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71653-06-0,MFCD00128126
Catalog No.:AA003JHH

71653-06-0 | 3-Hydroxyaspartic acid

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Purity
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Price(USD)
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250mg
98%
in stock  
$111.00   $78.00
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1g
>98.0%(T)(N)
in stock  
$120.00   $84.00
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5g
>98.0%(T)(N)
in stock  
$334.00   $234.00
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA003JHH
Chemical Name:
3-Hydroxyaspartic acid
CAS Number:
71653-06-0
Molecular Formula:
C4H7NO5
Molecular Weight:
149.1021
MDL Number:
MFCD00128126
SMILES:
C(C(C(=O)O)O)(C(=O)O)N
Properties
Properties
 
BP:
368.7°C at 760 mmHg  
Form:
Solid  
MP:
287-288℃ (decomposition)  
Storage:
Room Temperature;  

Computed Properties
 
Complexity:
156  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
10  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
4  
Rotatable Bond Count:
3  
Undefined Atom Stereocenter Count:
2  
XLogP3:
-4.4  

Downstream Synthesis Route

[1]Harada,Kaoru;Terasawa,Jun-ichi[ChemistryLetters,1980,p.441-444]

Literature

Title: A practical synthesis of N α-Fmoc protected L-threo-β-hydroxyaspartic acid derivatives for coupling via α- or β-carboxylic group.

Journal: Amino acids 20120101

Title: Antinociceptive effect of rat D-serine racemase inhibitors, L-serine-O-sulfate, and L-erythro-3-hydroxyaspartate in an arthritic pain model.

Journal: TheScientificWorldJournal 20120101

Title: Neuroprotective effect of CPDT on THA-induced cortical motor neuron death in an organotypic culture model.

Journal: Brain research bulletin 20101120

Title: Insights into the mechanism of Pseudomonas dacunhae aspartate beta-decarboxylase from rapid-scanning stopped-flow kinetics.

Journal: Biochemistry 20100622

Title: Neuroprotective effect of erythropoietin in amyotrophic lateral sclerosis (ALS) model in vitro. Ultrastructural study.

Journal: Folia neuropathologica 20100101

Title: Characterization of chronic glutamate-mediated motor neuron toxicity in organotypic spinal cord culture prepared from ALS model mice.

Journal: Neuroscience letters 20090424

Title: Neuroprotective effects of yokukansan, a traditional Japanese medicine, on glutamate-mediated excitotoxicity in cultured cells.

Journal: Neuroscience 20090410

Title: Iron is a potential key mediator of glutamate excitotoxicity in spinal cord motor neurons.

Journal: Brain research 20090227

Title: A concise, asymmetric synthesis of (2R,3R)-3-hydroxyaspartic acid.

Journal: Amino acids 20080801

Title: Genome-scale analysis of anti-metabolite directed strain engineering.

Journal: Metabolic engineering 20080301

Title: Non-heme hydroxylase engineering for simple enzymatic synthesis of L-threo-hydroxyaspartic acid.

Journal: Chembiochem : a European journal of chemical biology 20080215

Title: Huperzine A provides neuroprotection against several cell death inducers using in vitro model systems of motor neuron cell death.

Journal: Neurotoxicity research 20080101

Title: gamma-Glutamate and beta-hydroxyaspartate in proteins.

Journal: Methods in molecular biology (Clifton, N.J.) 20080101

Title: Tryptophan breakdown pathway in bipolar mania.

Journal: Journal of affective disorders 20070901

Title: Glutamate transporters of blood platelets as potential peripheral markers to analyze changes of glutamate transport activity in brain under altered gravity conditions.

Journal: Journal of gravitational physiology : a journal of the International Society for Gravitational Physiology 20070701

Title: Differential growth factor regulation of aspartyl-(asparaginyl)-beta-hydroxylase family genes in SH-Sy5y human neuroblastoma cells.

Journal: BMC cell biology 20060101

Title: Expression of GFP-tagged neuronal glutamate transporters in cerebellar Purkinje neurons.

Journal: Neuropharmacology 20051101

Title: Autophagic degeneration of motor neurons in a model of slow glutamate excitotoxicity in vitro.

Journal: Ultrastructural pathology 20050101

Title: [Modulating effect of glutamate transporter inhibitors on accumulation and release of the neuromediator by the brain nerve terminals in rats].

Journal: Ukrains'kyi biokhimichnyi zhurnal (1999 ) 20050101

Title: Structure, conformation and biological activity of a novel lipodepsipeptide from Pseudomonas corrugata: cormycin A.

Journal: The Biochemical journal 20041115

Title: Effects of the inhibitors on glutamate uptake by nerve terminals after exposure of rats to centrifuge-induced hypergravity.

Journal: Journal of gravitational physiology : a journal of the International Society for Gravitational Physiology 20040701

Title: Protective cap over CA1 synapses: extrasynaptic glutamate does not reach the postsynaptic density.

Journal: Brain research 20040618

Title: Identification of glutamate transporters and receptors in mouse testis.

