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60857-08-1,MFCD00674138
Catalog No.:AA01DP10

60857-08-1 | Prostratin

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1mg
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$156.00   $109.00
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5mg
≥98%
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10mg
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  • Technical Information
  • Properties
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA01DP10
Chemical Name:
Prostratin
CAS Number:
60857-08-1
Molecular Formula:
C22H30O6
Molecular Weight:
390.4700
MDL Number:
MFCD00674138
SMILES:
OCC1=C[C@H]2[C@H]3[C@@](C3(C)C)(OC(=O)C)C[C@H](C2(C2[C@@](C1)(O)C(=O)C(=C2)C)O)C
Properties
Computed Properties
 
Complexity:
825  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
7  
Heavy Atom Count:
28  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
3  
XLogP3:
0.7  

Literature

Title: The BET inhibitor OTX015 reactivates latent HIV-1 through P-TEFb.

Journal: Scientific reports 20160101

Title: Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: the case of chelerythrine.

Journal: Bioorganic & medicinal chemistry 20121115

Title: Reactivation of latent HIV-1 by inhibition of BRD4.

Journal: Cell reports 20121025

Title: Designed, synthetically accessible bryostatin analogues potently induce activation of latent HIV reservoirs in vitro.

Journal: Nature chemistry 20120901

Title: Histone methyltransferase inhibitors induce HIV-1 recovery in resting CD4(+) T cells from HIV-1-infected HAART-treated patients.

Journal: AIDS (London, England) 20120731

Title: Two new diterpenoids from the buds of Wikstroemia chamaedaphne.

Journal: Molecules (Basel, Switzerland) 20120529

Title: The ubiquitin ligase Siah1 controls ELL2 stability and formation of super elongation complexes to modulate gene transcription.

Journal: Molecular cell 20120511

Title: Achieving a cure for HIV infection: do we have reasons to be optimistic?

Journal: The Journal of antimicrobial chemotherapy 20120501

Title: Comparative characteristic of the inflammatory diterpenes in the roots of Euphorbia fischeriana with different preparation method using HPLC-ELSD.

Journal: Fitoterapia 20120401

Title: Bioactive components in the fruits of Ziziphus jujuba Mill. against the inflammatory irritant action of Euphorbia plants.

Journal: Phytomedicine : international journal of phytotherapy and phytopharmacology 20120215

Title: Novel structurally related compounds reactivate latent HIV-1 in a bcl-2-transduced primary CD4+ T cell model without inducing global T cell activation.

Journal: The Journal of antimicrobial chemotherapy 20120201

Title: A flexible model of HIV-1 latency permitting evaluation of many primary CD4 T-cell reservoirs.

Journal: PloS one 20120101

Title: Regulation of immune responses by histone deacetylase inhibitors.

Journal: ISRN hematology 20120101

Title: HIV RNA suppression and immune restoration: can we do better?

Journal: Clinical & developmental immunology 20120101

Title: Protein Kinase C: One Pathway towards the Eradication of Latent HIV-1 Reservoirs.

Journal: Advances in virology 20120101

Title: Network-based gene expression biomarkers for cold and heat patterns of rheumatoid arthritis in traditional chinese medicine.

Journal: Evidence-based complementary and alternative medicine : eCAM 20120101

Title: Molecular Understanding of HIV-1 Latency.

Journal: Advances in virology 20120101

Title: Control of HIV latency by epigenetic and non-epigenetic mechanisms.

Journal: Current HIV research 20111201

Title: Histonedeacetylase inhibitor Oxamflatin increase HIV-1 transcription by inducing histone modification in latently infected cells.

Journal: Molecular biology reports 20111101

Title: The anti-interferon activity of conserved viral dUTPase ORF54 is essential for an effective MHV-68 infection.

Journal: PLoS pathogens 20111001

Title: Gateway synthesis of daphnane congeners and their protein kinase C affinities and cell-growth activities.

Journal: Nature chemistry 20110801

Title: Epigenetic regulation of HIV-1 transcription.

Journal: Epigenomics 20110801

Title: The transposon-driven evolutionary origin and basis of histone deacetylase functions and limitations in disease prevention.

Journal: Clinical epigenetics 20110801

Title: Tigliane-type diterpenoid glycosides from Euphorbia fischeriana.

Journal: Journal of natural products 20110624

Title: HIV cure and eradication: how will we get from the laboratory to effective clinical trials?

