Home Amines 65-29-2
65-29-2,MFCD00011832
Catalog No.:AA00E9LE

65-29-2 | Gallamine Triethiodide

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100mg
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00E9LE
Chemical Name:
Gallamine Triethiodide
CAS Number:
65-29-2
Molecular Formula:
C30H60I3N3O3
Molecular Weight:
891.5291
MDL Number:
MFCD00011832
SMILES:
CC[N+](CCOc1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)(CC)CC.[I-].[I-].[I-]
Properties
Properties
 
BP:
502.6°C at 760 mmHg  
Form:
Solid  
MP:
235 °C (dec.)(lit.)  
Solubility:
H2O: 100 mg/mL  
Storage:
Light sensitive;Inert atmosphere;2-8℃;  

Computed Properties
 
Complexity:
489  
Covalently-Bonded Unit Count:
4  
Heavy Atom Count:
39  
Hydrogen Bond Acceptor Count:
6  
Rotatable Bond Count:
21  

Literature

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Title: Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).

Journal: PLoS computational biology 20111201

Title: Role of TNF-α in virus-induced airway hyperresponsiveness and neuronal M₂ muscarinic receptor dysfunction.

Journal: British journal of pharmacology 20110901

Title: [Intravenous procaine as analgesic in obstetrics. 1955].

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Title: Changes in blood pressure induced by electrical stimulation of the femur in anesthetized rats.

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Title: A predictive ligand-based Bayesian model for human drug-induced liver injury.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20101201

Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

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Title: [Three auxiliary medications in obstetrics. 1955].

Journal: Ginecologia y obstetricia de Mexico 20101101

Title: A fluorescence anisotropy assay for the muscarinic M1 G-protein-coupled receptor.

Journal: Assay and drug development technologies 20100601

Title: Investigating the interaction of McN-A-343 with the M2 muscarinic receptor using its nitrogen mustard derivative.

Journal: Biochemical pharmacology 20100401

Title: A fluorescence resonance energy transfer-based M2 muscarinic receptor sensor reveals rapid kinetics of allosteric modulation.

Journal: The Journal of biological chemistry 20100319

Title: The effect of memantine and levodopa/carbidopa on the responses of phrenic nerve-diaphragm preparations from aged rats.

Journal: Medical science monitor : international medical journal of experimental and clinical research 20091101

Title: Kinetics of inhibition of acetylcholinesterase in the presence of acetonitrile.

Journal: The FEBS journal 20090401

Title: An in vitro model for studying neuromuscular transmission in the mouse pharynx.

Journal: Dysphagia 20090301

Title: Use of acetylcholine mustard to study allosteric interactions at the M(2) muscarinic receptor.

Journal: The Journal of pharmacology and experimental therapeutics 20081101

Title: Acute anal stretch inhibits NMDA-dependent pelvic-urethra reflex potentiation via spinal GABAergic inhibition in anesthetized rats.

Journal: American journal of physiology. Renal physiology 20081001

Title: Binding of orthosteric ligands to the allosteric site of the M(2) muscarinic cholinergic receptor.

Journal: Molecular pharmacology 20080901

Title: Two-state models and the analysis of the allosteric effect of gallamine at the M2 muscarinic receptor.

Journal: The Journal of pharmacology and experimental therapeutics 20080601

Title: The impact of orthosteric radioligand depletion on the quantification of allosteric modulator interactions.

Journal: The Journal of pharmacology and experimental therapeutics 20080601

Title: [Neuromuscular monitoring: methods and machines].

Journal: Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS 20080501

Title: Acetylcholine mediates the release of IL-8 in human bronchial epithelial cells by a NFkB/ERK-dependent mechanism.

Journal: European journal of pharmacology 20080317

Title: Subtype-selective blockade of cardiac muscarinic receptors inhibits vagal chronotropic responses in cats.

Journal: Pflugers Archiv : European journal of physiology 20080201

Title: Autoantibodies enhance agonist action and binding to cardiac muscarinic receptors in chronic Chagas' disease.

Journal: Journal of receptor and signal transduction research 20080101

Title: First gallamine-tacrine hybrid: design and characterization at cholinesterases and the M2 muscarinic receptor.

