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658-48-0,MFCD00004187
Catalog No.:AA003NR4

658-48-0 | D,L-alpha-methyltyrosine

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1g
95%
in stock  
$17.00   $12.00
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5g
95%
in stock  
$71.00   $50.00
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10g
95%
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$139.00   $98.00
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA003NR4
Chemical Name:
D,L-alpha-methyltyrosine
CAS Number:
658-48-0
Molecular Formula:
C10H13NO3
Molecular Weight:
195.2151
MDL Number:
MFCD00004187
SMILES:
Oc1ccc(cc1)CC(C(=O)O)(N)C
Properties
Properties
 
BP:
383.7°C at 760 mmHg  
Form:
Solid  
MP:
>300 °C(lit.)  
Refractive Index:
1.5150 (estimate)  
Storage:
Keep in dry area;Room Temperature;  

Computed Properties
 
Complexity:
211  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
14  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
3  
Undefined Atom Stereocenter Count:
1  
XLogP3:
-1.6  

Literature

Title: Role of dopamine in the recruitment of immune cells to the nigro-striatal dopaminergic structures.

Journal: Neurotoxicology 20140301

Title: The protective effects of metyrosine, lacidipine, clonidine, and moxonidine on kidney damage induced by unilateral ureteral obstruction in rats.

Journal: Surgery today 20121101

Title: Dopamine-related deficit in reward learning after catecholamine depletion in unmedicated, remitted subjects with bulimia nervosa.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20120701

Title: Paradoxical sleep deprivation modulates tyrosine hydroxylase expression in the nigrostriatal pathway and attenuates motor deficits induced by dopaminergic depletion.

Journal: CNS & neurological disorders drug targets 20120601

Title: The involvement of noradrenergic mechanisms in the suppressive effects of diazepam on the hypothalamic-pituitary-adrenal axis activity in female rats.

Journal: Croatian medical journal 20120601

Title: The dopaminergic system in patients with functional dyspepsia analysed by single photon emission computed tomography (SPECT) and an alpha-methyl-para-tyrosine (AMPT) challenge test.

Journal: European journal of nuclear medicine and molecular imaging 20120401

Title: AMPA glutamate receptors mediate the antidepressant-like effects of N-acetylcysteine in the mouse tail suspension test.

Journal: Behavioural pharmacology 20120401

Title: Pharmacological mechanisms of antidepressant-like effect of tipepidine in the forced swimming test.

Journal: Behavioural brain research 20120115

Title: Developing brain as an endocrine organ: secretion of dopamine.

Journal: Molecular and cellular endocrinology 20120102

Title: Estrogen regulation of brain vasotocin secretion in the catfish Heteropneustes fossilis: an interaction with catecholaminergic system.

Journal: General and comparative endocrinology 20120101

Title: The effect of catecholamine deficit on the development of the immune system in rats.

Journal: Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections 20120101

Title: Endocrine function of dopaminergic neurons of the whole rat brain in ontogeny: control of prolactin secretion.

Journal: Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections 20120101

Title: Estradiol-17β modulates dose-dependently hypothalamic tyrosine hydroxylase activity inhibited by α-methylparatyrosine in the catfish Heteropneustes fossilis.

Journal: Endocrine 20111201

Title: Cytochrome P450 mediates dopamine formation in the brain in vivo.

Journal: Journal of neurochemistry 20110901

Title: Effects of epinephrine and cortisol on the analgesic activity of metyrosine in rats.

Journal: Archives of pharmacal research 20110901

Title: Endogenous morphine-like compound immunoreactivity increases in parkinsonism.

Journal: Brain : a journal of neurology 20110801

Title: Adipocytes as a new source of catecholamine production.

Journal: FEBS letters 20110721

Title: Knocking down the transcript of protein kinase C-lambda modulates hypothalamic glutathione peroxidase, melanocortin receptor and neuropeptide Y gene expression in amphetamine-treated rats.

Journal: Journal of psychopharmacology (Oxford, England) 20110701

Title: Central injection of ketone body suppresses luteinizing hormone release via the catecholaminergic pathway in female rats.

Journal: The Journal of reproduction and development 20110601

Title: Dopaminergic modulation of the human reward system: a placebo-controlled dopamine depletion fMRI study.

Journal: Journal of psychopharmacology (Oxford, England) 20110401

Title: Antipsychotic-induced DRD2 upregulation and its prevention by α-lipoic acid in SH-SY5Y neuroblastoma cells.

Journal: Synapse (New York, N.Y.) 20110401

Title: Synthesis and evaluation of amino acid-based radiotracer 99mTc-N4-AMT for breast cancer imaging.

