Home Bromides 74209-34-0
74209-34-0,MFCD00159910
Catalog No.:AA003J12

74209-34-0 | 3-Bromo-7-nitro-1H-indazole

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250mg
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1g
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5g
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10g
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25g
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100g
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA003J12
Chemical Name:
3-Bromo-7-nitro-1H-indazole
CAS Number:
74209-34-0
Molecular Formula:
C7H4BrN3O2
Molecular Weight:
242.0296
MDL Number:
MFCD00159910
SMILES:
[O-][N+](=O)c1cccc2c1[nH]nc2Br
Properties
Properties
 
BP:
248.9°C at 760 mmHg  
Form:
Solid  
MP:
175-185 °C  
Refractive Index:
1.6200 (estimate)  
Solubility:
ethanol: 25 mg/mL  
Stability:
Light Sensitive  
Storage:
Inert atmosphere;2-8℃;  

Computed Properties
 
Complexity:
220  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
13  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
1  
XLogP3:
2.4  

Literature

Title: S-Nitrosylation of parkin as a novel regulator of p53-mediated neuronal cell death in sporadic Parkinson's disease.

Journal: Molecular neurodegeneration 20130101

Title: Inhibition of neuronal nitric oxide synthase and soluble guanylate cyclase prevents depression-like behaviour in rats exposed to chronic unpredictable mild stress.

Journal: Basic & clinical pharmacology & toxicology 20120901

Title: Photoperiod-dependent effects of neuronal nitric oxide synthase inhibition on aggression in Siberian hamsters.

Journal: Hormones and behavior 20120201

Title: 3-Bromo-7-nitroindazole attenuates brain ischemic injury in diabetic stroke via inhibition of endoplasmic reticulum stress pathway involving CHOP.

Journal: Life sciences 20120116

Title: Evidence for the involvement of neuronal nitric oxide synthase and soluble guanylate cyclase on cognitive functions in rats.

Journal: Life sciences 20111205

Title: Lactate dilates cochlear capillaries via type V fibrocyte-vessel coupling signaled by nNOS.

Journal: American journal of physiology. Heart and circulatory physiology 20111001

Title: The mitochondrial permeability transition pore regulates nitric oxide-mediated apoptosis of neurons induced by target deprivation.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20110105

Title: Increase nitric oxide synthase activity in parotid glands from rats with experimental periodontitis.

Journal: Oral diseases 20101101

Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Journal: Bioorganic & medicinal chemistry letters 20101101

Title: Dynamic and interacting profiles of *NO and O2 in rat hippocampal slices.

Journal: Free radical biology & medicine 20100415

Title: Fluorinated indazoles as novel selective inhibitors of nitric oxide synthase (NOS): synthesis and biological evaluation.

Journal: Bioorganic & medicinal chemistry 20090901

Title: Paradoxical facilitation of pentylenetetrazole-induced convulsion susceptibility in mice lacking neuronal nitric oxide synthase.

Journal: Neuroscience 20090317

Title: Signaling mechanisms of interferon gamma induced apoptosis in chromaffin cells: involvement of nNOS, iNOS, and NFkappaB.

Journal: Journal of neurochemistry 20090201

Title: Inhibitory effects of a series of 7-substituted-indazoles toward nitric oxide synthases: particular potency of 1H-indazole-7-carbonitrile.

Journal: Bioorganic & medicinal chemistry 20080601

Title: Inhibition of neuronal nitric oxide reduces anxiety-like responses to pair housing.

Journal: Behavioural brain research 20080211

Title: NMDA inhibitors cause apoptosis of pyramidal neurons in mature piriform cortex: evidence for a nitric oxide-mediated effect involving inhibitory interneurons.

Journal: Neuropharmacology 20070601

Title: Impaired nitric oxide synthase signaling dissociates social investigation and aggression.

Journal: Behavioral neuroscience 20070401

Title: An AMPA glutamatergic receptor activation-nitric oxide synthesis step signals transsynaptic apoptosis in limbic cortex.

Journal: Neuropharmacology 20060701

Title: Effects of selective neuronal nitric oxide synthase inhibition on sleep and wakefulness in the rat.

Journal: Progress in neuro-psychopharmacology & biological psychiatry 20060101

Title: [Effects of new nitric oxide synthase inhibitors on spontaneous locomotor activity].

Journal: Medicinski pregled 20060101

Title: Effect of N-acetylaspartylglutamate (NAAG) on non-quantal and spontaneous quantal release of acetylcholine at the neuromuscular synapse of rat.

Journal: Journal of neurochemistry 20050701

Title: Sensory nitrergic meningeal vasodilatation and non-nitrergic plasma extravasation in anaesthesized rats.

Journal: European journal of pharmacology 20040830

Title: Study on the influence of potent inhibitors of neuronal nitric oxide synthase on the antinociceptive and anticonvulsant activity of benzodiazepines in mice.

Journal: Polish journal of pharmacology 20030101

Title: Inhibition of neuronal nitric oxide synthase-mediated activation of poly(ADP-ribose) polymerase in traumatic brain injury: neuroprotection by 3-aminobenzamide.

Journal: Neuroscience 20030101

Title: Consequences of nitric oxide generation in epileptic-seizure rodent models as studied by in vivo EPR.

Journal: Magnetic resonance in medicine 20021201

Title: Conformational changes in nitric oxide synthases induced by chlorzoxazone and nitroindazoles: crystallographic and computational analyses of inhibitor potency.

Journal: Biochemistry 20021126

Title: The vasorelaxant effect of pituitary adenylate cyclase activating polypeptide and vasoactive intestinal polypeptide in isolated rat basilar arteries is partially mediated by activation of nitrergic neurons.

Journal: Regulatory peptides 20020715

Title: Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells.

Journal: The Journal of biological chemistry 20020419

Title: Prolonged increase in ciliary beat frequency after short-term purinergic stimulation in human airway epithelial cells.

Journal: The Journal of physiology 20020115

Title: Crystal structure of nitric oxide synthase bound to nitro indazole reveals a novel inactivation mechanism.

Journal: Biochemistry 20011113

Title: Ischemia-reperfusion injury of the cochlea: effects of an iron chelator and nitric oxide synthase inhibitors.

Journal: Hearing research 20011001

Title: Differential frequency-dependent regulation of transmitter release by endogenous nitric oxide at the amphibian neuromuscular synapse.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20010215

Title: Neuronal NOS inhibitor that reduces oxidative DNA lesions and neuronal sensitivity increases the expression of intact c-fos transcripts after brain injury.

Journal: Journal of biomedical science 20010101

Title: nNOS inhibitors attenuate methamphetamine-induced dopaminergic neurotoxicity but not hyperthermia in mice.

Journal: Neuroreport 20000911

Title: Anticonvulsant activity of new and potent inhibitors of nitric oxide synthase.

Journal: Brain research bulletin 19970101

Title: 7-Nitro indazole derivatives are potent inhibitors of brain, endothelium and inducible isoforms of nitric oxide synthase.

Journal: Life sciences 19950101

Title: Gocmez SS, et al. The effect of a selective neuronal nitric oxide synthase inhibitor 3-bromo 7-nitroindazoleon spatial learning and memory in rats. Pharmacol Biochem Behav. 2015 Apr;131:19-25.

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