Journal: Journal of medicinal chemistry 20071115

Title: The effect of some curarizing drugs in unanaesthetized man. I. d-Tubocurarine chloride, gallamonium iodide, decamethonium iodide, succinylcholine iodide and its bis-monoethyl-substituted derivative in single or repeated doses. Acta Anaesth. Scandinav. 1957, 1, 15-39.

Journal: Acta anaesthesiologica Scandinavica 20070901

Title: Allosteric interaction of the neuromuscular blockers vecuronium and pancuronium with recombinant human muscarinic M2 receptors.

Journal: European journal of pharmacology 20070813

Title: Mutational disruption of a conserved disulfide bond in muscarinic acetylcholine receptors attenuates positive homotropic cooperativity between multiple allosteric sites and has subtype-dependent effects on the affinities of muscarinic allosteric ligands.

Journal: Molecular pharmacology 20070301

Title: Allosteric interactions with muscarinic acetylcholine receptors: complex role of the conserved tryptophan M2422Trp in a critical cluster of amino acids for baseline affinity, subtype selectivity, and cooperativity.

Journal: Molecular pharmacology 20060701

Title: Pharmacology and surface electrostatics of the K channel outer pore vestibule.

Journal: The Journal of membrane biology 20060701

Title: Inhibitory M2 muscarinic receptors are upregulated in both axotomized and intact small diameter dorsal root ganglion cells after peripheral nerve injury.

Journal: Neuroscience 20060619

Title: Cardiac activity and blood pressure in rats during selective blockade of various subtypes of muscarinic cholinoceptors.

Journal: Bulletin of experimental biology and medicine 20060601

Title: Identification of various allosteric interaction sites on M1 muscarinic receptor using 125I-Met35-oxidized muscarinic toxin 7.

Journal: Molecular pharmacology 20060501

Title: Effects of muscarinic antagonists on ZENK expression in the chicken retina.

Journal: Experimental eye research 20060301

Title: Allosteric site in M2 acetylcholine receptors: evidence for a major conformational change upon binding of an orthosteric agonist instead of an antagonist.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20060101

Title: Methoctramine and gallamine inhibit PI hydrolysis in guinea-pig gallbladder.

Journal: Vascular pharmacology 20051001

Title: Prevention of succinylcholine-induced fasciculation and myalgia: a meta-analysis of randomized trials.

Journal: Anesthesiology 20051001

Title: The first synthetic nondepolarizing muscle relaxant--gallamine.

Journal: Anaesthesia and intensive care 20051001

Title: Critical amino acid residues of the common allosteric site on the M2 muscarinic acetylcholine receptor: more similarities than differences between the structurally divergent agents gallamine and bis(ammonio)alkane-type hexamethylene-bis-[dimethyl-(3-phthalimidopropyl)ammonium]dibromide.

Journal: Molecular pharmacology 20050901

Title: Effects on heart rate of an anti-M2 acetylcholine receptor immune response in mice.

Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20050601

Title: Regulation of M2 muscarinic acetylcholine receptor expression and signaling by prolonged exposure to allosteric modulators.

Journal: The Journal of pharmacology and experimental therapeutics 20050101

Title: M2 muscarinic acetylcholine receptor knock-out mice show deficits in behavioral flexibility, working memory, and hippocampal plasticity.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20041110

Title: Effect of some cardiac and respiratory drugs on succinate-cytochrome c reductase.

Journal: Journal of enzyme inhibition and medicinal chemistry 20040801

Title: Two distinct classes of muscarinic action on hippocampal inhibitory synapses: M2-mediated direct suppression and M1/M3-mediated indirect suppression through endocannabinoid signalling.

Journal: The European journal of neuroscience 20040501

Title: Cholinergic modulation of nociceptive responses in vivo and neuropeptide release in vitro at the level of the primary sensory neuron.

Journal: Pain 20040101

Title: G-protein coupled receptors as allosteric machines.

Journal: Receptors & channels 20040101

Title: Future therapeutic strategies in autoimmune myasthenia gravis.

Journal: Annals of the New York Academy of Sciences 20030901

Title: Postsynaptic M1 and M3 receptors are responsible for the muscarinic enhancement of retrograde endocannabinoid signalling in the hippocampus.

