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6681-15-8,MFCD00238625
Catalog No.:AA006QXF

6681-15-8 | Jatrorrhizine Hydrochloride

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Purity
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1mg
≥98%
in stock  
$48.00   $33.00
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10mg
≥90%(HPLC)
in stock  
$140.00   $98.00
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250mg
98%
in stock  
$420.00   $294.00
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1g
98%
in stock  
$974.00   $682.00
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA006QXF
Chemical Name:
Jatrorrhizine Hydrochloride
CAS Number:
6681-15-8
Molecular Formula:
C20H20ClNO4
Molecular Weight:
373.8301
MDL Number:
MFCD00238625
SMILES:
COc1cc2c(cc1O)CC[n+]1c2cc2ccc(c(c2c1)OC)OC.[Cl-]
Properties
Properties
 
Form:
Solid  
MP:
>126ºC (dec.)  
Storage:
Inert atmosphere;Room Temperature;  

Computed Properties
 
Complexity:
461  
Covalently-Bonded Unit Count:
2  
Heavy Atom Count:
26  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
3  

Literature

Title: Quality evaluation and species differentiation of Rhizoma coptidis by using proton nuclear magnetic resonance spectroscopy.

Journal: Analytica chimica acta 20121017

Title: Isoquinoline alkaloids from Tinospora cordifolia inhibit rat lens aldose reductase.

Journal: Phytotherapy research : PTR 20120901

Title: Analysis of four alkaloids of Coptis chinensis in rat plasma by high performance liquid chromatography with electrochemical detection.

Journal: Analytica chimica acta 20120806

Title: Discrimination of Phellodendron amurense and P. chinense based on DNA analysis and the simultaneous analysis of alkaloids.

Journal: Archives of pharmacal research 20120601

Title: Pharmacokinetics and metabolism of jatrorrhizine, a gastric prokinetic drug candidate.

Journal: Biopharmaceutics & drug disposition 20120401

Title: Effect of jatrorrhizine on delayed gastrointestinal transit in rat postoperative ileus.

Journal: The Journal of pharmacy and pharmacology 20120301

Title: Determination of protoberberine alkaloids in Rhizoma Coptidis by ERETIC ¹H NMR method.

Journal: Journal of pharmaceutical and biomedical analysis 20120223

Title: Determination of berberine, palmatine and jatrorrhizine in rabbit plasma by liquid chromatography-electrospray ionization-mass spectrometry.

Journal: Journal of pharmaceutical and biomedical analysis 20111215

Title: Therapeutic potential of nucleic acid-binding isoquinoline alkaloids: binding aspects and implications for drug design.

Journal: Medicinal research reviews 20111101

Title: Micelle to solvent stacking of two alkaloids in nonaqueous capillary electrophoresis.

Journal: Journal of chromatography. A 20110826

Title: The effects of jatrorrhizine on contractile responses of rat ileum.

Journal: European journal of pharmacology 20110801

Title: Ionic liquid sensitized fluorescence determination of four isoquinoline alkaloids.

Journal: Talanta 20110715

Title: Neuroprotective effect of Jatrorrhizine on hydrogen peroxide-induced cell injury and its potential mechanisms in PC12 cells.

Journal: Neuroscience letters 20110712

Title: Synthesis of 9-substituted derivatives of berberine as anti-HIV agents.

Journal: European journal of medicinal chemistry 20110401

Title: Intestinal absorption mechanisms of berberine, palmatine, jateorhizine, and coptisine: involvement of P-glycoprotein.

Journal: Xenobiotica; the fate of foreign compounds in biological systems 20110401

Title: Bioactivities of berberine metabolites after transformation through CYP450 isoenzymes.

Journal: Journal of translational medicine 20110101

Title: Simultaneous determination of baicalin, baicalein, wogonin, berberine, palmatine and jatrorrhizine in rat plasma by liquid chromatography-tandem mass spectrometry and application in pharmacokinetic studies after oral administration of traditional Chinese medicinal preparations containing scutellaria-coptis herb couple.

