Synthesis of a new NIR fluorescent Nd complex labeling agent.

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Title: Preliminary evaluation of novel 68Ga-DOTAVAP-PEG-P2 peptide targeting vascular adhesion protein-1.

Journal: Clinical physiology and functional imaging 20100101

Title: Molecular imaging of atherosclerotic plaque with (64)Cu-labeled natriuretic peptide and PET.

Journal: Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20100101

Title: An improved synthesis and biological evaluation of a new cage-like bifunctional chelator, 4-((8-amino-3,6,10,13,16,19-hexaazabicyclo[6.6.6]icosane-1-ylamino)methyl)benzoic acid, for 64Cu radiopharmaceuticals.

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Title: Molecular optical imaging with radioactive probes.

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Title: Nanotargeted radionuclides for cancer nuclear imaging and internal radiotherapy.

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Title: Imaging and treating tumor vasculature with targeted radiolabeled carbon nanotubes.

Journal: International journal of nanomedicine 20100101

Title: 68Ga-DOTA-RGD peptide: biodistribution and binding into atherosclerotic plaques in mice.

Journal: European journal of nuclear medicine and molecular imaging 20091201

Title: Targeting of CCK-2 receptor-expressing tumors using a radiolabeled divalent gastrin peptide.

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Title: A new bifunctional Gd(III) complex of enhanced efficacy for MR-molecular imaging applications.

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Title: Effect of the regiochemistry of butyl amide substituents on the solution-state structures of lanthanide(III) DOTA-tetraamide complexes.

Journal: Inorganic chemistry 20091102

Title: Effect of DOTA position on melanoma targeting and pharmacokinetic properties of 111In-labeled lactam bridge-cyclized alpha-melanocyte stimulating hormone peptide.

Journal: Bioconjugate chemistry 20091101

Title: DOTA-M8: An extremely rigid, high-affinity lanthanide chelating tag for PCS NMR spectroscopy.

Journal: Journal of the American Chemical Society 20091021

Title: Bifunctional phage-based pretargeted imaging of human prostate carcinoma.

Journal: Nuclear medicine and biology 20091001

Title: In vivo imaging of human colorectal cancer using radiolabeled analogs of the uroguanylin peptide hormone.

Journal: Anticancer research 20091001

Title: In vitro characterization of (177)Lu-radiolabelled chimeric anti-CD20 monoclonal antibody and a preliminary dosimetry study.

Journal: European journal of nuclear medicine and molecular imaging 20090901

Title: A 2-helix small protein labeled with 68Ga for PET imaging of HER2 expression.

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Title: Evaluation of a 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid-conjugated bombesin-based radioantagonist for the labeling with single-photon emission computed tomography, positron emission tomography, and therapeutic radionuclides.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20090815

Title: Absolute temperature MR imaging with thulium 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetramethyl-1,4,7,10-tetraacetic acid (TmDOTMA-).

Journal: Magnetic resonance in medicine 20090801

Title: Comparative study on DOTA-derivatized bombesin analog labeled with 90Y and 177Lu: in vitro and in vivo evaluation.

Journal: Nuclear medicine and biology 20090801

Title: Dual functional molecular imaging probe targeting CD20 with PET and optical imaging.

Journal: Oncology reports 20090701

Title: Development of high-specific-activity (68)Ga-labeled DOTA-rhenium-cyclized alpha-MSH peptide analog to target MC1 receptors overexpressed by melanoma tumors.

Journal: Nuclear medicine and biology 20090701

Title: Evaluation of a novel radiofolate in tumour-bearing mice: promising prospects for folate-based radionuclide therapy.

Journal: European journal of nuclear medicine and molecular imaging 20090601

Title: 68Ga-labeling of biotin analogues and their characterization.

Journal: Bioconjugate chemistry 20090601

Title: Preparation and in vivo imaging of PEG-poly(L-lysine)-based polymeric micelle MRI contrast agents.

Journal: Journal of controlled release : official journal of the Controlled Release Society 20090521

Title: Glycosylated DOTA-alpha-melanocyte-stimulating hormone analogues for melanoma targeting: influence of the site of glycosylation on in vivo biodistribution.

Journal: Bioconjugate chemistry 20090520

Title: Gd(iii) complex of a monophosphinate-bis(phosphonate) DOTA analogue with a high relaxivity; Lanthanide(iii) complexes for imaging and radiotherapy of calcified tissues.

Journal: Dalton transactions (Cambridge, England : 2003) 20090507

Title: A novel neutrophil-specific PET imaging agent: cFLFLFK-PEG-64Cu.

Journal: Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20090501

Title: Radiolabeling of trastuzumab with 177Lu via DOTA, a new radiopharmaceutical for radioimmunotherapy of breast cancer.

Journal: Nuclear medicine and biology 20090501

Title: A simplified suite of methods to evaluate chelator conjugation of antibodies: effects on hydrodynamic radius and biodistribution.

Journal: Nuclear medicine and biology 20090501

Title: Quantification and excretion kinetics of a magnetic resonance imaging contrast agent by capillary electrophoresis-mass spectrometry.

Journal: Electrophoresis 20090501

Title: Noninvasive de novo imaging of human embryonic stem cell-derived teratoma formation.

Journal: Cancer research 20090401

Title: Noninvasive imaging of alphaVbeta3 function as a predictor of the antimigratory and antiproliferative effects of dasatinib.

Journal: Cancer research 20090401

Title: SPECT and PET imaging of EGF receptors with site-specifically labeled EGF and dimeric EGF.

Journal: Bioconjugate chemistry 20090401

Title: Improving tumor uptake and pharmacokinetics of (64)Cu-labeled cyclic RGD peptide dimers with Gly(3) and PEG(4) linkers.