Journal: Journal of biomedicine & biotechnology 20110101

Title: No effect of dopamine depletion on the binding of the high-affinity D 2/3 radiotracer [11C]FLB 457 in the human cortex.

Journal: Synapse (New York, N.Y.) 20101201

Title: 18F-FAMT-PET is useful for the diagnosis of lymph node metastasis in operable esophageal squamous cell carcinoma.

Journal: Annals of surgical oncology 20101201

Title: Assessment of therapy response in lung cancer with ¹⁸F-α-methyl tyrosine PET.

Journal: AJR. American journal of roentgenology 20101101

Title: Synthesis of (99m)Tc-EC-AMT as an imaging probe for amino acid transporter systems in breast cancer.

Journal: Nuclear medicine communications 20100801

Title: Dopamine is not essential for the development of methamphetamine-induced neurotoxicity.

Journal: Journal of neurochemistry 20100801

Title: Influence of central neurotransmitters on heart rate variability in outbred rats at rest and during acute stress: nature of very-low-wave spectrum component revisited.

Journal: Bulletin of experimental biology and medicine 20100701

Title: Inhibition of hCG-induced spawning by alpha-methylparatyrosine, a tyrosine hydroxylase inhibitor, in the catfish Heteropneustes fossilis (Bloch).

Journal: Indian journal of experimental biology 20100601

Title: [Clinical course of patient with malignant pheochromocytoma who was treated with CVD chemotherapy and alpha-methyl-p-tyrosine].

Journal: Nihon Hinyokika Gakkai zasshi. The japanese journal of urology 20100501

Title: Dephosphorylation/inactivation of tyrosine hydroxylase at the median eminence of the hypothalamus is required for suckling-induced prolactin and adrenocorticotrop hormone responses.

Journal: Brain research bulletin 20100429

Title: Antidepressant-like effect of the methanolic extract from Bupleurum falcatum in the tail suspension test.

Journal: Progress in neuro-psychopharmacology & biological psychiatry 20100317

Title: Increased synaptic dopamine function in associative regions of the striatum in schizophrenia.

Journal: Archives of general psychiatry 20100301

Title: Dysregulation of intracellular dopamine stores revealed in the R6/2 mouse striatum.

Journal: Journal of neurochemistry 20100201

Title: Endogenous catecholamine enhances the dysfunction of unfolded protein response and alpha-synuclein oligomerization in PC12 cells overexpressing human alpha-synuclein.

Journal: Neuroscience research 20100101

Title: In vivo [11C]dihydrotetrabenazine binding in rat striatum: sensitivity to dopamine concentrations.

Journal: Nuclear medicine and biology 20100101

Title: Gastric anti-ulcerative and anti-inflammatory activity of metyrosine in rats.

Journal: Pharmacological reports : PR 20100101

Title: Contribution of vesicular and cytosolic dopamine to the increased striatal dopamine efflux elicited by intrastriatal injection of SKF38393.

Journal: European journal of pharmacology 20091210

Title: Impairments of probabilistic response reversal and passive avoidance following catecholamine depletion.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20091201

Title: Alpha-methyltyrosine inhibits formation of reactive oxygen species and diminishes apoptosis in PC12 cells.

Journal: Brain research 20091103

Title: Dopamine-regulated adrenocorticotropic hormone secretion in lactating rats: functional plasticity of melanotropes.

Journal: Neuroendocrinology 20091101

Title: 18F-FMT uptake seen within primary cancer on PET helps predict outcome of non-small cell lung cancer.

Journal: Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20091101

Title: Lower level of endogenous dopamine in patients with cocaine dependence: findings from PET imaging of D(2)/D(3) receptors following acute dopamine depletion.

Journal: The American journal of psychiatry 20091001

Title: Baseline and amphetamine-stimulated dopamine activity are related in drug-naïve schizophrenic subjects.

Journal: Biological psychiatry 20090615

Title: Amphetamine-evoked rotation requires newly synthesized dopamine at 14 days but not 1 day after intranigral 6-OHDA and is consistently dissociated from sensorimotor behavior.

Journal: Behavioural brain research 20090608

Title: Short-latency activation of striatal spiny neurons via subcortical visual pathways.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20090513

Title: Correlation of angiogenesis with 18F-FMT and 18F-FDG uptake in non-small cell lung cancer.

Journal: Cancer science 20090401

Title: Accumbal noradrenaline that contributes to the alpha-adrenoceptor-mediated release of dopamine from reserpine-sensitive storage vesicles in the nucleus accumbens is derived from alpha-methyl-para-tyrosine-sensitive pools.

