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65646-68-6,MFCD00792674
Catalog No.:AA003QIA

65646-68-6 | Fenretinide

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1mg
98%
in stock  
$15.00   $11.00
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10mg
95%
in stock  
$29.00   $20.00
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50mg
98%
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$95.00   $67.00
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100mg
95%
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA003QIA
Chemical Name:
Fenretinide
CAS Number:
65646-68-6
Molecular Formula:
C26H33NO2
Molecular Weight:
391.5457
MDL Number:
MFCD00792674
SMILES:
O=C(Nc1ccc(cc1)O)/C=C(/C=C/C=C(/C=C/C1=C(C)CCCC1(C)C)\C)\C
Properties
Properties
 
BP:
597.6±42.0°C at 760 mmHg  
Form:
Solid  
MP:
162-163°C  
Storage:
Inert atmosphere;-20 ℃;  

Computed Properties
 
Complexity:
726  
Covalently-Bonded Unit Count:
1  
Defined Bond Stereocenter Count:
4  
Heavy Atom Count:
29  
Hydrogen Bond Acceptor Count:
2  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
6  
XLogP3:
7.3  

Literature

Title: From the Cover: Fenretinide, Troglitazone, and Elmiron Add to Weight of Evidence Support for Hemangiosarcoma Mode-of-Action From Studies in Mice.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20180101

Title: Glycogen synthase kinase 3 regulates cell death and survival signaling in tumor cells under redox stress.

Journal: Neoplasia (New York, N.Y.) 20140901

Title: Structure-assisted discovery of the first non-retinoid ligands for Retinol-Binding Protein 4.

Journal: Bioorganic & medicinal chemistry letters 20140701

Title: Identification of potent Yes1 kinase inhibitors using a library screening approach.

Journal: Bioorganic & medicinal chemistry letters 20130801

Title: N-(4-hydroxyphenyl)retinamide promotes apoptosis of resting and proliferating B-cell chronic lymphocytic leukemia cells and potentiates fludarabine and ABT-737 cytotoxicity.

Journal: Leukemia 20121001

Title: N-(4-hydroxyphenyl)retinamide inhibits breast cancer cell invasion through suppressing NF-KB activation and inhibiting matrix metalloproteinase-9 expression.

Journal: Journal of cellular biochemistry 20120901

Title: Identification of mammalian target of rapamycin as a direct target of fenretinide both in vitro and in vivo.

Journal: Carcinogenesis 20120901

Title: BCDO2 acts as a carotenoid scavenger and gatekeeper for the mitochondrial apoptotic pathway.

Journal: Development (Cambridge, England) 20120815

Title: Novel micelles based on amphiphilic branched PEG as carriers for fenretinide.

Journal: Nanomedicine : nanotechnology, biology, and medicine 20120801

Title: Two protein kinase C isoforms, δ and ε, regulate energy homeostasis in mitochondria by transmitting opposing signals to the pyruvate dehydrogenase complex.

Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20120801

Title: Identification of drug modulators targeting gene-dosage disease CMT1A.

Journal: ACS chemical biology 20120720

Title: Fenretinide cytotoxicity is independent of both constitutive and pharmacologically modulated glutathione levels in pediatric acute lymphoblastic leukemia cells cultured at hypoxia.

Journal: Pediatric blood & cancer 20120601

Title: Fenretinide prevents lipid-induced insulin resistance by blocking ceramide biosynthesis.

Journal: The Journal of biological chemistry 20120518

Title: Alterations in expression of specific microRNAs by combination of 4-HPR and EGCG inhibited growth of human malignant neuroblastoma cells.

Journal: Brain research 20120515

Title: Evaluation of a mucoadhesive fenretinide patch for local intraoral delivery: a strategy to reintroduce fenretinide for oral cancer chemoprevention.

Journal: Carcinogenesis 20120501

Title: Growth inhibition and mechanism of action of p-dodecylaminophenol against refractory human pancreatic cancer and cholangiocarcinoma.

Journal: Bioorganic & medicinal chemistry 20120415

Title: Mucoadhesive fenretinide patches for site-specific chemoprevention of oral cancer: enhancement of oral mucosal permeation of fenretinide by coincorporation of propylene glycol and menthol.

Journal: Molecular pharmaceutics 20120402

Title: Combinatorial chemotherapeutic efficacy in non-Hodgkin lymphoma can be predicted by a signaling model of CD20 pharmacodynamics.

Journal: Cancer research 20120401

Title: Dihydroceramide accumulation and reactive oxygen species are distinct and nonessential events in 4-HPR-mediated leukemia cell death.

Journal: Biochemistry and cell biology = Biochimie et biologie cellulaire 20120401

Title: Combined treatment with fenretinide and indomethacin induces AIF-mediated, non-classical cell death in human acute T-cell leukemia Jurkat cells.

Journal: Biochemical and biophysical research communications 20120316

Title: Detection and characterisation of multi-drug resistance protein 1 (MRP-1) in human mitochondria.

Journal: British journal of cancer 20120313

Title: Enhanced anti-neuroblastoma activity of a fenretinide complexed form after intravenous administration.

Journal: The Journal of pharmacy and pharmacology 20120201

Title: [Chemoprevention of oral cancer--clinical and experimental studies].

Journal: Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego 20120201

Title: Adiponectin: a risk biomarker and attractive target for chemoprevention.

Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20120110

Title: Prognostic effect of circulating adiponectin in a randomized 2 x 2 trial of low-dose tamoxifen and fenretinide in premenopausal women at risk for breast cancer.

Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20120110

Title: The impact of retinoic acid treatment on the sensitivity of neuroblastoma cells to fenretinide.

Journal: Oncology reports 20120101

Title: The mechanism of fenretinide (4-HPR) inhibition of β-carotene monooxygenase 1. New suspect for the visual side effects of fenretinide.

Journal: Advances in experimental medicine and biology 20120101

Title: Fenretinide ameliorates insulin resistance and fatty liver in obese mice.

Journal: Biological & pharmaceutical bulletin 20120101

Title: Fenretinide (4-HPR): a preventive chance for women at genetic and familial risk?

Journal: Journal of biomedicine & biotechnology 20120101

Title: Tetrathiomolybdate sensitizes ovarian cancer cells to anticancer drugs doxorubicin, fenretinide, 5-fluorouracil and mitomycin C.

Journal: BMC cancer 20120101

Title: AF1q: a novel mediator of basal and 4-HPR-induced apoptosis in ovarian cancer cells.

Journal: PloS one 20120101

Title: Phase III double-blind, placebo-controlled, prospective randomized trial of adjuvant tamoxifen vs. tamoxifen and fenretinide in postmenopausal women with positive receptors (EB193): an intergroup trial coordinated by the Eastern Cooperative Oncology Group.

Journal: Medical oncology (Northwood, London, England) 20111201

Title: Preclinical evaluation of lestaurtinib (CEP-701) in combination with retinoids for neuroblastoma.

Journal: Cancer chemotherapy and pharmacology 20111201

Title: 4-Hydroxybenzyl modification of the highly teratogenic retinoid, 4-[(1E)-2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-2-naphthalenyl)-1-propen-1-yl]benzoic acid (TTNPB), yields a compound that induces apoptosis in breast cancer cells and shows reduced teratogenicity.

Journal: Chemical research in toxicology 20111121

Title: Receptor tyrosine kinase inhibitors and cytotoxic drugs affect pleural mesothelioma cell proliferation: insight into EGFR and ERK1/2 as antitumor targets.

Journal: Biochemical pharmacology 20111115

Title: Synergistic activity of fenretinide and the Bcl-2 family protein inhibitor ABT-737 against human neuroblastoma.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20111115

Title: Synergistic efficacy of a novel combination therapy controls growth of Bcl-x(L) bountiful neuroblastoma cells by increasing differentiation and apoptosis.

Journal: Cancer biology & therapy 20111101

Title: Phase II study of oral capsular 4-hydroxyphenylretinamide (4-HPR/fenretinide) in pediatric patients with refractory or recurrent neuroblastoma: a report from the Children's Oncology Group.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20111101

Title: TMEM14A inhibits N-(4-hydroxyphenyl)retinamide-induced apoptosis through the stabilization of mitochondrial membrane potential.

Journal: Cancer letters 20111028

Title: Development and in vitro-in vivo evaluation of fenretinide-loaded oral mucoadhesive patches for site-specific chemoprevention of oral cancer.

Journal: Pharmaceutical research 20111001

Title: Promising effects of the 4HPR-BSO combination in neuroblastoma monolayers and spheroids.

Journal: Free radical biology & medicine 20110915

Title: Combination of N-(4-hydroxyphenyl) retinamide and apigenin suppressed starvation-induced autophagy and promoted apoptosis in malignant neuroblastoma cells.

Journal: Neuroscience letters 20110908

Title: Cytotoxic responses to N-(4-hydroxyphenyl)retinamide in human pancreatic cancer cells.

Journal: Cancer chemotherapy and pharmacology 20110801

Title: Identification of dihydroceramide desaturase as a direct in vitro target for fenretinide.

Journal: The Journal of biological chemistry 20110715

Title: Fenretinide derivatives act as disrupters of interactions of serum retinol binding protein (sRBP) with transthyretin and the sRBP receptor.

