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76963-41-2,MFCD00865660
Catalog No.:AA003AUD

76963-41-2 | Nizatidine

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Purity
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Price(USD)
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1g
98%
in stock  
$11.00   $8.00
- +
5g
98%
in stock  
$43.00   $30.00
- +
25g
97%
in stock  
$103.00   $73.00
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100g
97%
in stock  
$278.00   $195.00
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA003AUD
Chemical Name:
Nizatidine
CAS Number:
76963-41-2
Molecular Formula:
C12H21N5O2S2
Molecular Weight:
331.4574
MDL Number:
MFCD00865660
SMILES:
CN/C(=C\[N+](=O)[O-])/NCCSCc1csc(n1)CN(C)C
NSC Number:
759289
Properties
Properties
 
Form:
Solid  
MP:
130-1320C  
Storage:
Inert atmosphere;Room Temperature;  

Computed Properties
 
Complexity:
349  
Covalently-Bonded Unit Count:
1  
Defined Bond Stereocenter Count:
1  
Heavy Atom Count:
21  
Hydrogen Bond Acceptor Count:
8  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
9  
XLogP3:
1.6  

Literature

Title: Influence of H2-receptor antagonists and proton pump inhibitors on dasatinib pharmacokinetics in Japanese leukemia patients.

Journal: Cancer chemotherapy and pharmacology 20120401

Title: In vitro evaluation of phototoxic properties of proton pump inhibitors, H2-receptor antagonists and statins.

Journal: Acta dermato-venereologica 20120301

Title: Nizatidine improves clinical symptoms and gastric emptying in patients with functional dyspepsia accompanied by impaired gastric emptying.

Journal: Digestion 20120101

Title: Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).

Journal: PLoS computational biology 20111201

Title: Determination of ranitidine, nizatidine, and cimetidine by a sensitive fluorescent probe.

Journal: The Analyst 20111021

Title: The effects of nizatidine on transient lower esophageal sphincter relaxations (TLESRs) and acid reflux in healthy subjects.

Journal: Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi 20110101

Title: Multicenter, double-blind, placebo-controlled crossover study to assess the acute prokinetic efficacy of nizatidine-controlled release (150 and 300 mg) in patients with gastroesophageal reflux disease.

Journal: The American journal of the medical sciences 20101001

Title: Discovery of potent small-molecule inhibitors of multidrug-resistant Plasmodium falciparum using a novel miniaturized high-throughput luciferase-based assay.

Journal: Antimicrobial agents and chemotherapy 20100901

Title: Onset of relief of symptoms of gastroesophageal reflux disease: post hoc analysis of two previously published studies comparing pantoprazole 20 mg once daily with nizatidine or ranitidine 150 mg twice daily.

Journal: Clinical therapeutics 20100401

Title: The H2 receptor antagonist nizatidine is a P-glycoprotein substrate: characterization of its intestinal epithelial cell efflux transport.

Journal: The AAPS journal 20090601

Title: Does the use of nizatidine, as a pro-kinetic agent, improve gastric emptying in patients post-oesophagectomy?

Journal: Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract 20090301

Title: Sjogren's syndrome: promising, new treatment options besides nizatidine.

Journal: Modern rheumatology 20090101

Title: Predictors and correlates for weight changes in patients co-treated with olanzapine and weight mitigating agents; a post-hoc analysis.

Journal: BMC psychiatry 20090101

Title: Little necessity of acid inhibition against proton pump inhibitor rebound effects and prior helicobacter pylori eradication therapy in gastric ulcer patients: a randomized prospective study.

Journal: Hepato-gastroenterology 20090101

Title: Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2).

Journal: Journal of medicinal chemistry 20080612

Title: Nizatidine enhances salivary secretion in patients with dry mouth.

Journal: Auris, nasus, larynx 20080601

Title: Nizatidine and gastric emptying in functional dyspepsia.

Journal: Digestive diseases and sciences 20080201

Title: Spectrophotometric determination of H(2)-receptor antagonists via their oxidation with cerium(IV).

Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20080101

Title: Validated stability-indicating methods for the determination of nizatidine in the presence of its sulfoxide derivative.

Journal: Journal of AOAC International 20080101

Title: Effect of the H2 receptor antagonist nizatidine on xerostomia in patients with primary Sjögren's syndrome.

Journal: Modern rheumatology 20080101

Title: [Analytical application of phosphotungstic acid complexes. Fabrication and characterisation of membrane selective electrodes for some H2 antihistaminics].

