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6702-50-7,MFCD01321262
Catalog No.:AA003RPM

6702-50-7 | Methyl 3-hydroxy-4-methoxybenzoate

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1g
97%
in stock  
$14.00   $10.00
- +
5g
95%
in stock  
$18.00   $13.00
- +
25g
95%
in stock  
$31.00   $22.00
- +
100g
95%
in stock  
$105.00   $74.00
- +
  • Technical Information
  • Properties
  • Upstream Synthesis Route
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Upstream Synthesis Route
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA003RPM
Chemical Name:
Methyl 3-hydroxy-4-methoxybenzoate
CAS Number:
6702-50-7
Molecular Formula:
C9H10O4
Molecular Weight:
182.1733
MDL Number:
MFCD01321262
SMILES:
COC(=O)c1ccc(c(c1)O)OC
Properties
Properties
 
BP:
327.7°C at 760 mmHg  
Form:
Solid  
MP:
64-67 °C(lit.);  
Storage:
Keep in dry area;Room Temperature;  

Computed Properties
 
Complexity:
181  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
13  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
3  
XLogP3:
1.8  

Upstream Synthesis Route

[1]Patent:WO2005/9389,2005,A2,.Locationinpatent:Page/Pagecolumn139

[2]Patent:WO2005/9389,2005,A2,.Locationinpatent:Page/Pagecolumn139

[3]JournalofOrganicChemistry,1985,vol.50,#2,p.217-231

[4]BioorganicandMedicinalChemistryLetters,2002,vol.12,#20,p.2893-2897

[5]OrganicandBiomolecularChemistry,2016,vol.14,#11,p.3061-3068

[6]Patent:WO2006/117653,2006,A1,.Locationinpatent:Page/Pagecolumn46

[7]ChemicalCommunications,2003,#10,p.1170-1171

[8]BioorganicandMedicinalChemistryLetters,2010,vol.20,#2,p.718-721

[9]IndianJournalofChemistry-SectionBOrganicandMedicinalChemistry,2014,vol.53B,#10,p.1269-1274

[10]JournalofOrganicChemistry,2017,vol.82,#7,p.3990-3995

[11]BioorganicandMedicinalChemistryLetters,2011,vol.21,#12,p.3637-3640

[12]Patent:WO2008/125867,2008,A2,.Locationinpatent:Page/Pagecolumn25-26

[13]Patent:CN108752248,2018,A,.Locationinpatent:Paragraph0036-0038;0045-0047;0054-0056

