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6506-37-2,MFCD00866796
Catalog No.:AA00E909

6506-37-2 | Nimorazole

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Purity
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1mg
98%
in stock  
$14.00   $10.00
- +
5mg
99%(HPLC)
in stock  
$32.00   $23.00
- +
10mg
98%
in stock  
$45.00   $32.00
- +
25mg
99%(HPLC)
in stock  
$66.00   $46.00
- +
50mg
98%
in stock  
$101.00   $71.00
- +
100mg
99%(HPLC)
in stock  
$193.00   $135.00
- +
250mg
99%(HPLC)
in stock  
$259.00   $182.00
- +
1g
99%(HPLC)
in stock  
$991.00   $694.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA00E909
Chemical Name:
Nimorazole
CAS Number:
6506-37-2
Molecular Formula:
C9H14N4O3
Molecular Weight:
226.2325
MDL Number:
MFCD00866796
SMILES:
[O-][N+](=O)c1cncn1CCN1CCOCC1
NSC Number:
107524
Properties
Computed Properties
 
Complexity:
239  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
16  
Hydrogen Bond Acceptor Count:
5  
Rotatable Bond Count:
3  
XLogP3:
-0.4  

Downstream Synthesis Route

[1]JournaloftheChemicalSociety,DaltonTransactions,1985,p.795-802

Literature

Title: Trichomonas vaginalis antimicrobial drug resistance in 6 US cities, STD Surveillance Network, 2009-2010.

Journal: Emerging infectious diseases 20120601

Title: Gene expression classifier predicts for hypoxic modification of radiotherapy with nimorazole in squamous cell carcinomas of the head and neck.

Journal: Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 20120101

Title: Targeting tumor perfusion and oxygenation to improve the outcome of anticancer therapy.

Journal: Frontiers in pharmacology 20120101

Title: Does transfusion improve the outcome for HNSCC patients treated with radiotherapy? - results from the randomized DAHANCA 5 and 7 trials.

Journal: Acta oncologica (Stockholm, Sweden) 20111001

Title: [Development and use of test systems for the evaluation of sensitivity of Trichomonas vaginalisto preparations of the 5-nitroimidazole and 5-nitrofuran groups].

Journal: Zhurnal mikrobiologii, epidemiologii, i immunobiologii 20110101

Title: HPV-associated p16-expression and response to hypoxic modification of radiotherapy in head and neck cancer.

Journal: Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 20100101

Title: Tinidazole in the treatment of bacterial vaginosis.

Journal: International journal of women's health 20090101

Title: Enhanced local tumour control after single or fractionated radiation treatment using the hypoxic cell radiosensitizer doranidazole.

Journal: Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 20080601

Title: The nimorazole regimen in patients with head and neck cancer can increase the effect of vitamin K antagonists.

Journal: Acta oncologica (Stockholm, Sweden) 20080101

Title: Erythropoiesis-stimulating agents: benefits and risks in supportive care of cancer.

Journal: Current oncology (Toronto, Ont.) 20080101

Title: [The Oxygen effect: an old new target?].

Journal: Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique 20080101

Title: Carbonic anhydrase IX and response to postmastectomy radiotherapy in high-risk breast cancer: a subgroup analysis of the DBCG82 b and c trials.

Journal: Breast cancer research : BCR 20080101

Title: Evidence-based radiation oncology in head and neck squamous cell carcinoma.

Journal: Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 20071001

Title: The importance of radiobiology to cancer therapy: current practice and future perspectives.

Journal: Clinical oncology (Royal College of Radiologists (Great Britain)) 20070801

Title: Chemical radiosensitizers for use in radiotherapy.

Journal: Clinical oncology (Royal College of Radiologists (Great Britain)) 20070801

Title: Differential risk assessments from five hypoxia specific assays: The basis for biologically adapted individualized radiotherapy in advanced head and neck cancer patients.

