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6283-25-6,MFCD00007668
Catalog No.:AA003GWM

6283-25-6 | 2-Chloro-5-nitroaniline

Pack Size
Purity
Availability
Price(USD)
Quantity
  
25g
95%
in stock  
$16.00   $11.00
- +
500g
>98.0%(GC)
in stock  
$135.00   $95.00
- +
  • Technical Information
  • Properties
  • Upstream Synthesis Route
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Upstream Synthesis Route
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA003GWM
Chemical Name:
2-Chloro-5-nitroaniline
CAS Number:
6283-25-6
Molecular Formula:
C6H5ClN2O2
Molecular Weight:
172.5691
MDL Number:
MFCD00007668
SMILES:
[O-][N+](=O)c1ccc(c(c1)N)Cl
NSC Number:
7791
Properties
Properties
 
BP:
314.6°C at 760 mmHg  
Form:
Solid  
MP:
118-120 °C(lit.)  
Refractive Index:
1.5870 (estimate)  
Storage:
Inert atmosphere;Room Temperature;  

Computed Properties
 
Complexity:
159  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
11  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
1  
XLogP3:
2.1  

Upstream Synthesis Route

[1]Phytochemistry,2012,vol.74,p.159-165

[1]Patent:WO2007/48070,2007,A2,.Locationinpatent:Page/Pagecolumn112

[1]Patent:US5677321,1997,A,

[1]Patent:WO2010/123960,2010,A2,.Locationinpatent:Page/Pagecolumn104-105

[2]Patent:WO2010/123956,2010,A2,.Locationinpatent:Page/Pagecolumn106-107

[3]JournalofOrganicChemistryUSSR(EnglishTranslation),1968,vol.4,p.478-481

[4]ZhurnalOrganicheskoiKhimii,1968,vol.4,#3,p.490-493

[5]JournalofPharmacyandPharmacology,2001,vol.53,#5,p.669-680

[6]JournalofMedicinalChemistry,2006,vol.49,#12,p.3701-3709

[7]JournalofMedicinalChemistry,2007,vol.50,#16,p.3928-3936

[8]Patent:US6818765,2004,B1,.Locationinpatent:Pagecolumn3-4;5-7

[9]Patent:WO2010/123959,2010,A2,.Locationinpatent:Page/Pagecolumn57

[10]Patent:WO2013/156861,2013,A2,.Locationinpatent:Page/Pagecolumn18;19

[11]Patent:US2016/102051,2016,A1,.Locationinpatent:Paragraph0069-0070

[12]ChineseJournalofChemistry,2016,vol.34,#11,p.1135-1142

[1]JournalofHeterocyclicChemistry,1994,vol.31,#4,p.775-780

Downstream Synthesis Route

[1]CurrentPatentAssignee:GLAXOSMITHKLINEPLC-EP2566477,2015,B1Locationinpatent:Paragraph0170;0171

[2]Hodgson;Dodgson[JournaloftheChemicalSociety,1948,p.870,873]

[1]AttidellaAccademiaNazionaledeiLincei,ClassediScienzeFisiche,MatematicheeNaturali,Rendiconti,1913,vol.<5>22I,p.823    AttidellaAccademiaNazionaledeiLincei,ClassediScienzeFisiche,MatematicheeNaturali,Rendiconti,1914,vol.<5>23I,p.283Anm.

[1]Patent:WO2009/126863,2009,A2.Locationinpatent:Page/Pagecolumn87-88

[2]Patent:WO2012/76413,2012,A1.Locationinpatent:Page/Pagecolumn11

[3]Patent:EP2468726,2012,A1.Locationinpatent:Page/Pagecolumn6

[4]OrganicProcessResearchandDevelopment,2012,vol.16,p.1739-1745

[5]BioorganicandMedicinalChemistryLetters,2018,vol.28,p.2399-2402

[6]Patent:US2010/160389,2010,A1.Locationinpatent:Page/Pagecolumn50

[7]AngewandteChemie-InternationalEdition,2019,vol.58,p.13499-13506    Angew.Chem.,2019,vol.131,p.13633-13640,8

[8]Patent:US2014/18368,2014,A1.Locationinpatent:Paragraph0162;0163

[9]AttidellaAccademiaNazionaledeiLincei,ClassediScienzeFisiche,MatematicheeNaturali,Rendiconti,1913,vol.<5>22I,p.823    AttidellaAccademiaNazionaledeiLincei,ClassediScienzeFisiche,MatematicheeNaturali,Rendiconti,1914,vol.<5>23I,p.283Anm.

[10]BioorganicandMedicinalChemistryLetters,2009,vol.19,p.5576-5581

[11]ChemPlusChem,2015,vol.80,p.938-943

[12]OrganicProcessResearchandDevelopment,2016,vol.20,p.1509-1519

[13]ACSChemicalNeuroscience,2017,vol.8,p.1980-1994

[1]BulletindelaSocieteChimiquedeFrance,1930,vol.<4>47,p.749

Literature

Title: 1-(2-Chloro-5-nitro-phen-yl)-3-(2,2-di-methyl-propion-yl)thio-urea.

Journal: Acta crystallographica. Section E, Structure reports online 20090801

Title: 2-Chloro-5-nitro-aniline.

Journal: Acta crystallographica. Section E, Structure reports online 20090601

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