Journal: AIDS (London, England) 20110424

Title: Activation of latent HIV-1 expression by protein kinase C agonists. A novel therapeutic approach to eradicate HIV-1 reservoirs.

Journal: Current drug targets 20110301

Title: Finding a cure for HIV: will it ever be achievable?

Journal: Journal of the International AIDS Society 20110101

Title: Opposite effects of HIV-1 p17 variants on PTEN activation and cell growth in B cells.

Journal: PloS one 20110101

Title: Activation of latent HIV using drug-loaded nanoparticles.

Journal: PloS one 20110101

Title: Gene silencing in HIV-1 latency by polycomb repressive group.

Journal: Virology journal 20110101

Title: Limited redundancy in genes regulated by Cyclin T2 and Cyclin T1.

Journal: BMC research notes 20110101

Title: Latent HIV in primary T lymphocytes is unresponsive to histone deacetylase inhibitors.

Journal: Virology journal 20110101

Title: Control of Kaposi's sarcoma-associated herpesvirus reactivation induced by multiple signals.

Journal: PloS one 20110101

Title: Latency profiles of full length HIV-1 molecular clone variants with a subtype specific promoter.

Journal: Retrovirology 20110101

Title: Expression and reactivation of HIV in a chemokine induced model of HIV latency in primary resting CD4+ T cells.

Journal: Retrovirology 20110101

Title: Picomolar dichotomous activity of gnidimacrin against HIV-1.

Journal: PloS one 20110101

Title: New tigliane-type diterpenoids from Euphorbia aellenii Rech. f. with immunomodulatory activity.

Journal: Research in pharmaceutical sciences 20110101

Title: De novo assembly of Euphorbia fischeriana root transcriptome identifies prostratin pathway related genes.

Journal: BMC genomics 20110101

Title: The Role of RNA Polymerase II Elongation Control in HIV-1 Gene Expression, Replication, and Latency.

Journal: Genetics research international 20110101

Title: Cloning of casbene and neocembrene synthases from Euphorbiaceae plants and expression in Saccharomyces cerevisiae.

Journal: Phytochemistry 20100901

Title: Histone deacetylase inhibitor Scriptaid reactivates latent HIV-1 promoter by inducing histone modification in in vitro latency cell lines.

Journal: International journal of molecular medicine 20100801

Title: Immunotoxin complementation of HAART to deplete persisting HIV-infected cell reservoirs.

Journal: PLoS pathogens 20100601

Title: Molecular mechanisms of HIV-1 persistence in the monocyte-macrophage lineage.

Journal: Retrovirology 20100101

Title: Bryostatin modulates latent HIV-1 infection via PKC and AMPK signaling but inhibits acute infection in a receptor independent manner.

Journal: PloS one 20100101

Title: Cell line-dependent variability in HIV activation employing DNMT inhibitors.

Journal: Virology journal 20100101

Title: HIV reservoirs in vivo and new strategies for possible eradication of HIV from the reservoir sites.

Journal: HIV/AIDS (Auckland, N.Z.) 20100101

Title: CpG methylation controls reactivation of HIV from latency.

Journal: PLoS pathogens 20090801

Title: A simple analogue of tumor-promoting aplysiatoxin is an antineoplastic agent rather than a tumor promoter: development of a synthetically accessible protein kinase C activator with bryostatin-like activity.

Journal: Journal of the American Chemical Society 20090610

Title: Epigenetic regulation of HIV-1 latency by cytosine methylation.

Journal: PLoS pathogens 20090601

Title: SJ23B, a jatrophane diterpene activates classical PKCs and displays strong activity against HIV in vitro.

Journal: Biochemical pharmacology 20090315

Title: miR-198 inhibits HIV-1 gene expression and replication in monocytes and its mechanism of action appears to involve repression of cyclin T1.

Journal: PLoS pathogens 20090101

Title: Synergistic activation of HIV-1 expression by deacetylase inhibitors and prostratin: implications for treatment of latent infection.

Journal: PloS one 20090101

Title: Molecular control of HIV-1 postintegration latency: implications for the development of new therapeutic strategies.

Journal: Retrovirology 20090101

Title: Variability in content of the anti-AIDS drug candidate prostratin in Samoan populations of Homalanthus nutans.

Journal: Journal of natural products 20081226

Title: Short communication: Activating stimuli enhance immunotoxin-mediated killing of HIV-infected macrophages.

Journal: AIDS research and human retroviruses 20081101

Title: Giving Samoan healers credit for prostratin.