Journal: The European journal of neuroscience 20030701

Title: An unusual form of the association binding kinetics of N-[3H]methylscopolamine to the split muscarinic M2trunk/M2tail receptor.

Journal: The Journal of pharmacology and experimental therapeutics 20030501

Title: Gallamine-tetraphenylborate-modified carbon paste electrode for the potentiometric determination of gallamine triethiodide (flaxedil).

Journal: Journal of pharmaceutical and biomedical analysis 20030326

Title: Chemically modified carbon paste electrode for iodide determination on the basis of cetyltrimethylammonium iodide ion-pair.

Journal: Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 20030201

Title: Involvement of cholinoceptors in cadmium-induced endothelial dysfunction.

Journal: Journal of basic and clinical physiology and pharmacology 20030101

Title: Nuclear factor kappaB activation by muscarinic receptors in astroglial cells: effect of ethanol.

Journal: Neuroscience 20030101

Title: Cardiovascular effects of intravenous pentazocine and cyclazocine in conscious, curarized-conscious, and anesthetized dogs.

Journal: Journal of basic and clinical physiology and pharmacology 20030101

Title: Analogs of WIN 62,577 define a second allosteric site on muscarinic receptors.

Journal: Molecular pharmacology 20021201

Title: Role of muscarinic acetylcholine receptors in a guinea pig model of asthma.

Journal: International immunopharmacology 20021001

Title: The nature of the acetylcholine and 5-hydroxytryptamine receptors in buccal smooth muscle of the pest slug Deroceras reticulatum.

Journal: Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology 20020401

Title: Anionic cyclophanes as potential reversal agents of muscle relaxants by chemical chelation.

Journal: Bioorganic & medicinal chemistry letters 20020311

Title: Isobolographic analysis of non-depolarising muscle relaxant interactions at their receptor site.

Journal: European journal of pharmacology 20020301

Title: Muscle distribution of the neuromuscular blocker gallamine using microdialysis.

Journal: Journal of pharmaceutical sciences 20020301

Title: Pharmacology and chemistry of the venoms of solitary wasps.

Journal: Journal of natural toxins 20020201

Title: Cholinergic and serotonergic activities are required in triggering conditioned NK cell response.

Journal: Journal of neuroimmunology 20020201

Title: Systemic anaphylaxis induced by intradermal testing.

Journal: Allergie et immunologie 20020201

Title: Changes of cooperativity between N-methylscopolamine and allosteric modulators alcuronium and gallamine induced by mutations of external loops of muscarinic M(3) receptors.

Journal: Molecular pharmacology 20011001

Title: Muscarinic activation of inwardly rectifying K(+) conductance reduces EPSPs in rat hippocampal CA1 pyramidal cells.

Journal: The Journal of physiology 20010901

Title: Muscarinic allosteric modulation: M2/M3 subtype selectivity of gallamine is independent of G-protein coupling specificity.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20010801

Title: The influence of surface charges on quaternary ammonium block of shaker K+ channels.

Journal: The Journal of membrane biology 20010801

Title: Succinylcholine pretreatment using gallamine or mivacurium during rapid sequence induction in children: a randomized, controlled study.

Journal: Journal of clinical anesthesia 20010601

Title: Application of a high-performance liquid chromatographic assay for the neuromuscular blocker gallamine to analysis of rat plasma, muscle and microdialysate samples.

Journal: Journal of chromatography. B, Biomedical sciences and applications 20010425

Title: Cathodic adsorptive stripping voltammetric determination of muscle relaxant: gallamine triethiodide (flaxedil).

Journal: Journal of pharmaceutical and biomedical analysis 20010401

Title: Glucocorticoid treatment increases inhibitory m(2) muscarinic receptor expression and function in the airways.

Journal: American journal of respiratory cell and molecular biology 20010401

Title: The allosteric interaction of otenzepad (AF-DX 116) at muscarinic M2 receptors in guinea pig atria.

Journal: European journal of pharmacology 20010330

Title: Gallamine triethiodide selectively blocks voltage-gated potassium channels in Ranvier nodes.

Journal: General physiology and biophysics 20010301

Title: Allosteric interactions of staurosporine and other indolocarbazoles with N-[methyl-(3)H]scopolamine and acetylcholine at muscarinic receptor subtypes: identification of a second allosteric site.

