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622-58-2,MFCD00002029
Catalog No.:AA003TYN

622-58-2 | p-Tolyl Isocyanate

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Purity
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5g
98%
in stock  
$21.00   $15.00
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25g
98%
in stock  
$43.00   $30.00
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA003TYN
Chemical Name:
p-Tolyl Isocyanate
CAS Number:
622-58-2
Molecular Formula:
C8H7NO
Molecular Weight:
133.1473
MDL Number:
MFCD00002029
SMILES:
O=C=Nc1ccc(cc1)C
Properties
Properties
 
BP:
190.6°C at 760 mmHg  
Form:
Liquid  
Refractive Index:
n20/D 1.531(lit.)  
Stability:
Moisture Sensitive  
Storage:
Inert atmosphere;2-8℃;  

Computed Properties
 
Complexity:
141  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
10  
Hydrogen Bond Acceptor Count:
2  
Rotatable Bond Count:
1  
XLogP3:
3.3  

Downstream Synthesis Route

[1]JournaloftheAmericanChemicalSociety,1949,vol.71,p.2297,2299

[2]Patent:US4025517,1976,

42270-37-1    622-58-2   
4-thiazol-2-yl-piperazine-1-carboxylicacid<i>p</i>-toluidide 

[1]JournaloftheAmericanPharmaceuticalAssociation(1912),1954,vol.43,p.628,630

3201-21-6    622-58-2   
5-ethoxy-3-methyl-pyrazole-1-carboxylicacid<i>p</i>-toluidide 

[1]Henry;Dehn[JournaloftheAmericanChemicalSociety,1949,vol.71,p.2297,2299]

22715-74-8    622-58-2   
1-(4-bromo-phenyl)-3-<i>p</i>-tolyl-triazene-1-carboxylicacid<i>p</i>-toluidide 

[1]Goldschmidt;Molinari[ChemischeBerichte,1888,vol.21,p.2559]

6635-41-2    622-58-2   
2-nitro-benzaldehyde-((<i>E</i>)-<i>O</i>-<i>p</i>-tolylcarbamoyloxime) 

[1]Goldschmidt;vanRietschoten[ChemischeBerichte,1893,vol.26,p.2101]

[2]Goldschmidt;vanRietschoten[ChemischeBerichte,1893,vol.26,p.2101]

Literature

Title: Identification of contact and respiratory sensitizers according to IL-4 receptor α expression and IL-2 production.

Journal: Toxicology and applied pharmacology 20120415

Title: Structure-activity relationships, ligand efficiency, and lipophilic efficiency profiles of benzophenone-type inhibitors of the multidrug transporter P-glycoprotein.

Journal: Journal of medicinal chemistry 20120412

Title: Towards defining molecular determinants recognized by adaptive immunity in allergic disease: an inventory of the available data.

Journal: Journal of allergy 20100101

Title: Th2 Cytokines in Skin Draining Lymph Nodes and Serum IgE Do Not Predict Airway Hypersensitivity to Intranasal Isocyanate Exposure in Mice.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20071101

Title: Synthesis, structure, and reactivity of mononuclear RE(I) oximato complexes.

Journal: Inorganic chemistry 20070402

Title: Biomarkers for isocyanate exposure: Synthesis of isocyanate DNA adducts.

Journal: Chemical research in toxicology 20061201

Title: Inconsistencies between cytokine profiles, antibody responses, and respiratory hyperresponsiveness following dermal exposure to isocyanates.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20061101

Title: N-C bond formation promoted by a hafnocene dinitrogen complex: comparison of zirconium and hafnium congeners.

Journal: Journal of the American Chemical Society 20060823

Title: Determination of airborne isocyanates generated during the thermal degradation of car paint in body repair shops.

Journal: The Annals of occupational hygiene 20060601

Title: Investigation of the reactivity of arylamines, organo-hydrazines and tolylisocyanate towards [PW12-xMxO40]n- Keggin anions.

Journal: Dalton transactions (Cambridge, England : 2003) 20050521

Title: Cytokine mRNA profiles for isocyanates with known and unknown potential to induce respiratory sensitization.

Journal: Toxicology 20050227

Title: Reactivity of molybdenum and rhenium hydroxo-carbonyl complexes toward organic electrophiles.

Journal: Chemistry (Weinheim an der Bergstrasse, Germany) 20040402

Title: Synthesis and reactivity of calix[4]arene-supported group 4 imido complexes.

Journal: Chemistry (Weinheim an der Bergstrasse, Germany) 20030804

Title: Diisocyanate antigens that detect specific antibodies in exposed workers and guinea pigs.

Journal: Chemical research in toxicology 19880101

Title: Guinea pig pulmonary response to sensitization by five preformed monoisocyanate-ovalbumin conjugates.

Journal: Toxicology 19870101

Title: A study of serum antibody activity in workers with occupational exposure to diphenylmethane diisocyanate.

Journal: Allergy 19850701

Title: Use of hexyl isocyanate antigen to detect antibodies to hexamethylene diisocyanate (HDI) in sensitized guinea pigs and in a sensitized worker.

Journal: Fundamental and applied toxicology : official journal of the Society of Toxicology 19820101

Title: Hapten-specific respiratory hypersensitivity in guinea pigs.

Journal: American Industrial Hygiene Association journal 19780701

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