Journal: Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 20070601

Title: Lack of prognostic and predictive value of CA IX in radiotherapy of squamous cell carcinoma of the head and neck with known modifiable hypoxia: an evaluation of the DAHANCA 5 study.

Journal: Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 20070601

Title: Motexafin gadolinium injection for the treatment of brain metastases in patients with non-small cell lung cancer.

Journal: International journal of nanomedicine 20070301

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Title: Evaluation of hypoxic cell radio-sensitizers in terms of radio-sensitizing and repair-inhibiting potential. Dependency on p53 status of tumor cells and the effects on intratumor quiescent cells.

Journal: Anticancer research 20060101

Title: Plasma osteopontin levels in patients with head and neck cancer and cervix cancer are critically dependent on the choice of ELISA system.

Journal: BMC cancer 20060101

Title: Update on clinical radiobiology.

Journal: Biomedical imaging and intervention journal 20060101

Title: Reevaluation of the radiosensitizing effects of sanazole and nimorazole in vitro and in vivo.

Journal: Journal of radiation research 20051201

Title: Plasma osteopontin, hypoxia, and response to the hypoxia sensitiser nimorazole in radiotherapy of head and neck cancer: results from the DAHANCA 5 randomised double-blind placebo-controlled trial.

Journal: The Lancet. Oncology 20051001

Title: Nimorazole may increase the effect of phenprocoumon.

Journal: Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 20050301

Title: Probing NMR parameters, structure and dynamics of 5-nitroimidazole derivatives. Density functional study of prototypical radiosensitizers.

Journal: Magnetic resonance in chemistry : MRC 20050201

Title: Microenvironmental adaptation of experimental tumours to chronic vs acute hypoxia.

Journal: British journal of cancer 20040913

Title: Targeted radiosensitisation by pegylated liposome-encapsulated 3', 5'-O-dipalmitoyl 5-iodo-2'-deoxyuridine in a head and neck cancer xenograft model.

Journal: British journal of cancer 20040719

Title: Effect of the hypoxic cell sensitizer isometronidazole on local control of two human squamous cell carcinomas after fractionated irradiation.

Journal: Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] 20040601

Title: Five compared with six fractions per week of conventional radiotherapy of squamous-cell carcinoma of head and neck: DAHANCA 6 and 7 randomised controlled trial.

Journal: Lancet (London, England) 20030920

Title: Nitroheterocyclic drugs with broad spectrum activity.

Journal: Parasitology research 20030601

Title: Treatment of head and neck cancer with CHART and nimorazole: phase II study.

Journal: Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 20030101

Title: A systematic overview of radiation therapy effects in head and neck cancer.

Journal: Acta oncologica (Stockholm, Sweden) 20030101

Title: Structure/activity relationships for the enhancement by electron-affinic drugs of the anti-tumour effect of CCNU.

Journal: British journal of cancer 19820801

Title: Peter Wardman, et al. Nitroimidazoles as hypoxic cell radiosensitizers and hypoxia probes: misonidazole, myths and mistakes. Br J Radiol. 2019 Jan;92(1093):20170915.

Title: Zohreh Fakhrieh Kashan, et al. Therapeutic effects of Iranian herbal extracts against Trichomonas vaginalis. Iran Biomed J. 2017 Sep;21(5):285-93.

Title: Overgaard, J., et al., A randomized double-blind phase III study of nimorazole as a hypoxic radiosensitizer of primary radiotherapy in supraglottic larynx and pharynx carcinoma. Results of the Danish Head and Neck Cancer Study (DAHANCA) Protocol 5-85. Radiother Oncol, 1998. 46(2): p. 135-46.

Title: Roy, R.B., S.M. Laird, and L. Heasman, Treatment of trichomoniasis in the female. A comparison of metronidazole and nimorazole. Br J Vener Dis, 1975. 51(4): p. 281-4.

Title: Henk, J.M., K. Bishop, and S.F. Shepherd, Treatment of head and neck cancer with CHART and nimorazole: phase II study. Radiother Oncol, 2003. 66(1): p. 65-70.

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