Journal: Journal of medicinal chemistry 20110714

Title: Fenretinide metabolism in humans and mice: utilizing pharmacological modulation of its metabolic pathway to increase systemic exposure.

Journal: British journal of pharmacology 20110701

Title: Inhibition of acid ceramidase by a 2-substituted aminoethanol amide synergistically sensitizes prostate cancer cells to N-(4-hydroxyphenyl) retinamide.

Journal: The Prostate 20110701

Title: Preventive therapy for breast cancer: a consensus statement.

Journal: The Lancet. Oncology 20110501

Title: Oncogenic B-RAF signaling in melanoma impairs the therapeutic advantage of autophagy inhibition.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20110415

Title: ERK1/2 deactivation enhances cytoplasmic Nur77 expression level and improves the apoptotic effect of fenretinide in human liver cancer cells.

Journal: Biochemical pharmacology 20110401

Title: Enrichment of Nur77 mediated by retinoic acid receptor β leads to apoptosis of human hepatocellular carcinoma cells induced by fenretinide and histone deacetylase inhibitors.

Journal: Hepatology (Baltimore, Md.) 20110301

Title: Phase I trial of fenretinide lym-x-sorb oral powder in adults with solid tumors and lymphomas.

Journal: Anticancer research 20110301

Title: Preferential involvement of both ROS and ceramide in fenretinide-induced apoptosis of HL60 rather than NB4 and U937 cells.

Journal: Biochemical and biophysical research communications 20110211

Title: Characterization of the metabolism of fenretinide by human liver microsomes, cytochrome P450 enzymes and UDP-glucuronosyltransferases.

Journal: British journal of pharmacology 20110201

Title: The expression of retinal cell markers in human retinal pigment epithelial cells and their augmentation by the synthetic retinoid fenretinide.

Journal: Molecular vision 20110101

Title: Evaluation of bioactive sphingolipids in 4-HPR-resistant leukemia cells.

Journal: BMC cancer 20110101

Title: Heterogeneous role of the glutathione antioxidant system in modulating the response of ESFT to fenretinide in normoxia and hypoxia.

Journal: PloS one 20110101

Title: The hydroxyl functional group of N-(4-hydroxyphenyl)retinamide mediates cellular uptake and cytotoxicity in premalignant and malignant human epithelial cells.

Journal: Free radical biology & medicine 20101215

Title: HIF-1α-dependent autophagy protects HeLa cells from fenretinide (4-HPR)-induced apoptosis in hypoxia.

Journal: Pharmacological research 20101101

Title: Survivin knockdown and concurrent 4-HPR treatment controlled human glioblastoma in vitro and in vivo.

Journal: Neuro-oncology 20101101

Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Journal: Bioorganic & medicinal chemistry letters 20101101

Title: [Therapy approaches for geographic atrophy].

Journal: Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft 20101101

Title: Fenretinide-dependent upregulation of death receptors through ASK1 and p38α enhances death receptor ligand-induced cell death in Ewing's sarcoma family of tumours.

Journal: British journal of cancer 20101026

Title: A phase II study of fenretinide in patients with hormone refractory prostate cancer: a trial of the Cancer Therapeutics Research Group.

Journal: Cancer chemotherapy and pharmacology 20101001

Title: Relationship among pharmacokinetics and pharmacodynamics of fenretinide and plasma retinol reduction in neuroblastoma patients.

Journal: Cancer chemotherapy and pharmacology 20101001

Title: Targeting GRP78 to enhance melanoma cell death.

Journal: Pigment cell & melanoma research 20101001

Title: Development of PLGA-based injectable delivery systems for hydrophobic fenretinide.

Journal: Pharmaceutical research 20101001

Title: Alkaline ceramidase 2 (ACER2) and its product dihydrosphingosine mediate the cytotoxicity of N-(4-hydroxyphenyl)retinamide in tumor cells.

Journal: The Journal of biological chemistry 20100917

Title: Targeting X-linked inhibitor of apoptosis protein to increase the efficacy of endoplasmic reticulum stress-induced apoptosis for melanoma therapy.

Journal: The Journal of investigative dermatology 20100901

Title: Decreased expression of insulin-like growth factor binding protein-5 during N-(4-hydroxyphenyl)retinamide-induced neuronal differentiation of ARPE-19 human retinal pigment epithelial cells: regulation by CCAAT/enhancer-binding protein.

Journal: Journal of cellular physiology 20100901

Title: Angioprevention with fenretinide: targeting angiogenesis in prevention and therapeutic strategies.

Journal: Critical reviews in oncology/hematology 20100701

Title: Sphingolipidomics of A2780 human ovarian carcinoma cells treated with synthetic retinoids.

Journal: Journal of lipid research 20100701

Title: Dihydroorotate dehydrogenase is required for N-(4-hydroxyphenyl)retinamide-induced reactive oxygen species production and apoptosis.

Journal: Free radical biology & medicine 20100701

Title: Sphingosine kinase mediates resistance to the synthetic retinoid N-(4-hydroxyphenyl)retinamide in human ovarian cancer cells.

Journal: The Journal of biological chemistry 20100611

Title: The peptidomimetic, 1-adamantyl-substituted, and flex-het classes of retinoid-derived molecules: structure-activity relationships and retinoid receptor-independent anticancer activities.

Journal: Mini reviews in medicinal chemistry 20100601

Title: Induction and intracellular localization of Nur77 dictate fenretinide-induced apoptosis of human liver cancer cells.

Journal: Biochemical pharmacology 20100401

Title: Fenretinide promotes functional recovery and tissue protection after spinal cord contusion injury in mice.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20100303

Title: Fenretinide induces mitochondrial ROS and inhibits the mitochondrial respiratory chain in neuroblastoma.

Journal: Cellular and molecular life sciences : CMLS 20100301

Title: Regulation of endoplasmic reticulum stress-induced cell death by ATF4 in neuroectodermal tumor cells.

Journal: The Journal of biological chemistry 20100226

Title: Expression of neural stem cell markers in malignant rhabdoid tumor cell lines.

Journal: Oncology reports 20100201

Title: [Transcription factor Forkhead-box A1 and breast cancer].

Journal: Zhonghua bing li xue za zhi = Chinese journal of pathology 20100201

Title: The binding of synthetic retinoids to lipocalin beta-lactoglobulins.

Journal: Journal of medicinal chemistry 20100114

Title: The chemopreventive retinoid 4HPR impairs prostate cancer cell migration and invasion by interfering with FAK/AKT/GSK3beta pathway and beta-catenin stability.

Journal: Molecular cancer 20100101

Title: Brg-1 mediates the constitutive and fenretinide-induced expression of SPARC in mammary carcinoma cells via its interaction with transcription factor Sp1.

Journal: Molecular cancer 20100101

Title: MicroRNA expression in human retinal pigment epithelial (ARPE-19) cells: increased expression of microRNA-9 by N-(4-hydroxyphenyl)retinamide.

Journal: Molecular vision 20100101

Title: 4-oxo-N-(4-hydroxyphenyl)retinamide: two independent ways to kill cancer cells.

Journal: PloS one 20100101

Title: Fenretinide-associated multilayered retinal hemorrhage in a patient with hairy cell leukemia.

Journal: Ophthalmic surgery, lasers & imaging : the official journal of the International Society for Imaging in the Eye 20100101

Title: Phase II trial of fenretinide (NSC 374551) in patients with recurrent small cell lung cancer.

Journal: Investigational new drugs 20091201

Title: Langerhans cell histiocytosis in a patient with stage 4 neuroblastoma receiving oral fenretinide.

Journal: Pediatric blood & cancer 20091201

Title: Long-term Fenretinide treatment prevents high-fat diet-induced obesity, insulin resistance, and hepatic steatosis.

Journal: American journal of physiology. Endocrinology and metabolism 20091201

Title: Antimitotic effect of the retinoid 4-oxo-fenretinide through inhibition of tubulin polymerization: a novel mechanism of retinoid growth-inhibitory activity.

Journal: Molecular cancer therapeutics 20091201

Title: Fenretinide inhibits myeloma cell growth, osteoclastogenesis and osteoclast viability.

Journal: Cancer letters 20091101

Title: N-Myc down regulation induced differentiation, early cell cycle exit, and apoptosis in human malignant neuroblastoma cells having wild type or mutant p53.

Journal: Biochemical pharmacology 20091101

Title: Improvement of aqueous solubility of fenretinide and other hydrophobic anti-tumor drugs by complexation with amphiphilic dextrins.

Journal: Drug delivery 20091001

Title: American Society of Clinical Oncology clinical practice guideline update on the use of pharmacologic interventions including tamoxifen, raloxifene, and aromatase inhibition for breast cancer risk reduction.

Journal: Gynecologic oncology 20091001

Title: Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.

Journal: Nature chemical biology 20091001

Title: ROS-driven Akt dephosphorylation at Ser-473 is involved in 4-HPR-mediated apoptosis in NB4 cells.

Journal: Free radical biology & medicine 20090901

Title: Surrogate response biomarkers in prevention research: do they point the way or lead us astray?

Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20090810

Title: Randomized double-blind 2 x 2 trial of low-dose tamoxifen and fenretinide for breast cancer prevention in high-risk premenopausal women.

Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20090810

Title: Cystic fibrosis fatty acid imbalance is linked to ceramide deficiency and corrected by fenretinide.

Journal: American journal of respiratory cell and molecular biology 20090701

Title: Selective apoptosis induction by the cancer chemopreventive agent N-(4-hydroxyphenyl)retinamide is achieved by modulating mitochondrial bioenergetics in premalignant and malignant human prostate epithelial cells.

Journal: Apoptosis : an international journal on programmed cell death 20090701

Title: Enhanced in vivo antitumor efficacy of fenretinide encapsulated in polymeric micelles.

Journal: International journal of pharmaceutics 20090521

Title: N-(4-Hydroxyphenyl) retinamide potentiated paclitaxel for cell cycle arrest and apoptosis in glioblastoma C6 and RG2 cells.

Journal: Brain research 20090501

Title: PLAB induction in fenretinide-induced apoptosis of ovarian cancer cells occurs via a ROS-dependent mechanism involving ER stress and JNK activation.

Journal: Carcinogenesis 20090501

Title: Identification of ADP-ribosylation factor 4 as a suppressor of N-(4-hydroxyphenyl)retinamide-induced cell death.

Journal: Cancer letters 20090408

Title: Chemopreventive efficacies of rosiglitazone, fenretinide and their combination against rat mammary carcinogenesis.

Journal: Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico 20090401

Title: Comment re: continuous rather than intermittent administration of fenretinide in leukoplakia.

Journal: Cancer prevention research (Philadelphia, Pa.) 20090301

Title: Combining the endoplasmic reticulum stress-inducing agents bortezomib and fenretinide as a novel therapeutic strategy for metastatic melanoma.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20090215

Title: The combined therapeutic effects of bortezomib and fenretinide on neuroblastoma cells involve endoplasmic reticulum stress response.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20090215

Title: Application of an allosteric model to describe the interactions among retinol binding protein 4, transthyretin, and small molecule retinol binding protein 4 ligands.

Journal: Analytical biochemistry 20090115

Title: Plasma retinol and prognosis of postmenopausal breast cancer patients.

Journal: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20090101

Title: Cyclin D1 and cancer development in laryngeal premalignancy patients.

Journal: Cancer prevention research (Philadelphia, Pa.) 20090101

Title: High-dose fenretinide in oral leukoplakia.

Journal: Cancer prevention research (Philadelphia, Pa.) 20090101

Title: Anti-angiogenic properties of chemopreventive drugs: fenretinide as a prototype.

Journal: Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer 20090101

Title: Oral fenretinide in biochemically recurrent prostate cancer: a California cancer consortium phase II trial.

Journal: Clinical genitourinary cancer 20090101

Title: Fenretinide-induced caspase-8 activation and apoptosis in an established model of metastatic neuroblastoma.

Journal: BMC cancer 20090101

Title: Converting redox signaling to apoptotic activities by stress-responsive regulators HSF1 and NRF2 in fenretinide treated cancer cells.

Journal: PloS one 20090101

Title: Liposome-mediated therapy of neuroblastoma.

Journal: Methods in enzymology 20090101

Title: N-(4-hydroxyphenyl)all-trans-retinamide (4-HPR) high dose effect on DMBA-induced hamster oral cancer: a histomorphometric evaluation.

Journal: International journal of oral and maxillofacial surgery 20081201

Title: Substituted hippurates and hippurate analogs as substrates and inhibitors of peptidylglycine alpha-hydroxylating monooxygenase (PHM).

Journal: Bioorganic & medicinal chemistry 20081201

Title: Effect of fenretinide and low-dose tamoxifen on insulin sensitivity in premenopausal women at high risk for breast cancer.

Journal: Cancer research 20081115

Title: Total rod ERG suppression with high dose compassionate Fenretinide usage.

Journal: Documenta ophthalmologica. Advances in ophthalmology 20081101

Title: Manipulation of oxidative stress to induce cell death in Ewing's sarcoma family of tumours.

Journal: European journal of cancer (Oxford, England : 1990) 20081001

Title: BAY 11-7082 induces cell death through NF-kappaB-independent mechanisms in the Ewing's sarcoma family of tumours.

Journal: Cancer letters 20080918

Title: Pharmacokinetics of oral fenretinide in neuroblastoma patients: indications for optimal dose and dosing schedule also with respect to the active metabolite 4-oxo-fenretinide.

Journal: Cancer chemotherapy and pharmacology 20080901

Title: Selected natural and synthetic retinoids impair CCR7- and CXCR4-dependent cell migration in vitro and in vivo.

Journal: Journal of leukocyte biology 20080901

Title: N-(4-Hydroxyphenyl)retinamide increases dihydroceramide and synergizes with dimethylsphingosine to enhance cancer cell killing.

Journal: Molecular cancer therapeutics 20080901

Title: N-(4-Hydroxyphenyl) retinamide induced both differentiation and apoptosis in human glioblastoma T98G and U87MG cells.

Journal: Brain research 20080828

Title: Identification of cytochrome c oxidase subunit 6A1 as a suppressor of Bax-induced cell death by yeast-based functional screening.

Journal: Biochemical and biophysical research communications 20080815

Title: Design, synthesis of novel peptidomimetic derivatives of 4-HPR for rhabdoid tumors.

Journal: Bioorganic & medicinal chemistry letters 20080715

Title: Mitogen-activated protein kinase pathway mediates N-(4-hydroxyphenyl)retinamide-induced neuronal differentiation in the ARPE-19 human retinal pigment epithelial cell line.

Journal: Journal of neurochemistry 20080701

Title: Design and synthesis of 4-HPR derivatives for rhabdoid tumors.

Journal: Bioorganic & medicinal chemistry letters 20080701

Title: Increasing melanoma cell death using inhibitors of protein disulfide isomerases to abrogate survival responses to endoplasmic reticulum stress.

Journal: Cancer research 20080701

Title: Block copolymer design for stable encapsulation of N-(4-hydroxyphenyl)retinamide into polymeric micelles in mice.

Journal: International journal of pharmaceutics 20080605

Title: Synthetic triterpenoids have cytotoxicity in pediatric acute lymphoblastic leukemia cell lines but cytotoxicity is independent of induced ceramide increase in MOLT-4 cells.

Journal: Leukemia 20080601

Title: Involvement of Rac in fenretinide-induced apoptosis.

Journal: Cancer research 20080601

Title: Fenretinide prevents the development of osteoporosis in Cftr-KO mice.

Journal: Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society 20080501

Title: Fenretinide induces autophagic cell death in caspase-defective breast cancer cells.

Journal: Autophagy 20080501

Title: The PERK/eIF2 alpha signaling pathway of Unfolded Protein Response is essential for N-(4-hydroxyphenyl)retinamide (4HPR)-induced cytotoxicity in cancer cells.

Journal: Experimental cell research 20080501

Title: Pleiotropic effects of fenretinide in neuroblastoma cell lines and multicellular tumor spheroids.

Journal: International journal of oncology 20080501

Title: Mechanism of synergy of N-(4-hydroxyphenyl)retinamide and ABT-737 in acute lymphoblastic leukemia cell lines: Mcl-1 inactivation.

Journal: Journal of the National Cancer Institute 20080416

Title: N-(4-Hydroxyphenyl)retinamide induced differentiation with repression of telomerase and cell cycle to increase interferon-gamma sensitivity for apoptosis in human glioblastoma cells.

Journal: Cancer letters 20080308

Title: Inhibition of N-(4-hydroxyphenyl)retinamide-induced autophagy at a lower dose enhances cell death in malignant glioma cells.

Journal: Carcinogenesis 20080301

Title: 4-Hydroxyphenylretinamide (4HPR) derivatives regulate aromatase activity and expression in breast cancer cells.

Journal: The Journal of steroid biochemistry and molecular biology 20080301

Title: N-(4-hydroxyphenyl) retinamide augments laser-induced choroidal neovascularization in mice.

Journal: Investigative ophthalmology & visual science 20080301

Title: The sensitivity of the Ewing's sarcoma family of tumours to fenretinide-induced cell death is increased by EWS-Fli1-dependent modulation of p38(MAPK) activity.

Journal: Oncogene 20080207

Title: Computer-assisted image analysis of breast fine needle aspiration in a randomized chemoprevention trial of fenretinide vs. placebo in HRT users.

Journal: Breast (Edinburgh, Scotland) 20080201

Title: p-Dodecylaminophenol derived from the synthetic retinoid, fenretinide: antitumor efficacy in vitro and in vivo against human prostate cancer and mechanism of action.

Journal: International journal of cancer 20080201

Title: A rapid, sensitive and selective liquid chromatography/atmospheric pressure chemical ionization tandem mass spectrometry method for determination of fenretinide (4-HPR) in plasma.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20080201

Title: Inhibitors of EGFR signaling retard cytotoxicity of fenretinide in rat gliosarcoma cells.

Journal: Neurochemical research 20080101

Title: Fenretinide corrects newly found ceramide deficiency in cystic fibrosis.