Journal: Journal of pharmaceutical and biomedical analysis 20101102

Title: [Simultaneous determination of jatrorrhizine, palmatine, berberine, and obacunone in Phellodendri Amurensis Cortex by RP-HPLC].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20100801

Title: Rhizoma coptidis and berberine-induced activation of murine microglia N9 cells.

Journal: Journal of ethnopharmacology 20100504

Title: [Simultaneous determination of the five alkaloids in Rhizoma Coptidis by nonaqueous capillary electrophoresis].

Journal: Se pu = Chinese journal of chromatography 20100401

Title: [In situ intestinal absorption kinetics of berberine and jatrorrhizine from extractive Rhizoma Coptidis in rats].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20100301

Title: The application of digital image recognition to the analysis of two-dimensional fingerprints.

Journal: Analytica chimica acta 20100111

Title: [Preliminary study to investigate dynamic extract process of Huanglian Jiedu Tang and the mechanism of subsidence produce].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20100101

Title: [Effects of extracts and active components of Rhizoma Coptidis on contraction of circular smooth muscle isolated from guinea pig gastric antrum].

Journal: Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine 20090901

Title: [Pharmacokinetics of three alkaloids in Huanglianjiedu decoction in rat serum by LC-MS-MS].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20090501

Title: [Effect of additives on absorption of Coptis chinensis total alkaloids and pharmacokinetics in mice].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20090201

Title: Synthesis and antimicrobial activity of 3-octyloxy-8-alkyljatrorrhizine derivatives.

Journal: Journal of Asian natural products research 20090101

Title: Development of a rapid resolution liquid chromatographic method for simultaneous analysis of four alkaloids in Rhizoma coptidis under different cultivation conditions.

Journal: Journal of AOAC International 20090101

Title: Simple and reliable methods for the determination of sixteen marker components for quality control of Daochi pill by HPLC coupled with diode array detection.

Journal: Phytochemical analysis : PCA 20090101

Title: Chinese herbal medicinal ingredients inhibit secretion of IL-6, IL-8, E-selectin and TXB2 in LPS-induced rat intestinal microvascular endothelial cells.

Journal: Immunopharmacology and immunotoxicology 20090101

Title: LC/MS/MS for identification of in vivo and in vitro metabolites of jatrorrhizine.

Journal: Biomedical chromatography : BMC 20081201

Title: [Variation patterns of Coptis teeta biomass and its major active compounds along an altitude gradient].

Journal: Ying yong sheng tai xue bao = The journal of applied ecology 20080701

Title: Studies on alkaloids binding to GC-rich human survivin promoter DNA using positive and negative ion electrospray ionization mass spectrometry.

Journal: Journal of mass spectrometry : JMS 20080301

Title: Simultaneous determination of berberine, palmatine and jatrorrhizine by liquid chromatography-tandem mass spectrometry in rat plasma and its application in a pharmacokinetic study after oral administration of coptis-evodia herb couple.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20080301

Title: [Analysis of the main components of coptis-evodia herb couple by HPLC-DAD-MS].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20080301

Title: Synthesis and antimicrobial activity of 3-alkoxyjatrorrhizine derivatives.

Journal: Planta medica 20080201

Title: High performance liquid chromatography-mass spectrometry analysis of protoberberine alkaloids in medicine herbs.

Journal: Journal of separation science 20070401

Title: Pharmacokinetics of berberine and its main metabolites in conventional and pseudo germ-free rats determined by liquid chromatography/ion trap mass spectrometry.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20061201

Title: [Quality analysis and evaluation of Rhizoma Coptidis under different cultivation conditions].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20061001

Title: [Determination of 3 kinds of components in huanglian jiedu decoction by HPLC under different UV wavelengths].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20061001

Title: [Liquid chromatography-tandem electrospray ionization ion trap mass spectrometric assay for the metabolites of jatrorrhizine in rat urine].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20060901

Title: Spacer length and attaching position-dependent binding of synthesized protoberberine dimers to double-stranded DNA.