Journal: Bioconjugate chemistry 20090401

Title: Metastatic melanoma imaging with an (111)In-labeled lactam bridge-cyclized alpha-melanocyte-stimulating hormone peptide.

Journal: Nuclear medicine and biology 20090401

Title: Engineered knottin peptides: a new class of agents for imaging integrin expression in living subjects.

Journal: Cancer research 20090315

Title: Synthesis and evaluation of lanthanide ion DOTA-tetraamide complexes bearing peripheral hydroxyl groups.

Journal: Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 20090301

Title: A comparative study of 131I and 177Lu labeled somatostatin analogues for therapy of neuroendocrine tumours.

Journal: Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine 20090201

Title: Derivation of a compartmental model for quantifying 64Cu-DOTA-RGD kinetics in tumor-bearing mice.

Journal: Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20090201

Title: Development of [(90)Y]DOTA-conjugated bisphosphonate for treatment of painful bone metastases.

Journal: Nuclear medicine and biology 20090201

Title: Lanthanide(III) complexes of pyridine-N-oxide analogues of DOTA in solution and in the solid state. A new kind of isomerism in complexes of DOTA-like ligands.

Journal: Inorganic chemistry 20090119

Title: Pyridine-N-oxide analogues of DOTA and their gadolinium(III) complexes endowed with a fast water exchange on the square-antiprismatic isomer.

Journal: Inorganic chemistry 20090119

Title: Novel cell nucleus directed fluorescent tetraazacyclododecane-tetra-acetic acid compounds.

Journal: Medicinal chemistry (Shariqah (United Arab Emirates)) 20090101

Title: Chemotherapy synergizes with radioimmunotherapy targeting La autoantigen in tumors.

Journal: PloS one 20090101

Title: Hexa-arginine enhanced uptake and residualization of selective high affinity ligands by Raji lymphoma cells.

Journal: Molecular cancer 20090101

Title: Multimodal imaging of integrin receptor-positive tumors by bioluminescence, fluorescence, gamma scintigraphy, and single-photon emission computed tomography using a cyclic RGD peptide labeled with a near-infrared fluorescent dye and a radionuclide.

Journal: Molecular imaging 20090101

Title: Evaluation of [64Cu]Cu-DOTA and [64Cu]Cu-CB-TE2A chelates for targeted positron emission tomography with an alphavbeta6-specific peptide.

Journal: Molecular imaging 20090101

Title: The effect of the amide substituent on the biodistribution and tolerance of lanthanide(III) DOTA-tetraamide derivatives.

Journal: Investigative radiology 20081201

Title: Detection of electrophoretically separated cytochromes P450 by element-labelled monoclonal antibodies via laser ablation inductively coupled plasma mass spectrometry.

Journal: Analytical and bioanalytical chemistry 20081101

Title: Engineered antibody fragments with infinite affinity as reporter genes for PET imaging.

Journal: Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20081101

Title: Carbonic anhydrase inhibitors: design of membrane-impermeant copper(II) complexes of DTPA-, DOTA-, and TETA-tailed sulfonamides targeting the tumor-associated transmembrane isoform IX.

Journal: ChemMedChem 20081101

Title: Tetrafluorophenolate of HBED-CC: a versatile conjugation agent for 68Ga-labeled small recombinant antibodies.

Journal: European journal of nuclear medicine and molecular imaging 20081001

Title: Design, synthesis, and biological evaluation of an antagonist-bombesin analogue as targeting vector.

Journal: Bioconjugate chemistry 20081001

Title: An osteoclast-targeting agent for imaging and therapy of bone metastasis.

Journal: Bioorganic & medicinal chemistry letters 20080901

Title: Evaluation of the pharmacokinetic effects of various linking group using the 111In-DOTA-X-BBN(7-14)NH2 structural paradigm in a prostate cancer model.

Journal: Bioconjugate chemistry 20080901

Title: Rapid and efficient production of radiolabeled antibody conjugates using vacuum diafiltration guided by mathematical modeling.

Journal: Bioconjugate chemistry 20080901

Title: alpha(v)beta(3) Integrin-targeting radionuclide therapy and imaging with monomeric RGD peptide.

Journal: International journal of cancer 20080801

Title: Evaluation of a maleimido derivative of CHX-A'' DTPA for site-specific labeling of affibody molecules.

Journal: Bioconjugate chemistry 20080801

Title: PET/MRI dual-modality tumor imaging using arginine-glycine-aspartic (RGD)-conjugated radiolabeled iron oxide nanoparticles.

Journal: Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20080801

Title: Detailed analysis concerning the biodistribution and metabolism of human calcitonin-derived cell-penetrating peptides.

Journal: Bioconjugate chemistry 20080801

Title: Imaging of urokinase-type plasminogen activator receptor expression using a 64Cu-labeled linear peptide antagonist by microPET.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20080801

Title: Cyclin A probes by means of intermolecular sensitization of terbium-chelating peptides.

Journal: Journal of the American Chemical Society 20080730

Title: Novel DOTA-based prochelator for divalent peptide vectorization: synthesis of dimeric bombesin analogues for multimodality tumor imaging and therapy.

Journal: Chemical communications (Cambridge, England) 20080728

Title: Novel chemically modified analogues of neuropeptide Y for tumor targeting.

Journal: Bioconjugate chemistry 20080701

Title: Synthesis of 64Cu-labeled magnetic nanoparticles for multimodal imaging.

Journal: Bioconjugate chemistry 20080701

Title: The importance of high specific radioactivity in the performance of 68Ga-labeled peptide.

Journal: Nuclear medicine and biology 20080701

Title: The detection limit of a Gd3+-based T1 agent is substantially reduced when targeted to a protein microdomain.