Journal: American journal of respiratory cell and molecular biology 20080101

Title: Another negative chemoprevention trial: what can we learn?

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20080101

Title: Phase III prevention trial of fenretinide in patients with resected non-muscle-invasive bladder cancer.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20080101

Title: The Retinoic Acid Receptor-alpha mediates human T-cell activation and Th2 cytokine and chemokine production.

Journal: BMC immunology 20080101

Title: Antitumor activity of 4-(N-hydroxyphenyl)retinamide conjugated with poly(L-glutamic acid) against ovarian cancer xenografts.

Journal: Gynecologic oncology 20071201

Title: Flow cytometry analysis of single-strand DNA damage in neuroblastoma cell lines using the F7-26 monoclonal antibody.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20071101

Title: PAC1 is a direct transcription target of E2F-1 in apoptotic signaling.

Journal: Oncogene 20071004

Title: Fenretinide-polyvinylalcohol conjugates: new systems allowing fenretinide intravenous administration.

Journal: Biomacromolecules 20071001

Title: Polymeric retinoid prodrug PG-4HPR enhances the radiation response of lung cancer.

Journal: Oncology reports 20070901

Title: Combinational treatment with retinoic acid derivatives in non-small cell lung carcinoma in vitro.

Journal: Journal of Korean medical science 20070901

Title: The unhydrolyzable fenretinide analogue 4-hydroxybenzylretinone induces the proapoptotic genes GADD153 (CHOP) and Bcl-2-binding component 3 (PUMA) and apoptosis that is caspase- dependent and independent of the retinoic acid receptor.

Journal: Cancer research 20070701

Title: Involvement of dihydroceramide desaturase in cell cycle progression in human neuroblastoma cells.

Journal: The Journal of biological chemistry 20070608

Title: Analysis of gene expression identifies PLAB as a mediator of the apoptotic activity of fenretinide in human ovarian cancer cells.

Journal: Oncogene 20070607

Title: Transport of a novel anti-cancer agent, fenretinide across Caco-2 monolayers.

Journal: Investigational new drugs 20070601

Title: Improved oral delivery of N-(4-hydroxyphenyl)retinamide with a novel LYM-X-SORB organized lipid complex.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20070515

Title: Induction of endoplasmic reticulum stress by the pro-apoptotic retinoid N-(4-hydroxyphenyl)retinamide via a reactive oxygen species-dependent mechanism in human head and neck cancer cells.

Journal: Cancer biology & therapy 20070501

Title: 4-HPR-mediated leukemia cell cytotoxicity is triggered by ceramide-induced mitochondrial oxidative stress and is regulated downstream by Bcl-2.

Journal: Free radical research 20070501

Title: Prognostic effect of DNA aneuploidy from bladder washings in superficial bladder cancer.

Journal: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20070501

Title: Novel retinoic acid metabolism blocking agents have potent inhibitory activities on human breast cancer cells and tumour growth.

Journal: British journal of cancer 20070423

Title: Targeting homeostatic mechanisms of endoplasmic reticulum stress to increase susceptibility of cancer cells to fenretinide-induced apoptosis: the role of stress proteins ERdj5 and ERp57.

Journal: British journal of cancer 20070410

Title: Synthetic retinoid fenretinide in breast cancer chemoprevention.

Journal: Expert review of anticancer therapy 20070401

Title: Role of Noxa in p53-independent fenretinide-induced apoptosis of neuroectodermal tumours.

Journal: Apoptosis : an international journal on programmed cell death 20070301

Title: Fenretinide up-regulates DR5/TRAIL-R2 expression via the induction of the transcription factor CHOP and combined treatment with fenretinide and TRAIL induces synergistic apoptosis in colon cancer cell lines.

Journal: International journal of oncology 20070301

Title: A fluorescence microplate cytotoxicity assay with a 4-log dynamic range that identifies synergistic drug combinations.

Journal: Molecular cancer therapeutics 20070301

Title: Antagonistic effects of sodium butyrate and N-(4-hydroxyphenyl)-retinamide on prostate cancer.

Journal: Neoplasia (New York, N.Y.) 20070301

Title: Role of retinoids and their cognate nuclear receptors in breast cancer chemoprevention.

Journal: Central European journal of public health 20070301

Title: Increased expression of the MGMT repair protein mediated by cysteine prodrugs and chemopreventative natural products in human lymphocytes and tumor cell lines.

Journal: Carcinogenesis 20070201

Title: Solid phase-assisted synthesis and screening of a small library of N-(4-hydroxyphenyl)retinamide (4-HPR) analogs.

Journal: Bioorganic & medicinal chemistry letters 20070201

Title: Reactive oxygen species mediate N-(4-hydroxyphenyl)retinamide-induced cell death in malignant T cells and are inhibited by the HTLV-I oncoprotein Tax.

Journal: Leukemia 20070201

Title: Fenretinide and risk reduction of second breast cancer.

Journal: Nature clinical practice. Oncology 20070201

Title: Potent anticancer activities of novel aminophenol analogues against various cancer cell lines.

Journal: Bioorganic & medicinal chemistry 20070115

Title: Combination of 4-HPR and oral contraceptive in monkey model of chemoprevention of ovarian cancer.

Journal: Frontiers in bioscience : a journal and virtual library 20070101

Title: Anti-proliferative activity of fenretinide in human hepatoma cells in vitro and in vivo.

Journal: Anti-cancer drugs 20070101

Title: Understanding interactions between and among apoptosis inducing pathways in tumor cells.

Journal: In vivo (Athens, Greece) 20070101

Title: Fenretinide-induced apoptosis of Huh-7 hepatocellular carcinoma is retinoic acid receptor beta dependent.

Journal: BMC cancer 20070101

Title: Cell death induced by N-(4-hydroxyphenyl)retinamide in human epidermal keratinocytes is modulated by TGF-beta and diminishes during the progression of squamous cell carcinoma.

Journal: International journal of cancer 20061215

Title: N-(4-hydroxyphenyl)retinamide induces apoptosis in human retinal pigment epithelial cells: retinoic acid receptors regulate apoptosis, reactive oxygen species generation, and the expression of heme oxygenase-1 and Gadd153.

Journal: Journal of cellular physiology 20061201

Title: A generalized response surface model with varying relative potency for assessing drug interaction.

Journal: Biometrics 20061201

Title: Inhibition of IL-8 release from CFTR-deficient lung epithelial cells following pre-treatment with fenretinide.

Journal: International immunopharmacology 20061101

Title: Amphiphilic poly(vinyl alcohol) derivatives as complexing agents for fenretinide.

Journal: Biomacromolecules 20061101

Title: Fenretinide-induced neuronal differentiation of ARPE-19 human retinal pigment epithelial cells is associated with the differential expression of Hsp70, 14-3-3, pax-6, tubulin beta-III, NSE, and bag-1 proteins.

Journal: Molecular vision 20061101

Title: Structural relaxation made simple.

Journal: Physical review letters 20061027

Title: Hypoxia-mediated fenretinide (4-HPR) resistance in childhood acute lymphoblastic leukemia cells.

Journal: Cancer chemotherapy and pharmacology 20061001

Title: Regulation of lipocalin-2 gene by the cancer chemopreventive retinoid 4-HPR.

Journal: International journal of cancer 20061001

Title: Mechanism of 4-HPR-induced apoptosis in glioma cells: evidences suggesting role of mitochondrial-mediated pathway and endoplasmic reticulum stress.

Journal: Carcinogenesis 20061001

Title: Mechanisms of fenretinide-induced apoptosis.

Journal: Apoptosis : an international journal on programmed cell death 20061001

Title: Involvement of mitochondrial and Akt signaling pathways in augmented apoptosis induced by a combination of low doses of celecoxib and N-(4-hydroxyphenyl) retinamide in premalignant human bronchial epithelial cells.

Journal: Cancer research 20061001

Title: A phase I-II preoperative biomarker trial of fenretinide in ascitic ovarian cancer.

Journal: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20061001

Title: 4-HPR modulates gene expression in ovarian cells.

Journal: International journal of cancer 20060901

Title: Comparing the effect of ATRA, 4-HPR, and CD437 in bladder cancer cells.

Journal: Frontiers in bioscience : a journal and virtual library 20060901

Title: Intravesical N-(4-hydroxyphenyl) retinamide and adriamycin induces apoptosis in bladder cancer.

Journal: Frontiers in bioscience : a journal and virtual library 20060901

Title: Microplate screening assay for binding of ligands to bovine or reindeer beta-lactoglobulins.

Journal: Journal of biochemical and biophysical methods 20060831

Title: Quality of life assessment in a chemoprevention trial: fenretinide and oral or transdermal HRT.

Journal: Maturitas 20060820

Title: N-all-trans-retinoyl-L-proline inhibits metastatic potential of hepatocellular carcinoma cells.

Journal: Cell biology international 20060801

Title: Phase I trial of oral fenretinide in children with high-risk solid tumors: a report from the Children's Oncology Group (CCG 09709).

Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20060720

Title: Retinoids activate the RXR/SXR-mediated pathway and induce the endogenous CYP3A4 activity in Huh7 human hepatoma cells.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20060701

Title: Fifteen-year results of a randomized phase III trial of fenretinide to prevent second breast cancer.

