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Catalog No.:AA00ILMV

65369-76-8 | 1-(3-CHLOROPHENYL)PIPERAZINE MONOHYDROCHLORIDE

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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00ILMV
Chemical Name:
1-(3-CHLOROPHENYL)PIPERAZINE MONOHYDROCHLORIDE
CAS Number:
65369-76-8
Molecular Formula:
C10H14Cl2N2
Molecular Weight:
233.1376
MDL Number:
MFCD00039032
SMILES:
C1CN(CCN1)C2=CC(=CC=C2)Cl.Cl
NSC Number:
134746
Properties
Computed Properties
 
Complexity:
157  
Covalently-Bonded Unit Count:
2  
Heavy Atom Count:
14  
Hydrogen Bond Acceptor Count:
2  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
1  

Literature

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Journal: Journal of biochemical and molecular toxicology 20170601

Title: BF-1--a novel selective 5-HT2B receptor antagonist blocking neurogenic dural plasma protein extravasation in guinea pigs.

Journal: European journal of pharmacology 20150315

Title: Additive inhibition of human α1β2γ2 GABAA receptors by mixtures of commonly used drugs of abuse.

Journal: Neurotoxicology 20130301

Title: Activation of 5-HT(2C) receptors in the dorsal periaqueductal gray increases antinociception in mice exposed to the elevated plus-maze.

Journal: Behavioural brain research 20121101

Title: A double dissociation in the effects of 5-HT2A and 5-HT2C receptors on the acquisition and expression of conditioned defeat in Syrian hamsters.

Journal: Behavioral neuroscience 20120801

Title: Serotonin 5-HT2C receptor-mediated inhibition of the M-current in hypothalamic POMC neurons.

Journal: American journal of physiology. Endocrinology and metabolism 20120601

Title: Effects of serotonin 2C receptor agonists on the behavioral and neurochemical effects of cocaine in squirrel monkeys.

Journal: The Journal of pharmacology and experimental therapeutics 20120501

Title: Methamphetamine, amphetamine, MDMA ('ecstasy'), MDA and mCPP modulate electrical and cholinergic input in PC12 cells.

Journal: Neurotoxicology 20120301

Title: Influence of serotonergic 5-HT2C receptor antagonist mesulergine in the reversal of memory deficits induced by mCPP.

Journal: Journal of the College of Physicians and Surgeons--Pakistan : JCPSP 20120201

Title: Estradiol increases the anorexia associated with increased 5-HT(2C) receptor activation in ovariectomized rats.

Journal: Physiology & behavior 20120118

Title: [Behavioral effects of ketanserine in prenatally stressed female rats].

Journal: Eksperimental'naia i klinicheskaia farmakologiia 20120101

Title: Modulation of human GABAA receptor function: a novel mode of action of drugs of abuse.

Journal: Neurotoxicology 20111201

Title: Safety, tolerability, and pharmacokinetics of once-daily trazodone extended-release caplets in healthy subjects.

Journal: International journal of clinical pharmacology and therapeutics 20111201

Title: Differences in serotonin receptor expression in the brainstem may explain the differential ability of a serotonin agonist to block seizure-induced sudden death in DBA/2 vs. DBA/1 mice.

Journal: Brain research 20111018

Title: Mirtazapine antagonises the subjective, hormonal and neuronal effects of m-chlorophenylpiperazine (mCPP) infusion: a pharmacological-challenge fMRI (phMRI) study.

Journal: NeuroImage 20110915

Title: Control of hippocampal theta rhythm by serotonin: role of 5-HT2c receptors.

Journal: Neuropharmacology 20110901

Title: Serotonin 2C receptor activates a distinct population of arcuate pro-opiomelanocortin neurons via TRPC channels.

Journal: Neuron 20110811

Title: Hypophagic and hypolocomotive effects of metachloro phenyl piperazine in rats treated with theophylline and caffeine.

Journal: Pakistan journal of pharmaceutical sciences 20110701

Title: The trazodone metabolite meta-chlorophenylpiperazine can cause false-positive urine amphetamine immunoassay results.

Journal: Journal of analytical toxicology 20110701

Title: Pharmacologically induced alcohol craving in treatment seeking alcoholics correlates with alcoholism severity, but is insensitive to acamprosate.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20110501

Title: The autonomic stress-induced hyperthermia response is not enhanced by several anxiogenic drugs.

Journal: Physiology & behavior 20110110

Title: Separation of positional CPP isomers by chiral HPLC-DAD of seized tablets.

Journal: International journal of legal medicine 20110101

Title: Altered 5-HT2C receptor agonist-induced responses and 5-HT2C receptor RNA editing in the amygdala of serotonin transporter knockout mice.

Journal: BMC pharmacology 20110101

Title: [Effects of 5-HT1 and 5-HT2 serotonin receptors on anxiety- and depression-like behavior in female rats].

Journal: Eksperimental'naia i klinicheskaia farmakologiia 20110101

Title: [Influence of 2-ethyl-6-methyl-3-hydroxypyridine hemisuccinate on cerebral blood perfusion in rats under experimental pathology conditions].

Journal: Eksperimental'naia i klinicheskaia farmakologiia 20110101

Title: [Cerebrovascular and antiserotoninergic activity of the combination of tropoxin and mexidol].

Journal: Eksperimental'naia i klinicheskaia farmakologiia 20110101

Title: Dose proportionality of once-daily trazodone extended-release caplets under fasting conditions.

Journal: Journal of clinical pharmacology 20101201

Title: Blockade of 5-HT2A/2C-type receptors impairs learning in female rats in the course of estrous cycle.