Journal: Magnetic resonance imaging 20080601

Title: Synthesis, potentiometric, kinetic, and NMR Studies of 1,4,7,10-tetraazacyclododecane-1,7-bis(acetic acid)-4,10-bis(methylenephosphonic acid) (DO2A2P) and its complexes with Ca(II), Cu(II), Zn(II) and lanthanide(III) ions.

Journal: Inorganic chemistry 20080505

Title: 111In-labeled galectin-3-targeting peptide as a SPECT agent for imaging breast tumors.

Journal: Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20080501

Title: Bifunctional ligands based on the DOTA-monoamide cage.

Journal: Organic & biomolecular chemistry 20080407

Title: Value of apoptin's 40-amino-acid C-terminal fragment for the differentiation between human tumor and non-tumor cells.

Journal: Apoptosis : an international journal on programmed cell death 20080401

Title: Preclinical radioimmunotargeting of folate receptor alpha using the monoclonal antibody conjugate DOTA-MORAb-003.

Journal: Nuclear medicine and biology 20080401

Title: Antibody-dendrimer conjugates: the number, not the size of the dendrimers, determines the immunoreactivity.

Journal: Bioconjugate chemistry 20080401

Title: Receptor-binding, biodistribution, and metabolism studies of 64Cu-DOTA-cetuximab, a PET-imaging agent for epidermal growth-factor receptor-positive tumors.

Journal: Cancer biotherapy & radiopharmaceuticals 20080401

Title: Role of the antenna in tissue selective probes built of lanthanide-organic chelates.

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Title: PET (positron emission tomography) imaging of biomolecules using metal-DOTA complexes: a new collaborative challenge by chemists, biologists, and physicians for future diagnostics and exploration of in vivo dynamics.

Journal: Organic & biomolecular chemistry 20080307

Title: Novel dual labelled nucleus-directed conjugates containing correct and mutant nuclear localisation sequences.

Journal: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20080303

Title: Improved syntheses and applicability of different DOTA building blocks for multiply derivatized scaffolds.

Journal: Bioorganic & medicinal chemistry 20080301

Title: Lanthanide(III) complexes of bis(phosphonate) monoamide analogues of DOTA: bone-seeking agents for imaging and therapy.

Journal: Journal of medicinal chemistry 20080214

Title: The synthesis and chelation chemistry of DOTA-peptide conjugates.

Journal: Bioconjugate chemistry 20080201

Title: Plasma clearance of bacteriophage Qbeta particles as a function of surface charge.

Journal: Journal of the American Chemical Society 20080130

Title: Development and evaluation of peptidic ligands targeting tumour-associated urokinase plasminogen activator receptor (uPAR) for use in alpha-emitter therapy for disseminated ovarian cancer.

Journal: European journal of nuclear medicine and molecular imaging 20080101

Title: In vivo imaging of 64Cu-labeled polymer nanoparticles targeted to the lung endothelium.

Journal: Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20080101

Title: In vivo MRI assessment of a novel GdIII-based contrast agent designed for high magnetic field applications.

Journal: Contrast media & molecular imaging 20080101

Title: New synthesis of a high molecular weight ligand derived from dota; thermodynamic stability of the MRI contrast agent formed with gadolinium.

Journal: Contrast media & molecular imaging 20080101

Title: Synthesis of novel neutrophil-specific imaging agents for Positron Emission Tomography (PET) imaging.

Journal: Bioorganic & medicinal chemistry letters 20071215

Title: Kinetic stability studies on yttrium(III)-1,4,7,10- tetraazacyclododecane-1,4,7,10-tetraacetic acid by free-ion selective radiotracer extraction.

Journal: Analytical chemistry 20071215

Title: A metal-coded affinity tag approach to quantitative proteomics.

Journal: Molecular & cellular proteomics : MCP 20071101

Title: Dual-function probe for PET and near-infrared fluorescence imaging of tumor vasculature.

Journal: Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20071101

Title: MRI detection of paramagnetic chemical exchange effects in mice kidneys in vivo.

Journal: Magnetic resonance in medicine 20071001

Title: Improved tumor targeting and decreased normal tissue accumulation through extracorporeal affinity adsorption in a two-step pretargeting strategy.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20070915

Title: Influence of chelate conjugation on a newly identified tumor-targeting peptide.

Journal: Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20070901

Title: Monopropionate analogues of DOTA4- and DTPA5-: kinetics of formation and dissociation of their lanthanide(III) complexes.

Journal: Dalton transactions (Cambridge, England : 2003) 20070828

Title: DOTA-PESIN, a DOTA-conjugated bombesin derivative designed for the imaging and targeted radionuclide treatment of bombesin receptor-positive tumours.

Journal: European journal of nuclear medicine and molecular imaging 20070801

Title: In vivo evaluation and small-animal PET/CT of a prostate cancer mouse model using 64Cu bombesin analogs: side-by-side comparison of the CB-TE2A and DOTA chelation systems.

Journal: Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20070801

Title: Are radiogallium-labelled DOTA-conjugated somatostatin analogues superior to those labelled with other radiometals?

Journal: European journal of nuclear medicine and molecular imaging 20070701

Title: The 68Ge/ 68Ga generator has high potential, but when can we use 68Ga-labelled tracers in clinical routine?

Journal: European journal of nuclear medicine and molecular imaging 20070701

Title: (64)Cu-labeled tetrameric and octameric RGD peptides for small-animal PET of tumor alpha(v)beta(3) integrin expression.

Journal: Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20070701

Title: Preparation and biological evaluation of 111In-, 177Lu- and 90Y-labeled DOTA analogues conjugated to B72.3.

Journal: Nuclear medicine and biology 20070701

Title: Carbon nanotubes: potential benefits and risks of nanotechnology in nuclear medicine.

