Home Bromides 74209-34-0
74209-34-0,MFCD00159910
Catalog No.:AA003J12
74209-34-0 | 3-Bromo-7-nitro-1H-indazole
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1g
98%
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$29.00   $20.00
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5g
98%
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$58.00   $40.00
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25g
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Technical Information
Catalog Number:
AA003J12
Chemical Name:
3-Bromo-7-nitro-1H-indazole
CAS Number:
74209-34-0
Molecular Formula:
C7H4BrN3O2
Molecular Weight:
242.0296
MDL Number:
MFCD00159910
IUPAC Name:
3-bromo-7-nitro-2H-indazole
InChI:
InChI=1S/C7H4BrN3O2/c8-7-4-2-1-3-5(11(12)13)6(4)9-10-7/h1-3H,(H,9,10)
InChI Key:
NFSTZPMYAZRZPC-UHFFFAOYSA-N
SMILES:
[O-][N+](=O)c1cccc2c1[nH]nc2Br
Properties
Computed Properties
 
Complexity:
220  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
240.949g/mol
Formal Charge:
0
Heavy Atom Count:
13  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
1  
Isotope Atom Count:
0
Molecular Weight:
242.032g/mol
Monoisotopic Mass:
240.949g/mol
Rotatable Bond Count:
0
Topological Polar Surface Area:
74.5A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
2.4  

Synonyms
 
3-Br-7-NI 
3-bromo-7-nitroindazole 
AK-27879 
EU-0100161 
FT-0615185 
ST50306995 
Y5539 
09B340 
B 2050 
Q-1092 
1W-0945 
3-Bromo-7-nitroindazole, >=98% (TLC), powder 
I10-1086 
SR-01000075708 
I10-1446 
SR-01000075708-1 
SR-01000075708-3 
SR-01000075708-6 
BRD-K24689407-001-03-0 
BRD-K24689407-001-04-8 
BRD-K24689407-001-05-5 
C7H4BrN3O2 
D0U6ZT 
D0X5QJ 
3-bromo-7NI 
3-Br-7-NI 
CID1649 
A15784 
A15928 
C106731 
945761-95-5 
INE 
3-Br-7-Nitroindazole 
Tocris-0735 
AC1L1BXC 
Lopac-B-2050 
3-Br-7NI 
Lopac0_000161 
BSPBio_001502 
3-Bromo-7-nitro-1H-indazole 
BSPBio_002434 
KBioGR_000222 
KBioSS_000222 
SCHEMBL499421 
SCHEMBL499422 
SPECTRUM1505105 
GTPL5113 
BCBcMAP01_000129 
CTK5D9545 
KBio2_000222 
3-bromo-7-nitroindazole 
KBio2_002790 
KBio2_005358 
KBio3_000443 
KBio3_000444 
DTXSID90274319 
OR6862T 
3-Bromo-7-nitro-1H-indazole # 
Bio1_000424 
Bio1_000913 
Bio1_001402 
74209-34-0 
Bio2_000222 
Bio2_000702 
HMS1361L04 
HMS1791L04 
HMS1989L04 
HMS3260B03 
HMS3266N19 
HMS3402L04 
HMS3649K16 
HMS3675F05 
1H-Indazole,3-bromo-7-nitro- 
KS-000006NQ 
ZINC3870920 
ZX-AT001376 
Tox21_500161 
ANW-57370 
BDBM50270528 
BS0227 
HSCI1_000239 
SBB099519 
AKOS005070136 
3-bromo-7-nitro-2H-indazole 
CB-3929 
CCG-204256 
CS-W020666 
DB01997 
FCH1322644 
LP00161 
MCULE-1752377285 
PB13032 
RP13826 
SB19947 
CHEMBL479014 
TRA0074231 
VI20026 
IDI1_033972 
NCGC00015143-01 
NCGC00015143-02 
NCGC00015143-03 
NCGC00015143-04 
NCGC00015143-05 
NCGC00015143-06 
NCGC00015143-07 
NFSTZPMYAZRZPC-UHFFFAOYSA-N 
NCGC00015143-08 
NCGC00015143-09 
NCGC00015143-10 
NCGC00024756-01 
NCGC00024756-02 
NCGC00024756-03 
NCGC00024756-04 
NCGC00024756-05 
NCGC00024756-06 
NCGC00024756-07 
MFCD00159910 
NCGC00024756-08 
NCGC00260846-01 
AJ-46338 
QC-10364 
SC-61310 
AB0038182 
AX8085266 
ST1100585 
TR-023986 
B6426 
Literature

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Journal: Molecular neurodegeneration 20130101

Title: Inhibition of neuronal nitric oxide synthase and soluble guanylate cyclase prevents depression-like behaviour in rats exposed to chronic unpredictable mild stress.

Journal: Basic & clinical pharmacology & toxicology 20120901

Title: Photoperiod-dependent effects of neuronal nitric oxide synthase inhibition on aggression in Siberian hamsters.

Journal: Hormones and behavior 20120201

Title: 3-Bromo-7-nitroindazole attenuates brain ischemic injury in diabetic stroke via inhibition of endoplasmic reticulum stress pathway involving CHOP.

Journal: Life sciences 20120116

Title: Evidence for the involvement of neuronal nitric oxide synthase and soluble guanylate cyclase on cognitive functions in rats.

