Home Other Building Blocks 729589-58-6
729589-58-6,MFCD08460329
Catalog No.:AA00F9WW

729589-58-6 | 2-(2-FUROYL)-LEU-ILE-GLY-ARG-LEU-ORN-NH2

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
≥95%
in stock  
$241.00   $169.00
- +
5mg
≥95%
in stock  
$611.00   $428.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00F9WW
Chemical Name:
2-(2-FUROYL)-LEU-ILE-GLY-ARG-LEU-ORN-NH2
CAS Number:
729589-58-6
Molecular Formula:
C36H63N11O8
Molecular Weight:
777.9543
MDL Number:
MFCD08460329
SMILES:
NCCC[C@@H](C(=O)N)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)CNC(=O)[C@H]([C@H](CC)C)NC(=O)[C@@H](NC(=O)c1ccco1)CC(C)C)CCCNC(=N)N)CC(C)C
Properties
Computed Properties
 
Complexity:
1310  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
6  
Heavy Atom Count:
55  
Hydrogen Bond Acceptor Count:
10  
Hydrogen Bond Donor Count:
10  
Rotatable Bond Count:
26  
XLogP3:
0.4  

Literature

Title: Resveratrol inhibits proteinase-activated receptor-2-induced release of soluble vascular endothelial growth factor receptor-1 from human endothelial cells.

Journal: EXCLI journal 20130101

Title: An antagonist of human protease activated receptor-2 attenuates PAR2 signaling, macrophage activation, mast cell degranulation, and collagen-induced arthritis in rats.

Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20120701

Title: Antagonism of protease-activated receptor 2 protects against experimental colitis.

Journal: The Journal of pharmacology and experimental therapeutics 20120201

Title: Protease-activated receptor 2-dependent fluid secretion from airway submucosal glands by house dust mite extract.

Journal: The Journal of allergy and clinical immunology 20120201

Title: Epigallocatechin-3-gallate inhibits proliferation and migration of human colon cancer SW620 cells in vitro.

Journal: Acta pharmacologica Sinica 20120101

Title: Protease-activated receptor 2 mediates mucus secretion in the airway submucosal gland.

Journal: PloS one 20120101

Title: Preserved arterial vasodilatation via endothelial protease-activated receptor-2 in obese type 2 diabetic mice.

Journal: British journal of pharmacology 20110901

Title: Proteinase-activated receptor 2-mediated calcium signaling in hepatocellular carcinoma cells.

Journal: Journal of cancer research and clinical oncology 20110601

Title: Regulation of the incorporation of tissue factor into microparticles by serine phosphorylation of the cytoplasmic domain of tissue factor.

Journal: The Journal of biological chemistry 20110408

Title: Effect of PAR2 in regulating TNF-α and NAD(P)H oxidase in coronary arterioles in type 2 diabetic mice.

Journal: Basic research in cardiology 20110101

Title: Protection of protease-activated receptor 2 mediated vasodilatation against angiotensin II-induced vascular dysfunction in mice.

Journal: BMC pharmacology 20110101

Title: Olopatadine hydrochloride inhibits scratching behavior induced by a proteinase-activated receptor 2 agonist in mice.

Journal: Journal of dermatological science 20091101

Title: Role of mast cells and protease-activated receptor-2 in cyclooxygenase-2 expression in urothelial cells.

Journal: American journal of physiology. Regulatory, integrative and comparative physiology 20091001

Title: Discovery of potent and selective small-molecule PAR-2 agonists.

Journal: Journal of medicinal chemistry 20080925

Title: Derivatized 2-furoyl-LIGRLO-amide, a versatile and selective probe for proteinase-activated receptor 2: binding and visualization.

Journal: The Journal of pharmacology and experimental therapeutics 20080801

Title: Role of capsaicin-sensitive sensory nerves in protease-activated receptor-2-mediated contraction of rat urinary bladder.

Journal: European journal of pharmacology 20070813

Title: Colonic hyperalgesia triggered by proteinase-activated receptor-2 in mice: involvement of endogenous bradykinin.

Journal: Neuroscience letters 20060710

Title: Suppression of pancreatitis-related allodynia/hyperalgesia by proteinase-activated receptor-2 in mice.

Journal: British journal of pharmacology 20060501

Title: Binding of a highly potent protease-activated receptor-2 (PAR2) activating peptide, [3H]2-furoyl-LIGRL-NH2, to human PAR2.

Journal: British journal of pharmacology 20050501

Title: 2-Furoyl-LIGRL-NH2, a potent agonist for proteinase-activated receptor-2, as a gastric mucosal cytoprotective agent in mice.

Journal: British journal of pharmacology 20050101

Title: A protease activated receptor-2 (PAR-2) activating peptide, tc-LIGRLO-NH2, induces protease release from mast cells: role in TNF degradation.

Journal: BMC pharmacology 20040101

Title: McGuire JJ, et al. 2-furoyl-LIGRLO-amide: a potent and selective proteinase-activated receptor 2 agonist. J Pharmacol Exp Ther. 2004 Jun;309(3):1124-31.

Title: Lohman RJ, et al. An antagonist of human protease activated receptor-2 attenuates PAR2 signaling, macrophage activation, mast cell degranulation, and collagen-induced arthritis in rats. FASEB J. 2012 Jul;26(7):2877-87.

Title: Jiahui Zhao, et al. PAR2 Mediates Itch via TRPV3 Signaling in Keratinocytes. J Invest Dermatol

Quotation Request
Company Name:
*
Contact Person:
*
Email:
*
Quantity Required:
*
Country:
Additional Info:
SDS
Related Products of 729589-58-6
Tags:729589-58-6 Molecular Formula|729589-58-6 MDL|729589-58-6 SMILES|729589-58-6 2-(2-FUROYL)-LEU-ILE-GLY-ARG-LEU-ORN-NH2