Journal: Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20070701

Title: Potentiometric and relaxometric properties of a gadolinium-based MRI contrast agent for sensing tissue pH.

Journal: Inorganic chemistry 20070625

Title: Synthesis, biodistribution and excretion of radiolabeled poly(2-alkyl-2-oxazoline)s.

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Title: Evaluation of CD20, CD22, and HLA-DR targeting for radioimmunotherapy of B-cell lymphomas.

Journal: Cancer research 20070615

Title: Therapeutic efficacy of a 177Lu-labeled DOTA conjugated alpha-melanocyte-stimulating hormone peptide in a murine melanoma-bearing mouse model.

Journal: Cancer biotherapy & radiopharmaceuticals 20070601

Title: Results of individual patient dosimetry in peptide receptor radionuclide therapy with 177Lu DOTA-TATE and 177Lu DOTA-NOC.

Journal: Cancer biotherapy & radiopharmaceuticals 20070601

Title: Preparation of TH227-labeled radioimmunoconjugates, assessment of serum stability and antigen binding ability.

Journal: Cancer biotherapy & radiopharmaceuticals 20070601

Title: Solid-phase oligonucleotide labeling with DOTA.

Journal: Current protocols in nucleic acid chemistry 20070601

Title: Indium-labeled macrocyclic conjugates of naltrindole: high-affinity radioligands for in vivo studies of peripheral delta opioid receptors.

Journal: Journal of medicinal chemistry 20070503

Title: A bridge to coordination isomer selection in lanthanide(III) DOTA-tetraamide complexes.

Journal: Inorganic chemistry 20070402

Title: In vitro and in vivo comparison of DTPA- and DOTA-conjugated antiferritin monoclonal antibody for imaging and therapy of pancreatic cancer.

Journal: Nuclear medicine and biology 20070401

Title: Synthesis of DOTA-conjugated multivalent cyclic-RGD peptide dendrimers via 1,3-dipolar cycloaddition and their biological evaluation: implications for tumor targeting and tumor imaging purposes.

Journal: Organic & biomolecular chemistry 20070321

Title: Alpha v beta 3 integrin-targeting of intraperitoneally growing tumors with a radiolabeled RGD peptide.

Journal: International journal of cancer 20070201

Title: Reduced myelotoxicity with sustained tumor concentration of radioimmunoconjugates in rats after extracorporeal depletion.

Journal: Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20070201

Title: Somatostatin-receptor-targeted alpha-emitting 213Bi is therapeutically more effective than beta(-)-emitting 177Lu in human pancreatic adenocarcinoma cells.

Journal: Nuclear medicine and biology 20070201

Title: Gadolinium(III) complexes of mono- and diethyl esters of monophosphonic acid analogue of DOTA as potential MRI contrast agents: solution structures and relaxometric studies.

Journal: Dalton transactions (Cambridge, England : 2003) 20070128

Title: Radioiodinated versus radiometal-labeled anti-carcinoembryonic antigen single-chain Fv-Fc antibody fragments: optimal pharmacokinetics for therapy.

Journal: Cancer research 20070115

Title: Evaluation of a new biotin-DOTA conjugate for pretargeted antibody-guided radioimmunotherapy (PAGRIT).

Journal: European journal of nuclear medicine and molecular imaging 20070101

Title: Long-range-distance NMR effects in a protein labeled with a lanthanide-DOTA chelate.

Journal: Chemistry (Weinheim an der Bergstrasse, Germany) 20070101

Title: Effects of linker variation on the in vitro and in vivo characteristics of an 111In-labeled RGD peptide.

Journal: Nuclear medicine and biology 20070101

Title: Influence of different spacers on the biological profile of a DOTA-somatostatin analogue.

Journal: Bioconjugate chemistry 20070101

Title: Synthesis of Poly[APMA]-DOTA-64Cu conjugates for interventional radionuclide therapy of prostate cancer: assessment of intratumoral retention by micro-positron emission tomography.

Journal: Molecular imaging 20070101

Title: Peptidyl molecular imaging contrast agents using a new solid-phase peptide synthesis approach.

Journal: Bioconjugate chemistry 20070101

Title: 64Cu-labeled alpha-melanocyte-stimulating hormone analog for microPET imaging of melanocortin 1 receptor expression.

Journal: Bioconjugate chemistry 20070101

Title: Synthesis and radiolabeling of selective high-affinity ligands designed to target non-Hodgkin's lymphoma and leukemia.

Journal: Bioconjugate chemistry 20070101

Title: Synthesis of novel 1,4,7,10-tetraazacyclodecane-1,4,7,10-tetraacetic acid (DOTA) derivatives for chemoselective attachment to unprotected polyfunctionalized compounds.

Journal: Chemistry (Weinheim an der Bergstrasse, Germany) 20070101

Title: In vitro and in vivo evaluation of 64Cu-labeled DOTA-linker-bombesin(7-14) analogues containing different amino acid linker moieties.

Journal: Bioconjugate chemistry 20070101

Title: Design and synthesis of mono- and multimeric targeted radiopharmaceuticals based on novel cyclen ligands coupled to anti-MUC1 aptamers for the diagnostic imaging and targeted radiotherapy of cancer.

Journal: Bioconjugate chemistry 20070101

Title: Synthesis and evaluation of intercalating somatostatin receptor binding peptide conjugates for endoradiotherapy.

Journal: Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques 20070101

Title: PET imaging of soluble yttrium-86-labeled carbon nanotubes in mice.

Journal: PloS one 20070101

Title: Labeling of oligonucleotides with DTPA and DOTA on solid phase.

Journal: Nucleosides, nucleotides & nucleic acids 20070101

Title: Dimeric DOTA-alpha-melanocyte-stimulating hormone analogs: synthesis and in vivo characteristics of radiopeptides with high in vitro activity.

