Home Iodos 696-07-1
696-07-1,MFCD00006020
Catalog No.:AA003MQL

696-07-1 | 5-Iodopyrimidine-2,4(1H,3H)-dione

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5g
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$18.00   $13.00
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25g
95%
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$32.00   $23.00
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100g
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500g
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA003MQL
Chemical Name:
5-Iodopyrimidine-2,4(1H,3H)-dione
CAS Number:
696-07-1
Molecular Formula:
C4H3IN2O2
Molecular Weight:
237.9833
MDL Number:
MFCD00006020
SMILES:
Ic1c[nH]c(=O)[nH]c1=O
NSC Number:
57848
Properties
Properties
 
Form:
Solid  
MP:
274-276 °C (dec.)(lit.)  
Solubility:
Very faint turbidity in NH3aq. Soluble in 1M NaOH.  
Stability:
Light Sensitive  
Storage:
Keep in dry area;Room Temperature;  

Computed Properties
 
Complexity:
199  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
9  
Hydrogen Bond Acceptor Count:
2  
Hydrogen Bond Donor Count:
2  

Literature

Title: Protonation preferentially stabilizes minor tautomers of the halouracils: IRMPD action spectroscopy and theoretical studies.

Journal: Journal of the American Society for Mass Spectrometry 20120901

Title: C(5) modified uracil derivatives showing antiproliferative and erythroid differentiation inducing activities on human chronic myelogenous leukemia K562 cells.

Journal: European journal of pharmacology 20111215

Title: Chimeric aptamers in cancer cell-targeted drug delivery.

Journal: Critical reviews in biochemistry and molecular biology 20111201

Title: Synthesis and properties of triplex-forming oligonucleotides containing 2'-O-(2-methoxyethyl)-5-(3-aminoprop-1-ynyl)-uridine.

Journal: Bioorganic & medicinal chemistry 20100901

Title: Herpes simplex virus-1 helicase-primase: roles of each subunit in DNA binding and phosphodiester bond formation.

Journal: Biochemistry 20091103

Title: Structures of native human thymidine phosphorylase and in complex with 5-iodouracil.

Journal: Biochemical and biophysical research communications 20090904

Title: Synthesis of N-substituted 5-iodouracils as antimicrobial and anticancer agents.

Journal: Molecules (Basel, Switzerland) 20090727

Title: [Myocardial single photon emission tomography imaging of reporter gene expression in rabbits].

Journal: Zhonghua xin xue guan bing za zhi 20090601

Title: Aluminium(III), chromium(III) and iron(III) complexes with 5-iodouracil and 5-iodouracil-histidine and their antitumour activity.

Journal: Journal of enzyme inhibition and medicinal chemistry 20090201

Title: Redetermination of 5-iodo-uracil.

Journal: Acta crystallographica. Section E, Structure reports online 20080201

Title: A simple crosslinking method, CLAMP, to map the sites of RNA-contacting domains within a protein.

Journal: Methods in molecular biology (Clifton, N.J.) 20080101

Title: Functionalization of unprotected uracil derivatives using the halogen-magnesium exchange.

Journal: Organic letters 20070426

Title: Synthesis of novel 2'-methyl carbovir analogues as potent antiviral agents.

Journal: Archives of pharmacal research 20070201

Title: N-1 regioselective Michael-type addition of 5-substituted uracils to (2-hydroxyethyl) acrylate.

Journal: Beilstein journal of organic chemistry 20070101

Title: Synthesis of new, base-modified PNA monomers.

Journal: Nucleosides, nucleotides & nucleic acids 20070101

Title: The DNA N-glycosylase MED1 exhibits preference for halogenated pyrimidines and is involved in the cytotoxicity of 5-iododeoxyuridine.

Journal: Cancer research 20060801

Title: Simple synthesis of novel acyclic (e)-bromovinyl nucleosides as potential antiviral agents.