Journal: Journal of neural transmission (Vienna, Austria : 1996) 20090401

Title: Spinal cord stimulation restores locomotion in animal models of Parkinson's disease.

Journal: Science (New York, N.Y.) 20090320

Title: Prolactin secretion after hypothalamic deafferentation in beef calves: response to haloperidol, alpha-methyl-rho-tyrosine, thyrotropin-releasing hormone and ovariectomy.

Journal: Animal reproduction science 20090301

Title: Evaluation of thoracic tumors with (18)F-FMT and (18)F-FDG PET-CT: a clinicopathological study.

Journal: International journal of cancer 20090301

Title: The influence of catecholamine on the migration of gonadotropin-releasing hormone-producing neurons in the rat foetuses.

Journal: Brain structure & function 20090201

Title: Evidence for dopamine involvement in ambulation promoted by menthone in mice.

Journal: Pharmacology, biochemistry, and behavior 20090101

Title: Reduced D2-mediated signaling activity and trans-synaptic upregulation of D1 and D2 dopamine receptors in mice overexpressing the dopamine transporter.

Journal: Cellular signalling 20090101

Title: alpha(2)-Adrenoceptors mediate the acute inhibitory effect of fluoxetine on locus coeruleus noradrenergic neurons.

Journal: Neuropharmacology 20090101

Title: Homeostatic plasticity of striatal neurons intrinsic excitability following dopamine depletion.

Journal: PloS one 20090101

Title: Norepinephrine transporter regulation mediates the long-term behavioral effects of the antidepressant desipramine.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20081201

Title: Cyclic rapid fluctuation of hypertension and hypotension in pheochromocytoma.

Journal: Journal of clinical hypertension (Greenwich, Conn.) 20081201

Title: Dibutyryl cyclic AMP induces differentiation of human neuroblastoma SH-SY5Y cells into a noradrenergic phenotype.

Journal: Neuroscience letters 20081010

Title: The rewarding efficacy of brain stimulation and its modulation by dopaminergic drugs in young adult and old BN F344F1 rats.

Journal: Pharmacology, biochemistry, and behavior 20081001

Title: Role of alpha2-adrenoceptors in enhancement of antinociceptive effect in diabetic mice.

Journal: European journal of pharmacology 20080911

Title: Recurrent inhibitory network among striatal cholinergic interneurons.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20080827

Title: AMPT-induced monoamine depletion in humans: evaluation of two alternative [123I]IBZM SPECT procedures.

Journal: European journal of nuclear medicine and molecular imaging 20080701

Title: Antidepressant-like effect of rutin isolated from the ethanolic extract from Schinus molle L. in mice: evidence for the involvement of the serotonergic and noradrenergic systems.

Journal: European journal of pharmacology 20080610

Title: Small effect of dopamine release and no effect of dopamine depletion on [18F]fallypride binding in healthy humans.

Journal: Synapse (New York, N.Y.) 20080601

Title: The analgesic effect of paeoniflorin on neonatal maternal separation-induced visceral hyperalgesia in rats.

Journal: The journal of pain : official journal of the American Pain Society 20080601

Title: Twenty years of dopamine research: individual differences in the response of accumbal dopamine to environmental and pharmacological challenges.

Journal: European journal of pharmacology 20080513

Title: Neural response to catecholamine depletion in unmedicated subjects with major depressive disorder in remission and healthy subjects.

Journal: Archives of general psychiatry 20080501

Title: Endogenous dopamine (DA) renders dopaminergic cells vulnerable to challenge of proteasome inhibitor MG132.

Journal: Free radical research 20080501

Title: Endogenous dopamine enhances the neurotoxicity of 3-nitropropionic acid in the striatum through the increase of mitochondrial respiratory inhibition and free radicals production.

Journal: Neurotoxicology 20080301

Title: Polychlorinated biphenyl-induced oxidative stress in organotypic co-cultures: experimental dopamine depletion prevents reductions in GABA.

Journal: Neurotoxicology 20080301

Title: Effect of catecholamine depletion on increased blood pressure lability upon emergence from halothane anesthesia in rats: the role of sympathetic nervous activity in postanesthetic circulatory instability.

Journal: Journal of anesthesia 20080101

Title: Interaction of dopamine, female pheromones, locomotion and sex behavior in Drosophila melanogaster.

Journal: Journal of insect physiology 20080101

Title: Sympathetic nervous system and lymphocyte proliferation in the Fischer 344 rat spleen: a longitudinal study.

Journal: Neuroimmunomodulation 20080101

Title: Effect of endogenous catecholamines on apoptosis of Con A-activated lymphocytes of rats.