Journal: Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi 20080101

Title: Simple and universal HPLC-UV method to determine cimetidine, ranitidine, famotidine and nizatidine in urine: application to the analysis of ranitidine and its metabolites in human volunteers.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20071215

Title: Comments on 'Weight gain management in patients with schizophrenia during treatment with olanzapine in association with nizatidine'.

Journal: Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999) 20070301

Title: Effect of pantoprazole in older patients with erosive esophagitis.

Journal: Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus 20070101

Title: [Analytical application of phosphotungstic acid complexes. Synthesis and characterisation].

Journal: Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi 20070101

Title: Weight gain management in patients with schizophrenia during treatment with olanzapine in association with nizatidine.

Journal: Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999) 20061201

Title: [Safety of proton pump inhibitors].

Journal: Medicina clinica 20061125

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Title: Validation of a new high-performance liquid chromatography assay for nizatidine.

Journal: Therapeutic drug monitoring 20060401

Title: Gastric inflammatory polyposis after long-term intermittent use of nonsteroidal anti-inflammatory drugs and histamine2-receptor antagonists.

Journal: Endoscopy 20050701

Title: Effects of antisecretory agents on angiogenesis during healing of gastric ulcers.

Journal: Journal of gastroenterology 20050701

Title: Prediction of genotoxicity of chemical compounds by statistical learning methods.

Journal: Chemical research in toxicology 20050601

Title: Adiabatic pulses in 1H-15N direct and long-range heteronuclear correlations.

Journal: Magnetic resonance in chemistry : MRC 20050401

Title: Bioequivalence of two oral formulations of nizatidine capsules in healthy male volunteers.

Journal: Biopharmaceutics & drug disposition 20050401

Title: Nizatidine for the treatment of pediatric gastroesophageal reflux symptoms: an open-label, multiple-dose, randomized, multicenter clinical trial in 210 children.

Journal: Clinical therapeutics 20050401

Title: Comparative study of nizatidine and famotidine for maintenance therapy of erosive esophagitis.

Journal: Journal of gastroenterology and hepatology 20050201

Title: Pharmacokinetics of ranitidine and nizatidine in very elderly patients.

Journal: American journal of therapeutics 20050101

Title: Pantoprazole provides rapid and sustained symptomatic relief in patients treated for erosive oesophagitis.

Journal: Alimentary pharmacology & therapeutics 20041115

Title: Extrapyramidal symptoms related to adjunctive nizatidine therapy in an adolescent receiving quetiapine and paroxetine.

Journal: Pharmacotherapy 20040701

Title: Spectrophotometric determination of nizatidine and ranitidine through charge transfer complex formation.

Journal: Archives of pharmacal research 20040701

Title: Aplastic anemia associated with initiation of nizatidine therapy in a hemodialysis patient.

Journal: Clinical and experimental nephrology 20040601

Title: Teprenone, but not H2-receptor blocker or sucralfate, suppresses corpus Helicobacter pylori colonization and gastritis in humans: teprenone inhibition of H. pylori-induced interleukin-8 in MKN28 gastric epithelial cell lines.

Journal: Helicobacter 20040401

Title: Developmental pharmacokinetics and pharmacodynamics of nizatidine.

Journal: Journal of pediatric gastroenterology and nutrition 20040401

Title: Nizatidine and cisapride increase salivary secretion in rats.

Journal: Digestive diseases and sciences 20040301

Title: Nizatidine for the treatment of patients with quetiapine-induced weight gain.

Journal: Human psychopharmacology 20040101

Title: Clinical study on the effects of nizatidine on gastric motility and cardiac autonomic function. Investigations using electrogastrography and spectral analysis of heart rate variability.

Journal: Arzneimittel-Forschung 20040101

Title: [Treatment of gastroesophageal reflux disease].

Journal: Orvosi hetilap 20031228

Title: Pantoprazole rapidly improves health-related quality of life in patients with heartburn: a prospective, randomized, double blind comparative study with nizatidine.

Journal: Journal of clinical gastroenterology 20030801

Title: Effect of nizatidine on olanzapine-associated weight gain in schizophrenic patients in Korea: a pilot study.

Journal: Human psychopharmacology 20030801

Title: Nizatidine treatment and its relationship with leptin levels in patients with olanzapine-induced weight gain.

Journal: Human psychopharmacology 20030801

Title: Meta-analysis: proton pump inhibitor or H2-receptor antagonist for Helicobacter pylori eradication.

Journal: Alimentary pharmacology & therapeutics 20030515

Title: Validation of the GSFQ, a self-administered symptom frequency questionnaire for patients with gastroesophageal reflux disease.

Journal: Canadian journal of gastroenterology = Journal canadien de gastroenterologie 20030501

Title: Spectrophotometric and titrimetric determination of nizatidine in capsules.