Journal: Bulletin of experimental biology and medicine 20101201

Title: Trazodone, meta-chlorophenylpiperazine (an hallucinogenic drug and trazodone metabolite), and the hallucinogen trifluoromethylphenylpiperazine cross-react with the EMIT®II ecstasy immunoassay in urine.

Journal: Journal of analytical toxicology 20101101

Title: [Behavioral effects of m-CPP and ketanserine during ovarian cycle in female rats].

Journal: Eksperimental'naia i klinicheskaia farmakologiia 20101101

Title: Hypothalamic orexin and pro-opiomelanocortin activities are essential for the anorexic effects of m-chlorophenylpiperazine in mice.

Journal: The international journal of neuropsychopharmacology 20101001

Title: Multiple anxiogenic drugs recruit a parvalbumin-containing subpopulation of GABAergic interneurons in the basolateral amygdala.

Journal: Progress in neuro-psychopharmacology & biological psychiatry 20101001

Title: 5-HT2C receptor activation prevents stress-induced enhancement of brain 5-HT turnover and extracellular levels in the mouse brain: modulation by chronic paroxetine treatment.

Journal: Journal of neurochemistry 20101001

Title: Detection of 1-benzylpiperazine, 1-(3-trifluoromethylphenyl)-piperazine, and 1-(3-chlorophenyl)-piperazine in 3,4-methylenedioxymethamphetamine-positive urine samples.

Journal: Journal of analytical toxicology 20101001

Title: mCPP: an undesired addition to the ecstasy market.

Journal: Journal of psychopharmacology (Oxford, England) 20100901

Title: [Effect of tropoxin on cerebrovascular effects of meta-chlorophenylpiperazine and serotonin].

Journal: Eksperimental'naia i klinicheskaia farmakologiia 20100901

Title: Fear-potentiated startle, but not light-enhanced startle, is enhanced by anxiogenic drugs.

Journal: Pharmacology, biochemistry, and behavior 20100701

Title: Tolerance to 3,4-methylenedioxymethamphetamine is associated with impaired serotonin release.

Journal: Addiction biology 20100701

Title: Acute SSRI-induced anxiogenic and brain metabolic effects are attenuated 6 months after initial MDMA-induced depletion.

Journal: Behavioural brain research 20100305

Title: The effects of the 5-HT2C agonist m-chlorophenylpiperazine on elite athletes with unexplained underperformance syndrome (overtraining).

Journal: British journal of sports medicine 20100301

Title: Acquisition session length modulates consolidation effects produced by 5-HT2C ligands in a mouse autoshaping-operant procedure.

Journal: Behavioural pharmacology 20100301

Title: Neuronal correlates and serotonergic modulation of behavioural inhibition and reward in healthy and antisocial individuals.

Journal: Journal of psychiatric research 20100201

Title: 5-hydroxytryptamine receptor stimulation of mitochondrial biogenesis.

Journal: The Journal of pharmacology and experimental therapeutics 20100201

Title: Role of spinal serotonergic pathways in sneeze-induced urethral continence reflex in rats.

Journal: American journal of physiology. Renal physiology 20091001

Title: Characterizing the effects of 5-HT(2C) receptor ligands on motor activity and feeding behaviour in 5-HT(2C) receptor knockout mice.

Journal: Neuropharmacology 20090901

Title: Serotonin 5-HT2C receptor-independent expression of hypothalamic NOR1, a novel modulator of food intake and energy balance, in mice.

Journal: Biochemical and biophysical research communications 20090821

Title: Individual differences in the sensitivity to serotonergic drugs: a pharmacobehavioural approach using rats selected on the basis of their response to novelty.

Journal: Psychopharmacology 20090801

Title: Fluvoxamine exerts anorexic effect in 5-HT2C receptor mutant mice with heterozygous mutation of beta-endorphin gene.

Journal: The international journal of neuropsychopharmacology 20090501

Title: Selective serotonin reuptake inhibitors modify physiological gastrointestinal motor activities via 5-HT2c receptor and acyl ghrelin.

Journal: Biological psychiatry 20090501

Title: 1-(m-Chlorophenyl)piperazine induces depressogenic-like behaviour in rodents by stimulating the neuronal 5-HT(2A) receptors: proposal of a modified rodent antidepressant assay.

Journal: European journal of pharmacology 20090417

Title: Synergistic actions of apomorphine and m-chlorophenylpiperazine on ejaculation, but not penile erection in rats.

Journal: Biomedical research (Tokyo, Japan) 20090401

Title: Behavioral and neurochemical profile of m-CPP following exposure to single restraint stress in rat.

Journal: Acta neurologica Belgica 20090301

Title: Subthalamic neurons show increased firing to 5-HT2C receptor activation in 6-hydroxydopamine-lesioned rats.

Journal: Brain research 20090223

Title: Creation and application of psychoactive designer drugs data library using liquid chromatography with photodiode array spectrophotometry detector and gas chromatography-mass spectrometry.

Journal: Talanta 20090215

Title: Prevalence of ergot derivatives in natural ryegrass pastures: detection and pathogenicity in the horse.

Journal: Theriogenology 20090201

Title: Distribution and neurochemical characterization of neurons within the nucleus of the solitary tract responsive to serotonin agonist-induced hypophagia.

Journal: Behavioural brain research 20090103

Title: Trazodone generates m-CPP: in 2008 risks from m-CPP might outweigh benefits of trazodone.