Journal: Journal of neuroimmunology 20071201

Title: Disruption of dopamine homeostasis underlies selective neurodegeneration mediated by alpha-synuclein.

Journal: The European journal of neuroscience 20071201

Title: An intact dopaminergic system is required for context-conditioned release of 5-HT in the nucleus accumbens of postweaning isolation-reared rats.

Journal: Neuroscience 20071026

Title: Role of neuronal nitric oxide in the regulation of vasopressin expression and release in response to inhibition of catecholamine synthesis and dehydration.

Journal: Neuroscience letters 20071022

Title: The effect of catecholamine depletion by alpha-methyl-para-tyrosine on measures of cognitive performance and sleep in abstinent MDMA users.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20070801

Title: Effects of acute dopamine depletion on the electrophysiological properties of striatal neurons.

Journal: Neuroscience research 20070701

Title: Antidepressant-like effect of lamotrigine in the mouse forced swimming test: evidence for the involvement of the noradrenergic system.

Journal: European journal of pharmacology 20070622

Title: Indirect role of alpha2-adrenoreceptors in anti-ulcer effect mechanism of nimesulide in rats.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20070501

Title: Methylamine-dependent release of nitric oxide and dopamine in the CNS modulates food intake in fasting rats.

Journal: British journal of pharmacology 20070401

Title: Effect of local (intracerebral and intracerebroventricular) administration of tyrosine hydroxylase inhibitor on the neuroendocrine dopaminergic neurons and prolactin release.

Journal: Ideggyogyaszati szemle 20070330

Title: Differential contribution of storage pools to the extracellular amount of accumbal dopamine in high and low responders to novelty: effects of reserpine.

Journal: Journal of neurochemistry 20070201

Title: Metyrosine in psychosis associated with 22q11.2 deletion syndrome: case report.

Journal: Journal of child and adolescent psychopharmacology 20070201

Title: The effects of age and streptozotocin diabetes on the sympathetic innervation in the rat penis.

Journal: Molecular and cellular biochemistry 20070101

Title: Differences in the cellular mechanism underlying the effects of amphetamine on prepulse inhibition in apomorphine-susceptible and apomorphine-unsusceptible rats.

Journal: Psychopharmacology 20070101

Title: Constant illumination causes spatially discrete dopamine depletion in the normal and degenerate retina.

Journal: Journal of chemical neuroanatomy 20070101

Title: Low dose alpha-methyl-para-tyrosine (AMPT) in the treatment of dystonia and dyskinesia.

Journal: The Journal of neuropsychiatry and clinical neurosciences 20070101

Title: Iron storage within dopamine neurovesicles revealed by chemical nano-imaging.

Journal: PloS one 20070101

Title: Subjective and behavioural consequences of striatal dopamine depletion in schizophrenia--findings from an in vivo SPECT study.

Journal: Schizophrenia research 20061201

Title: Appropriate premedication risk reduction during adrenal ablation.

Journal: Journal of vascular and interventional radiology : JVIR 20060801

Title: Tetrahydrobiopterin stimulates L-DOPA release from striatal tissue.

Journal: European journal of pharmacology 20060710

Title: Cocaine increases dopamine release by mobilization of a synapsin-dependent reserve pool.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20060322

Title: The partial dopamine D2-like receptor agonist terguride functions as an agonist in preweanling rats after a 5-day reserpine regimen.

Journal: Psychopharmacology 20060301

Title: Combined SPECT/CT imaging using 123I-IMT in the detection of recurrent or persistent head and neck cancer.

Journal: European radiology 20060201

Title: Dopamine-mediated actions of ephedrine in the rat substantia nigra.

Journal: Brain research 20060119

Title: Dopamine-related and caspase-independent apoptosis in dopaminergic neurons induced by overexpression of human wild type or mutant alpha-synuclein.

Journal: Experimental cell research 20060115

Title: [NO-synthase involvement in regulation of vasopressinergic neurons of rat hypothalamus during early stages of postnatal development].

Journal: Zhurnal evoliutsionnoi biokhimii i fiziologii 20060101

Title: [Catecholamines and NO involvement in apoptosis regulation of nonapetidergetic neurons of neonatal rats].

Journal: Zhurnal evoliutsionnoi biokhimii i fiziologii 20060101

Title: Effects of alpha-methyl-p-tyrosine on extracellular dopamine levels in the nucleus accumbens and the dorsal striatum of freely moving rats.

Journal: Journal of oral science 20051201

Title: Locomotor activity and evoked dopamine release are reduced in mice overexpressing A30P-mutated human alpha-synuclein.