[14]JournalofHeterocyclicChemistry,1990,vol.27,#7,p.1957-1961

[15]Tetrahedron,2001,vol.57,#2,p.319-329

[16]JournaloftheChemicalSociety,1939,p.1159

[17]JournaloftheChemicalSociety,1948,p.265

[18]JournaloftheChemicalSociety,1930,p.817,818

[19]ChemischeBerichte,1941,vol.74,p.79,94

[20]JournalofAgriculturalandFoodChemistry,2003,vol.51,#24,p.6953-6956

[21]JournalofMedicinalChemistry,2005,vol.48,#9,p.3290-3312

[22]Patent:WO2007/58338,2007,A2,.Locationinpatent:Page/Pagecolumn45

[23]Patent:EP2119702,2009,A1,.Locationinpatent:Page/Pagecolumn107

[24]Patent:EP1217000,2002,A1,.Locationinpatent:Page38

[25]ACSMedicinalChemistryLetters,2010,vol.1,#4,p.145-149

[26]Patent:WO2014/34958,2014,A1,.Locationinpatent:Page/Pagecolumn59

[27]ChemistryofNaturalCompounds,2015,vol.51,#4,p.620-625

[28]Khim.Prir.Soedin.,2015,vol.51,#4,p.536-540,5

[29]AngewandteChemie-InternationalEdition,2016,vol.55,#27,p.7821-7825

[30]Angew.Chem.,2016,vol.128,p.7952-7956,5

[31]Patent:WO2017/199227,2017,A1,.Locationinpatent:Page/Pagecolumn9-10

[32]JournalofMedicinalChemistry,2017,vol.60,#24,p.10188-10204

[33]JournalofOrganicChemistry,2018,vol.83,#17,p.9667-9681

[34]Patent:EP973746,2003,B1,.Locationinpatent:Page/Pagecolumn52

[1]Patent:CN105153065,2017,B,.Locationinpatent:Paragraph0157;0158;0159

[2]OrganicandBiomolecularChemistry,2005,vol.3,#12,p.2271-2281

[3]JournalofMolecularLiquids,2017,vol.242,p.1085-1095

[1]Patent:WO2014/158209,2014,A1,.Locationinpatent:Page/Pagecolumn10

[1]Patent:US2002/173656,2002,A1,

[2]Patent:US2002/198195,2002,A1,

[3]Patent:US5208247,1993,A,

[4]Patent:US5603868,1997,A,

[5]Patent:US6268387,2001,B1,

[6]Patent:US6384080,2002,B1,

[1]Patent:US6169093,2001,A,

Downstream Synthesis Route

[1]Patent:WO2005/9389,2005,A2.Locationinpatent:Page/Pagecolumn139

[2]JournalofOrganicChemistry,1985,vol.50,p.217-231

[3]BioorganicandMedicinalChemistryLetters,2002,vol.12,p.2893-2897

[4]OrganicandBiomolecularChemistry,2016,vol.14,p.3061-3068

[5]Patent:WO2006/117653,2006,A1.Locationinpatent:Page/Pagecolumn46

[6]ChemicalCommunications,2003,p.1170-1171

[7]BioorganicandMedicinalChemistryLetters,2010,vol.20,p.718-721

[8]IndianJournalofChemistry-SectionBOrganicandMedicinalChemistry,2014,vol.53B,p.1269-1274

[9]JournalofOrganicChemistry,2017,vol.82,p.3990-3995

[10]BioorganicandMedicinalChemistryLetters,2011,vol.21,p.3637-3640

[11]Patent:WO2008/125867,2008,A2.Locationinpatent:Page/Pagecolumn25-26

[12]Patent:CN108752248,2018,A.Locationinpatent:Paragraph0036-0038;0045-0047;0054-0056

[13]JournalofHeterocyclicChemistry,1990,vol.27,p.1957-1961

[14]Tetrahedron,2001,vol.57,p.319-329

[15]JournaloftheChemicalSociety,1939,p.1159    JournaloftheChemicalSociety,1948,p.265

[16]ChemischeBerichte,1941,vol.74,p.79,94

[17]JournalofAgriculturalandFoodChemistry,2003,vol.51,p.6953-6956

[18]JournalofMedicinalChemistry,2005,vol.48,p.3290-3312

[19]Patent:WO2007/58338,2007,A2.Locationinpatent:Page/Pagecolumn45

[20]Patent:EP2119702,2009,A1.Locationinpatent:Page/Pagecolumn107

[21]Patent:EP1217000,2002,A1.Locationinpatent:Page38

[22]ACSMedicinalChemistryLetters,2010,vol.1,p.145-149

[23]Patent:WO2014/34958,2014,A1.Locationinpatent:Page/Pagecolumn59

[24]ChemistryofNaturalCompounds,2015,vol.51,p.620-625    Khim.Prir.Soedin.,2015,vol.51,p.536-540,5

[25]AngewandteChemie-InternationalEdition,2016,vol.55,p.7821-7825    Angew.Chem.,2016,vol.128,p.7952-7956,5

[26]Patent:WO2017/199227,2017,A1.Locationinpatent:Page/Pagecolumn9-10

[27]JournalofMedicinalChemistry,2017,vol.60,p.10188-10204

[28]JournalofOrganicChemistry,2018,vol.83,p.9667-9681

[29]Patent:EP973746,2003,B1.Locationinpatent:Page/Pagecolumn52

[1]IndianJournalofChemistry-SectionBOrganicandMedicinalChemistry,2014,vol.53B,p.1269-1274

[2]JournaloftheChemicalSociety,1930,p.817,818

[1]Patent:WO2015/161830,2015,A1.Locationinpatent:Paragraph00326

[2]JournalofHeterocyclicChemistry,1990,vol.27,p.1957-1961

[3]EuropeanJournalofMedicinalChemistry,2018,vol.151,p.389-400

[1]Tetrahedron,2013,vol.69,p.6959-6968

[2]BioorganicandMedicinalChemistryLetters,2009,vol.19,p.738-741

[3]OrganicLetters,2017,vol.19,p.2889-2892

[4]JournalofChemicalResearch,Miniprint,1991,p.1240-1254

67-56-1    6141-58-8    6702-50-7   
(1S,2S,6R,7S)-10,10-Dimethoxy-4-methyl-11-oxo-3-oxa-tricyclo5.2.2.02,6undeca-4,8-diene-5,8-dicarboxylicaciddimethylester 

[1]Chen;Rao;Liao[JournaloftheAmericanChemicalSociety,1998,vol.120,#50,p.13254-13255]

Literature

Title: Synthesis of gefitinib from methyl 3-hydroxy-4-methoxy-benzoate.

Journal: Molecules (Basel, Switzerland) 20070328

Title: Withdrawn paper: Li, M.D.; Zheng, Y.G.; Ji, M. Synthesis of gefitinib from methyl 3-hydroxy-4-methoxybenzoate. Molecules 2007,12,673-678.

Journal: Molecules (Basel, Switzerland) 20070101

Title: Protective constituents against sepsis in mice from the root cortex of Paeonia suffruticosa.

Journal: Archives of pharmacal research 20041101

Title: Tyrosinase inhibitor from black rice bran.

Journal: Journal of agricultural and food chemistry 20031119

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