Journal: The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry 20090101

Title: Anti-inflammatory effects of m-chlorophenylpiperazine in brain glia cells.

Journal: International immunopharmacology 20081210

Title: Dopaminergic and serotonergic modulation of persistent behaviour in the reinforced spatial alternation model of obsessive-compulsive disorder.

Journal: Psychopharmacology 20081101

Title: Relationship of the serotonin transporter with prolactin response to meta-chlorophenylpiperazine in cocaine dependence.

Journal: Journal of psychiatric research 20081001

Title: Effects of chemotherapeutic agents 5-fluorouracil and methotrexate alone and combined in a mouse model of learning and memory.

Journal: Psychopharmacology 20080901

Title: Hypersensitivity of 5-HT2 receptors in OCD patients. An increased prolactin response after a challenge with meta-chlorophenylpiperazine and pre-treatment with ritanserin and placebo.

Journal: Journal of psychiatric research 20080901

Title: Taste-dependent sociophobia: when food and company do not mix.

Journal: Behavioural brain research 20080822

Title: HPLC analysis of the antidepressant trazodone and its main metabolite m-CPP in human plasma.

Journal: Journal of pharmaceutical and biomedical analysis 20080805

Title: High throughput and sensitive determination of trazodone and its primary metabolite, m-chlorophenylpiperazine, in human plasma by liquid chromatography-tandem mass spectrometry.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20080801

Title: Exercise is associated with reduction in the anxiogenic effect of mCPP on acoustic startle.

Journal: Behavioral neuroscience 20080801

Title: 5-HT(2C) receptor activation is a common mechanism on proerectile effects of apomorphine, oxytocin and melanotan-II in rats.

Journal: European journal of pharmacology 20080728

Title: Serotonin systems upregulate the expression of hypothalamic NUCB2 via 5-HT2C receptors and induce anorexia via a leptin-independent pathway in mice.

Journal: Biochemical and biophysical research communications 20080718

Title: Behavioral effects of 1-(m-chlorophenyl)piperazine (m-CPP) in a rat model of tardive dyskinesia.

Journal: Pakistan journal of pharmaceutical sciences 20080701

Title: Antagonism of AMPA receptors produces anxiolytic-like behavior in rodents: effects of GYKI 52466 and its novel analogues.

Journal: Psychopharmacology 20080601

Title: Rikkunshito, an herbal medicine, suppresses cisplatin-induced anorexia in rats via 5-HT2 receptor antagonism.

Journal: Gastroenterology 20080601

Title: Acute chlorophenylpiperazine overdose: a case report and review of the literature.

Journal: Therapeutic drug monitoring 20080601

Title: Detection of novel reactive metabolites of trazodone: evidence for CYP2D6-mediated bioactivation of m-chlorophenylpiperazine.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20080501

Title: Effects of a Cannabinoid1 receptor antagonist and Serotonin2C receptor agonist alone and in combination on motivation for palatable food: a dose-addition analysis study in mice.

Journal: The Journal of pharmacology and experimental therapeutics 20080501

Title: Behavioral characterization of serotonergic activation in the flatworm Planaria.

Journal: Behavioural pharmacology 20080501

Title: m-CPP induced hypolocomotion does not interfere in the assessment of memory functions in rats.

Journal: Pakistan journal of pharmaceutical sciences 20080401

Title: Stereotypic behaviour in the deer mouse: pharmacological validation and relevance for obsessive compulsive disorder.

Journal: Progress in neuro-psychopharmacology & biological psychiatry 20080215

Title: 5-HT2 receptor activation in the midbrain periaqueductal grey (PAG) reduces anxiety-like behaviour in mice.

Journal: Behavioural brain research 20080211

Title: Ejaculatory response induced by a 5-HT2 receptor agonist m-CPP in rats: differential roles of 5-HT2 receptor subtypes.

Journal: Pharmacology, biochemistry, and behavior 20080201

Title: Serotonin 2C receptor agonists improve type 2 diabetes via melanocortin-4 receptor signaling pathways.

Journal: Cell metabolism 20071107

Title: MDMA-like behavioral effects of N-substituted piperazines in the mouse.

Journal: Pharmacology, biochemistry, and behavior 20071101

Title: Fluvoxamine, a selective serotonin reuptake inhibitor, and 5-HT2C receptor inactivation induce appetite-suppressing effects in mice via 5-HT1B receptors.

Journal: The international journal of neuropsychopharmacology 20071001

Title: Behavioural effects of rapid intravenous administration of meta-chlorophenylpiperazine (m-CPP) in patients with generalized social anxiety disorder, panic disorder and healthy controls.

Journal: European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20071001

Title: Adrenergic and serotoninergic regulation of myocardial contractility in patients with various morphofunctional changes in the heart resulting from chronic heart failure.

Journal: Bulletin of experimental biology and medicine 20071001

Title: Proof of a 1-(3-chlorophenyl)piperazine (mCPP) intake: use as adulterant of cocaine resulting in drug-drug interactions?

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20070815

Title: Trazodone inhibits T-type calcium channels.

Journal: Neuropharmacology 20070801

Title: Possible involvement of spinal noradrenergic mechanisms in the antiallodynic effect of intrathecally administered 5-HT2C receptor agonists in the rats with peripheral nerve injury.

Journal: European journal of pharmacology 20070712

Title: Amygdala-prefrontal disconnection in borderline personality disorder.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20070701

Title: Neurochemical and behavioral effects of m-CPP in a rat model of tardive dyskinesia.