Journal: Acta pharmacologica Sinica 20040301

Title: Glutamate spillover in the striatum depresses dopaminergic transmission by activating group I metabotropic glutamate receptors.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20031119

Title: Serine racemase homologue of Saccharomyces cerevisiae has L-threo-3-hydroxyaspartate dehydratase activity.

Journal: FEMS microbiology letters 20030829

Title: A novel enzyme, D-3-hydroxyaspartate aldolase from Paracoccus denitrificans IFO 13301: purification, characterization, and gene cloning.

Journal: Applied microbiology and biotechnology 20030701

Title: Electrical and pharmacological properties of the slow depolarization induced by Schaffer collateral stimulation in astrocytes of the rat hippocampal CA1 region.

Journal: Neuroscience letters 20030605

Title: Metabotropic glutamate receptor-mediated hetero-synaptic interaction of red- and green-cone inputs to LHC of carp retina.

Journal: Brain research bulletin 20030415

Title: Neuronal glutamate uptake Contributes to GABA synthesis and inhibitory synaptic strength.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20030315

Title: The glutamate transporters EAAT2 and EAAT3 mediate cysteine uptake in cortical neuron cultures.

Journal: Journal of neurochemistry 20030301

Title: Modulation of glutamatergic transmission by bergmann glial cells in rat cerebellum in situ.

Journal: Journal of neurophysiology 20030201

Title: Involvement of acetylated tubulin in the regulation of Na+,K+ -ATPase activity in cultured astrocytes.

Journal: FEBS letters 20030116

Title: Isoflurane preconditioning reduces purkinje cell death in an in vitro model of rat cerebellar ischemia.

Journal: Neuroscience 20030101

Title: Activation of protein kinase C reduces GLAST in the plasma membrane of rat Müller cells in primary culture.

Journal: Visual neuroscience 20030101

Title: Local application of L- threo-hydroxyaspartate and malonate in rats in vivo induces rigidity and damages neurons of the substantia nigra, pars compacta.

Journal: Journal of neural transmission (Vienna, Austria : 1996) 20021001

Title: Glutamate-induced calcium increase in myotubes depends on up-regulation of a sodium-dependent transporter.

Journal: FEBS letters 20020911

Title: Beta-amyloid enhances glial glutamate uptake activity and attenuates synaptic efficacy.

Journal: The Journal of biological chemistry 20020830

Title: Inhibitor of glutamate transport alters synaptic transmission at sensorimotor synapses in Aplysia.

Journal: Journal of neurophysiology 20020601

Title: gamma-glutamate and beta-hydroxyaspartate in proteins.

Journal: Methods in molecular biology (Clifton, N.J.) 20020101

Title: Feeding-induced decrease in extracellular glutamate level in the rat nucleus accumbens: dependence on glutamate uptake.

Journal: Neuroscience 20020101

Title: Differing effects of substrate and non-substrate transport inhibitors on glutamate uptake reversal.

Journal: Journal of neurochemistry 20011201

Title: Effects of threo-beta-hydroxyaspartate derivatives on excitatory amino acid transporters (EAAT4 and EAAT5).

Journal: Journal of neurochemistry 20011001

Title: Methylmercury inhibits cysteine uptake in cultured primary astrocytes, but not in neurons.

Journal: Brain research 20010928

Title: Kinetics and activation of postsynaptic kainate receptors at thalamocortical synapses: role of glutamate clearance.

Journal: Journal of neurophysiology 20010901

Title: Release of D,L-threo-beta-hydroxyaspartate as a false transmitter from excitatory amino acid-releasing nerve terminals.

Journal: Neurochemistry international 20010701

Title: Methylmercury-mediated inhibition of 3H-D-aspartate transport in cultured astrocytes is reversed by the antioxidant catalase.

Journal: Brain research 20010525

Title: Regulation of mitochondrial glutamine/glutamate metabolism by glutamate transport: studies with (15)N.

Journal: American journal of physiology. Cell physiology 20010501

Title: A Na+-dependent electrogenic glutamate transporter current in voltage-clamped cells of corpora allata in the cricket Gryllus bimaculatus.

Journal: Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology 20010501

Title: Transient increase in the high affinity [3H]-L-glutamate uptake activity during in vitro development of hippocampal neurons in culture.

Journal: Neurochemistry international 20010401

Title: Effects of glial glutamate transporter inhibitors on intracellular Na+ in mouse astrocytes.

Journal: Brain research 20010302

Title: Possible linkage between glutamate transporter and mitogen-activated protein kinase cascade in cultured rat cortical astrocytes.

Journal: Journal of neurochemistry 20010101

Title: Dopamine-dependent inhibition of glycine release in the nucleus accumbens of the rat brain during food consumption.

Journal: Neuroscience and behavioral physiology 20010101

Title: Effect of ionotropic glutamate receptors antagonists on the modifications in extracellular glutamate and aspartate levels during picrotoxin seizures: a microdialysis study in freely moving rats.

Journal: Neurochemistry international 20001001

Title: DL-threo-beta-benzyloxyaspartate, a potent blocker of excitatory amino acid transporters.

Journal: Molecular pharmacology 19980201

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