Home Other Building Blocks 729589-58-6
729589-58-6,MFCD08460329
Catalog No.:AA00F9WW
729589-58-6 | 2-(2-FUROYL)-LEU-ILE-GLY-ARG-LEU-ORN-NH2
Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
≥95%
1 week  
$135.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Q & A
  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00F9WW
Chemical Name:
2-(2-FUROYL)-LEU-ILE-GLY-ARG-LEU-ORN-NH2
CAS Number:
729589-58-6
Molecular Formula:
C36H63N11O8
Molecular Weight:
777.9543
MDL Number:
MFCD08460329
IUPAC Name:
N-[(2S)-1-[[(2S,3S)-1-[[2-[[(2S)-5-(diaminomethylideneamino)-1-[[(2S)-1-[[(2S)-1,5-diamino-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1-oxopentan-2-yl]amino]-2-oxoethyl]amino]-3-methyl-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]furan-2-carboxamide
InChI:
InChI=1S/C36H63N11O8/c1-7-22(6)29(47-33(52)26(18-21(4)5)46-34(53)27-13-10-16-55-27)35(54)42-19-28(48)43-24(12-9-15-41-36(39)40)31(50)45-25(17-20(2)3)32(51)44-23(30(38)49)11-8-14-37/h10,13,16,20-26,29H,7-9,11-12,14-15,17-19,37H2,1-6H3,(H2,38,49)(H,42,54)(H,43,48)(H,44,51)(H,45,50)(H,46,53)(H,47,52)(H4,39,40,41)/t22-,23-,24-,25-,26-,29-/m0/s1
InChI Key:
OSKIRYSKGDEIOG-WTWMNNMUSA-N
SMILES:
NCCC[C@@H](C(=O)N)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)CNC(=O)[C@H]([C@H](CC)C)NC(=O)[C@@H](NC(=O)c1ccco1)CC(C)C)CCCNC(=N)N)CC(C)C
Properties
Computed Properties
 
Complexity:
1310  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
6  
Defined Bond Stereocenter Count:
0
Exact Mass:
777.486g/mol
Formal Charge:
0
Heavy Atom Count:
55  
Hydrogen Bond Acceptor Count:
10  
Hydrogen Bond Donor Count:
10  
Isotope Atom Count:
0
Molecular Weight:
777.969g/mol
Monoisotopic Mass:
777.486g/mol
Rotatable Bond Count:
26  
Topological Polar Surface Area:
321A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
0.4  

Synonyms
 
2-furoyl-leucyl-isoleucyl-glycyl-arginyl-leucyl-amide 
2-furoyl-LIGRLO-amide 
2-(2-Furoyl)-leu-ile-gly-arg-leu-orn-nh2 
J3.551.595J 
PAR2-AP peptide 
PAR2-activating peptide 
CID10395438 
CID 10395438 
C487404 
2-furoyl-leucyl-isoleucyl-glycyl-arginyl-leucyl-amide 
PAR2-activating peptide 
PAR2-AP peptide 
2-furoyl-LIGRLO-amide 
729589-58-6 
CHEMBL509819 
BDBM50412718 
ZINC95616027 
AKOS024457384 
Literature

Title: Resveratrol inhibits proteinase-activated receptor-2-induced release of soluble vascular endothelial growth factor receptor-1 from human endothelial cells.

Journal: EXCLI journal 20130101

Title: An antagonist of human protease activated receptor-2 attenuates PAR2 signaling, macrophage activation, mast cell degranulation, and collagen-induced arthritis in rats.

Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20120701

Title: Antagonism of protease-activated receptor 2 protects against experimental colitis.

Journal: The Journal of pharmacology and experimental therapeutics 20120201

Title: Protease-activated receptor 2-dependent fluid secretion from airway submucosal glands by house dust mite extract.

Journal: The Journal of allergy and clinical immunology 20120201

Title: Epigallocatechin-3-gallate inhibits proliferation and migration of human colon cancer SW620 cells in vitro.

Journal: Acta pharmacologica Sinica 20120101

Title: Protease-activated receptor 2 mediates mucus secretion in the airway submucosal gland.

Journal: PloS one 20120101

Title: Preserved arterial vasodilatation via endothelial protease-activated receptor-2 in obese type 2 diabetic mice.

Journal: British journal of pharmacology 20110901

Title: Proteinase-activated receptor 2-mediated calcium signaling in hepatocellular carcinoma cells.

Journal: Journal of cancer research and clinical oncology 20110601

Title: Regulation of the incorporation of tissue factor into microparticles by serine phosphorylation of the cytoplasmic domain of tissue factor.

Journal: The Journal of biological chemistry 20110408

Title: Effect of PAR2 in regulating TNF-α and NAD(P)H oxidase in coronary arterioles in type 2 diabetic mice.

Journal: Basic research in cardiology 20110101

Title: Protection of protease-activated receptor 2 mediated vasodilatation against angiotensin II-induced vascular dysfunction in mice.

Journal: BMC pharmacology 20110101

Title: Olopatadine hydrochloride inhibits scratching behavior induced by a proteinase-activated receptor 2 agonist in mice.

Journal: Journal of dermatological science 20091101

Title: Role of mast cells and protease-activated receptor-2 in cyclooxygenase-2 expression in urothelial cells.

Journal: American journal of physiology. Regulatory, integrative and comparative physiology 20091001

Title: Discovery of potent and selective small-molecule PAR-2 agonists.

Journal: Journal of medicinal chemistry 20080925

Title: Derivatized 2-furoyl-LIGRLO-amide, a versatile and selective probe for proteinase-activated receptor 2: binding and visualization.

Journal: The Journal of pharmacology and experimental therapeutics 20080801

Title: Role of capsaicin-sensitive sensory nerves in protease-activated receptor-2-mediated contraction of rat urinary bladder.

Journal: European journal of pharmacology 20070813

Title: Colonic hyperalgesia triggered by proteinase-activated receptor-2 in mice: involvement of endogenous bradykinin.

Journal: Neuroscience letters 20060710

Title: Suppression of pancreatitis-related allodynia/hyperalgesia by proteinase-activated receptor-2 in mice.

Journal: British journal of pharmacology 20060501

Title: Binding of a highly potent protease-activated receptor-2 (PAR2) activating peptide, [3H]2-furoyl-LIGRL-NH2, to human PAR2.

Journal: British journal of pharmacology 20050501

Title: 2-Furoyl-LIGRL-NH2, a potent agonist for proteinase-activated receptor-2, as a gastric mucosal cytoprotective agent in mice.

Journal: British journal of pharmacology 20050101

Title: A protease activated receptor-2 (PAR-2) activating peptide, tc-LIGRLO-NH2, induces protease release from mast cells: role in TNF degradation.

Journal: BMC pharmacology 20040101

Quotation Request
Company Name:
*
Contact Person:
*
Email:
*
Quantity Required:
*
Additional Info:
Q & A
Related Products