Journal: Pakistan journal of pharmaceutical sciences 20070701

Title: 5-HT2 modulation of AY-9944 induced atypical absence seizures.

Journal: Neuroscience letters 20070511

Title: High-throughput quantitation of nefazodone and its metabolites in human plasma by high flow direct-injection LC-MS/MS.

Journal: Journal of pharmaceutical and biomedical analysis 20070411

Title: Anxiogenic-like effects of mCPP microinfusions into the amygdala (but not dorsal or ventral hippocampus) in mice exposed to elevated plus-maze.

Journal: Behavioural brain research 20070312

Title: 5-Hydroxytryptamine2C receptor contribution to m-chlorophenylpiperazine and N-methyl-beta-carboline-3-carboxamide-induced anxiety-like behavior and limbic brain activation.

Journal: The Journal of pharmacology and experimental therapeutics 20070301

Title: Effect of meta-chlorophenylpiperazine and cholecystokinin on food intake of Osborne-Mendel and S5B/P1 rats.

Journal: Obesity (Silver Spring, Md.) 20070301

Title: Influence of diltiazem on the behavior of zolpidem-treated mice in the elevated-plus maze test.

Journal: Journal of neural transmission (Vienna, Austria : 1996) 20070201

Title: Amphetamine and mCPP effects on dopamine and serotonin striatal in vivo microdialysates in an animal model of hyperactivity.

Journal: Neurotoxicity research 20070201

Title: Anxiolytic activity of a novel potent serotonin 5-HT2C receptor antagonist FR260010: a comparison with diazepam and buspirone.

Journal: European journal of pharmacology 20061228

Title: Hyperphagia alters expression of hypothalamic 5-HT2C and 5-HT1B receptor genes and plasma des-acyl ghrelin levels in Ay mice.

Journal: Endocrinology 20061201

Title: Serotonin dysfunction in pathological gamblers: increased prolactin response to oral m-CPP versus placebo.

Journal: CNS spectrums 20061201

Title: Polymorphism in the serotonin transporter gene and moderators of prolactin response to meta-chlorophenylpiperazine in African-American cocaine abusers and controls.

Journal: Psychiatry research 20061115

Title: [Role of the serotonergic nervous system in anxiety disorders and the anxiolytic mechanism of selective serotonin reuptake inhibitors].

Journal: Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology 20061101

Title: Role of the 5-HT2C receptor in improving weight-supported stepping in adult rats spinalized as neonates.

Journal: Brain research 20060927

Title: Relationship of prolactin response to meta-chlorophenylpiperazine with severity of drug use in cocaine dependence.

Journal: Human psychopharmacology 20060801

Title: Functional magnetic resonance imaging and c-Fos mapping in rats following an anorectic dose of m-chlorophenylpiperazine.

Journal: NeuroImage 20060701

Title: Effects of soybean food pellets on m-CPP-induced anxiety model of mice.

Journal: Biological & pharmaceutical bulletin 20060701

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Title: Pharmacological evaluation of the stress-induced social avoidance model of anxiety.

Journal: Brain research bulletin 20060331

Title: Childhood sexual abuse in relation to neurobiological challenge tests in patients with borderline personality disorder and normal controls.

Journal: Psychiatry research 20060330

Title: A negative feedback system between brain serotonin systems and plasma active ghrelin levels in mice.

Journal: Biochemical and biophysical research communications 20060317

Title: Relationship of disinhibition and aggression to blunted prolactin response to meta-chlorophenylpiperazine in cocaine-dependent patients.

Journal: Psychopharmacology 20060301

Title: Serotonin 1B and 2C receptor interactions in the modulation of feeding behaviour in the mouse.

Journal: Psychopharmacology 20060301

Title: 5-HT2c receptor activation induces grooming behaviour in rats: possible correlations with obsessive-compulsive disorder.

Journal: Neuropsychopharmacologia Hungarica : a Magyar Pszichofarmakologiai Egyesulet lapja = official journal of the Hungarian Association of Psychopharmacology 20060301

Title: Does meta-chlorophenylpiperazine (mCPP) activate human platelets?

Journal: Platelets 20060201

Title: gamma-Aminobutyric acid-serotonin interactions in healthy men: implications for network models of psychosis and dissociation.

Journal: Biological psychiatry 20060115

Title: Medial parabrachial nucleus neurons modulate d-fenfluramine-induced anorexia through 5HT2C receptors.

Journal: Brain research 20060105

Title: Discriminative stimulus effects of 3,4-methylenedioxymethamphetamine (MDMA) in humans trained to discriminate among d-amphetamine, meta-chlorophenylpiperazine and placebo.

Journal: Drug and alcohol dependence 20060104

Title: Effects of mu-CPP and mesulergine on dietary choices in deprived rats: possible mechanisms of their action.

Journal: Progress in neuro-psychopharmacology & biological psychiatry 20060101

Title: [Metachlorophenylpiperazine (mCPP): a new designer drug].

Journal: Therapie 20060101

Title: Development of a solid phase extraction for 13 'new' generation antidepressants and their active metabolites for gas chromatographic-mass spectrometric analysis.

Journal: Journal of chromatography. A 20051209

Title: Estradiol supplementation modulates neuroendocrine response to M-chlorophenylpiperazine in menstrual status migrainosus triggered by oral contraception-free interval.

Journal: Human reproduction (Oxford, England) 20051201

Title: Selective and nonselective serotonin antagonists block the aversive stimulus properties of MK212 and m-chlorophenylpiperazine (mCPP) in mice.

Journal: Neuropharmacology 20051201

Title: Methylone and mCPP, two new drugs of abuse?

