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6336-50-1,MFCD00076061
Catalog No.:AA00EFXF

6336-50-1 | 6-Benzyl-2-mercaptopyrimidin-4(3h)-one

Pack Size
Purity
Availability
Price(USD)
Quantity
  
25mg
95%
in stock  
$65.00   $45.00
- +
50mg
95%
in stock  
$103.00   $72.00
- +
100mg
95%
in stock  
$155.00   $108.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA00EFXF
Chemical Name:
6-Benzyl-2-mercaptopyrimidin-4(3h)-one
CAS Number:
6336-50-1
Molecular Formula:
C11H10N2OS
Molecular Weight:
218.2749
MDL Number:
MFCD00076061
SMILES:
O=c1cc(Cc2ccccc2)[nH]c(=S)[nH]1
Properties
Properties
 
Form:
Solid  
MP:
219 - 221°C  
Storage:
Keep in dry area;2-8℃;  

Computed Properties
 
Complexity:
306  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
15  
Hydrogen Bond Acceptor Count:
2  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
2  
XLogP3:
1.6  

Downstream Synthesis Route

[1]BioorganicandMedicinalChemistry,2010,vol.18,p.3231-3237

[2]JournaloftheAmericanChemicalSociety,1938,vol.60,p.2941,2943

[3]EuropeanJournalofMedicinalChemistry,1988,vol.23,p.53-62

[4]MedicinalChemistryResearch,2000,vol.10,p.30-39

[5]JournalofMedicinalChemistry,2012,vol.55,p.2242-2250

[6]Molecules,2014,vol.19,p.7104-7121

[7]MedChemComm,2015,vol.6,p.1438-1443

[8]BioorganicandMedicinalChemistry,2018,vol.26,p.1573-1578

[1]JournalofMedicinalChemistry,1995,vol.38,p.3258-3263

[1]Zhang,Liang;Tang,Xiaowan;Cao,Yuanyuan;Wu,Shaotong;Zhang,Yu;Zhao,Jianxiong;Guo,Ying;Tian,Chao;Zhang,Zhili;Liu,Junyi;Wang,Xiaowei[Molecules,2014,vol.19,#6,p.7104-7121]

[2]CurrentPatentAssignee:PEKINGUNIVERSITY-CN103864699,2016,BLocationinpatent:Paragraph0032;0033;0034;0035

[1]Molecules,2014,vol.19,p.7104-7121

[2]Patent:CN103864699,2016,B.Locationinpatent:Paragraph0036;0037;0038

[3]MedChemComm,2015,vol.6,p.1438-1443

[1]Molecules,2014,vol.19,p.7104-7121

[2]Patent:CN103864699,2016,B.Locationinpatent:Paragraph0039;0040;0041;0042

Literature

Title: [Antineutrophil cytoplasmic antibodies and associated diseases].

Journal: Pathologie-biologie 20090701

Title: Prevalence of antineutrophil cytoplasmic antibodies during treatment with benzylthiouracil.

Journal: Pathologie-biologie 20090701

Title: [Neutrophilic dermatosis associated with anti-neutrophilic cytoplasmic antibodies (ANCA) after benzylthiouracil therapy].

Journal: Annales de dermatologie et de venereologie 20090501

Title: [Benzylthiouracil induced ANCA-positive vasculitis: study of three cases and review of the literature].

Journal: Annales d'endocrinologie 20081201

Title: [Vasculitis with renal involvement and antineutrophil cytoplasmic antibodies (ANCA) in a child receiving benzylthiouracil].

Journal: Nephrologie & therapeutique 20070701

Title: The impact of thyroid activity variations on some oxidizing-stress parameters in rats.

Journal: Comptes rendus biologies 20070201

Title: ANCA-associated diffuse alveolar hemorrhage due to benzylthiouracil.

Journal: European journal of pediatrics 20060701

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Title: [Benzylthiouracil induced ANCA-positive vasculitis].

Journal: Presse medicale (Paris, France : 1983) 20041106

Title: Myeloperoxidase-antineutrophil cytoplasmic antibody-positive crescentic glomerulonephritis associated with benzylthiouracil therapy: report of the first case.

Journal: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20031101

Title: [ANCA associated glomerulonephritis related to benzylthiouracil].

Journal: La Revue de medecine interne 20021001

Title: [Vasculitis with renal and pulmonary involvement in a patient receiving benzylthiouracil for Graves disease].

Journal: La Revue de medecine interne 20021001

Title: Structure-activity relationship of ligands of uracil phosphoribosyltransferase from Toxoplasma gondii.

Journal: Biochemical pharmacology 19940817

Title: Toxic hepatitis induced by antithyroid drugs: four cases including one with cross-reactivity between carbimazole and benzylthiouracil.

Journal: The European journal of medicine 19930101

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