Journal: Science (New York, N.Y.) 20080620

Title: Practical synthesis of prostratin, DPP, and their analogs, adjuvant leads against latent HIV.

Journal: Science (New York, N.Y.) 20080502

Title: Differential effects of phorbol-13-monoesters on human immunodeficiency virus reactivation.

Journal: Biochemical pharmacology 20080315

Title: Cyclin T1-dependent genes in activated CD4 T and macrophage cell lines appear enriched in HIV-1 co-factors.

Journal: PloS one 20080101

Title: HMBA releases P-TEFb from HEXIM1 and 7SK snRNA via PI3K/Akt and activates HIV transcription.

Journal: PLoS pathogens 20071001

Title: A quantitative synthesis of the medicinal ethnobotany of the Malinké of Mali and the Asháninka of Peru, with a new theoretical framework.

Journal: Journal of ethnobiology and ethnomedicine 20070101

Title: HIV type 1 inhibition by protein kinase C modulatory compounds.

Journal: AIDS research and human retroviruses 20060901

Title: Nuclear retention of multiply spliced HIV-1 RNA in resting CD4+ T cells.

Journal: PLoS pathogens 20060701

Title: Diterpenoids from the roots of Euphorbia fischeriana.

Journal: Journal of natural products 20060601

Title: Attacking latent HIV provirus: from mechanism to therapeutic strategies.

Journal: Current opinion in HIV and AIDS 20060301

Title: Latency: the hidden HIV-1 challenge.

Journal: Retrovirology 20060101

Title: Effects of prostratin on Cyclin T1/P-TEFb function and the gene expression profile in primary resting CD4+ T cells.

Journal: Retrovirology 20060101

Title: Prostratin as a new therapeutic agent targeting HIV viral reservoirs.

Journal: Drug news & perspectives 20051001

Title: Prostratin and bortezomib are novel inducers of latent Kaposi's sarcoma-associated herpesvirus.

Journal: Antiviral therapy 20050101

Title: Prostratin antagonizes HIV latency by activating NF-kappaB.

Journal: The Journal of biological chemistry 20041001

Title: Dual role of prostratin in inhibition of infection and reactivation of human immunodeficiency virus from latency in primary blood lymphocytes and lymphoid tissue.

Journal: Journal of virology 20041001

Title: Prostratin induces HIV activation and downregulates HIV receptors in peripheral blood lymphocytes.

Journal: Antiviral therapy 20040801

Title: Mechanisms of HIV receptor and co-receptor down-regulation by prostratin: role of conventional and novel PKC isoforms.

Journal: Antiviral chemistry & chemotherapy 20040701

Title: Expression of latent HAART-persistent HIV type 1 induced by novel cellular activating agents.

Journal: AIDS research and human retroviruses 20040501

Title: Potent and selective inhibition of HIV and SIV by prostratin interacting with viral entry.

Journal: Antiviral chemistry & chemotherapy 20031101

Title: Molecular characterization, reactivation, and depletion of latent HIV.

Journal: Immunity 20030901

Title: Activation of latent HIV-1 expression by the potent anti-tumor promoter 12-deoxyphorbol 13-phenylacetate.

Journal: Antiviral research 20030701

Title: Prostratin: activation of latent HIV-1 expression suggests a potential inductive adjuvant therapy for HAART.

Journal: Blood 20011115

Title: Iridals are a novel class of ligands for phorbol ester receptors with modest selectivity for the RasGRP receptor subfamily.

Journal: Journal of medicinal chemistry 20011108

Title: An optimized protein kinase C activating diacylglycerol combining high binding affinity (Ki) with reduced lipophilicity (log P).

Journal: Journal of medicinal chemistry 20010607

Title: New kinds of treatment.

Journal: AIDS treatment news 20010125

Title: Ensuring equitable benefits: the falealupo covenant and the isolation of anti-viral drug prostratin from a samoan medicinal plant.

Journal: Pharmaceutical biology 20010101

Title: Antireplicative and anticytopathic activities of prostratin, a non-tumor-promoting phorbol ester, against human immunodeficiency virus (HIV).

Journal: Antiviral research 19970101

Title: A nonpromoting phorbol from the samoan medicinal plant Homalanthus nutans inhibits cell killing by HIV-1.

Journal: Journal of medicinal chemistry 19920529

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Tags:60857-08-1 Molecular Formula|60857-08-1 MDL|60857-08-1 SMILES|60857-08-1 Prostratin