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74163-81-8,MFCD00144533
Catalog No.:AA00ICEL

74163-81-8 | L-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1g
98%
in stock  
$7.00   $5.00
- +
5g
98%
in stock  
$9.00   $7.00
- +
10g
98%
in stock  
$12.00   $8.00
- +
25g
98%
in stock  
$27.00   $19.00
- +
100g
95%
in stock  
$96.00   $67.00
- +
500g
98%
in stock  
$227.00   $159.00
- +
  • Technical Information
  • Properties
  • Upstream Synthesis Route
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Upstream Synthesis Route
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA00ICEL
Chemical Name:
L-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid
CAS Number:
74163-81-8
Molecular Formula:
C10H11NO2
Molecular Weight:
177.1998
MDL Number:
MFCD00144533
SMILES:
OC(=O)[C@H]1NCc2c(C1)cccc2 C10H11NO2
Properties
Properties
 
BP:
309.12°C (rough estimate)  
Form:
Solid  
MP:
>300 °C(lit.)  
Refractive Index:
-166 ° (C=1, 1mol/L NaOH)  
Storage:
Inert atmosphere;2-8℃;  

Computed Properties
 
Complexity:
205  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
1  
Heavy Atom Count:
13  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
1  
XLogP3:
-1.3  

Upstream Synthesis Route

[1]EuropeanJournalofMedicinalChemistry,2011,vol.46,#5,p.1672-1681

[2]BioorganicandMedicinalChemistryLetters,2015,vol.25,#20,p.4434-4436

[3]Patent:CN106986825,2017,A,

[4]JournalofAgriculturalandFoodChemistry,2018,vol.66,#34,p.8957-8965

[1]Patent:CN106986825,2017,A,

[2]JournalofAgriculturalandFoodChemistry,2018,vol.66,#34,p.8957-8965

[1]JournaloftheChemicalSociety-PerkinTransactions1,1999,#20,p.2883-2889

[2]JournalofOrganicChemistry,1998,vol.63,#22,p.7795-7804

[3]BioorganicandMedicinalChemistryLetters,2005,vol.15,#18,p.4033-4036

[4]OrganicandBiomolecularChemistry,2018,vol.16,#38,p.6961-6968

[5]JournalofMedicinalChemistry,1999,vol.42,#11,p.1982-1990

[6]ChemicalCommunications,2011,vol.47,#38,p.10746-10748

[7]EuropeanJournalofMedicinalChemistry,2013,vol.66,p.407-414

[1]Patent:WO2017/153513,2017,A1,.Locationinpatent:Page/Pagecolumn78

[2]Patent:WO2017/153515,2017,A1,.Locationinpatent:Page/Pagecolumn62

[3]Patent:WO2017/153520,2017,A1,.Locationinpatent:Page/Pagecolumn44;47

[4]Patent:WO2017/153519,2017,A1,.Locationinpatent:Page/Pagecolumn56;59

[5]TetrahedronLetters,2001,vol.42,#43,p.7559-7561

[6]BioorganicandMedicinalChemistryLetters,2005,vol.15,#21,p.4828-4832

[7]BioorganicandMedicinalChemistryLetters,2005,vol.15,#21,p.4833-4837

[8]TetrahedronLetters,2004,vol.45,#38,p.7081-7085

[9]OrganicLetters,2016,vol.18,#19,p.5070-5073

[10]Patent:WO2011/61318,2011,A1,.Locationinpatent:Page/Pagecolumn22

[11]Patent:WO2016/34673,2016,A1,.Locationinpatent:Page/Pagecolumn71;74

[12]JournalofMaterialsChemistryB,2017,vol.5,#5,p.917-927

[13]InternationalJournalofNanomedicine,2018,vol.13,p.1139-1158

[14]OrganicLetters,2017,vol.19,#21,p.5826-5829

[15]BioorganicandMedicinalChemistry,2002,vol.10,#6,p.1719-1729

[16]EuropeanJournalofOrganicChemistry,2002,#23,p.3936-3943

[17]EuropeanJournalofMedicinalChemistry,2009,vol.44,#12,p.4904-4919

[18]BioorganicandMedicinalChemistry,2011,vol.19,#2,p.871-882

[19]Tetrahedron,2014,vol.70,#23,p.3707-3713

[20]JournaloftheChemicalSociety-PerkinTransactions1,1999,#24,p.3623-3631

[21]JournaloftheChemicalSociety-PerkinTransactions1,1999,#20,p.2883-2889

[22]TetrahedronAsymmetry,2010,vol.21,#9-10,p.1238-1245