Journal: Annals of oncology : official journal of the European Society for Medical Oncology 20060701

Title: Fenretinide in the prevention of breast cancer in premenopausal women: fluke or fact?

Journal: Annals of oncology : official journal of the European Society for Medical Oncology 20060701

Title: Fenretinide activity in retinoid-resistant oral leukoplakia.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20060515

Title: N-(4-hydroxyphenyl)retinamide-induced apoptosis triggered by reactive oxygen species is mediated by activation of MAPKs in head and neck squamous carcinoma cells.

Journal: Oncogene 20060504

Title: Synthesis and preliminary chemotherapeutic evaluation of the fully C-linked glucuronide of N-(4-hydroxyphenyl)retinamide.

Journal: Bioorganic & medicinal chemistry 20060501

Title: Statistical analysis of combined dose effects for experiments with two agents.

Journal: Artificial intelligence in medicine 20060501

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Title: Overexpression of RARgamma increases death of SH-SY5Y neuroblastoma cells in response to retinoic acid but not fenretinide.

Journal: Cell death and differentiation 20060401

Title: 4-oxo-fenretinide, a recently identified fenretinide metabolite, induces marked G2-M cell cycle arrest and apoptosis in fenretinide-sensitive and fenretinide-resistant cell lines.

Journal: Cancer research 20060315

Title: N-(4-Hydroxyphenyl)retinamide and nitric oxide pro-drugs exhibit apoptotic and anti-invasive effects against bone metastatic breast cancer cells.

Journal: Carcinogenesis 20060301

Title: Clinical trials with retinoids for breast cancer chemoprevention.

Journal: Endocrine-related cancer 20060301

Title: The CLN9 protein, a regulator of dihydroceramide synthase.

Journal: The Journal of biological chemistry 20060203

Title: Targeting cyclin D1, a downstream effector of INI1/hSNF5, in rhabdoid tumors.

Journal: Oncogene 20060202

Title: Fenretinide inhibits HIV infection by promoting viral endocytosis.

Journal: Antiviral research 20060201

Title: Chemoprevention of skin carcinogenesis by phenylretinamides: retinoid receptor-independent tumor suppression.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20060201

Title: Anticancer effects of fenretinide in human medulloblastoma.

Journal: Cancer letters 20060118

Title: Preliminary results on safety and activity of a randomized, double-blind, 2 x 2 trial of low-dose tamoxifen and fenretinide for breast cancer prevention in premenopausal women.

Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20060101

Title: Cholecalciferol (vitamin D3) and the retinoid N-(4-hydroxyphenyl)retinamide (4-HPR) are synergistic for chemoprevention of prostate cancer.

Journal: Journal of experimental therapeutics & oncology 20060101

Title: A phase I clinical and pharmacokinetic study of fenretinide combined with paclitaxel and cisplatin for refractory solid tumors.

Journal: Investigational new drugs 20051201

Title: BBC3 mediates fenretinide-induced cell death in neuroblastoma.

Journal: Oncogene 20051201

Title: Cervical chromosome 9 polysomy: validation and use as a surrogate endpoint biomarker in a 4-HPR chemoprevention trial.

Journal: Gynecologic oncology 20051201

Title: Reductions in serum vitamin A arrest accumulation of toxic retinal fluorophores: a potential therapy for treatment of lipofuscin-based retinal diseases.

Journal: Investigative ophthalmology & visual science 20051201

Title: [Mechanisms of fenretinide-triggered apoptosis in leukemic cells].

Journal: Zhongguo shi yan xue ye xue za zhi 20051201

Title: Human T-cell lymphotropic virus type I-transformed T-cells have a partial defect in ceramide synthesis in response to N-(4-hydroxyphenyl)retinamide.

Journal: The Biochemical journal 20051115

Title: Cyclooxygenase-2 protein reduces tamoxifen and N-(4-hydroxyphenyl)retinamide inhibitory effects in breast cancer cells.

Journal: Laboratory investigation; a journal of technical methods and pathology 20051101

Title: PPAR activation and decreased proliferation in oral carcinoma cells with 4-HPR.

Journal: Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery 20051101

Title: The role of gangliosides in fenretinide-induced apoptosis of neuroblastoma.

Journal: Cancer letters 20051018

Title: N-(4-hydroxyphenyl)retinamide inhibits invasion, suppresses osteoclastogenesis, and potentiates apoptosis through down-regulation of I(kappa)B(alpha) kinase and nuclear factor-kappaB-regulated gene products.

Journal: Cancer research 20051015

Title: Inhibitory effects of N-(4-hydrophenyl) retinamide on liver cancer and malignant melanoma cells.

Journal: World journal of gastroenterology 20051007

Title: Flexible heteroarotinoids (Flex-Hets) exhibit improved therapeutic ratios as anti-cancer agents over retinoic acid receptor agonists.

Journal: Investigational new drugs 20051001

Title: Increased level of the p67phox subunit of NADPH oxidase by 4HPR in head and neck squamous carcinoma cells.

Journal: International journal of oncology 20050901

Title: Retinamide-induced apoptosis in glioblastomas is associated with down-regulation of Bcl-xL and Bcl-2 proteins.

Journal: Journal of neuro-oncology 20050901

Title: IB1/JIP-1 controls JNK activation and increased during prostatic LNCaP cells neuroendocrine differentiation.

Journal: Cellular signalling 20050801

Title: In vitro model of normal, immortalized ovarian surface epithelial and ovarian cancer cells for chemoprevention of ovarian cancer.

Journal: Gynecologic oncology 20050801

Title: Sensitivity to DNA damage is a common component of hormone-based strategies for protection of the mammary gland.

Journal: Molecular cancer research : MCR 20050801

Title: Could the combination of celecoxib and 4HPR be an effective lung cancer treatment?

Journal: Cancer biology & therapy 20050801

Title: Randomized trial of fenretinide (4-HPR) to prevent recurrences, new localizations and carcinomas in patients operated on for oral leukoplakia: long-term results.

Journal: International journal of cancer 20050701

Title: ROS mediates 4HPR-induced posttranscriptional expression of the Gadd153 gene.

Journal: Free radical biology & medicine 20050615

Title: The transforming growth factor-beta family members bone morphogenetic protein-2 and macrophage inhibitory cytokine-1 as mediators of the antiangiogenic activity of N-(4-hydroxyphenyl)retinamide.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20050615

Title: Fenretinide: a p53-independent way to kill cancer cells.

Journal: Biochemical and biophysical research communications 20050610

Title: [The role of reactive oxygen species in N-[4-hydroxyphenyl] retinamide induced apoptosis in bladder cancer cell lineT24].

Journal: Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases 20050601

Title: N-(4-Hydroxyphenyl)retinamide is more potent than other phenylretinamides in inhibiting the growth of BRCA1-mutated breast cancer cells.

Journal: Carcinogenesis 20050501

Title: The NF-kappaB pathway mediates fenretinide-induced apoptosis in SH-SY5Y neuroblastoma cells.

Journal: Apoptosis : an international journal on programmed cell death 20050501

Title: p38MAPK-Dependent sensitivity of Ewing's sarcoma family of tumors to fenretinide-induced cell death.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20050415

Title: Identification of the genes involved in enhanced fenretinide-induced apoptosis by parthenolide in human hepatoma cells.

Journal: Cancer research 20050401

Title: Enhanced growth inhibition and apoptosis induction in NSCLC cell lines by combination of celecoxib and 4HPR at clinically relevant concentrations.

Journal: Cancer biology & therapy 20050401

Title: Expression of gastrointestinal glutathione peroxidase is inversely correlated to the presence of hepatitis C virus subgenomic RNA in human liver cells.

Journal: The Journal of biological chemistry 20050311

Title: Regulation of ultraviolet B radiation-mediated activation of AP1 signaling by retinoids in primary keratinocytes.

Journal: Radiation research 20050301

Title: Phase II trial of fenretinide in advanced renal carcinoma.

Journal: Investigational new drugs 20050301

Title: Effect of the synthetic retinoid fenretinide on circulating free prostate-specific antigen, insulin-like growth factor-I, and insulin-like growth factor binding protein-3 levels in men with superficial bladder cancer.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20050301

Title: Induction of apoptosis in primary meningioma cultures by fenretinide.

Journal: Cancer research 20050215

Title: Chemopreventive N-(4-hydroxyphenyl)retinamide (fenretinide) targets deregulated NF-{kappa}B and Mat1A genes in the early stages of rat liver carcinogenesis.

Journal: Carcinogenesis 20050201

Title: Aromatase inhibition by 15-deoxy-prostaglandin J(2) (15-dPGJ(2)) and N-(4-hydroxyphenyl)-retinamide (4HPR) is associated with enhanced ceramide production.

Journal: The Journal of steroid biochemistry and molecular biology 20050201

Title: Induction of reactive oxygen species renders mutant and wild-type K-ras pancreatic carcinoma cells susceptible to Ad.mda-7-induced apoptosis.

Journal: Oncogene 20050120

Title: Endogenous fluorescence spectroscopy of cell suspensions for chemopreventive drug monitoring.