Journal: Molecular pharmacology 20000701

Title: Intubation conditions and postoperative myalgia in outpatient dental surgery: a comparison of succinylcholine with mivacurium.

Journal: Anaesthesia and intensive care 20000401

Title: The influence of peripheral site ligands on the reaction of symmetric and chiral organophosphates with wildtype and mutant acetylcholinesterases.

Journal: Chemico-biological interactions 19990514

Title: Myoclonic and tonic seizures elicited by microinjection of cholinergic drugs into the inferior colliculus.

Journal: Therapie 19990101

Title: Interaction of neuromuscular blocking drugs with recombinant human m1-m5 muscarinic receptors expressed in Chinese hamster ovary cells.

Journal: British journal of pharmacology 19981101

Title: Binding of the labelled muscarinic toxin 125I-MT1 to rat brain muscarinic M1 receptors.

Journal: European journal of pharmacology 19960603

Title: Assessment of the muscarinic receptor subtypes involved in pilocarpine-induced seizures in mice.

Journal: Neuroscience letters 19940227

Title: Adverse reaction to neuromuscular blockers: frequency, investigation, and epidemiology.

Journal: Acta anaesthesiologica Scandinavica. Supplementum 19940101

Title: The best prophylaxis for succinylcholine myalgias: extension of a previous meta-analysis.

Journal: Anesthesia and analgesia 19931101

Title: Ranitidine reverses gallamine paralysis in rats.

Journal: Anesthesia and analgesia 19930301

Title: Differential effects of neuromuscular blocking agents on suxamethonium-induced fasciculations and myalgia.

Journal: British journal of anaesthesia 19880301

Title: [Does diazepam prevent fasciculation and myalgias caused by suxamethonium? A double-blind study].

Journal: Ugeskrift for laeger 19870202

Title: Subclassification of muscarinic receptors in the heart, urinary bladder and sympathetic ganglia in the pithed rat. Selectivity of some classical agonists.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 19851201

Title: Postoperative spasticity and shivering. A review with personal observations of 500 patients.

Journal: Anaesthesia 19840101

Title: Reduction of post-suxamethonium pain by pretreatment with four non-depolarizing agents.

Journal: British journal of anaesthesia 19810501

Title: Relation of precurarization to suxamethonium to provide ease of intubation and to prevent post-suxamethonium muscle pains.

Journal: Canadian Anaesthetists' Society journal 19790301

Title: Anesthesia related muscle paralysis in renal failure.

Journal: Clinical nephrology 19780701

Title: Comparative effects of nondepolarizing muscle relaxants on succinycholine-induced fasciculations and postoperative pain.

Journal: Southern medical journal 19770901

Title: The inhibitory effect of gallamine on muscarinic receptors.

Journal: British journal of pharmacology 19761101

Title: The effect of blood flow upon the activity of gallamine triethiodide.

Journal: British journal of anaesthesia 19760201

Title: Accidental subarachnoid injection of gallamine. A case report.

Journal: British journal of anaesthesia 19750801

Title: Comparison of gallamine with d-tubocurarine effects on fasciculations after succinylcholine.

Journal: Anesthesia and analgesia 19750101

Title: Accidental intrathecal injection of gallamine triethiodide.

Journal: Anaesthesia 19740501

Title: Cardiovascular collapse following succinylcholine in a paraplegic patient.

Journal: Paraplegia 19731101

Title: Quantitative aspects of the chronotropic and neuromuscular effects of gallamine in anesthetized man.

Journal: Anesthesiology 19711201

Title: Inhibition of succinylcholine-induced increased intragastric pressure by nondepolarizing muscle relaxants and lidocaine.

Journal: Anesthesiology 19710201

Title: Recurarization--fact or fiction.

Journal: Anesthesia and analgesia 19710101

Title: Analysis of anesthetic-related morbidity in human recipients of renal homografts.

Journal: Anesthesia and analgesia 19710101

Title: http://en.wikipedia.org/wiki/Gallamine_triethiodide

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Tags:65-29-2 Molecular Formula|65-29-2 MDL|65-29-2 SMILES|65-29-2 Gallamine Triethiodide