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603288-22-8,MFCD20526532
Catalog No.:AA00ECB7

603288-22-8 | LY2090314

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
99%
in stock  
$24.00   $17.00
- +
5mg
99%
in stock  
$81.00   $57.00
- +
50mg
99%
in stock  
$341.00   $239.00
- +
100mg
99%
in stock  
$609.00   $426.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA00ECB7
Chemical Name:
LY2090314
CAS Number:
603288-22-8
Molecular Formula:
C28H25FN6O3
Molecular Weight:
512.5349
MDL Number:
MFCD20526532
SMILES:
Fc1cc2CN(CCn3c2c(c1)c(c3)C1=C(C(=O)NC1=O)c1cnc2n1cccc2)C(=O)N1CCCCC1
Properties
Computed Properties
 
Complexity:
1030  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
38  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
2  
XLogP3:
2.5  

Downstream Synthesis Route

[1]Engler,ThomasA.;Henry,JamesR.;Malhotra,Sushant;Cunningham,Brian;Furness,Kelly;Brozinick,Joseph;Burkholder,TimothyP.;Clay,MichaelP.;Clayton,Joshua;Diefenbacher,Clive;Hawkins,Eric;Iversen,PhilipW.;Li,Yihong;Lindstrom,TerryD.;Marquart,AngelaL.;McLean,Johnathan;Mendel,David;Misener,Elizabeth;Briere,Daniel;O'Toole,JohnC.;Porter,WarrenJ.;Queener,Steven;Reel,JonK.;Owens,RebeccaA.;Brier,RichardA.;Eessalu,ThomasE.;Wagner,JillR.;Campbell,RobertM.;Vaughn,Renee[JournalofMedicinalChemistry,2004,vol.47,#16,p.3934-3937]

[1]Engler,ThomasA.;Henry,JamesR.;Malhotra,Sushant;Cunningham,Brian;Furness,Kelly;Brozinick,Joseph;Burkholder,TimothyP.;Clay,MichaelP.;Clayton,Joshua;Diefenbacher,Clive;Hawkins,Eric;Iversen,PhilipW.;Li,Yihong;Lindstrom,TerryD.;Marquart,AngelaL.;McLean,Johnathan;Mendel,David;Misener,Elizabeth;Briere,Daniel;O'Toole,JohnC.;Porter,WarrenJ.;Queener,Steven;Reel,JonK.;Owens,RebeccaA.;Brier,RichardA.;Eessalu,ThomasE.;Wagner,JillR.;Campbell,RobertM.;Vaughn,Renee[JournalofMedicinalChemistry,2004,vol.47,#16,p.3934-3937]

[1]Engler,ThomasA.;Henry,JamesR.;Malhotra,Sushant;Cunningham,Brian;Furness,Kelly;Brozinick,Joseph;Burkholder,TimothyP.;Clay,MichaelP.;Clayton,Joshua;Diefenbacher,Clive;Hawkins,Eric;Iversen,PhilipW.;Li,Yihong;Lindstrom,TerryD.;Marquart,AngelaL.;McLean,Johnathan;Mendel,David;Misener,Elizabeth;Briere,Daniel;O'Toole,JohnC.;Porter,WarrenJ.;Queener,Steven;Reel,JonK.;Owens,RebeccaA.;Brier,RichardA.;Eessalu,ThomasE.;Wagner,JillR.;Campbell,RobertM.;Vaughn,Renee[JournalofMedicinalChemistry,2004,vol.47,#16,p.3934-3937]

[1]Engler,ThomasA.;Henry,JamesR.;Malhotra,Sushant;Cunningham,Brian;Furness,Kelly;Brozinick,Joseph;Burkholder,TimothyP.;Clay,MichaelP.;Clayton,Joshua;Diefenbacher,Clive;Hawkins,Eric;Iversen,PhilipW.;Li,Yihong;Lindstrom,TerryD.;Marquart,AngelaL.;McLean,Johnathan;Mendel,David;Misener,Elizabeth;Briere,Daniel;O'Toole,JohnC.;Porter,WarrenJ.;Queener,Steven;Reel,JonK.;Owens,RebeccaA.;Brier,RichardA.;Eessalu,ThomasE.;Wagner,JillR.;Campbell,RobertM.;Vaughn,Renee[JournalofMedicinalChemistry,2004,vol.47,#16,p.3934-3937]

[1]Engler,ThomasA.;Henry,JamesR.;Malhotra,Sushant;Cunningham,Brian;Furness,Kelly;Brozinick,Joseph;Burkholder,TimothyP.;Clay,MichaelP.;Clayton,Joshua;Diefenbacher,Clive;Hawkins,Eric;Iversen,PhilipW.;Li,Yihong;Lindstrom,TerryD.;Marquart,AngelaL.;McLean,Johnathan;Mendel,David;Misener,Elizabeth;Briere,Daniel;O'Toole,JohnC.;Porter,WarrenJ.;Queener,Steven;Reel,JonK.;Owens,RebeccaA.;Brier,RichardA.;Eessalu,ThomasE.;Wagner,JillR.;Campbell,RobertM.;Vaughn,Renee[JournalofMedicinalChemistry,2004,vol.47,#16,p.3934-3937]

Literature

Title: Fragment and knowledge-based design of selective GSK-3beta inhibitors using virtual screening models.

Journal: European journal of medicinal chemistry 20090601

Title: Glycogen synthase kinase-3 (GSK3): inflammation, diseases, and therapeutics.

Journal: Neurochemical research 20070101

Title: Substituted 3-imidazo[1,2-a]pyridin-3-yl- 4-(1,2,3,4-tetrahydro-[1,4]diazepino-[6,7,1-hi]indol-7-yl)pyrrole-2,5-diones as highly selective and potent inhibitors of glycogen synthase kinase-3.

Journal: Journal of medicinal chemistry 20040729

Title: GSK-3: tricks of the trade for a multi-tasking kinase.

Journal: Journal of cell science 20030401

Title: Zamek-Gliszczynski MJ, et al. Pharmacokinetics, metabolism, and excretion of the glycogen synthase kinase-3 inhibitor LY2090314 in rats, dogs, and humans: a case study in rapid clearance by extensive metabolism with low circulating metabolite exposure. Dr

Title: Atkinson JM, et al. Activating the Wnt/β-Catenin Pathway for the Treatment of Melanoma--Application of LY2090314, a Novel Selective Inhibitor of Glycogen Synthase Kinase-3. PLoS One. 2015 Apr 27;10(4):e0125028.

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SDS
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