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75431-54-8,MFCD00057007
Catalog No.:AA005L12

75431-54-8 | 3'-Adenylic acid,5'-(dihydrogen phosphate), disodium salt (9CI)

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1mg
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5mg
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA005L12
Chemical Name:
3'-Adenylic acid,5'-(dihydrogen phosphate), disodium salt (9CI)
CAS Number:
75431-54-8
Molecular Formula:
C10H13N5Na2O10P2
Molecular Weight:
471.1648
MDL Number:
MFCD00057007
SMILES:
O[C@@H]1[C@H](OP(=O)(O)[O-])[C@H](O[C@H]1n1cnc2c1ncnc2N)COP(=O)(O)[O-].[Na+].[Na+]
Properties
Computed Properties
 
Complexity:
627  
Covalently-Bonded Unit Count:
3  
Defined Atom Stereocenter Count:
4  
Heavy Atom Count:
29  
Hydrogen Bond Acceptor Count:
14  
Hydrogen Bond Donor Count:
4  
Rotatable Bond Count:
6  

Literature

Title: 3'-5' phosphoadenosine phosphate is an inhibitor of PARP-1 and a potential mediator of the lithium-dependent inhibition of PARP-1 in vivo.

Journal: The Biochemical journal 20120415

Title: The human gene SLC25A17 encodes a peroxisomal transporter of coenzyme A, FAD and NAD+.

Journal: The Biochemical journal 20120401

Title: An improved HPLC method for the quantitation of 3'-phosphoadenosine 5'-phosphate (PAP) to assay sulfotransferase enzyme activity in HepG2 cells.

Journal: Journal of pharmaceutical and biomedical analysis 20120325

Title: Effects of fou8/fry1 mutation on sulfur metabolism: is decreased internal sulfate the trigger of sulfate starvation response?

Journal: PloS one 20120101

Title: Retrograde signaling: a new candidate signaling molecule.

Journal: The Plant cell 20111101

Title: Evidence for a SAL1-PAP chloroplast retrograde pathway that functions in drought and high light signaling in Arabidopsis.

Journal: The Plant cell 20111101

Title: Reaction product affinity regulates activation of human sulfotransferase 1A1 PAP sulfation.

Journal: Archives of biochemistry and biophysics 20110215

Title: A nucleotide metabolite controls stress-responsive gene expression and plant development.

Journal: PloS one 20110101

Title: The bifunctional abiotic stress signalling regulator and endogenous RNA silencing suppressor FIERY1 is required for lateral root formation.

Journal: Plant, cell & environment 20101201

Title: The human estrogen sulfotransferase: a half-site reactive enzyme.

Journal: Biochemistry 20100615

Title: Crystal structures of the glycopeptide sulfotransferase Teg12 in a complex with the teicoplanin aglycone.

Journal: Biochemistry 20100518

Title: para-Nitrophenyl sulfate activation of human sulfotransferase 1A1 is consistent with intercepting the E[middle dot]PAP complex and reformation of E[middle dot]PAPS.

Journal: The Journal of biological chemistry 20091023

Title: Crystal structure of Saccharomyces cerevisiae 3'-phosphoadenosine-5'-phosphosulfate reductase complexed with adenosine 3',5'-bisphosphate.

Journal: Biochemistry 20081202

Title: Novel 3'-phosphoadenosine-5'-phosphatases from extremely halotolerant Hortaea werneckii reveal insight into molecular determinants of salt tolerance of black yeasts.

Journal: Fungal genetics and biology : FG & B 20071101

Title: Structural and chemical profiling of the human cytosolic sulfotransferases.

Journal: PLoS biology 20070501

Title: Crystal structures of human sulfotransferases SULT1B1 and SULT1C1 complexed with the cofactor product adenosine-3'- 5'-diphosphate (PAP).

Journal: Proteins 20060901

Title: Sodium-induced GCN4 expression controls the accumulation of the 5' to 3' RNA degradation inhibitor, 3'-phosphoadenosine 5'-phosphate.

Journal: The Journal of biological chemistry 20060210

Title: The structure of human SULT1A1 crystallized with estradiol. An insight into active site plasticity and substrate inhibition with multi-ring substrates.

Journal: The Journal of biological chemistry 20051216

Title: Crystal structure of human sulfotransferase SULT1A3 in complex with dopamine and 3'-phosphoadenosine 5'-phosphate.

Journal: Biochemical and biophysical research communications 20050923

Title: Kinetic measurements and mechanism determination of Stf0 sulfotransferase using mass spectrometry.