Journal: Addiction biology 20051201

Title: Ethanol substitutes for the discriminative stimulus effects of m-chlorophenylpiperazine.

Journal: Brain research 20051116

Title: m-Chlorophenylpiperazine exacerbates perception of salicylate-induced tinnitus in rats.

Journal: The European journal of neuroscience 20051101

Title: Effect of 5-hydroxytryptamine on neurogenic vasoconstriction in the isolated, autoperfused hindquarters of the rat.

Journal: Clinical and experimental pharmacology & physiology 20051001

Title: Association of the promoter polymorphism -1438G/A of the 5-HT2A receptor gene with behavioral impulsiveness and serotonin function in women with bulimia nervosa.

Journal: American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 20050805

Title: Serotonergic/glutamatergic interactions: potentiation of phencyclidine-induced stimulus control by citalopram.

Journal: Pharmacology, biochemistry, and behavior 20050701

Title: Brain angiotensin and anxiety-related behavior: the transgenic rat TGR(ASrAOGEN)680.

Journal: Brain research 20050607

Title: The use of sudden darkness in mice: a behavioural and pharmacological approach.

Journal: Psychopharmacology 20050601

Title: Effects of 5,7-dihydroxytryptamine lesion of the dorsal raphe nucleus on ethanol discrimination in the rat.

Journal: Alcohol (Fayetteville, N.Y.) 20050601

Title: Reinforced spatial alternation as an animal model of obsessive-compulsive disorder (OCD): investigation of 5-HT2C and 5-HT1D receptor involvement in OCD pathophysiology.

Journal: Biological psychiatry 20050515

Title: Trazodone and its active metabolite m-chlorophenylpiperazine as partial agonists at 5-HT1A receptors assessed by [35S]GTPgammaS binding.

Journal: Journal of psychopharmacology (Oxford, England) 20050501

Title: Effects of serotonin and serotonergic agonists and antagonists on the production of tumor necrosis factor alpha and interleukin-6.

Journal: Psychiatry research 20050430

Title: Effect of the activation of central 5-HT2C receptors by the 5-HT2C agonist mCPP on blood pressure and heart rate in rats.

Journal: Brain research 20050408

Title: Measurement and characterization of energy intake in the mouse.

Journal: Current protocols in pharmacology 20050401

Title: Agonist diversity in 5-HT(2C) receptor-mediated weight control in rats.

Journal: Psychopharmacology 20050301

Title: m-CPP, a 5-HT2C receptor agonist that modifies the perfusion pressure of the hindquarter vascular bed of anesthetized rat.

Journal: Pharmacology 20050201

Title: Serotonergic systems associated with arousal and vigilance behaviors following administration of anxiogenic drugs.

Journal: Neuroscience 20050101

Title: Anxiety-like state associates with taste to produce conditioned taste aversion.

Journal: Biological psychiatry 20041201

Title: Neuroimaging and 5-HT2C receptor polymorphism: a HMPAO-SPECT study in healthy male probands using mCPP-challenge of the 5-HT2C receptor.

Journal: Pharmacopsychiatry 20041101

Title: Reduced hypophagic effects of d-fenfluramine and the 5-HT2C receptor agonist mCPP in 5-HT1B receptor knockout mice.

Journal: Psychopharmacology 20041001

Title: Behavioural effects of rapid intravenous administration of meta-chlorophenylpiperazine in patients with panic disorder and controls.

Journal: European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20041001

Title: Increased repetitive behaviours and prolactin responsivity to oral m-chlorophenylpiperazine in adults with autism spectrum disorders.

Journal: The international journal of neuropsychopharmacology 20040901

Title: Differential effects of 5-HT1 and 5-HT2 receptor agonists on hindlimb movements in paraplegic mice.

Journal: Progress in neuro-psychopharmacology & biological psychiatry 20040901

Title: A 5-HT2C agonist elicits hyperactivity and oral dyskinesia with hypophagia in rabbits.

Journal: Physiology & behavior 20040801

Title: Chronic treatment with fluvoxamine desensitizes 5-HT2C receptor-mediated hypolocomotion in rats.

Journal: Pharmacology, biochemistry, and behavior 20040801

Title: Pharmacokinetics of m-chlorophenylpiperazine after intravenous and oral administration in healthy male volunteers: implication for the pharmacodynamic profile.

Journal: Pharmacopsychiatry 20040701

Title: Vasoconstrictor responses to 5-hydroxytryptamine in the autoperfused hindquarters of spontaneously hypertensive rats.

Journal: Pharmacology 20040601

Title: Serotonin function, personality-trait variations, and childhood abuse in women with bulimia-spectrum eating disorders.

Journal: The Journal of clinical psychiatry 20040601

Title: mCPP-induced hyperactivity in 5-HT2C receptor mutant mice is mediated by activation of multiple 5-HT receptor subtypes.

Journal: Neuropharmacology 20040401

Title: The application of the principles of clinical drug development to pharmacological challenge tests of the serotonergic system.

Journal: Journal of psychopharmacology (Oxford, England) 20040301

Title: m-Chlorophenylpiperazine (mCPP) modulates the discriminative stimulus effects of cocaine through actions at the 5-HT2C receptor.

Journal: Behavioral neuroscience 20040201

Title: Neurobiological correlates of diagnosis and underlying traits in patients with borderline personality disorder compared with normal controls.

Journal: Psychiatry research 20040101

Title: Modification of human 5-HT(2C) receptor function by Cys23Ser, an abundant, naturally occurring amino-acid substitution.

