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614749-78-9,MFCD31657399
Catalog No.:AA01EO60

614749-78-9 | SM 16

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
97%
in stock  
$21.00   $15.00
- +
5mg
97%
in stock  
$48.00   $34.00
- +
10mg
97%
in stock  
$66.00   $47.00
- +
25mg
97%
in stock  
$105.00   $74.00
- +
50mg
97%
in stock  
$174.00   $122.00
- +
100mg
97%
in stock  
$271.00   $190.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA01EO60
Chemical Name:
SM 16
CAS Number:
614749-78-9
Molecular Formula:
C25H26N4O3
Molecular Weight:
430.4989
MDL Number:
MFCD31657399
SMILES:
Cc1cccc(n1)c1[nH]c(nc1c1ccc2c(c1)OCO2)C12CCC(CC1)(CC2)C(=O)N
Properties
Computed Properties
 
Complexity:
707  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
32  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
4  
XLogP3:
3.1  

Literature

Title: Suzuki E, et al. A novel small-molecule inhibitor of transforming growth factor beta type I receptor kinase (SM16) inhibits murine mesothelioma tumor growth in vivo and prevents tumor recurrence after surgical resection. Cancer Res. 2007 Mar 1;67(5):2351-9.

Title: Fu K, et al. SM16, an orally active TGF-beta type I receptor inhibitor prevents myofibroblast induction and vascular fibrosis in the rat carotid injury model. Arterioscler Thromb Vasc Biol. 2008 Apr;28(4):665-71.

Title: Engebretsen KV, et al. Attenuated development of cardiac fibrosis in left ventricular pressure overload by SM16, an orally active inhibitor of ALK5. J Mol Cell Cardiol. 2014 Nov;76:148-57.

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SDS
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