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6133-30-8,MFCD00055819
Catalog No.:AA0034WL

6133-30-8 | (S)-2-Guanidinosuccinic acid

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50mg
≥95%
in stock  
$82.00   $57.00
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100mg
≥95%
in stock  
$153.00   $107.00
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250mg
≥95%
in stock  
$218.00   $152.00
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500mg
≥95%
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$393.00   $275.00
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA0034WL
Chemical Name:
(S)-2-Guanidinosuccinic acid
CAS Number:
6133-30-8
Molecular Formula:
C5H9N3O4
Molecular Weight:
175.1427
MDL Number:
MFCD00055819
SMILES:
NC(=N)N[C@H](C(=O)O)CC(=O)O
Properties
Properties
 
Form:
Solid  
Storage:
2-8℃;  

Computed Properties
 
Complexity:
221  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
1  
Heavy Atom Count:
12  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
4  
Rotatable Bond Count:
4  
XLogP3:
-2  

Downstream Synthesis Route

[1]Ratneretal.[JournalofBiologicalChemistry,1953,vol.204,p.95,108]

[1]Walker[ArchivesofBiochemistry,1955,vol.59,p.233,234,240]

[1]Pant,E.[Hoppe-Seyler'sZeitschriftfurPhysiologischeChemie,1964,vol.335,p.272-274]

Literature

Title: Metabolomics with LC-QTOF-MS permits the prediction of disease stage in aortic abdominal aneurysm based on plasma metabolic fingerprint.

Journal: PloS one 20120101

Title: [Analysis of transporter function and development to clinical application].

Journal: Seikagaku. The Journal of Japanese Biochemical Society 20110401

Title: Simultaneous determination of guanidinosuccinic acid and guanidinoacetic acid in urine using high performance liquid chromatography/tandem mass spectrometry.

Journal: Analytica chimica acta 20100916

Title: Impact of increasing haemodialysis frequency versus haemodialysis duration on removal of urea and guanidino compounds: a kinetic analysis.

Journal: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20090701

Title: First indications demonstrating the preventive effects of NZ-419, a novel intrinsic antioxidant, on the initiation and/or progression of chronic renal failure in rats.

Journal: Biological & pharmaceutical bulletin 20090701

Title: Accumulation of methylguanidine and changes in guanidino compound levels in plasma, urine, and kidneys of furosemide-treated rats.

Journal: Metabolism: clinical and experimental 20080601

Title: Guanidino compounds after creatine supplementation in renal failure patients and their relation to inflammatory status.

Journal: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20080401

Title: Premature aging in uremia.

Journal: Molecular and cellular biochemistry 20070401

Title: Anisoin: a useful pre-chromatographic derivatization fluorogenic reagent for LC analysis of guanidino compounds.

Journal: Journal of pharmaceutical and biomedical analysis 20060911

Title: Biochemical validation of a rat model for polycystic kidney disease: comparison of guanidino compound profile with the human condition.

Journal: Kidney international 20060601

Title: Substrate specificity of the human renal sodium dicarboxylate cotransporter, hNaDC-3, under voltage-clamp conditions.

Journal: American journal of physiology. Renal physiology 20050401

Title: GSA: behavioral, histological, electrophysiological and neurochemical effects.

Journal: Physiology & behavior 20050215

Title: [Guanidino compounds derivatives (guanidinosuccinic acid, guanidinoacetic acid)].

Journal: Nihon rinsho. Japanese journal of clinical medicine 20041101

Title: Effect of NaCN on currents evoked by uremic retention solutes in dissociated mouse neurons.

Journal: Brain research 20040515

Title: Involvement of voltage- and ligand-gated Ca2+ channels in the neuroexcitatory and synergistic effects of putative uremic neurotoxins.

Journal: Kidney international 20030501

Title: Inhibition of arginine synthesis by urea: a mechanism for arginine deficiency in renal failure which leads to increased hydroxyl radical generation.

Journal: Molecular and cellular biochemistry 20030201

Title: Methyl group deficiency and guanidino production in uremia.

Journal: Molecular and cellular biochemistry 20030201

Title: Methyl group deficiency States.

Journal: Nephron 20020901

Title: Long-term effect of partial nephrectomy on biological parameters, kidney histology, and guanidino compound levels in mice.

Journal: Metabolism: clinical and experimental 20011201

Title: Influence of 72% injury in one kidney on several organs involved in guanidino compound metabolism: a time course study.

Journal: Pflugers Archiv : European journal of physiology 20010701

Title: Role of nitric oxide in the synthesis of guanidinosuccinic acid, an activator of the N-methyl-D-aspartate receptor.

Journal: Kidney international. Supplement 20010201

Title: Erythrocyte transketolase activity and guanidino compounds in hemodialysis patients.

Journal: Kidney international. Supplement 20010201

Title: Milstien S, et al. Role of intestinal microflora in the metabolism of guanidinosuccinic acid. J Bacteriol. 1973 May;114(2):641-4.

Title: D'Hooge R, et al. Behavioral toxicity of guanidinosuccinic acid in adult and young mice. Toxicol Lett. 1992 Dec;64-65 Spec No:773-7.

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