Journal: Molecular psychiatry 20040101

Title: Bulimia nervosa with co-morbid avoidant personality disorder: behavioural characteristics and serotonergic function.

Journal: Psychological medicine 20040101

Title: Serotonergic dissection of obsessive compulsive symptoms: a challenge study with m-chlorophenylpiperazine and sumatriptan.

Journal: Neuropsychobiology 20040101

Title: 5-HT2C receptors inhibit and 5-HT1A receptors activate the generation of spike-wave discharges in a genetic rat model of absence epilepsy.

Journal: Experimental neurology 20031201

Title: Implications of compulsive and impulsive traits for serotonin status in women with bulimia nervosa.

Journal: Psychiatry research 20031015

Title: A PET study after treatment with an anxiety-provoking agent, m-chlorophenyl-piperazine, in conscious rhesus monkeys.

Journal: Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20030901

Title: Central 5-HT2B/2C and 5-HT3 receptor stimulation decreases salt intake in sodium-depleted rats.

Journal: Brain research 20030815

Title: Discriminative stimulus effects of m-chlorophenylpiperazine as a model of the role of serotonin receptors in anxiety.

Journal: Life sciences 20030801

Title: Serotonin in the dorsal periaqueductal gray modulates inhibitory avoidance and one-way escape behaviors in the elevated T-maze.

Journal: European journal of pharmacology 20030725

Title: Neuroendocrine response to the serotonin agonist M-chlorophenylpiperazine in women with menstrual status migrainosus.

Journal: Neuroendocrinology 20030701

Title: m-CPP-induced self-grooming is mediated by 5-HT2C receptors.

Journal: Behavioural brain research 20030616

Title: Effects of single and repeated electroconvulsive shock on the social and agonistic behaviour of resident rats.

Journal: Neuropharmacology 20030601

Title: Oral administration of the 5-HT2Creceptor agonist, mCPP, reduces body weight gain in rats over 28 days as a result of maintained hypophagia.

Journal: Psychopharmacology 20030501

Title: Experimental anxiety and antiepileptics: the effects of valproate and vigabatrin in the mirrored chamber test.

Journal: Methods and findings in experimental and clinical pharmacology 20030501

Title: Effects of m-CPP in altering neuronal function: blocking depolarization in invertebrate motor and sensory neurons but exciting rat dorsal horn neurons.

Journal: Brain research 20030418

Title: Neurogenic dural protein extravasation induced by meta-chlorophenylpiperazine (mCPP) involves nitric oxide and 5-HT2B receptor activation.

Journal: Cephalalgia : an international journal of headache 20030301

Title: Reduced social interaction following 3,4-methylenedioxymethamphetamine is not associated with enhanced 5-HT 2C receptor responsivity.

Journal: Neuropharmacology 20030301

Title: Induction of c-Fos expression in specific areas of the fear circuitry in rat forebrain by anxiogenic drugs.

Journal: Biological psychiatry 20030215

Title: Effect of repeated administration of dexfenfluramine on feeding and brain Fos in mice.

Journal: Physiology & behavior 20030201

Title: Central serotonergic effects of m-chlorophenylpiperazine (mCPP) among normal control adolescents.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20030101

Title: 5-HT1B receptor knockout mice show a compensatory reduction in 5-HT2C receptor function.

Journal: The European journal of neuroscience 20030101

Title: Piperazine-derived designer drug 1-(3-chlorophenyl)piperazine (mCPP): GC-MS studies on its metabolism and its toxicological detection in rat urine including analytical differentiation from its precursor drugs trazodone and nefazodone.

Journal: Journal of analytical toxicology 20030101

Title: Anxiolytic-like profile of propofol, a general anesthetic, in the plus-maze test in mice.

Journal: Polish journal of pharmacology 20030101

Title: Neuroendocrine response to meta-chlorophenylpiperazine and ipsapirone in relation to anxiety and aggression.

Journal: Psychiatry research 20021215

Title: Sleep-wake effects of meta-chlorophenyl piperazine and mianserin in the behaviorally depressed rat.

Journal: European journal of pharmacology 20021122

Title: 2'-NH(2)-MPTP [1-methyl-4-(2'-aminophenyl)-1,2,3,6-tetrahydropyridine] depletes serotonin and norepinephrine in rats: a comparison with 2'-CH(3)-MPTP [1-methyl-4-(2'-methylphenyl)-1,2,3,6-tetrahydropyridine].

Journal: The Journal of pharmacology and experimental therapeutics 20021101

Title: 5-HT2C receptor mediation of unconditioned escape behaviour in the unstable elevated exposed plus maze.

Journal: Psychopharmacology 20021101

Title: The effects of gender and gonadal steroids on the neuroendocrine and temperature response to m-chlorophenylpiperazine in leuprolide-induced hypogonadism in women and men.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20021101

Title: Allelic variants of the serotonin(2C) receptor and neuroendocrinological responses to the serotonin(2C) receptor agonist m-chlorophenylpiperazine in healthy male volunteers.

Journal: Pharmacopsychiatry 20021101

Title: Effects of GABA(A) compounds on mCPP drug discrimination in rats.

Journal: Life sciences 20021018

Title: mCPP-induced hypophagia in rats is unaffected by the profile of dietary unsaturated fatty acids.

Journal: Pharmacology, biochemistry, and behavior 20021001

Title: p-Methylthioamphetamine and 1-(m-chlorophenyl)piperazine, two non-neurotoxic 5-HT releasers in vivo, differ from neurotoxic amphetamine derivatives in their mode of action at 5-HT nerve endings in vitro.