Journal: Life sciences 20111205

Title: Lactate dilates cochlear capillaries via type V fibrocyte-vessel coupling signaled by nNOS.

Journal: American journal of physiology. Heart and circulatory physiology 20111001

Title: The mitochondrial permeability transition pore regulates nitric oxide-mediated apoptosis of neurons induced by target deprivation.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20110105

Title: Increase nitric oxide synthase activity in parotid glands from rats with experimental periodontitis.

Journal: Oral diseases 20101101

Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Journal: Bioorganic & medicinal chemistry letters 20101101

Title: Dynamic and interacting profiles of *NO and O2 in rat hippocampal slices.

Journal: Free radical biology & medicine 20100415

Title: Fluorinated indazoles as novel selective inhibitors of nitric oxide synthase (NOS): synthesis and biological evaluation.

Journal: Bioorganic & medicinal chemistry 20090901

Title: Paradoxical facilitation of pentylenetetrazole-induced convulsion susceptibility in mice lacking neuronal nitric oxide synthase.

Journal: Neuroscience 20090317

Title: Signaling mechanisms of interferon gamma induced apoptosis in chromaffin cells: involvement of nNOS, iNOS, and NFkappaB.

Journal: Journal of neurochemistry 20090201

Title: Inhibitory effects of a series of 7-substituted-indazoles toward nitric oxide synthases: particular potency of 1H-indazole-7-carbonitrile.

Journal: Bioorganic & medicinal chemistry 20080601

Title: Inhibition of neuronal nitric oxide reduces anxiety-like responses to pair housing.

Journal: Behavioural brain research 20080211

Title: NMDA inhibitors cause apoptosis of pyramidal neurons in mature piriform cortex: evidence for a nitric oxide-mediated effect involving inhibitory interneurons.

Journal: Neuropharmacology 20070601

Title: Impaired nitric oxide synthase signaling dissociates social investigation and aggression.

Journal: Behavioral neuroscience 20070401

Title: An AMPA glutamatergic receptor activation-nitric oxide synthesis step signals transsynaptic apoptosis in limbic cortex.

Journal: Neuropharmacology 20060701

Title: Effects of selective neuronal nitric oxide synthase inhibition on sleep and wakefulness in the rat.

Journal: Progress in neuro-psychopharmacology & biological psychiatry 20060101

Title: [Effects of new nitric oxide synthase inhibitors on spontaneous locomotor activity].

Journal: Medicinski pregled 20060101

Title: Effect of N-acetylaspartylglutamate (NAAG) on non-quantal and spontaneous quantal release of acetylcholine at the neuromuscular synapse of rat.

Journal: Journal of neurochemistry 20050701

Title: Sensory nitrergic meningeal vasodilatation and non-nitrergic plasma extravasation in anaesthesized rats.

Journal: European journal of pharmacology 20040830

Title: Study on the influence of potent inhibitors of neuronal nitric oxide synthase on the antinociceptive and anticonvulsant activity of benzodiazepines in mice.

Journal: Polish journal of pharmacology 20030101

Title: Inhibition of neuronal nitric oxide synthase-mediated activation of poly(ADP-ribose) polymerase in traumatic brain injury: neuroprotection by 3-aminobenzamide.

Journal: Neuroscience 20030101

Title: Consequences of nitric oxide generation in epileptic-seizure rodent models as studied by in vivo EPR.

Journal: Magnetic resonance in medicine 20021201

Title: Conformational changes in nitric oxide synthases induced by chlorzoxazone and nitroindazoles: crystallographic and computational analyses of inhibitor potency.

Journal: Biochemistry 20021126

Title: The vasorelaxant effect of pituitary adenylate cyclase activating polypeptide and vasoactive intestinal polypeptide in isolated rat basilar arteries is partially mediated by activation of nitrergic neurons.

Journal: Regulatory peptides 20020715

Title: Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells.

Journal: The Journal of biological chemistry 20020419

Title: Prolonged increase in ciliary beat frequency after short-term purinergic stimulation in human airway epithelial cells.

Journal: The Journal of physiology 20020115

Title: Crystal structure of nitric oxide synthase bound to nitro indazole reveals a novel inactivation mechanism.

Journal: Biochemistry 20011113

Title: Ischemia-reperfusion injury of the cochlea: effects of an iron chelator and nitric oxide synthase inhibitors.

Journal: Hearing research 20011001

Title: Differential frequency-dependent regulation of transmitter release by endogenous nitric oxide at the amphibian neuromuscular synapse.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20010215

Title: Neuronal NOS inhibitor that reduces oxidative DNA lesions and neuronal sensitivity increases the expression of intact c-fos transcripts after brain injury.

Journal: Journal of biomedical science 20010101

Title: nNOS inhibitors attenuate methamphetamine-induced dopaminergic neurotoxicity but not hyperthermia in mice.

Journal: Neuroreport 20000911

Title: Anticonvulsant activity of new and potent inhibitors of nitric oxide synthase.

Journal: Brain research bulletin 19970101

Title: 7-Nitro indazole derivatives are potent inhibitors of brain, endothelium and inducible isoforms of nitric oxide synthase.

Journal: Life sciences 19950101

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