Home Amines 73-67-6
73-67-6,MFCD00849239
Catalog No.:AA005BWO

73-67-6 | (4-Amino-2-methyl-5-pyrimidinyl)methanol

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200mg
>98.0%(GC)(T)
in stock  
$82.00   $57.00
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1g
95%
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$95.00   $67.00
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  • Technical Information
  • Properties
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Technical Information
Catalog Number:
AA005BWO
Chemical Name:
(4-Amino-2-methyl-5-pyrimidinyl)methanol
CAS Number:
73-67-6
Molecular Formula:
C6H9N3O
Molecular Weight:
139.1552
MDL Number:
MFCD00849239
SMILES:
OCc1cnc(nc1N)C
NSC Number:
28247
Properties
Properties
 
Form:
Solid  
MP:
190 - 191 °C  
Storage:
Inert atmosphere;Room Temperature;  

Computed Properties
 
Complexity:
109  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
10  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
1  
XLogP3:
-0.1  

Literature

Title: The upregulation of thiamine (vitamin B1) biosynthesis in Arabidopsis thaliana seedlings under salt and osmotic stress conditions is mediated by abscisic acid at the early stages of this stress response.

Journal: BMC plant biology 20120101

Title: Structure of trifunctional THI20 from yeast.

Journal: Acta crystallographica. Section D, Biological crystallography 20110901

Title: Simultaneous molecular imaging based on electron paramagnetic resonance of 14N- and 15N-labelled nitroxyl radicals.

Journal: Chemical communications (Cambridge, England) 20110321

Title: Plasticity in the purine-thiamine metabolic network of Salmonella.

Journal: Genetics 20110201

Title: Purification, crystallization and preliminary X-ray diffraction analysis of the thiaminase type II from Staphylococcus aureus.

Journal: Acta crystallographica. Section F, Structural biology and crystallization communications 20110101

Title: Thiamin (vitamin B1) biosynthesis and regulation: a rich source of antimicrobial drug targets?

Journal: International journal of biological sciences 20110101

Title: Exploring metabolic pathway reconstruction and genome-wide expression profiling in Lactobacillus reuteri to define functional probiotic features.

Journal: PloS one 20110101

Title: Identification of inhibitors against Mycobacterium tuberculosis thiamin phosphate synthase, an important target for the development of anti-TB drugs.

Journal: PloS one 20110101

Title: HMP binding protein ThiY and HMP-P synthase THI5 are structural homologues.

Journal: Biochemistry 20101019

Title: The genome of a pathogenic rhodococcus: cooptive virulence underpinned by key gene acquisitions.

Journal: PLoS genetics 20100901

Title: Mechanistic and functional versatility of radical SAM enzymes.

Journal: F1000 biology reports 20100101

Title: The ADP-dependent sugar kinase family: kinetic and evolutionary aspects.

Journal: IUBMB life 20090701

Title: E-zyme: predicting potential EC numbers from the chemical transformation pattern of substrate-product pairs.

Journal: Bioinformatics (Oxford, England) 20090615

Title: Reaction of AdoMet with ThiC generates a backbone free radical.

Journal: Biochemistry 20090120

Title: The vitamin B1 metabolism of Staphylococcus aureus is controlled at enzymatic and transcriptional levels.

Journal: PloS one 20090101

Title: Reconstitution of ThiC in thiamine pyrimidine biosynthesis expands the radical SAM superfamily.

Journal: Nature chemical biology 20081201

Title: ThiC is an [Fe-S] cluster protein that requires AdoMet to generate the 4-amino-5-hydroxymethyl-2-methylpyrimidine moiety in thiamin synthesis.

Journal: Biochemistry 20080902

Title: Involvement of thiaminase II encoded by the THI20 gene in thiamin salvage of Saccharomyces cerevisiae.

Journal: FEMS yeast research 20080301

Title: The genes and enzymes involved in the biosynthesis of thiamin and thiamin diphosphate in yeasts.

Journal: Cellular & molecular biology letters 20080101

Title: Molecular characterization of the thi3 gene involved in thiamine biosynthesis in Zea mays: cDNA sequence and enzymatic and structural properties of the recombinant bifunctional protein with 4-amino-5-hydroxymethyl-2-methylpyrimidine (phosphate) kinase and thiamine monophosphate synthase activities.

Journal: The Biochemical journal 20071201

Title: Patterns and implications of gene gain and loss in the evolution of Prochlorococcus.

Journal: PLoS genetics 20071201

Title: A new thiamin salvage pathway.

Journal: Nature chemical biology 20070801

Title: Recent progress in understanding thiamin biosynthesis and its genetic regulation in Saccharomyces cerevisiae.

Journal: Applied microbiology and biotechnology 20060801

Title: A connection between iron-sulfur cluster metabolism and the biosynthesis of 4-amino-5-hydroxymethyl-2-methylpyrimidine pyrophosphate in Salmonella enterica.

Journal: Microbiology (Reading, England) 20060801

Title: Vitamin B1 de novo synthesis in the human malaria parasite Plasmodium falciparum depends on external provision of 4-amino-5-hydroxymethyl-2-methylpyrimidine.

Journal: Biological chemistry 20060101

Title: Thi20, a remarkable enzyme from Saccharomyces cerevisiae with dual thiamin biosynthetic and degradation activities.

Journal: Bioorganic chemistry 20050801

Title: Structural characterization of the regulatory proteins TenA and TenI from Bacillus subtilis and identification of TenA as a thiaminase II.

Journal: Biochemistry 20050222

Title: Biosynthesis of the thiamin pyrimidine: the reconstitution of a remarkable rearrangement reaction.

Journal: Organic & biomolecular chemistry 20040907

Title: Chromatographic study of photolysis of aqueous cyanocobalamin solution in presence of vitamins B and C.

Journal: Pakistan journal of pharmaceutical sciences 20040101

Title: Crystal structure of 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate kinase from Salmonella typhimurium at 2.3 A resolution.

Journal: Structure (London, England : 1993) 20020201

Title: Mechanistic studies on thiamin phosphate synthase: evidence for a dissociative mechanism.

Journal: Biochemistry 20010828

Title: Structural characterization of the enzyme-substrate, enzyme-intermediate, and enzyme-product complexes of thiamin phosphate synthase.

Journal: Biochemistry 20010828

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Tags:73-67-6 Molecular Formula|73-67-6 MDL|73-67-6 SMILES|73-67-6 (4-Amino-2-methyl-5-pyrimidinyl)methanol