Journal: Journal of receptor and signal transduction research 20070101

Title: Radiolabelling of glucose-Tyr3-octreotate with 125I and analysis of its metabolism in rats: comparison with radiolabelled DOTA-Tyr3-octreotate.

Journal: Anticancer research 20070101

Title: Gallium-68 PET: a new frontier in receptor cancer imaging.

Journal: Anticancer research 20070101

Title: Environmental effects on the structure of metal ion-DOTA complexes: an ab initio study of radiopharmaceutical metals.

Journal: Inorganic chemistry 20061113

Title: Evaluation of 177Lu-DOTA-labeled aglycosylated monoclonal anti-L1-CAM antibody chCE7: influence of the number of chelators on the in vitro and in vivo properties.

Journal: Nuclear medicine and biology 20061001

Title: Design, synthesis, and biological evaluation of somatostatin-based radiopeptides.

Journal: Chemistry & biology 20061001

Title: An HPLC/mass spectrometry platform for the development of multimodality contrast agents and targeted therapeutics: prostate-specific membrane antigen small molecule derivatives.

Journal: Contrast media & molecular imaging 20060901

Title: In vitro and in vivo magnetic resonance detection of tumor cells by targeting glutamine transporters with Gd-based probes.

Journal: Journal of medicinal chemistry 20060810

Title: A high-frequency EPR study of frozen solutions of Gd(III) complexes: straightforward determination of the zero-field splitting parameters and simulation of the NMRD profiles.

Journal: Journal of the American Chemical Society 20060621

Title: Relaxometric and solution NMR structural studies on ditopic lanthanide(III) complexes of a phosphinate analogue of DOTA with a fast rate of water exchange.

Journal: Dalton transactions (Cambridge, England : 2003) 20060521

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Title: A phase I trial of (90)Y-DOTA-anti-CEA chimeric T84.66 (cT84.66) radioimmunotherapy in patients with metastatic CEA-producing malignancies.

Journal: Cancer biotherapy & radiopharmaceuticals 20060401

Title: Internalization of sst2, sst3, and sst5 receptors: effects of somatostatin agonists and antagonists.

Journal: Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20060301

Title: Synthesis of aminooxy-functionalized lanthanide(III) chelates for carbonyl-group conjugation.

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Title: Non-invasive temperature imaging with thulium 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetramethyl-1,4,7,10-tetraacetic acid (TmDOTMA-).

Journal: NMR in biomedicine 20060201

Title: Improved biodistribution and radioimmunoimaging with poly(ethylene glycol)-DOTA-conjugated anti-CEA diabody.

Journal: Bioconjugate chemistry 20060101

Title: Radiolanthanide-labeled monoclonal antibody CC49 for radioimmunotherapy of cancer: biological comparison of DOTA conjugates and 149Pm, 166Ho, and 177Lu.

Journal: Bioconjugate chemistry 20060101

Title: Simple synthesis of a building block for solid-phase labeling of oligonucleotides with 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA).

Journal: Bioconjugate chemistry 20060101

Title: Selective targeting of E. coli heat-stable enterotoxin analogs to human colon cancer cells.

Journal: Anticancer research 20060101

Title: Targeting of lanthanide(III) chelates of DOTA-type glycoconjugates to the hepatic asyaloglycoprotein receptor: cell internalization and animal imaging studies.

Journal: Contrast media & molecular imaging 20060101

Title: Conjugation of DOTA-like chelating agents to peptides and radiolabeling with trivalent metallic isotopes.

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Title: Density-functional theory structures of 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid complexes for ions across the lanthanide series.

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Title: A bisphosphonate monoamide analogue of DOTA: a potential agent for bone targeting.

Journal: Journal of the American Chemical Society 20051130

Title: Structural and chiroptical properties of the two coordination isomers of YbDOTA-type complexes.

Journal: Inorganic chemistry 20051114

Title: Regressive DOTA labelling performance with indium-111 and yttrium-90 over a week of use.

Journal: European journal of nuclear medicine and molecular imaging 20051101

Title: Development of tumor targeting bioprobes ((111)In-chimeric L6 monoclonal antibody nanoparticles) for alternating magnetic field cancer therapy.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20051001

Title: Determining maximal tolerable dose of the monoclonal antibody BR96 labeled with 90Y or 177Lu in rats: establishment of a syngeneic tumor model to evaluate means to improve radioimmunotherapy.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20051001

Title: Does paclitaxel (Taxol) given after (111)In-labeled monoclonal antibodies increase tumor-cumulated activity in epithelial cancers?

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Title: Blood pharmacokinetics of various monoclonal antibodies labeled with a new trifunctional chelating reagent for simultaneous conjugation with 1,4,7,10-tetraazacyclododecane-N,N',N'',N'''-tetraacetic acid and biotin before radiolabeling.

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Title: On-resonance low B1 pulses for imaging of the effects of PARACEST agents.

Journal: Journal of magnetic resonance (San Diego, Calif. : 1997) 20050901

Title: Derivatization of phosphopeptides with mercapto- and amino-functionalized conjugate groups by phosphate elimination and subsequent Michael addition.

Journal: Organic & biomolecular chemistry 20050821

Title: High-dose radioimmunotherapy combined with fixed, low-dose paclitaxel in metastatic prostate and breast cancer by using a MUC-1 monoclonal antibody, m170, linked to indium-111/yttrium-90 via a cathepsin cleavable linker with cyclosporine to prevent human anti-mouse antibody.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20050815

Title: An estradiol-conjugate for radiolabelling with 177Lu: an attempt to prepare a radiotherapeutic agent.

Journal: Bioorganic & medicinal chemistry 20050701

Title: Are gadolinium contrast agents suitable for gadolinium neutron capture therapy?