Journal: Journal of neurochemistry 20020901

Title: 5-HT(2C) receptor activation by m-chlorophenylpiperazine detected in humans with fMRI.

Journal: Neuroreport 20020827

Title: Relationship between plasma concentrations of trazodone and its active metabolite, m-chlorophenylpiperazine, and its clinical effect in depressed patients.

Journal: Therapeutic drug monitoring 20020801

Title: Metachlorophenylpiperazine (m-CPP) induced intracavernous pressure responses in anaesthetized rats.

Journal: International journal of impotence research 20020801

Title: The effects of serotonin agonists on the hypothalamic regulation of sexual receptivity in Syrian hamsters.

Journal: Hormones and behavior 20020801

Title: Central administration of mCPP, a serotonin 5-HT(2B/2C) agonist, decreases water intake in rats.

Journal: Pharmacology, biochemistry, and behavior 20020701

Title: Blunted prefrontal cortical 18fluorodeoxyglucose positron emission tomography response to meta-chlorophenylpiperazine in impulsive aggression.

Journal: Archives of general psychiatry 20020701

Title: Ritanserin antagonism of m-chlorophenylpiperazine effects in neuroleptic-free schizophrenics patients: support for serotonin-2 receptor modulation of schizophrenia symptoms.

Journal: Psychopharmacology 20020601

Title: Ethopharmacological analysis of the unstable elevated exposed plus maze, a novel model of extreme anxiety: predictive validity and sensitivity to anxiogenic agents.

Journal: Psychopharmacology 20020501

Title: Altered prolactin response to M-chlorophenylpiperazine in monkeys previously treated with 3,4-methylenedioxymethamphetamine (MDMA) or fenfluramine.

Journal: Synapse (New York, N.Y.) 20020401

Title: Serotonin 2C receptor agonists and the behavioural satiety sequence in mice.

Journal: Pharmacology, biochemistry, and behavior 20020401

Title: Alteration in 5-hydroxytryptamine agonist-induced behaviour following a corticosterone implant in adult rats.

Journal: Pharmacology, biochemistry, and behavior 20020401

Title: Role of 5-hT2C receptors in the hypophagic effect of m-CPP, ORG 37684 and CP-94,253 in the rat.

Journal: Progress in neuro-psychopharmacology & biological psychiatry 20020401

Title: Comparison of the potency of MDL 100,907 and SB 242084 in blocking the serotonin (5-HT)(2) receptor agonist-induced increases in rat serum corticosterone concentrations: evidence for 5-HT(2A) receptor mediation of the HPA axis.

Journal: Neuropharmacology 20020201

Title: Effects of fenfluramine, m-CPP and triazolam on repeated-acquisition in squirrel monkeys before and after neurotoxic MDMA administration.

Journal: Psychopharmacology 20020201

Title: Perturbations of plasma cortisol and DHEA-S following discontinuation of cocaine use in cocaine addicts.

Journal: Psychoneuroendocrinology 20020101

Title: The subjective effects of MDMA and mCPP in moderate MDMA users.

Journal: Drug and alcohol dependence 20011201

Title: The effect of olanzapine treatment on m-chlorophenylpiperazine-induced hormone release in schizophrenia.

Journal: Journal of clinical psychopharmacology 20011201

Title: The 5-HT2C/2B receptor agonist m-chlorophenylpiperazine (mCPP) inhibits 2-deoxy-D-glucose (2-DG)-induced hyperphagia in rats.

Journal: Biological & pharmaceutical bulletin 20011201

Title: Anxiety-like effects induced by acute fluoxetine, sertraline or m-CPP treatment are reversed by pretreatment with the 5-HT2C receptor antagonist SB-242084 but not the 5-HT1A receptor antagonist WAY-100635.

Journal: The international journal of neuropsychopharmacology 20011201

Title: m-CPP hypolocomotion is selectively antagonized by compounds with high affinity for 5-HT(2C) receptors but not 5-HT(2A) or 5-HT(2B) receptors.

Journal: Behavioural pharmacology 20011201

Title: Altered responsiveness to 5-HT at the crayfish neuromuscular junction due to chronic p-CPA and m-CPP treatment.

Journal: Brain research 20011019

Title: Association of serotonin and cortisol indices with childhood abuse in bulimia nervosa.

Journal: Archives of general psychiatry 20010901

Title: Mapping of brain activation in response to pharmacological agents using fMRI in the rat.

Journal: Magnetic resonance imaging 20010901

Title: Agonist-induced functional desensitization of recombinant human 5-HT2 receptors expressed in CHO-K1 cells.

Journal: Biochemical pharmacology 20010815

Title: Self-destructiveness and serotonin function in bulimia nervosa.

Journal: Psychiatry research 20010805

Title: Pedophilia is accompanied by increased plasma concentrations of catecholamines, in particular epinephrine.

Journal: Psychiatry research 20010805

Title: Tryptophan hydroxylase gene and major psychoses.

Journal: Psychiatry research 20010805

Title: Altered response to meta-chlorophenylpiperazine in anorexia nervosa: support for a persistent alteration of serotonin activity after short-term weight restoration.

Journal: The International journal of eating disorders 20010701

Title: Effect of a low tryptophan diet on the prolactin responses to the 5-HT2A agonist DOI in the rat.

Journal: Pharmacopsychiatry 20010701

Title: The serotonergic 5-HT(2C) agonist m-chlorophenylpiperazine increases weight-supported locomotion without development of tolerance in rats with spinal transections.