Journal: Neurobiology of disease 20051101

Title: Tyrosine and tyramine increase endogenous ganglionic morphine and dopamine levels in vitro and in vivo: cyp2d6 and tyrosine hydroxylase modulation demonstrates a dopamine coupling.

Journal: Medical science monitor : international medical journal of experimental and clinical research 20051101

Title: Effect of endogenous catecholamines in lymphocytes on lymphocyte function.

Journal: Journal of neuroimmunology 20051001

Title: Halothane enhances dopamine metabolism at presynaptic sites in a calcium-independent manner in rat striatum.

Journal: British journal of anaesthesia 20051001

Title: Reirradiation of recurrent high-grade gliomas using amino acid PET (SPECT)/CT/MRI image fusion to determine gross tumor volume for stereotactic fractionated radiotherapy.

Journal: International journal of radiation oncology, biology, physics 20051001

Title: Subjective experiences during dopamine depletion.

Journal: The American journal of psychiatry 20050901

Title: Dopamine-independent locomotor actions of amphetamines in a novel acute mouse model of Parkinson disease.

Journal: PLoS biology 20050801

Title: A developmental role for catecholamines in Drosophila behavior.

Journal: Pharmacology, biochemistry, and behavior 20050801

Title: Characterization of noradrenaline release in the locus coeruleus of freely moving awake rats by in vivo microdialysis.

Journal: Psychopharmacology 20050701

Title: Differential modulation of anterior cingulate cortical activity by afferents from ventral tegmental area and mediodorsal thalamus.

Journal: The European journal of neuroscience 20050601

Title: Dopamine-dependent neurotoxicity of lipopolysaccharide in substantia nigra.

Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20050301

Title: L-dopa and dopamine enhance the formation of aggregates under proteasome inhibition in PC12 cells.

Journal: FEBS letters 20050214

Title: The non-peptidic delta opioid receptor agonist TAN-67 enhances dopamine efflux in the nucleus accumbens of freely moving rats via a mechanism that involves both glutamate and free radicals.

Journal: Neuroscience 20050101

Title: The effect of endogenous dopamine in rotenone-induced toxicity in PC12 cells.

Journal: Antioxidants & redox signaling 20050101

Title: Contribution of vesicular and cytosolic dopamine to the increased striatal dopamine efflux elicited by intrastriatal injection of dexamphetamine.

Journal: Neuroscience 20050101

Title: [Catecholamines in regulation of development of GnRH neurons of rat fetuses].

Journal: Ontogenez 20050101

Title: Role of alpha-synuclein in presynaptic dopamine recruitment.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20041208

Title: Development and validation of a liquid chromatography-tandem mass spectrometric method for the determination of alpha-methyltyrosine in human plasma.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20041025

Title: Effects of blocking the dopamine biosynthesis and of neurotoxic dopamine depletion with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) on voluntary wheel running in mice.

Journal: Behavioural brain research 20041005

Title: Effect of catecholamines on IL-2 production and NK cytotoxicity of rats in vitro.

Journal: Acta pharmacologica Sinica 20041001

Title: Music improves dopaminergic neurotransmission: demonstration based on the effect of music on blood pressure regulation.

Journal: Brain research 20040806

Title: Female-specific regulation of cuticular hydrocarbon biosynthesis by dopamine in Drosophila melanogaster.

Journal: Insect biochemistry and molecular biology 20040801

Title: Inhibition of dopamine synthesis with alpha-methyl-p-tyrosine abolishes the enhancement of methamphetamine-induced extracellular dopamine levels in the amygdala of rats with excitotoxic lesions of the entorhinal cortex.

Journal: Neuroscience letters 20040206

Title: Methamphetamine produces neuronal inclusions in the nigrostriatal system and in PC12 cells.

Journal: Journal of neurochemistry 20040101

Title: Expression of tyrosine hydroxylase in lymphocytes and effect of endogenous catecholamines on lymphocyte function.

Journal: Neuroimmunomodulation 20040101

Title: [Effect of catecholamines on migration and differentiation of gonadotropin releasing hormone-neurons in rats].

Journal: Ontogenez 20040101

Title: Depletion and restoration of endogenous monoamines affects beta-CIT binding to serotonin but not dopamine transporters in non-human primates.

Journal: Journal of neural transmission. Supplementum 20040101

Title: Pheochromocytoma.

Journal: Scandinavian journal of surgery : SJS : official organ for the Finnish Surgical Society and the Scandinavian Surgical Society 20040101

Title: Dopamine is involved in selectivity of dopaminergic neuronal death by rotenone.

Journal: Neuroreport 20031219

Title: Comparison of effects of dual transporter inhibitors on monoamine transporters and extracellular levels in rats.