Journal: Neurological research 20050601

Title: Dendrimeric Gd(III) complex of a monophosphinated DOTA analogue: optimizing relaxivity by reducing internal motion.

Journal: Chemical communications (Cambridge, England) 20050514

Title: Gallium-68-DOTA-albumin as a PET blood-pool marker: experimental evaluation in vivo.

Journal: Nuclear medicine and biology 20050401

Title: Noninvasive MR thermometry using paramagnetic lanthanide complexes of 1,4,7,10-tetraazacyclodoecane-alpha,alpha',alpha'',alpha'''-tetramethyl-1,4,7,10-tetraacetic acid (DOTMA4-).

Journal: Magnetic resonance in medicine 20050201

Title: Synthesis of a bifunctional monophosphinic acid DOTA analogue ligand and its lanthanide(III) complexes. A gadolinium(III) complex endowed with an optimal water exchange rate for MRI applications.

Journal: Organic & biomolecular chemistry 20050107

Title: Conjugation of DOTA using isolated phenolic active esters: the labeling and biodistribution of albumin as blood pool marker.

Journal: Bioconjugate chemistry 20050101

Title: MicroPET imaging of MCF-7 tumors in mice via unr mRNA-targeted peptide nucleic acids.

Journal: Bioconjugate chemistry 20050101

Title: Spectral properties of pro-multimodal imaging agents derived from a NIR dye and a metal chelator.

Journal: Photochemistry and photobiology 20050101

Title: Synthesis of novel polydiamidopropanoate dendrimer PNA-peptide chimeras for non-invasive magnetic resonance imaging of cancer.

Journal: Nucleosides, nucleotides & nucleic acids 20050101

Title: Medicinal chemistry of somatostatin analogs leading to the DTPA and DOTA conjugates of the multi-receptor-ligand SOM230.

Journal: Journal of endocrinological investigation 20050101

Title: Lanthanide(III) complexes of DOTA-glycoconjugates: a potential new class of lectin-mediated medical imaging agents.

Journal: Chemistry (Weinheim an der Bergstrasse, Germany) 20041105

Title: Quantitation and visualization of tumor-specific T cells in the secondary lymphoid organs during and after tumor elimination by PET.

Journal: Nuclear medicine and biology 20041101

Title: Complexing mechanism of the lanthanide cations Eu3+, Gd3+, and Tb3+ with 1,4,7,10-tetrakis(carboxymethyl)-1,4,7,10-tetraazacyclododecane (dota)-characterization of three successive complexing phases: study of the thermodynamic and structural properties of the complexes by potentiometry, luminescence spectroscopy, and EXAFS.

Journal: Chemistry (Weinheim an der Bergstrasse, Germany) 20041011

Title: 68Ga-labelled DOTA-derivatised peptide ligands.

Journal: European journal of nuclear medicine and molecular imaging 20040801

Title: 177Lu-DOTA-lanreotide: a novel tracer as a targeted agent for tumor therapy.

Journal: Nuclear medicine and biology 20040801

Title: Conjugates of gadolinium complexes to bile acids as hepatocyte-directed contrast agents for magnetic resonance imaging.

Journal: Journal of medicinal chemistry 20040701

Title: Imaging the pharmacodynamics of HER2 degradation in response to Hsp90 inhibitors.

Journal: Nature biotechnology 20040601

Title: An image worth a thousand lives?

Journal: Nature biotechnology 20040601

Title: Solution dynamics and stability of lanthanide(III) (S)-2-(p-nitrobenzyl)DOTA complexes.

Journal: Inorganic chemistry 20040503

Title: Novel gadolinium(III) polyaminocarboxylate macrocyclic complexes as potential magnetic resonance imaging contrast agents.

Journal: Journal of inorganic biochemistry 20040501

Title: Comparative in vivo stability of copper-64-labeled cross-bridged and conventional tetraazamacrocyclic complexes.

Journal: Journal of medicinal chemistry 20040311

Title: Radioimmunotherapy of prostate cancer in human xenografts using monoclonal antibodies specific to prostate specific membrane antigen (PSMA): studies in nude mice.

Journal: The Prostate 20040201

Title: Evaluation of a cathepsin-cleavable peptide linked radioimmunoconjugate of a panadenocarcinoma MAb, m170, in mice and patients.

Journal: Cancer biotherapy & radiopharmaceuticals 20040201

Title: Conformation and structure of polymeric contrast agents for medical imaging.

Journal: Biomacromolecules 20040101

Title: 90Y and 111In complexes of a DOTA-conjugated integrin alpha v beta 3 receptor antagonist: different but biologically equivalent.

Journal: Bioconjugate chemistry 20040101

Title: Production and applications of copper-64 radiopharmaceuticals.

Journal: Methods in enzymology 20040101

Title: Generation of DOTA-conjugated antibody fragments for radioimmunoimaging.

Journal: Methods in enzymology 20040101

Title: Microwave-supported preparation of (68)Ga bioconjugates with high specific radioactivity.

Journal: Bioconjugate chemistry 20040101

Title: Synthesis, characterization, and X-ray crystal structure of In(DOTA-AA) (AA = p-aminoanilide): a model for 111In-labeled DOTA-biomolecule conjugates.

Journal: Inorganic chemistry 20031229

Title: Radioimmunotherapy of non-Hodgkin's lymphoma with 90Y-DOTA humanized anti-CD22 IgG (90Y-Epratuzumab): do tumor targeting and dosimetry predict therapeutic response?

Journal: Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20031201

Title: pH-sensitive modulation of the second hydration sphere in lanthanide(III) tetraamide-DOTA complexes: a novel approach to smart MR contrast media.

Journal: Chemistry (Weinheim an der Bergstrasse, Germany) 20031006

Title: PARACEST agents: modulating MRI contrast via water proton exchange.

