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644-78-0,MFCD00016449
Catalog No.:AA003HCN

644-78-0 | 3-(2-Hydroxyphenyl)-1-phenylprop-2-en-1-one

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Purity
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Price(USD)
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5g
98%
in stock  
$23.00   $16.00
- +
25g
98%
in stock  
$96.00   $68.00
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100g
98%
in stock  
$363.00   $254.00
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA003HCN
Chemical Name:
3-(2-Hydroxyphenyl)-1-phenylprop-2-en-1-one
CAS Number:
644-78-0
Molecular Formula:
C15H12O2
Molecular Weight:
224.2546
MDL Number:
MFCD00016449
SMILES:
O=C(c1ccccc1)/C=C/c1ccccc1O
Properties
Properties
 
BP:
396.566°C at 760 mmHg  
Form:
Solid  
MP:
144-150℃(lit.)  
Storage:
Inert atmosphere;2-8℃;  

Computed Properties
 
Complexity:
277  
Covalently-Bonded Unit Count:
1  
Defined Bond Stereocenter Count:
1  
Heavy Atom Count:
17  
Hydrogen Bond Acceptor Count:
2  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
3  
XLogP3:
3.3  

Downstream Synthesis Route

[1]ChemistryofHeterocyclicCompounds,1991,vol.27,p.205-210    KhimiyaGeterotsiklicheskikhSoedinenii,1991,p.250-255

67-56-1    644-78-0    75630-71-6   
((2R,3S)-5,7-Dibromo-3-methoxy-2,3-dihydro-benzofuran-2-yl)-phenyl-methanone 

[1]Litkei,Gyoergy;Gulacsi,Katalin;Antus,Sandor;Dinya,Zoltan[SyntheticCommunications,1996,vol.26,#16,p.3061-3074]

[1]Litkei,Gyoergy;Gulacsi,Katalin;Antus,Sandor;Dinya,Zoltan[SyntheticCommunications,1996,vol.26,#16,p.3061-3074]

[2]Litkei,Gyoergy;Gulacsi,Katalin;Antus,Sandor;Dinya,Zoltan[SyntheticCommunications,1996,vol.26,#16,p.3061-3074]

[3]Mangini[GazzettaChimicaItaliana,1937,vol.67,p.39,43]

[1]Amir,Mohd;Kumar,Shikha[IndianJournalofChemistry-SectionBOrganicandMedicinalChemistry,2005,vol.44,#12,p.2532-2537]

[2]Pathak,VijaiN.;Gupta,Ragini;Tiwari,Ranjana;Gupta,Rekha;Sareen,Vineeta;Varshney,Bindu[SyntheticCommunications,2007,vol.37,#6,p.977-984]

[3]Seo,WooDuck;Kim,JinHyo;Kang,JaeEun;Ryu,HyungWon;Curtis-Long,MarcusJ.;Lee,HyunSun;Yang,MinSuk;Park,KiHun[BioorganicandMedicinalChemistryLetters,2005,vol.15,#24,p.5514-5516]

[4]Batovska;Parushev;Slavova;Bankova;Tsvetkova;Ninova;Najdenski[EuropeanJournalofMedicinalChemistry,2007,vol.42,#1,p.87-92]

[1]Pathak,VijaiN.;Gupta,Ragini;Tiwari,Ranjana;Gupta,Rekha;Sareen,Vineeta;Varshney,Bindu[SyntheticCommunications,2007,vol.37,#6,p.977-984]

[2]Stirrett,KarenL.;Ferreras,JulianA.;Jayaprakash,Venkatesan;Sinha,BarijN.;Ren,Tao;Quadri,LuisE.N.[BioorganicandMedicinalChemistryLetters,2008,vol.18,#8,p.2662-2668]

[3]NagendraChowdary;Umashankara;Dinesh;Girish;RameshaBaba[AsianJournalofChemistry,2019,vol.31,#1,p.45-50]

Literature

Title: Synthesis and anti Methicillin resistant Staphylococcus aureus activity of substituted chalcones alone and in combination with non-beta-lactam antibiotics.

Journal: Bioorganic & medicinal chemistry letters 20120715

Title: Chalcone-based inhibitors against hypoxia-inducible factor 1--structure activity relationship studies.

Journal: Bioorganic & medicinal chemistry letters 20110101

Title: The enzymatic asymmetric conjugate umpolung reaction.

Journal: Angewandte Chemie (International ed. in English) 20100903

Title: Study on the substituents' effects of a series of synthetic chalcones against the yeast Candida albicans.

Journal: European journal of medicinal chemistry 20070101

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Title: Sun Young Kim, et al. 2-Hydroxychalcone and Xanthohumol Inhibit Invasion of Triple Negative Breast Cancer Cells. Chem Biol Interact. 2013 May 25;203(3):565-72.

Title: B Madan, et al. 2'-hydroxychalcone Inhibits Nuclear factor-kappaB and Blocks Tumor Necrosis Factor-Alpha- And Lipopolysaccharide-Induced Adhesion of Neutrophils to Human Umbilical Vein Endothelial Cells. Mol Pharmacol. 2000 Sep;58(3):526-34.

Title: BABITA MADAN, et al. 2-Hydroxychalcone Inhibits Nuclear Factor-kB and Blocks Tumor Necrosis Factor-a- and Lipopolysaccharide-Induced Adhesion of Neutrophils to Human Umbilical Vein Endothelial Cells. Mol Pharmacol 58:526–534, 2000.

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