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613-92-3,MFCD00031485
Catalog No.:AA003NXR

613-92-3 | N-Hydroxy-benzamidine

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Purity
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250mg
97%
in stock  
$6.00   $4.00
- +
1g
97%
in stock  
$8.00   $6.00
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10g
95%
in stock  
$30.00   $21.00
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25g
97%
in stock  
$47.00   $33.00
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA003NXR
Chemical Name:
N-Hydroxy-benzamidine
CAS Number:
613-92-3
Molecular Formula:
C7H8N2O
Molecular Weight:
136.1512
MDL Number:
MFCD00031485
SMILES:
O/N=C(/c1ccccc1)\N
NSC Number:
13999
Properties
Properties
 
BP:
307.4°C at 760 mmHg  
Form:
Solid  
MP:
77 °C  
Storage:
Inert atmosphere;Room Temperature;  

Computed Properties
 
Complexity:
128  
Covalently-Bonded Unit Count:
1  
Defined Bond Stereocenter Count:
1  
Heavy Atom Count:
10  
Hydrogen Bond Acceptor Count:
2  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
1  
XLogP3:
1.1  

Literature

Title: The mitochondrial Amidoxime Reducing Component (mARC) is involved in detoxification of N-hydroxylated base analogues.

Journal: Chemical research in toxicology 20121119

Title: Insight into technetium amidoxime complex: oxo technetium(V) complex of N-substituted benzamidoxime as new basic structure for molecular imaging.

Journal: Inorganic chemistry 20110207

Title: Reduction of N(ω)-hydroxy-L-arginine by the mitochondrial amidoxime reducing component (mARC).

Journal: The Biochemical journal 20110115

Title: Convenient synthesis and biological profile of 5-amino-substituted 1,2,4-oxadiazole derivatives.

Journal: European journal of medicinal chemistry 20101201

Title: A novel and specific fluorescence reaction for uracil.

Journal: Analytica chimica acta 20100803

Title: The fourth molybdenum containing enzyme mARC: cloning and involvement in the activation of N-hydroxylated prodrugs.

Journal: Journal of medicinal chemistry 20081225

Title: Involvement of stearoyl-CoA desaturase in the reduction of amidoxime prodrugs.

Journal: Xenobiotica; the fate of foreign compounds in biological systems 20080901

Title: N,N'-dihydroxyamidines: a new prodrug principle to improve the oral bioavailability of amidines.

Journal: Journal of medicinal chemistry 20071227

Title: Identification of the missing component in the mitochondrial benzamidoxime prodrug-converting system as a novel molybdenum enzyme.

Journal: The Journal of biological chemistry 20061117

Title: Hepatic, extrahepatic, microsomal, and mitochondrial activation of the N-hydroxylated prodrugs benzamidoxime, guanoxabenz, and Ro 48-3656 ([[1-[(2s)-2-[[4-[(hydroxyamino)iminomethyl]benzoyl]amino]-1-oxopropyl]-4-piperidinyl]oxy]-acetic acid).

Journal: Drug metabolism and disposition: the biological fate of chemicals 20051101

Title: Characterization and partial purification of the rat and human enzyme systems active in the reduction of N-hydroxymelagatran and benzamidoxime.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20050401

Title: Metabolism of benzamidoxime (N-hydroxyamidine) in human hepatocytes and role of UDP-glucuronosyltransferases.

Journal: Xenobiotica; the fate of foreign compounds in biological systems 20050101

Title: N-Aryl N'-hydroxyguanidines, a new class of NO-donors after selective oxidation by nitric oxide synthases: structure-activity relationship.

Journal: Journal of medicinal chemistry 20020214

Title: Phase 2 metabolites of N-hydroxylated amidines (amidoximes): synthesis, in vitro formation by pig hepatocytes, and mutagenicity testing.

Journal: Chemical research in toxicology 20010301

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