Journal: Accounts of chemical research 20031001

Title: Improved radiotracing of oxytocin receptor-expressing tumours using the new [111In]-DOTA-Lys8-deamino-vasotocin analogue.

Journal: British journal of cancer 20030901

Title: Synthesis and visualization of a membrane-permeable MRI contrast agent.

Journal: Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 20030901

Title: Preclinical evaluation of cathepsin-degradable peptide linkers for radioimmunoconjugates.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20030901

Title: Enhanced therapeutic index of radioimmunotherapy (RIT) in prostate cancer patients: comparison of radiation dosimetry for 1,4,7,10-tetraazacyclododecane-N,N',N',N''-tetraacetic acid (DOTA)-peptide versus 2IT-DOTA monoclonal antibody linkage for RIT.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20030901

Title: Stabilised 111In-labelled DTPA- and DOTA-conjugated neurotensin analogues for imaging and therapy of exocrine pancreatic cancer.

Journal: European journal of nuclear medicine and molecular imaging 20030801

Title: Synthesis and evaluation of novel bifunctional chelating agents based on 1,4,7,10-tetraazacyclododecane-N,N',N',N''-tetraacetic acid for radiolabeling proteins.

Journal: Nuclear medicine and biology 20030801

Title: Design, synthesis, and evaluation of radiolabeled integrin alpha v beta 3 receptor antagonists for tumor imaging and radiotherapy.

Journal: Cancer biotherapy & radiopharmaceuticals 20030801

Title: A new biotin derivative-DOTA conjugate as a candidate for pretargeted diagnosis and therapy of tumors.

Journal: Journal of medicinal chemistry 20030703

Title: Optimising conditions for radiolabelling of DOTA-peptides with 90Y, 111In and 177Lu at high specific activities.

Journal: European journal of nuclear medicine and molecular imaging 20030601

Title: DOTA alpha-melanocyte-stimulating hormone analogues for imaging metastatic melanoma lesions.

Journal: Annals of the New York Academy of Sciences 20030601

Title: Preparation and in vitro evaluation of GdDOTA-(BOM)4; a novel angiographic MRI contrast agent.

Journal: Organic & biomolecular chemistry 20030521

Title: Equilibrium, 1H and 13C NMR spectroscopy, and X-ray diffraction studies on the complexes Bi(DOTA)- and Bi(DO3A-Bu).

Journal: Inorganic chemistry 20030407

Title: A rare earth-DOTA-binding antibody: probe properties and binding affinity across the lanthanide series.

Journal: Journal of the American Chemical Society 20030326

Title: Isotachophoretic determination of stability constants of Ho and Y complexes with diethylenetriaminepentaacetic acid and 1,4,7,10-tetraazadodecane-N,N',N'',N'''-tetraacetic acid.

Journal: Journal of chromatography. A 20030321

Title: Comparison of immunoscintigraphy, efficacy, and toxicity of conventional and pretargeted radioimmunotherapy in CD20-expressing human lymphoma xenografts.

Journal: Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20030301

Title: The addition of DTPA to [177Lu-DOTA0,Tyr3]octreotate prior to administration reduces rat skeleton uptake of radioactivity.

Journal: European journal of nuclear medicine and molecular imaging 20030201

Title: 90Y-DOTA-hLL2: an agent for radioimmunotherapy of non-Hodgkin's lymphoma.

Journal: Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20030101

Title: Radiolabeled alpha-melanocyte-stimulating hormone analogs for receptor-mediated targeting of melanoma: from tritium to indium.

Journal: Journal of molecular recognition : JMR 20030101

Title: Synthesis of radiometal-labeled and fluorescent cell-permeating peptide-PNA conjugates for targeting the bcl-2 proto-oncogene.

Journal: Bioconjugate chemistry 20030101

Title: Towards the rational design of magnetic resonance imaging contrast agents: isolation of the two coordination isomers of lanthanide DOTA-type complexes.

Journal: Angewandte Chemie (International ed. in English) 20030101

Title: A novel DOTA-alpha-melanocyte-stimulating hormone analog for metastatic melanoma diagnosis.

Journal: Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20021201

Title: Evaluation of 90Y-DTPA and 90Y-DOTA for potential application in intra-vascular radionuclide therapy.

Journal: Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine 20020901

Title: From monomers to micelles: investigation of the parameters influencing proton relaxivity.

Journal: Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 20020901

Title: Early distribution dynamics of polymeric magnetic resonance imaging contrast agents in rats.

Journal: Academic radiology 20020801

Title: Synthesis and evaluation of a monoreactive DOTA derivative for indium-111-based residualizing label to estimate protein pharmacokinetics.

Journal: The Journal of pharmacy and pharmacology 20020801

Title: Modification of the structure of a metallopeptide: synthesis and biological evaluation of (111)In-labeled DOTA-conjugated rhenium-cyclized alpha-MSH analogues.

Journal: Journal of medicinal chemistry 20020704

Title: Pretargeting radioimmunotherapy of a murine model of adult T-cell leukemia with the alpha-emitting radionuclide, bismuth 213.

Journal: Blood 20020701

Title: Conformational characterization of lanthanide(III)-DOTA complexes by ab initio investigation in vacuo and in aqueous solution.

Journal: Journal of the American Chemical Society 20020501

Title: Optimization of the small-scale synthesis of DOTA-Tyr3 -octreotide.

Journal: Nuclear medicine communications 20020501

Title: Formation kinetics and stability studies on the lanthanide complexes of 1,4,7,10-tetraazacyclododecane-N,N',N',N''-tetraacetic acid by capillary electrophoresis.

Journal: Electrophoresis 20020501

Title: Pm-149 DOTA bombesin analogs for potential radiotherapy. in vivo comparison with Sm-153 and Lu-177 labeled DO3A-amide-betaAla-BBN(7-14)NH(2).