Journal: Nucleosides, nucleotides & nucleic acids 20060101

Title: Evaluation of novel one-electron reduction with metal in DNA.

Journal: Nucleic acids symposium series (2004) 20060101

Title: Identification of base-specific contacts in protein-DNA complexes by photocrosslinking and mass spectrometry: a case study using the restriction endonuclease SsoII.

Journal: Molecular bioSystems 20050701

Title: Influence of halogenation on the properties of uracil and its noncovalent interactions with alkali metal ions. Threshold collision-induced dissociation and theoretical studies.

Journal: Journal of the American Chemical Society 20041215

Title: A protein sensor for siRNA asymmetry.

Journal: Science (New York, N.Y.) 20041119

Title: Highly efficient photochemical 2'-deoxyribonolactone formation at the diagonal loop of a 5-iodouracil-containing antiparallel G-quartet.

Journal: Journal of the American Chemical Society 20040526

Title: Anti-cowpox virus activities of certain adenosine analogs, arabinofuranosyl nucleosides, and 2'-fluoro-arabinofuranosyl nucleosides.

Journal: Nucleosides, nucleotides & nucleic acids 20040101

Title: Design and synthesis of the tumor-activated prodrug of dihydropyrimidine dehydrogenase (DPD) inhibitor, RO0094889 for combination therapy with capecitabine.

Journal: Bioorganic & medicinal chemistry letters 20030310

Title: Efficient C2'alpha-hydroxylation of deoxyribose in protein-induced Z-form DNA.

Journal: Journal of the American Chemical Society 20030212

Title: Photoreactivity of 5-iodouracil-containing telomeric DNA.

Journal: Nucleic acids research. Supplement (2001) 20030101

Title: Nucleobase modified peptide nucleic acid.

Journal: Nucleosides, nucleotides & nucleic acids 20030101

Title: Acyclic nucleoside analogues as novel inhibitors of human mitochondrial thymidine kinase.

Journal: Journal of medicinal chemistry 20020912

Title: Crystal structure of the productive ternary complex of dihydropyrimidine dehydrogenase with NADPH and 5-iodouracil. Implications for mechanism of inhibition and electron transfer.

Journal: The Journal of biological chemistry 20020412

Title: Photoreactivity of 5-iodouracil-containing DNA-Sso7d complex in solution: the protein-induced DNA kink causes intrastrand hydrogen abstraction from the 5-methyl of thymine at the 5' side.

Journal: Journal of the American Chemical Society 20020313

Title: Synthesis of 1-(2-hydroxy-3-methoxypropyl)uracils and their activity against L1210 and macrophage raw 264.7 cells.

Journal: Nucleosides, nucleotides & nucleic acids 20020101

Title: Mass spectrometric analysis of a UV-cross-linked protein-DNA complex: tryptophans 54 and 88 of E. coli SSB cross-link to DNA.

Journal: Protein science : a publication of the Protein Society 20011001

Title: N(1)-C(5')-linked dimer hydrates of 5-substituted uracils produced by anodic oxidation in aqueous solution.

Journal: The Journal of organic chemistry 20010406

Title: Synthesis of pyrrolidine C-nucleosides via Heck reaction.

Journal: Organic letters 20010208

Title: Photoreactivity of 5-iodouracil-containing DNA-Z alpha complex.

Journal: Nucleic acids research. Supplement (2001) 20010101

Title: Structure-activity relationship of ligands of uracil phosphoribosyltransferase from Toxoplasma gondii.

Journal: Biochemical pharmacology 19940817

Title: Synthesis, structure, and antitumor and antiviral activities of a series of 5-halouridine cyclic 3',5'-monophosphates.

Journal: Journal of medicinal chemistry 19860401

Title: Interaction of monoclonal antibodies directed against bromodeoxyuridine with pyrimidine bases, nucleosides, and DNA.

Journal: Journal of immunology (Baltimore, Md. : 1950) 19860301

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