Journal: Photochemistry and photobiology 20050101

Title: Action of fenretinide (4-HPR) on ovarian cancer and endothelial cells.

Journal: Anticancer research 20050101

Title: Inhibition of mammary tumor growth by a novel nontoxic retinoid: chemotherapeutic evaluation of a C-linked analog of 4-HPR-glucuronide.

Journal: Anticancer research 20050101

Title: Intracellular glutathione levels determine cell sensitivity to apoptosis induced by the antineoplasic agent N-(4-hydroxyphenyl) retinamide.

Journal: Anticancer research 20050101

Title: Different ways to induce apoptosis by fenretinide and all-trans-retinoic acid in human B lymphoma cells.

Journal: Anticancer research 20050101

Title: Novel retinoic acid metabolism blocking agents endowed with multiple biological activities are efficient growth inhibitors of human breast and prostate cancer cells in vitro and a human breast tumor xenograft in nude mice.

Journal: Journal of medicinal chemistry 20041230

Title: Molecular mechanisms of fenretinide-induced apoptosis of neuroblastoma cells.

Journal: Annals of the New York Academy of Sciences 20041201

Title: Fenretinide stimulates redox-sensitive ceramide production in breast cancer cells: potential role in drug-induced cytotoxicity.

Journal: British journal of cancer 20041115

Title: Fenretinide induces sustained-activation of JNK/p38 MAPK and apoptosis in a reactive oxygen species-dependent manner in neuroblastoma cells.

Journal: International journal of cancer 20041101

Title: Phase II study of fenretinide (NSC 374551) in adults with recurrent malignant gliomas: A North American Brain Tumor Consortium study.

Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20041101

Title: Breast cancer progression in MCF10A series of cell lines is associated with alterations in retinoic acid and retinoid X receptors and with differential response to retinoids.

Journal: International journal of oncology 20041001

Title: Synergistic growth-inhibitory effects of fenretinide with either cisplatin or paclitaxel on human epithelial ovarian cancer cell line (SKOV-3).

Journal: Journal of the Medical Association of Thailand = Chotmaihet thangphaet 20041001

Title: Identification of the fenretinide metabolite 4-oxo-fenretinide present in human plasma and formed in human ovarian carcinoma cells through induction of cytochrome P450 26A1.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20040915

Title: Liquid chromatography method for quantifying N-(4-hydroxyphenyl)retinamide and N-(4-methoxyphenyl)retinamide in tissues.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20040905

Title: Fenretinide activates a distinct apoptotic pathway.

Journal: Journal of the National Cancer Institute 20040901

Title: Gangliosides link the acidic sphingomyelinase-mediated induction of ceramide to 12-lipoxygenase-dependent apoptosis of neuroblastoma in response to fenretinide.

Journal: Journal of the National Cancer Institute 20040901

Title: Fenretinide cytotoxicity for Ewing's sarcoma and primitive neuroectodermal tumor cell lines is decreased by hypoxia and synergistically enhanced by ceramide modulators.

Journal: Cancer research 20040801

Title: Quantitative histopathology and chromosome 9 polysomy in a clinical trial of 4-HPR.

Journal: Gynecologic oncology 20040801

Title: A two-by-two factorial trial comparing oral with transdermal estrogen therapy and fenretinide with placebo on breast cancer biomarkers.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20040701

Title: Synthetic retinoids as inducers of apoptosis in ovarian carcinoma cell lines.

Journal: Journal of cellular physiology 20040601

Title: How retinoids regulate breast cancer cell proliferation and apoptosis.

Journal: Cellular and molecular life sciences : CMLS 20040601

Title: Fenretinide enhances rituximab-induced cytotoxicity against B-cell lymphoma xenografts through a caspase-dependent mechanism.

Journal: Blood 20040501

Title: N-(4-hydroxyphenyl) retinamide (4HPR) enhances TRAIL-mediated apoptosis through enhancement of a mitochondrial-dependent amplification loop in ovarian cancer cell lines.

Journal: Cell death and differentiation 20040501

Title: Stage-specific effect of N-(4-hydroxyphenyl)retinamide on cell growth in squamous cell carcinogenesis.

Journal: Molecular carcinogenesis 20040501

Title: Synthesis and biological activity of novel retinamide and retinoate derivatives.

Journal: Chemical & pharmaceutical bulletin 20040501

Title: [Recent advances in neuroblastoma research].

Journal: Seikagaku. The Journal of Japanese Biochemical Society 20040501

Title: Nuclear retinoid receptors are involved in N-(4-hydroxyphenyl) retinamide (Fenretinide)-induced gene expression and growth inhibition in HL-60 acute myeloid leukemia cells.

Journal: Leukemia & lymphoma 20040501

Title: Inhibition of N-(4-hydroxyphenyl)retinamide-induced apoptosis in breast cancer cells by galectin-3.

Journal: Cancer biology & therapy 20040501

Title: Re: Lanvers C et al. Pharmacology of all-trans-retinoic acid in children with acute promyelocytic leukemia. Med Pediatr Oncol 2003;40:293-301.

Journal: Pediatric blood & cancer 20040401

Title: Identification of retinoid-modulated proteins in squamous carcinoma cells using high-throughput immunoblotting.

Journal: Cancer research 20040401

Title: Involvement of c-Fos in fenretinide-induced apoptosis in human ovarian carcinoma cells.

Journal: Cell death and differentiation 20040301

Title: N-(4-hydroxyphenyl)retinamide induces growth arrest and apoptosis in HTLV-I-transformed cells.

Journal: Leukemia 20040301

Title: Potent effect of 5-HPBR, a butanoate derivative of 4-HPR, on cell growth and apoptosis in cancer cells.

Journal: International journal of cancer 20040301

Title: The chemopreventive agents 4-HPR and DFMO inhibit growth and induce apoptosis in uterine leiomyomas.

Journal: American journal of obstetrics and gynecology 20040301

Title: Cyclooxygenase-2 is essential for HER2/neu to suppress N- (4-hydroxyphenyl)retinamide apoptotic effects in breast cancer cells.

Journal: Cancer research 20040215

Title: Synthesis of flexible sulfur-containing heteroarotinoids that induce apoptosis and reactive oxygen species with discrimination between malignant and benign cells.

Journal: Journal of medicinal chemistry 20040212

Title: Efficacy of 9-cis-retinoic acid and N-(4-hydroxyphenyl) retinamide alone and in combination in mammary cancer prevention.

Journal: Oncology reports 20040201

Title: Progress in chemoprevention of breast cancer.

Journal: Critical reviews in oncology/hematology 20040201

Title: Antisense BAG-1 sensitizes HeLa cells to apoptosis by multiple pathways.

Journal: Biochemical and biophysical research communications 20031219

Title: Growth and DNA damage-inducible transcription factor 153 mediates apoptosis in response to fenretinide but not synergy between fenretinide and chemotherapeutic drugs in neuroblastoma.

Journal: Molecular pharmacology 20031201

Title: Heterogeneous role of caspase-8 in fenretinide-induced apoptosis in epithelial ovarian carcinoma cell lines.

Journal: Molecular pharmacology 20031201

Title: Pharmacological prevention of breast cancer: quo vadis?

Journal: Breast (Edinburgh, Scotland) 20031201

Title: Inhibition of Kaposi's sarcoma in vivo by fenretinide.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20031201

Title: [Inhibitory effects on hepatocarcinoma and B16 melanoma cells by N-(4-hydrophenyl) retinamide].

Journal: Shi yan sheng wu xue bao 20031201

Title: Hydrolysis of 4-HPR to atRA occurs in vivo but is not required for retinamide-induced apoptosis.

Journal: Archives of biochemistry and biophysics 20031115

Title: Fenretinide: a prototype cancer prevention drug.

Journal: Expert opinion on investigational drugs 20031101

Title: Bak: a downstream mediator of fenretinide-induced apoptosis of SH-SY5Y neuroblastoma cells.

Journal: Cancer research 20031101

Title: All-trans retinoic acid- and N-(4-hydroxyphenil)-retinamide-induced growth arrest and apoptosis in orbital fibroblasts in Graves' disease.

Journal: Metabolism: clinical and experimental 20031101

Title: Relationships between plasma insulin-like growth factor-I and insulin-like growth factor binding protein-3 and second breast cancer risk in a prevention trial of fenretinide.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20031015

Title: HER2/neu reduces the apoptotic effects of N-(4-hydroxyphenyl)retinamide (4-HPR) in breast cancer cells by decreasing nitric oxide production.

Journal: Oncogene 20031002

Title: Retinoid receptor-dependent and independent biological activities of novel fenretinide analogues and metabolites.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20031001

Title: N-(4-Hydroxyphenyl)retinamide (4-HPR) induces leukemia cell death via generation of reactive oxygen species.

Journal: International journal of hematology 20031001

Title: The chemopreventive agent N-(4-hydroxyphenyl)retinamide induces apoptosis through a mitochondrial pathway regulated by proteins from the Bcl-2 family.

Journal: Oncogene 20030918

Title: Transcriptional regulation of the human transferrin gene by GADD153 in hepatoma cells.

Journal: Hepatology (Baltimore, Md.) 20030901

Title: Enhanced effectiveness of last generation antiblastic compounds vs. cisplatin on malignant pleural mesothelioma cell lines.