Journal: Neuropharmacology 20031201

Title: Monoamine depletion in psychiatric and healthy populations: review.

Journal: Molecular psychiatry 20031101

Title: Gliomatosis cerebri evaluated by 18Falpha-methyl tyrosine positron-emission tomography.

Journal: Neuroradiology 20031001

Title: The new neurokinin 1-sensitive receptor mediates the facilitation by endogenous tachykinins of the NMDA-evoked release of acetylcholine after suppression of dopaminergic transmission in the matrix of the rat striatum.

Journal: Journal of neurochemistry 20031001

Title: Parkin gene inactivation alters behaviour and dopamine neurotransmission in the mouse.

Journal: Human molecular genetics 20030915

Title: Neurochemical aspects of susceptibility to depression.

Journal: JAMA 20030910

Title: Dopamine depletion and in vivo binding of PET D1 receptor radioligands: implications for imaging studies in schizophrenia.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20030901

Title: Regional brain metabolic correlates of alpha-methylparatyrosine-induced depressive symptoms: implications for the neural circuitry of depression.

Journal: JAMA 20030618

Title: Evidence for a monoamine mediated, opioid-independent, antihyperalgesic effect of venlafaxine, a non-tricyclic antidepressant, in a neurogenic pain model in rats.

Journal: Pain 20030601

Title: Anterograde delivery of brain-derived neurotrophic factor to striatum via nigral transduction of recombinant adeno-associated virus increases neuronal death but promotes neurogenic response following stroke.

Journal: The European journal of neuroscience 20030601

Title: Modulation of the ability of clozapine to facilitate NMDA- and electrically evoked responses in pyramidal cells of the rat medial prefrontal cortex by dopamine: pharmacological evidence.

Journal: The European journal of neuroscience 20030301

Title: The L-DOPA-sparing effect of R-(-)-1-(benzofuran-2-yl)-2-propylaminopentane hydrochloride [(-)-BPAP] in reserpine-pretreated rats.

Journal: Life sciences 20030207

Title: Catecholamines in a macrophage cell line.

Journal: Journal of neuroimmunology 20030201

Title: Evidence for the involvement of dopamine in ambulation promoted by menthol in mice.

Journal: Journal of pharmacological sciences 20030201

Title: Effects of catecholamine depletion on D2 receptor binding, mood, and attentiveness in humans: a replication study.

Journal: Pharmacology, biochemistry, and behavior 20030101

Title: Brain tyrosine hydroxylase in the catfish Heteropneustes fossilis: annual and circadian variations, and sex and regional differences in enzyme activity and some kinetic properties.

Journal: General and comparative endocrinology 20030101

Title: [Effect of catecholamines synthesis blockade on functional status of hypothalamic vasopressinergic neurons in dehydrated rats].

Journal: Zhurnal evoliutsionnoi biokhimii i fiziologii 20030101

Title: Concomitant effect of acetylcholine and dopamine on carotid chemosensory activity in catecholamine depleted cats.

Journal: Advances in experimental medicine and biology 20030101

Title: Catecholamine production and tyrosine hydroxylase expression in peripheral blood mononuclear cells from multiple sclerosis patients: effect of cell stimulation and possible relevance for activation-induced apoptosis.

Journal: Journal of neuroimmunology 20021201

Title: Noninvasive grading of untreated gliomas: a comparative study of MR imaging and 3-(iodine 123)-L-alpha-methyltyrosine SPECT.

Journal: Radiology 20021101

Title: Modulation of stress-induced and stimulated hyperprolactinemia with the group II metabotropic glutamate receptor selective agonist, LY379268.

Journal: Neuropharmacology 20021001

Title: Role of cerebral dopamine but not plasma insulin, leptin and glucocorticoid in the development of tolerance to the anorectic effect of amphetamine.

Journal: Neuroscience research 20020901

Title: Interaction of stress and noradrenergic drugs in the control of picrotoxin-induced seizures.

Journal: Epilepsy research 20020901

Title: Neurochemical changes in mice following physical or psychological stress exposures.

Journal: Behavioural brain research 20020821

Title: The fetal and neonatal brain protein neuronatin protects PC12 cells against certain types of toxic insult.

Journal: Brain research. Developmental brain research 20020630

Title: Endocrine effects of centrally injected nociceptin in the rat.

Journal: Brain research 20020531

Title: Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells.

Journal: The Journal of biological chemistry 20020419

Title: Peripheral 5-HT(2A)-receptor-mediated formation of an inhibitor of atrial natriuretic peptide binding involves inflammation.