[23]ChineseChemicalLetters,2012,vol.23,#3,p.297-300

[24]Chemistry-AEuropeanJournal,2015,vol.21,#51,p.18589-18593

[25]JournalofAgriculturalandFoodChemistry,2018,vol.66,#34,p.8957-8965

[1]BioorganicandMedicinalChemistry,2007,vol.15,#24,p.7773-7788

Downstream Synthesis Route

[1]Heterocycles,2006,vol.68,p.59-69

[2]EuropeanJournalofMedicinalChemistry,2013,vol.66,p.407-414

[3]BioorganicandMedicinalChemistryLetters,2011,vol.21,p.1019-1022

[4]EuropeanJournalofOrganicChemistry,2018,vol.2018,p.5456-5459

[5]BioorganicandMedicinalChemistry,2008,vol.16,p.9574-9587

[6]Patent:WO2018/53552,2018,A2.Locationinpatent:Paragraph000476-000478

[7]Patent:WO2018/71455,2018,A1.Locationinpatent:Paragraph0009;00114;00122-00124

[8]Patent:CN106986825,2017,A.Locationinpatent:Paragraph0023;0029;0030

[9]JournaloftheAmericanChemicalSociety,1993,vol.115,p.3957-3965

[10]JournalofMedicinalChemistry,1983,vol.26,p.1267-1277

[11]JournalofAgriculturalandFoodChemistry,2018,vol.66,p.8957-8965

[1]JournalofMaterialsChemistryB,2017,vol.5,p.917-927

[2]InternationalJournalofNanomedicine,2018,vol.13,p.1139-1158

[3]BioorganicandMedicinalChemistry,2007,vol.15,p.7773-7788

[4]EuropeanJournalofMedicinalChemistry,2013,vol.66,p.407-414

[5]OrganicandBiomolecularChemistry,2018,vol.16,p.6961-6968

[6]EuropeanJournalofMedicinalChemistry,2009,vol.44,p.4904-4919

[7]BioorganicandMedicinalChemistry,2011,vol.19,p.871-882

[8]BioorganicandMedicinalChemistry,2008,vol.16,p.9574-9587

[9]EuropeanJournalofMedicinalChemistry,2011,vol.46,p.1672-1681

[10]Patent:CN111233849,2020,A.Locationinpatent:Paragraph0021-0022;0024

[11]Synlett,2011,p.3005-3007

[12]BulletinoftheChemicalSocietyofJapan,1991,vol.64,p.3729-3731

[13]JournaloftheAmericanChemicalSociety,1993,vol.115,p.3957-3965

[14]Chimia,1996,vol.50,p.532-537

[15]Patent:CN106986825,2017,A.Locationinpatent:Paragraph0023;0027;0028

[16]JournalofOrganicChemistry,1998,vol.63,p.7795-7804

[17]BioorganicandMedicinalChemistryLetters,2011,vol.21,p.1019-1022

[18]JournalofMedicinalChemistry,1991,vol.34,p.3125-3132

[19]JournalofMedicinalChemistry,1988,vol.31,p.2092-2097

[20]TetrahedronAsymmetry,2010,vol.21,p.1238-1245

[21]JournalofMedicinalChemistry,1983,vol.26,p.1267-1277

[22]JournalofAgriculturalandFoodChemistry,2018,vol.66,p.8957-8965

[23]MedChemComm,2019,vol.10,p.280-293

[24]ChemicalCommunications,2019,vol.55,p.5902-5905

[1]JournalofMedicinalChemistry,1992,vol.35,p.2562-2572

[1]AdvancedSynthesisandCatalysis,2019,vol.361,p.3191-3199

[2]BulletinoftheChemicalSocietyofJapan,1991,vol.64,p.3729-3731

[3]TetrahedronAsymmetry,2001,vol.12,p.1399-1401

[4]TetrahedronAsymmetry,2001,vol.12,p.1399-1401

[5]Synthesis,1992,p.1157-1160

[1]BulletinoftheChemicalSocietyofJapan,1991,vol.64,p.3729-3731

Literature

Title: pH-Dependent nanostructure based on isoquinoline-cyclodextrin conjugate for thrombosis therapy.

Journal: Nanomedicine : nanotechnology, biology, and medicine 20121001

Title: A class of novel N-(3S-1,2,3,4-tetrahydroisoquinoline-3-carbonyl)-L-amino acid derivatives: their synthesis, anti-thrombotic activity evaluation, and 3D QSAR analysis.

Journal: European journal of medicinal chemistry 20091201

Title: (3S)-N-(L-Aminoacyl)-1,2,3,4-tetrahydroisoquinolines, a class of novel antithrombotic agents: synthesis, bioassay, 3D QSAR, and ADME analysis.

Journal: Bioorganic & medicinal chemistry 20081101

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