Journal: European journal of pharmacology 20030725

Title: Immunoliposomal fenretinide: a novel antitumoral drug for human neuroblastoma.

Journal: Cancer letters 20030718

Title: Induction of GADD153 and Bak: novel molecular targets of fenretinide-induced apoptosis of neuroblastoma.

Journal: Cancer letters 20030718

Title: Fenretinide as an anti-angiogenic agent in neuroblastoma.

Journal: Cancer letters 20030718

Title: Glucosylceramide synthase and its functional interaction with RTN-1C regulate chemotherapeutic-induced apoptosis in neuroepithelioma cells.

Journal: Cancer research 20030715

Title: Fenretinide induces cytochrome c release, caspase 9 activation and apoptosis in the absence of mitochondrial membrane depolarisation.

Journal: Cell death and differentiation 20030701

Title: Effects on M5076-hepatic metastasis of retinoic acid and N-(4-hydroxyphenyl) retinamide, fenretinide entrapped in SG-liposomes.

Journal: Biological & pharmaceutical bulletin 20030701

Title: Breast tissue accumulation of retinamides in a randomized short-term study of fenretinide.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20030701

Title: Mechanisms of free-radical induction in relation to fenretinide-induced apoptosis of neuroblastoma.

Journal: Journal of cellular biochemistry 20030701

Title: Phase I trial and pharmacokinetics of fenretinide in children with neuroblastoma.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20030601

Title: Comparison of the mechanism of induction of apoptosis in ovarian carcinoma cells by the conformationally restricted synthetic retinoids CD437 and 4-HPR.

Journal: Journal of cellular biochemistry 20030515

Title: In vitro and in vivo antitumor activity of liposomal Fenretinide targeted to human neuroblastoma.

Journal: International journal of cancer 20030501

Title: Increasing intracellular ceramide: an approach that enhances the cytotoxic response in prostate cancer cells.

Journal: Urology 20030501

Title: Cyclin d1 overexpression sensitizes breast cancer cells to fenretinide.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20030501

Title: [Breakthrough in breast cancer chemoprevention].

Journal: Orvosi hetilap 20030330

Title: N-(4-Hydroxylphenyl)retinamide (fenretinide, 4-HPR), a retinoid compound with antileukemic and proapoptotic activity in acute lymphoblastic leukemia (ALL).

Journal: Leukemia research 20030301

Title: Differentiation of human retinal pigment epithelial cells into neuronal phenotype by N-(4-hydroxyphenyl)retinamide.

Journal: Journal of neurochemistry 20030301

Title: N-(4-hydroxyphenyl)retinamide inhibits retinoblastoma growth through reactive oxygen species-mediated cell death.

Journal: Molecular pharmacology 20030301

Title: Requirement of c-jun for testosterone-induced sensitization to N-(4-hydroxyphenyl)retinamide-induced apoptosis.

Journal: Molecular carcinogenesis 20030301

Title: Breast cancer chemoprevention: additional observations.

Journal: International journal of clinical practice 20030301

Title: Altered sphingolipid metabolism in N-(4-hydroxyphenyl)-retinamide-resistant A2780 human ovarian carcinoma cells.

Journal: The Journal of biological chemistry 20030221

Title: Retinoic acid receptor beta and telomerase catalytic subunit expression in bronchial epithelium of heavy smokers.

Journal: Journal of the National Cancer Institute 20030115

Title: Effect of 4-hydroxyphenylretinamide on human cervical epithelial and cancer cell lines.

Journal: Journal of the Society for Gynecologic Investigation 20030101

Title: Fenretinide breast cancer prevention trial: drug and retinol plasma levels in relation to age and disease outcome.

Journal: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20030101

Title: Specific keynote: chemoprevention of ovarian cancer: the journey begins.

Journal: Gynecologic oncology 20030101

Title: Antiangiogenic activity of chemopreventive drugs.

Journal: The International journal of biological markers 20030101

Title: Induction of apoptosis by fenretinide in tumor cell lines correlates with DLX2, DLX3 and DLX4 gene expression.

Journal: Oncology reports 20030101

Title: Evaluation of anti-tumour effects of oral fenretinide (4-HPR) in rats with human neuroblastoma xenografts.

Journal: Oncology reports 20030101

Title: Breast cancer prevention trials using retinoids.

Journal: Journal of mammary gland biology and neoplasia 20030101

Title: Ceramide signaling in fenretinide-induced endothelial cell apoptosis.

Journal: The Journal of biological chemistry 20021220

Title: Elucidation of molecular events mediating induction of apoptosis by synthetic retinoids using a CD437-resistant ovarian carcinoma cell line.

Journal: The Journal of biological chemistry 20021122

Title: Upregulation of GADD153 expression in the apoptotic signaling of N-(4-hydroxyphenyl)retinamide (4HPR).

Journal: International journal of cancer 20021101

Title: Contributions of mitogen-activated protein kinase and nuclear factor kappa B to N-(4-hydroxyphenyl)retinamide-induced apoptosis in prostate cancer cells.

Journal: Molecular carcinogenesis 20021101

Title: Biological activity of p-methylaminophenol, an essential structural component of N-(4-hydroxyphenyl)retinamide, fenretinide.

Journal: Journal of biochemistry 20021101

Title: GADD153-mediated anticancer effects of N-(4-hydroxyphenyl)retinamide on human hepatoma cells.

Journal: The Journal of biological chemistry 20021011

Title: A novel mechanism by which N-(4-hydroxyphenyl)retinamide inhibits breast cancer cell growth: the production of nitric oxide.

Journal: Molecular cancer therapeutics 20021001

Title: Cyclosporin A enhances the apoptotic effects of N-(4-hydroxyphenyl)retinamide in breast cancer cells.

Journal: International journal of cancer 20020920

Title: GADD153 and 12-lipoxygenase mediate fenretinide-induced apoptosis of neuroblastoma.

Journal: Cancer research 20020915

Title: 9-cis-retinoic acid but not 4-(hydroxyphenyl)retinamide inhibits prostate intraepithelial neoplasia in Noble rats.

Journal: Cancer research 20020915

Title: Distinct patterns of mitochondrial changes precede induction of apoptosis by all-trans-retinoic acid and N-(4-hydroxyphenyl)retinamide in MCF7 breast cancer cells.

Journal: Experimental cell research 20020910

Title: Effect of transdermal estradiol and oral conjugated estrogen on C-reactive protein in retinoid-placebo trial in healthy women.

Journal: Circulation 20020903

Title: An improved synthesis of the C-linked glucuronide of N-(4-hydroxyphenyl)retinamide.

Journal: Bioorganic & medicinal chemistry letters 20020902

Title: Phase II clinical trial of N-(4-Hydroxyphenyl)retinamide and tamoxifen administration before definitive surgery for breast neoplasia.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20020901

Title: Is growth inhibition and induction of apoptosis in lung cancer cell lines by fenretinide [N-(4-hydroxyphenyl)retinamide] sufficient for cancer therapy?

Journal: International journal of cancer 20020810

Title: Effect of fenretinide on ovarian carcinoma occurrence.

Journal: Gynecologic oncology 20020701

Title: N-(4-hydroxyphenyl)retinamide (4-HPR) modulates GADD45 expression in radiosensitive bladder cancer cell lines.

Journal: Cancer letters 20020628

Title: Re: Effects of N-(4-hydroxy-phenyl)retinamide on hTERT expression in the bronchial epithelium of cigarette smokers.

Journal: Journal of the National Cancer Institute 20020619

Title: Implication of mitochondria-derived ROS and cardiolipin peroxidation in N-(4-hydroxyphenyl)retinamide-induced apoptosis.

Journal: British journal of cancer 20020617

Title: Tissue transglutaminase protects against apoptosis by modifying the tumor suppressor protein p110 Rb.

Journal: The Journal of biological chemistry 20020607

Title: OVCA2 is downregulated and degraded during retinoid-induced apoptosis.

Journal: International journal of cancer 20020510

Title: N-(4-hydroxyphenyl)retinamide increases ceramide and is cytotoxic to acute lymphoblastic leukemia cell lines, but not to non-malignant lymphocytes.

Journal: Leukemia 20020501

Title: Correspondence re: M. Follen et al., a randomized clinical trial of 4-hydroxyphenylretinamide for high-grade squamous intraepithelial lesions of the cervix.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20020501

Title: [Telomere and telomerase in lung cancer].

Journal: Nihon rinsho. Japanese journal of clinical medicine 20020501

Title: Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells.

Journal: The Journal of biological chemistry 20020419

Title: Retinoids enhance cisplatin-based chemoradiation in cervical cancer cells in vitro.

Journal: Gynecologic oncology 20020401

Title: Classical and novel retinoids: their targets in cancer therapy.

Journal: Leukemia 20020401

Title: Apoptosis of squamous cells at different stages of carcinogenesis following 4-HPR treatment.

Journal: Carcinogenesis 20020301

Title: Cytochrome c oxidase subunit III: a molecular marker for N-(4-hydroxyphenyl)retinamise-induced oxidative stress in hepatoma cells.