Journal: European journal of pharmacology 20020405

Title: Monoamine depletion in unmedicated depressed subjects.

Journal: Biological psychiatry 20020315

Title: Activation by serotonin and noradrenaline of vasopressin and oxytocin expression in the mouse paraventricular and supraoptic nuclei.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20020301

Title: Effect of depleting vesicular and cytoplasmic dopamine on methylenedioxymethamphetamine neurotoxicity.

Journal: Journal of neurochemistry 20020301

Title: Pretreatment evaluation of carcinomas of the hypopharynx and larynx with 18F-fluorodeoxyglucose, 123I-alpha-methyl-L-tyrosine and 99mTc-hexakis-2-methoxyisobutylisonitrile.

Journal: European journal of nuclear medicine and molecular imaging 20020301

Title: Noradrenergic content and turnover rate in kidney and heart shows gender and strain differences.

Journal: Journal of applied physiology (Bethesda, Md. : 1985) 20020201

Title: Clinical value of iodine-123-alpha-methyl-L-tyrosine single-photon emission tomography in the differential diagnosis of recurrent brain tumor in patients pretreated for glioma at follow-up.

Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20020115

Title: Effects of pharmacological agents upon a transgenic model of Parkinson's disease in Drosophila melanogaster.

Journal: The Journal of pharmacology and experimental therapeutics 20020101

Title: Dopamine depletion results in increased neostriatal D(2), but not D(1), receptor binding in humans.

Journal: Molecular psychiatry 20020101

Title: Nitecapone and selegiline as effective adjuncts to L-DOPA in reserpine-induced catatonia in mice.

Journal: Methods and findings in experimental and clinical pharmacology 20020101

Title: The effects of dopamine synthesis inhibitors and dopamine antagonists on regeneration in the hydra Hydra attenuata.

Journal: Neuroscience and behavioral physiology 20020101

Title: I-123-lodo-alpha-methyl tyrosine SPECT in non-parenchymal brain tumours.

Journal: Nuklearmedizin. Nuclear medicine 20020101

Title: Involvement of serotonergic and dopaminergic mechanisms in hyperthermia induced by a serotonin-releasing drug, p-chloroamphetamine in mice.

Journal: European journal of pharmacology 20011102

Title: Subjective effects of AMPT-induced dopamine depletion in schizophrenia: correlation between dysphoric responses and striatal D(2) binding ratios on SPECT imaging.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20011101

Title: Effects of alpha-methyl-para-tyrosine-induced catecholamine depletion in patients with seasonal affective disorder in summer remission.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20011101

Title: Role of monoamine oxidase inhibition and monoamine depletion in fenfluramine-induced neurotoxicity and serotonin release.

Journal: Pharmacology & toxicology 20011101

Title: Catecholamines in murine bone marrow derived mast cells.

Journal: Journal of neuroimmunology 20011001

Title: Dopamine mediates striatal malonate toxicity via dopamine transporter-dependent generation of reactive oxygen species and D2 but not D1 receptor activation.

Journal: Journal of neurochemistry 20011001

Title: Uraemia suppresses central dopaminergic metabolism and impairs motor activity in rats.

Journal: Intensive care medicine 20011001

Title: Schwannoma of the extremities: the role of PET in preoperative planning.

Journal: European journal of nuclear medicine 20011001

Title: Antidepressant-like behavioral effects in 5-hydroxytryptamine(1A) and 5-hydroxytryptamine(1B) receptor mutant mice.

Journal: The Journal of pharmacology and experimental therapeutics 20010901

Title: A simple method to measure baseline occupancy of neostriatal dopamine D2 receptors by dopamine in vivo in healthy subjects.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20010801

Title: Effect of neonatal treatment with monosodium glutamate on dopaminergic and L-DOPA-ergic neurons of the medial basal hypothalamus and on prolactin and MSH secretion of rats.

Journal: Brain research bulletin 20010801

Title: Detection of malignant tumors: whole-body PET with fluorine 18 alpha-methyl tyrosine versus FDG--preliminary study.

Journal: Radiology 20010701

Title: Effects of cannabinoids on prefrontal neuronal responses to ventral tegmental area stimulation.

Journal: The European journal of neuroscience 20010701

Title: Effect of alpha-MPT on imipramine induced antinociception in rats.

Journal: Indian journal of physiology and pharmacology 20010701

Title: Evidence against an essential role of endogenous brain dopamine in methamphetamine-induced dopaminergic neurotoxicity.

Journal: Journal of neurochemistry 20010601

Title: Sympathetic nervous system activity in adipose tissues during pregnancy and lactation of the rat.

