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69819-86-9,MFCD17215931
Catalog No.:AA00FGIJ

69819-86-9 | Glycine, L-γ-glutaMyl-S-(diMethylarsino)-L-cysteinyl-

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1mg
≥95%
in stock  
$46.00   $32.00
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5mg
≥95%
in stock  
$188.00   $131.00
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10mg
in stock  
$283.00   $198.00
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25mg
in stock  
$528.00   $370.00
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50mg
in stock  
$854.00   $598.00
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100mg
in stock  
$1,431.00   $1,002.00
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500mg
in stock  
$4,477.00   $3,134.00
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1000mg
in stock  
$7,126.00   $4,988.00
- +
  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00FGIJ
Chemical Name:
Glycine, L-γ-glutaMyl-S-(diMethylarsino)-L-cysteinyl-
CAS Number:
69819-86-9
Molecular Formula:
C12H22AsN3O6S
Molecular Weight:
411.3062
MDL Number:
MFCD17215931
SMILES:
C[As](SC[C@@H](C(=O)NCC(=O)O)NC(=O)CC[C@@H](C(=O)O)N)C
Properties
Computed Properties
 
Complexity:
449  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
2  
Heavy Atom Count:
23  
Hydrogen Bond Acceptor Count:
8  
Hydrogen Bond Donor Count:
5  
Rotatable Bond Count:
11  

Literature

Title: The novel organic arsenical darinaparsin induces MAPK-mediated and SHP1-dependent cell death in T-cell lymphoma and Hodgkin lymphoma cells and human xenograft models.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20141201

Title: The novel arsenical Darinaparsin circumvents BRG1-dependent, HO-1-mediated cytoprotection in leukemic cells.

Journal: Leukemia 20131101

Title: Darinaparsin: solid tumor hypoxic cytotoxin and radiosensitizer.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20120615

Title: A multicenter phase II study of darinaparsin in relapsed or refractory Hodgkin's and non-Hodgkin's lymphoma.

Journal: American journal of hematology 20120101

Title: Darinaparsin is a multivalent chemotherapeutic which induces incomplete stress response with disruption of microtubules and Shh signaling.

Journal: PloS one 20110101

Title: Phase II study of darinaparsin in patients with advanced hepatocellular carcinoma.

Journal: Investigational new drugs 20101001

Title: Darinaparsin: a novel organic arsenical with promising anticancer activity.

Journal: Expert opinion on investigational drugs 20091101

Title: Efficacy of an Andrographis paniculata composition for the relief of rheumatoid arthritis symptoms: a prospective randomized placebo-controlled trial.

Journal: Clinical rheumatology 20090801

Title: A phase I clinical trial of darinaparsin in patients with refractory solid tumors.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20090715

Title: Darinaparsin induces a unique cellular response and is active in an arsenic trioxide-resistant myeloma cell line.

Journal: Molecular cancer therapeutics 20090501

Title: Chemical and clinical development of darinaparsin, a novel organic arsenic derivative.

Journal: Anti-cancer agents in medicinal chemistry 20081201

Title: A novel arsenical has antitumor activity toward As2O3-resistant and MRP1/ABCC1-overexpressing cell lines.

Journal: Leukemia 20081001

Title: Development of mass spectrometric methods for detecting arsenic-glutathione complexes.

Journal: Journal of the American Society for Mass Spectrometry 20081001

Title: Pentavalent arsenic can bind to biomolecules.

Journal: Angewandte Chemie (International ed. in English) 20070101

Title: Toxicity of a trivalent organic arsenic compound, dimethylarsinous glutathione in a rat liver cell line (TRL 1215).

Journal: British journal of pharmacology 20061201

Title: Cytotoxic effects of S-(dimethylarsino)-glutathione: a putative intermediate metabolite of inorganic arsenicals.

Journal: Toxicology 20061003

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Tags:69819-86-9 Molecular Formula|69819-86-9 MDL|69819-86-9 SMILES|69819-86-9 Glycine, L-γ-glutaMyl-S-(diMethylarsino)-L-cysteinyl-