Journal: The Journal of biological chemistry 20020208

Title: Modulation of cyclophilin gene expression by N-4-(hydroxyphenyl)retinamide: association with reactive oxygen species generation and apoptosis.

Journal: Molecular carcinogenesis 20020101

Title: Fluorescence spectroscopy as a biomarker in a cell culture and in a nonhuman primate model for ovarian cancer chemopreventive agents.

Journal: Journal of biomedical optics 20020101

Title: Selective estrogen receptor modulators (SERMs) and retinoids in breast cancer chemoprevention.

Journal: Environmental and molecular mutagenesis 20020101

Title: [Are mitochondria targets of anticancer drugs responsible for apoptosis?].

Journal: Annales de biologie clinique 20020101

Title: Retinoid-induced growth arrest of breast carcinoma cells involves co-activation of multiple growth-inhibitory genes.

Journal: Cancer biology & therapy 20020101

Title: How much do we know about retinoid-regulated genes?

Journal: Cancer biology & therapy 20020101

Title: Experimental studies on the effects of the combined use of N-(4-hydroxyphenyl)retinamide (4-HPR) and tamoxifen (TAM) for estrogen receptor (ER)-negative breast cancer.

Journal: The Kurume medical journal 20020101

Title: Effects of body weight gain reduction resulting from chemopreventive agent treatment on mammary gland morphology.

Journal: Nutrition and cancer 20020101

Title: N-(4-hydroxyphenyl)-retinamide selectively increases All-TRANS retinoic acid inhibitory effects in HER2/NEU-overexpressing breast cancer cells.

Journal: Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 20020101

Title: Antiproliferative mechanism of retinoid derivatives in ovarian cancer cells.

Journal: Cancer letters 20011228

Title: Mitochondrial respiration is uniquely associated with the prooxidant and apoptotic effects of N-(4-hydroxyphenyl)retinamide.

Journal: The Journal of biological chemistry 20011207

Title: Activation of caspase-8 during N-(4-hydroxyphenyl)retinamide-induced apoptosis in Fas-defective hepatoma cells.

Journal: Hepatology (Baltimore, Md.) 20011201

Title: Clinical trials referral resource. Current clinical trials of fenretinide.

Journal: Oncology (Williston Park, N.Y.) 20011201

Title: Beyond tamoxifen new endpoints for breast cancer chemoprevention, new drugs for breast cancer prevention.

Journal: Annals of the New York Academy of Sciences 20011201

Title: A randomized clinical trial of 4-hydroxyphenylretinamide for high-grade squamous intraepithelial lesions of the cervix.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20011101

Title: Inhibition of neuroblastoma-induced angiogenesis by fenretinide.

Journal: International journal of cancer 20011101

Title: Mechanism of fenretinide (4-HPR)-induced cell death.

Journal: Apoptosis : an international journal on programmed cell death 20011001

Title: Long-term effects of fenretinide, a retinoic acid derivative, on the insulin-like growth factor system in women with early breast cancer.

Journal: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20011001

Title: Sequential tumor biopsies in early phase clinical trials of anticancer agents for pharmacodynamic evaluation.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20011001

Title: Retinoid therapy of childhood cancer.

Journal: Hematology/oncology clinics of North America 20011001

Title: Rhesus macaque model for ovarian cancer chemoprevention.

Journal: Comparative medicine 20011001

Title: N-(4-hydroxyphenyl)retinamide (4-HPR) decreases neoplastic properties of human prostate cells: an agent for prevention.

Journal: Mutation research 20010920

Title: Effects of tissue transglutaminase on retinoic acid-induced cellular differentiation and protection against apoptosis.

Journal: The Journal of biological chemistry 20010907

Title: Effects of N-(4-hydroxyphenyl)retinamide on hTERT expression in the bronchial epithelium of cigarette smokers.

Journal: Journal of the National Cancer Institute 20010815

Title: Biomarker modulation in a nonhuman rhesus primate model for ovarian cancer chemoprevention.

Journal: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20010801

Title: Synergistic effects of the fenretinide (4-HPR) and anti-CD20 monoclonal antibodies on apoptosis induction of malignant human B cells.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20010801

Title: Effects of dietary N-(4-hydroxyphenyl)retinamide on N-nitrosomethylbenzylamine metabolism and esophageal tumorigenesis in the Fischer 344 rat.

Journal: Journal of the National Cancer Institute 20010704

Title: N-(4-hydroxyphenyl)retinamide elevates ceramide in neuroblastoma cell lines by coordinate activation of serine palmitoyltransferase and ceramide synthase.

Journal: Cancer research 20010701

Title: An unhydrolyzable analogue of N-(4-hydroxyphenyl)retinamide. synthesis and preliminary biological studies.

Journal: Bioorganic & medicinal chemistry letters 20010618

Title: Decrease in drug accumulation and in tumour aggressiveness marker expression in a fenretinide-induced resistant ovarian tumour cell line.

Journal: British journal of cancer 20010601

Title: Up-regulation of prosaposin by the retinoid HPR and its effect on ceramide production and integrin receptors.

Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20010601

Title: Identification of retinamides that are more potent than N-(4-hydroxyphenyl)retinamide in inhibiting growth and inducing apoptosis of human head and neck and lung cancer cells.

Journal: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20010601

Title: Retinoids for ovarian cancer prevention: laboratory data set the stage for thoughtful clinical trials.

Journal: Journal of the National Cancer Institute 20010404

Title: Effects of retinoids on cancerous phenotype and apoptosis in organotypic cultures of ovarian carcinoma.

Journal: Journal of the National Cancer Institute 20010404

Title: Bayesian monitoring of a phase 2 chemoprevention trial in high-risk cohorts for prostate cancer.

Journal: Urology 20010401

Title: Effects of novel phenylretinamides on cell growth and apoptosis in bladder cancer.

Journal: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20010401

Title: Safety of the synthetic retinoid fenretinide: long-term results from a controlled clinical trial for the prevention of contralateral breast cancer.

Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20010315

Title: The retinoid fenretinide inhibits proliferation and downregulates cyclooxygenase-2 gene expression in human colon adenocarcinoma cell lines.

Journal: Cancer letters 20010310

Title: Suppression of pRB expression in normal human mammary epithelial cells is associated with resistance to all-trans-retinoic acid but not N-(4-hydroxylphenyl)-retinamide.

Journal: Breast cancer research and treatment 20010301

Title: Re: Randomized trial of fenretinide to prevent second breast malignancy in women with early breast cancer.

Journal: Journal of the National Cancer Institute 20010207

Title: 4-(N-hydroxyphenyl)retinamide can selectively induce apoptosis in human epidermoid carcinoma cells but not in normal dermal fibroblasts.

Journal: Cancer investigation 20010101

Title: Chemoprevention of breast cancer with fenretinide.

Journal: Drugs 20010101

Title: Effect of high retinoid doses on RAR-beta mRNA expression in female B6D2F1 mice.

Journal: Anticancer research 20010101

Title: Chemotherapeutic evaluation of 4-hydroxybenzylretinone (4-HBR), a nonhydrolyzable C-linked analog of N-(4-hydroxyphenyl) retinamide (4-HPR) against mammary carcinogenesis.

Journal: Anticancer research 20010101

Title: Comparative ability of ibuprofen and N-(4-hydroxyphenyl)retinamide to inhibit development of rat mammary adenocarcinomas associated with differential inhibition of gene expression of cyclooxygenase isoforms.

Journal: Anticancer research 19990101

Title: Retinoid-induced apoptosis and Sp1 cleavage occur independently of transcription and require caspase activation.

Journal: Molecular and cellular biology 19971101

Title: Regulation of apoptosis induced by the retinoid N-(4-hydroxyphenyl) retinamide and effect of deregulated bcl-2.

Journal: Blood 19950115

Title: Phase II trial of fenretinide [N-(4-hydroxyphenyl) retinamide] in myelodysplasia: possible retinoid-induced disease acceleration.

Journal: Leukemia research 19890101

Title: Abnormal retinal function associated with fenretinide, a synthetic retinoid.

Journal: Archives of ophthalmology (Chicago, Ill. : 1960) 19860101

Title: Subacute toxicity of all-trans- and 13-cis-isomers of N-ethyl retinamide, N-2-hydroxyethyl retinamide, and N-4-hydroxyphenyl retinamide.

Journal: Toxicology and applied pharmacology 19830915

Title: Apraiz, Aintzane., et al. Dihydroceramide accumulation and reactive oxygen species are distinct and nonessential events in 4-HPR-mediated leukemia cell death. Biochemistry and Cell Biology (2012), 90(2), 209-223.

Title: Bikman, Benjamin T., et al. Fenretinide Prevents Lipid-induced Insulin Resistance by Blocking Ceramide Biosynthesis. Journal of Biological Chemistry (2012), 287(21), 17426-17437.

Title: Cooper JP, et al. Fenretinide metabolism in humans and mice: utilizing pharmacological modulation of its metabolic pathway to increase systemic exposure. Br J Pharmacol. 2011 Jul;163(6):1263-75.

Title: Golubkov V, et al. Action of fenretinide (4-HPR) on ovarian cancer and endothelial cells. Anticancer Res. 2005 Jan-Feb;25(1A):249-53.

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