Journal: Experimental neurology 20010601

Title: A neurotoxic dose of 3,4-methylenedioxymethamphetamine (MDMA; ecstasy) to rats results in a long-term defect in thermoregulation.

Journal: Psychopharmacology 20010601

Title: 1-(m-chlorophenyl)piperazine (mCPP) dissociates in vivo serotonin release from long-term serotonin depletion in rat brain.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20010501

Title: Dissociation of systemic and hippocampal modulation of rat locomotor activity by 5-HT(2C) receptors.

Journal: Neuroscience research 20010501

Title: Decreased tryptophan availability but normal post-synaptic 5-HT2c receptor sensitivity in chronic fatigue syndrome.

Journal: Psychological medicine 20010501

Title: Effects of genetic polymorphism of CYP1A2 inducibility on the steady-state plasma concentrations of trazodone and its active metabolite m-chlorophenylpiperazine in depressed Japanese patients.

Journal: Pharmacology & toxicology 20010501

Title: Effect of aerobic exercise on behavioral and neuroendocrine responses to meta-chlorophenylpiperazine and to ipsapirone in untrained healthy subjects.

Journal: Psychopharmacology 20010501

Title: Neuroendocrine and behavioral responses to mCPP in Obsessive-Compulsive Disorder.

Journal: Psychoneuroendocrinology 20010201

Title: Increased m-CPP-induced oral dyskinesia after lesion of serotonergic neurons.

Journal: Pharmacology, biochemistry, and behavior 20010201

Title: Investigations into migraine pathogenesis: time course for effects of m-CPP, BW723C86 or glyceryl trinitrate on appearance of Fos-like immunoreactivity in rat trigeminal nucleus caudalis (TNC).

Journal: Cephalalgia : an international journal of headache 20010201

Title: Low versus standard dose mCPP challenge in obsessive-compulsive patients.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20010101

Title: Lower baseline plasma cortisol and prolactin together with increased body temperature and higher mCPP-induced cortisol responses in men with pedophilia.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20010101

Title: Implications of impulsive and affective symptoms for serotonin function in bulimia nervosa.

Journal: Psychological medicine 20010101

Title: Evidence that orexin-A-evoked grooming in the rat is mediated by orexin-1 (OX1) receptors, with downstream 5-HT2C receptor involvement.

Journal: Psychopharmacology 20010101

Title: m-Chlorophenylpiperazine excites non-dopaminergic neurons in the rat substantia nigra and ventral tegmental area by activating serotonin-2C receptors.

Journal: Neuroscience 20010101

Title: Cloning, expression, and characterization of ferret 5-HT(3) receptor subunit.

Journal: European journal of pharmacology 20000707

Title: Serotonin(2C) receptors appear to mediate genetic sensitivity to cocaine-induced convulsions.

Journal: Psychopharmacology 19991001

Title: Nefazodone, meta-chlorophenylpiperazine, and their metabolites in vitro: cytochromes mediating transformation, and P450-3A4 inhibitory actions.

Journal: Psychopharmacology 19990701

Title: Trazodone is metabolized to m-chlorophenylpiperazine by CYP3A4 from human sources.

Journal: Drug metabolism and disposition: the biological fate of chemicals 19980601

Title: Effect of fenfluramine challenge on cocaine craving in addicted male users.

Journal: The American journal on addictions 19980101

Title: The putative 5-HT1A receptor antagonist DU125530 blocks the discriminative stimulus of the 5-HT1A receptor agonist flesinoxan in pigeons.

Journal: European journal of pharmacology 19970501

Title: SB 242084, a selective and brain penetrant 5-HT2C receptor antagonist.

Journal: Neuropharmacology 19970101

Title: In vitro and in vivo profile of SB 206553, a potent 5-HT2C/5-HT2B receptor antagonist with anxiolytic-like properties.

Journal: British journal of pharmacology 19960201

Title: Post-synaptic 5-HT1A receptor involvement in yawning and penile erections induced by apomorphine, physostigmine and mCPP in rats.

Journal: Psychopharmacology 19950801

Title: Trazodone treatment increases plasma prolactin concentrations in depressed patients.

Journal: International clinical psychopharmacology 19950601

Title: Penile erection and yawning induced by 5-HT1C receptor agonists in male rats: relationship with dopaminergic and oxytocinergic transmission.

Journal: European journal of pharmacology 19940811

Title: Prolonged penile erections induced by hydroxyzine: possible mechanism of action.

Journal: Neuropsychobiology 19940101

Title: d-Fenfluramine- and d-norfenfluramine-induced hypophagia: differential mechanisms and involvement of postsynaptic 5-HT receptors.

Journal: European journal of pharmacology 19930921

Title: Trazodone induction of migraine headache through mCPP.

Journal: The American journal of psychiatry 19920501

Title: A pilot placebo-controlled study of chronic m-CPP administration in Alzheimer's disease.

Journal: Biological psychiatry 19910715

Title: Serotonergic responsivity in obsessive-compulsive disorder. Effects of chronic clomipramine treatment.

Journal: Archives of general psychiatry 19880201

Title: 1-m-Chlorophenylpiperazine is an active metabolite common to the psychotropic drugs trazodone, etoperidone and mepiprazole.

Journal: The Journal of pharmacy and pharmacology 19821001

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Tags:65369-76-8 Molecular Formula|65369-76-8 MDL|65369-76-8 SMILES|65369-76-8 1-(3-CHLOROPHENYL)PIPERAZINE MONOHYDROCHLORIDE