Journal: Nuclear medicine and biology 20020501

Title: In vivo comparison of macrocyclic and acyclic ligands for radiolabeling of monoclonal antibodies with 177Lu for radioimmunotherapeutic applications.

Journal: Nuclear medicine and biology 20020501

Title: Neuroendocrine tumor targeting: study of novel gallium-labeled somatostatin radiopeptides in a rat pancreatic tumor model.

Journal: International journal of cancer 20020420

Title: Paramagnetic lanthanide(III) complexes as pH-sensitive chemical exchange saturation transfer (CEST) contrast agents for MRI applications.

Journal: Magnetic resonance in medicine 20020401

Title: Alpha-melanocyte-stimulating hormone peptide analogs labeled with technetium-99m and indium-111 for malignant melanoma targeting.

Journal: Cancer 20020215

Title: Vinyl sulfone bifunctional derivatives of DOTA allow sulfhydryl- or amino-directed coupling to antibodies. Conjugates retain immunoreactivity and have similar biodistributions.

Journal: Bioconjugate chemistry 20020101

Title: Chemical synthesis of Escherichia coli ST(h) analogues by regioselective disulfide bond formation: biological evaluation of an (111)In-DOTA-Phe(19)-ST(h) analogue for specific targeting of human colon cancers.

Journal: Bioconjugate chemistry 20020101

Title: Non-invasive magnetic resonance thermometry using thulium-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetate (TmDOTA(-)).

Journal: International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group 20020101

Title: Comparison of yttrium and indium complexes of DOTA-BA and DOTA-MBA: models for (90)Y- and (111)In-labeled DOTA-biomolecule conjugates.

Journal: Bioconjugate chemistry 20020101

Title: Trifunctional conjugation reagents. Reagents that contain a biotin and a radiometal chelation moiety for application to extracorporeal affinity adsorption of radiolabeled antibodies.

Journal: Bioconjugate chemistry 20020101

Title: Toxicity and dosimetry of (177)Lu-DOTA-Y3-octreotate in a rat model.

Journal: International journal of cancer 20011215

Title: Evaluation of an (111)In-DOTA-rhenium cyclized alpha-MSH analog: a novel cyclic-peptide analog with improved tumor-targeting properties.

Journal: Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20011201

Title: Anti-HLA-DR/anti-DOTA diabody construction in a modular gene design platform: bispecific antibodies for pretargeted radioimmunotherapy.

Journal: Cancer biotherapy & radiopharmaceuticals 20011201

Title: Tumor therapy with targeted atomic nanogenerators.

Journal: Science (New York, N.Y.) 20011116

Title: Molecular modeling of bifunctional chelate peptide conjugates. 1. Copper and indium parameters for the AMBER force field.

Journal: Inorganic chemistry 20010924

Title: Ligand preorganization in metal ion complexation: molecular mechanics/dynamics, kinetics, and laser-excited luminescence studies of trivalent lanthanide complex formation with macrocyclic ligands TETA and DOTA.

Journal: Inorganic chemistry 20010702

Title: TmDOTA-: a sensitive probe for MR thermometry in vivo.

Journal: Journal of magnetic resonance (San Diego, Calif. : 1997) 20010701

Title: 111In-labeled 1,4,7,10-tetraazacyclododecane-N,N',N',N''-tetraacetic acid-lys(8)-vasotocin: a new powerful radioligand for oxytocin receptor-expressing tumors.

Journal: Cancer research 20010601

Title: Radioimmunotherapy of a human lung cancer xenograft with monoclonal antibody RS7: evaluation of (177)Lu and comparison of its efficacy with that of (90)Y and residualizing (131)I.

Journal: Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20010601

Title: Relaxivity and water exchange studies of a cationic macrocyclic gadolinium(III) complex.

Journal: Chemistry (Weinheim an der Bergstrasse, Germany) 20010401

Title: Frequency decoding of fast calcium oscillations by calpain.

Journal: Cell calcium 20010301

Title: [DOTA-bis(amide)]lanthanide complexes: NMR evidence for differences in water-molecule exchange rates for coordination isomers.

Journal: Chemistry (Weinheim an der Bergstrasse, Germany) 20010105

Title: Size optimization of synthetic graft copolymers for in vivo angiogenesis imaging.

Journal: Bioconjugate chemistry 20010101

Title: Tumor targeting of radiometal labeled anti-CEA recombinant T84.66 diabody and t84.66 minibody: comparison to radioiodinated fragments.

Journal: Bioconjugate chemistry 20010101

Title: Metabolism and renal clearance of 111In-labeled DOTA-conjugated antibody fragments.

Journal: Bioconjugate chemistry 20010101

Title: An improved method for conjugating monoclonal antibodies with N-hydroxysulfosuccinimidyl DOTA.

Journal: Bioconjugate chemistry 20010101

Title: Stabilization of (90)y-labeled DOTA-biomolecule conjugates using gentisic acid and ascorbic acid.

Journal: Bioconjugate chemistry 20010101

Title: (90)Y and (177)Lu labeling of a DOTA-conjugated vitronectin receptor antagonist useful for tumor therapy.

Journal: Bioconjugate chemistry 20010101

Title: DOTA tris(phenylmethyl) ester: a new useful synthon for the synthesis of DOTA monoamides containing acid-labile bonds.

Journal: Bioconjugate chemistry 20010101

Title: Antibody responses to macrocycles in lymphoma.

Journal: Journal of nuclear medicine : official publication, Society of Nuclear Medicine 19960301

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Tags:60239-18-1 Molecular Formula|60239-18-1 MDL|60239-18-1 SMILES|60239-18-1 DOTA