Journal: Bioorganic & medicinal chemistry 20060701

Title: Nonaqueous capillary electrophoresis coupled with laser-induced native fluorescence detection for the analysis of berberine, palmatine, and jatrorrhizine in Chinese herbal medicines.

Journal: Journal of separation science 20060601

Title: [Qualitative and quantitative determination of the main components of huanglianjiedu decoction by HPLC-UV/MS].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20060401

Title: Capillary electrochromatography with a neutral monolithic column for classification of analytes and determination of basic drugs in human serum.

Journal: Electrophoresis 20050901

Title: [Chemical constituents from Corydalis humosa].

Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20050701

Title: [Quality assessment of Coptis chinensis in China].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20050401

Title: Binding of the bioactive component jatrorrhizine to human serum albumin.

Journal: Biochimica et biophysica acta 20050211

Title: Analysis of protoberberine alkaloids in several herbal drugs and related medicinal preparations by non-aqueous capillary electrophoresis.

Journal: Journal of separation science 20050101

Title: Hypoglycemic activity of jatrorrhizine.

Journal: Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 20050101

Title: [Establishment of the control substance of plant drug and fingerprints of Coptis chinensis].

Journal: Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae 20041201

Title: Structural elucidation and identification of alkaloids in Rhizoma Coptidis by electrospray ionization tandem mass spectrometry.

Journal: Journal of mass spectrometry : JMS 20041101

Title: Oxygen activation by photoexcited protoberberinium alkaloids from Mahonia aquifolium.

Journal: Phytotherapy research : PTR 20040801

Title: Antimicrobial activity of Mahonia aquifolium crude extract and its major isolated alkaloids.

Journal: Phytotherapy research : PTR 20040801

Title: [Distribution of four alkaloids in plants of Berberis].

Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20040201

Title: [Determination of four alkaloids in Berberis plants by HPLC].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20031201

Title: High-performance capillary electrophoresis for determining the contents of berberine, jatrorrhizine and palmatine in Gegenqinlian decoction.

Journal: Di 1 jun yi da xue xue bao = Academic journal of the first medical college of PLA 20030701

Title: [Study on the solubility changes of Rhizoma Coptidis' main chemical constituents influenced by the proportion of Rhizoma Coptidis and Fructus Evodiae].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20030701

Title: Effect of Mahonia aquifolium active compounds on interleukin-8 production in the human monocytic cell line THP-1.

Journal: Planta medica 20020301

Title: Identification of three sulfate-conjugated metabolites of berberine chloride in healthy volunteers' urine after oral administration.

Journal: Acta pharmacologica Sinica 20020101

Title: Potential antimutagenic activity of berberine, a constituent of Mahonia aquifolium.

Journal: BMC complementary and alternative medicine 20020101

Title: [Study on active constituents of traditional Chinese medicine reversing multidrug resistance of tumor cells in vitro].

Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20010901

Title: Evaluation of natural products as inhibitors of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase.

Journal: Journal of natural products 19910101

Title: Sun S, et al. Jatrorrhizine reduces 5-HT and NE uptake via inhibition of uptake-2 transporters and produces antidepressant-like action in mice. Xenobiotica. 2019 Oct;49(10):1237-1243.

Title: Xiaofei Jiang, et al. Synthesis and Biological Evaluation of Novel Jatrorrhizine Derivatives with Amino Groups Linked at the 3-Position as Inhibitors of Acetylcholinesterase. Research Article Volume 2017

Title: C W Wright, et al. In vitro antiplasmodial, antiamoebic, and cytotoxic activities of some monomeric isoquinoline alkaloids. J Nat Prod. 2000 Dec;63(12):1638-40.

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