Journal: Analytical biochemistry 20050601

Title: Molecular cloning and biochemical characterization of a 3'(2'),5'-bisphosphate nucleotidase from Debaryomyces hansenii.

Journal: Yeast (Chichester, England) 20050430

Title: Fluorometric assay for alcohol sulfotransferase.

Journal: Analytical biochemistry 20050401

Title: Alteration of lithium pharmacology through manipulation of phosphoadenosine phosphate metabolism.

Journal: The Journal of biological chemistry 20050218

Title: Sulfotransferase structural biology and inhibitor discovery.

Journal: Drug discovery today 20041201

Title: Study of enzyme kinetics of phenol sulfotransferase by electrophoretically mediated microanalysis.

Journal: Journal of chromatography. A 20040402

Title: Histidine residues in human phenol sulfotransferases.

Journal: Biochemical pharmacology 20040401

Title: Inhibition of 5' to 3' mRNA degradation under stress conditions in Saccharomyces cerevisiae: from GCN4 to MET16.

Journal: RNA (New York, N.Y.) 20040301

Title: Crystal structure of human cholesterol sulfotransferase (SULT2B1b) in the presence of pregnenolone and 3'-phosphoadenosine 5'-phosphate. Rationale for specificity differences between prototypical SULT2A1 and the SULT2BG1 isoforms.

Journal: The Journal of biological chemistry 20031107

Title: L-DOPA biotransformation: correlations of dosage, erythrocyte catechol O-methyltransferase and platelet SULT1A3 activities with metabolic pathways in Parkinsonian patients.

Journal: Journal of neural transmission (Vienna, Austria : 1996) 20030801

Title: Identification and purification of sulfotransferases for 20-hydroxysteroid from the larval fat body of a fleshfly, Sarcophaga peregrina.

Journal: Bioscience, biotechnology, and biochemistry 20030801

Title: Effect of clopidogrel administration to healthy volunteers on platelet phosphorylation events triggered by ADP.

Journal: British journal of haematology 20030201

Title: Synthesis of a bisubstrate analogue targeting estrogen sulfotransferase.

Journal: The Journal of organic chemistry 20030110

Title: Agonist concentration-dependent differential responsivity of a human platelet purinergic receptor: pharmacological and kinetic studies of aggregation, deaggregation and shape change responses mediated by the purinergic P2Y1 receptor in vitro.

Journal: Platelets 20030101

Title: A potent and highly selective sulfotransferase inhibitor.

Journal: Journal of the American Chemical Society 20021211

Title: A single mutation converts the nucleotide specificity of phenol sulfotransferase from PAP to AMP.

Journal: Biochemistry 20021029

Title: Role of ADP receptor P2Y(12) in platelet adhesion and thrombus formation in flowing blood.

Journal: Arteriosclerosis, thrombosis, and vascular biology 20020401

Title: Identification of structural motifs and amino acids within the structure of human heparan sulfate 3-O-sulfotransferase that mediate enzymatic function.

Journal: Biochemical and biophysical research communications 20020201

Title: Protein kinase A cascade regulates quantal release dispersion at frog muscle endplate.

Journal: The Journal of physiology 20020201

Title: Crystal structure of an enzyme displaying both inositol-polyphosphate-1-phosphatase and 3'-phosphoadenosine-5'-phosphate phosphatase activities: a novel target of lithium therapy.

Journal: Journal of molecular biology 20020125

Title: Blockade of adenosine diphosphate receptors P2Y(12) and P2Y(1) is required to inhibit platelet aggregation in whole blood under flow.

Journal: Blood 20011201

Title: [Structural biology of heparan sulfate sulfotransferase].

Journal: Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 20010701

Title: The mechanism of lithium action: state of the art, ten years later.

Journal: Progress in neuro-psychopharmacology & biological psychiatry 20010501

Title: Activation of Gi-coupled receptors releases a tonic state of inhibited platelet aggregation.

Journal: Platelets 20010301

Title: Sulphonation of N-hydroxy-2-acetylaminofluorene by human dehydroepiandrosterone sulphotransferase.

Journal: Xenobiotica; the fate of foreign compounds in biological systems 20000301

Title: Pharmacological characterization of the human P2Y11 receptor.

Journal: British journal of pharmacology 19991101

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Tags:75431-54-8 Molecular Formula|75431-54-8 MDL|75431-54-8 SMILES|75431-54-8 3'-Adenylic acid,5'-(dihydrogen phosphate), disodium salt (9CI)