Journal: Journal of dairy science 20010601

Title: Effect of ultraviolet radiation on melanogenesis in four different types of cultured bovine ocular pigmented cells.

Journal: Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie 20010401

Title: Dialysate dihydroxyphenylglycol as a window for in situ axoplasmic norepinephrine disposition.

Journal: Neurochemistry international 20010301

Title: Involvement of tyrosine hydroxylase upregulation in cyclosporine-induced hypertension.

Journal: Japanese journal of pharmacology 20010301

Title: Early changes in neuropeptide mRNA expression in the striatum following reserpine treatment.

Journal: Experimental neurology 20010201

Title: Dopaminergic input to the ventromedial hypothalamus facilitates the oestrogen-induced luteinizing hormone surge in ewes.

Journal: Neuroendocrinology 20010201

Title: Characterization of 3-[(123)I]iodo-L-alpha-methyl tyrosine transport in astrocytes of neonatal rats.

Journal: Journal of neurochemistry 20010101

Title: Antagonist of pituitary adenylate cyclase activating polypeptide suppresses prolactin secretion without changing the activity of dopamine neurons in lactating rats.

Journal: Neuroendocrinology 20010101

Title: Glutamate regulates the spontaneous and evoked release of dopamine in the rat striatum.

Journal: Neuroscience 20010101

Title: Short-time application of latanoprost does not stimulate melanogenesis in bovine ocular melanin-containing cells in vitro.

Journal: Ophthalmic research 20010101

Title: Prolonged inhibition of presynaptic catecholamine synthesis with alpha-methyl-para-tyrosine attenuates the circadian rhythm of human TSH secretion.

Journal: Journal of the Society for Gynecologic Investigation 20010101

Title: Involvement of tyrosine hydroxylase up regulation in dexamethasone-induced hypertension of rats.

Journal: Life sciences 20000908

Title: Efficacy of pramipexole, a new dopamine receptor agonist, to relieve the parkinsonian-like muscle rigidity in rats.

Journal: European journal of pharmacology 19991126

Title: alpha2C adrenoceptors inhibit adenylyl cyclase in mouse striatum: potential activation by dopamine.

Journal: The Journal of pharmacology and experimental therapeutics 19990601

Title: Effects of N-propargyl-1-(R)aminoindan (rasagiline) in models of motor and cognition disorders.

Journal: Journal of neural transmission. Supplementum 19980101

Title: Non-amphetaminic mechanism of stimulant locomotor effect of modafinil in mice.

Journal: European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 19951201

Title: Does reserpine induce parkinsonian rigidity?

Journal: Journal of neural transmission. Parkinson's disease and dementia section 19950101

Title: Noradrenaline but not dopamine involved in NMDA receptor-mediated hyperalgesia induced by theophylline in awake rats.

Journal: European journal of pharmacology 19940124

Title: The involvement of noradrenaline, 5-hydroxytryptamine and acetylcholine in imipramine-induced seizures in mice.

Journal: Experientia 19931015

Title: Rapid development of dopaminergic supersensitivity in reserpine-treated rats demonstrated with 14C-2-deoxyglucose autoradiography.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 19920701

Title: The role of oxytocin-dopamine interactions in cocaine-induced locomotor hyperactivity.

Journal: Neuropharmacology 19900401

Title: Oxytocin attenuates the cocaine-induced exploratory hyperactivity in mice.

Journal: Neuroreport 19900101

Title: A dystonia-like syndrome after neuropeptide (MSH/ACTH) stimulation of the rat locus ceruleus.

Journal: Advances in neurology 19880101

Title: alpha-Methyltyrosine blocks methylamphetamine-induced degeneration in the rat somatosensory cortex.

Journal: Brain research 19860212

Title: Pharmacologic studies of the central action of zopiclone: effects on locomotor activity and brain monoamines in rats.

Journal: International journal of clinical pharmacology, therapy, and toxicology 19850301

Title: Effects of dopamine agonists, catecholamine depletors, and cholinergic and GABAergic drugs on acute dyskinesias in squirrel monkeys.

Journal: Psychopharmacology 19840101

Title: Effect of alpha-methyl-p-tyrosine on neuroleptic-induced catalepsy in rat.

Journal: Indian journal of physiology and pharmacology 19830101

Title: Long-term treatment of tardive dyskinesia with presynaptically acting dopamine-depleting agents.

Journal: Advances in neurology 19830101

Title: Biochemical and pharmacologic effects of alpha-methyltyrosine in man.

Journal: The Journal of clinical investigation 19680301

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Tags:658-48-0 Molecular Formula|658-48-0 MDL|658-48-0 SMILES|658-48-0 D,L-alpha-methyltyrosine