Journal: Journal of pharmaceutical and biomedical analysis 20030401

Title: Nizatidine for prevention of weight gain with olanzapine: a double-blind placebo-controlled trial.

Journal: European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20030301

Title: The bioequivalence of nizatidine (Axid) in two extemporaneously and one commercially prepared oral liquid formulations compared with capsule.

Journal: Journal of clinical pharmacology 20030201

Title: Pharmacokinetics and pharmacodynamics of a novel nizatidine controlled-release formulation in healthy subjects.

Journal: Journal of clinical pharmacology 20030101

Title: Influence of anti-ulcer drugs used in Japan on the result of (13)C-urea breath test for the diagnosis of Helicobacter pylori infection.

Journal: Journal of gastroenterology 20030101

Title: Comparison of the efficacy of pantoprazole vs. nizatidine in the treatment of erosive oesophagitis: a randomized, active-controlled, double-blind study.

Journal: Alimentary pharmacology & therapeutics 20021201

Title: Lack of effect of nizatidine-induced elevation of gastric pH on the oral bioavailability of dapsone in healthy volunteers.

Journal: Pharmacotherapy 20021101

Title: Effects of histamine H(2)-receptor antagonists on human plasma levels of calcitonin gene-related peptide, substance P and vasoactive intestinal peptide.

Journal: The Journal of pharmacy and pharmacology 20021101

Title: Single-dose pharmacokinetics of nizatidine (Axid) in children.

Journal: Journal of clinical pharmacology 20021001

Title: Nonisothermal stability tests of famotidine and nizatidine.

Journal: Farmaco (Societa chimica italiana : 1989) 20020901

Title: Effect of preoperative oral use of erythromycin and nizatidine on gastric pH and volume.

Journal: Anaesthesia and intensive care 20020801

Title: Options for pharmacological management of obesity in patients treated with atypical antipsychotics.

Journal: International clinical psychopharmacology 20020701

Title: Effect of nizatidine on paracetamol and its metabolites in human plasma.

Journal: The Journal of pharmacy and pharmacology 20020601

Title: Susceptibility of the H2-receptor antagonists cimetidine, famotidine and nizatidine, to metabolism by the gastrointestinal microflora.

Journal: International journal of pharmaceutics 20020426

Title: Nizatidine and omeprazole enhance the effect of metronidazole on Helicobacter pylori in vitro.

Journal: International journal of antimicrobial agents 20020301

Title: Nizatidine and cisapride enhance salivary secretion in humans.

Journal: Alimentary pharmacology & therapeutics 20020201

Title: Kinetic spectrophotometric determination of nizatidine and ranitidine in pharmaceutical preparations.

Journal: Journal of pharmaceutical and biomedical analysis 20020101

Title: H2 histamine receptor blockade in the treatment of Alzheimer disease: a randomized, double-blind, placebo-controlled trial of nizatidine.

Journal: Alzheimer disease and associated disorders 20020101

Title: Spectrophotometric determination of three anti-ulcer drugs through charge-transfer complexation.

Journal: Journal of AOAC International 20020101

Title: Kinetic spectrophotometric method for the determination of ranitidine and nizatidine in pharmaceuticals.

Journal: Journal of AOAC International 20020101

Title: Nizatidine enhances the gastrocolonic response and the colonic peristaltic reflex in humans.

Journal: The Journal of pharmacology and experimental therapeutics 20011001

Title: Effectiveness and safety of nizatidine, 75 mg, for the relief of episodic heartburn.

Journal: Alimentary pharmacology & therapeutics 20011001

Title: Symptom relief in gastroesophageal reflux disease: a randomized, controlled comparison of pantoprazole and nizatidine in a mixed patient population with erosive esophagitis or endoscopy-negative reflux disease.

Journal: The American journal of gastroenterology 20011001

Title: pH-Metric log K calculations of famotidine, naproxen, nizatidine, ranitidine and salicylic acid.

Journal: Farmaco (Societa chimica italiana : 1989) 20010901

Title: Head-column field-amplified sample stacking in capillary electrophoresis for the determination of cimetidine, famotidine, nizatidine, and ranitidine-HCl in plasma.

Journal: Electrophoresis 20010801

Title: Simultaneous determination of cimetidine, famotidine, nizatidine, and ranitidine in tablets by capillary zone electrophoresis.

Journal: Electrophoresis 20010801

Title: ElogD(oct): a tool for lipophilicity determination in drug discovery. 2. Basic and neutral compounds.

Journal: Journal of medicinal chemistry 20010719

Title: Inhibition of drug metabolism in human liver microsomes by nizatidine, cimetidine and omeprazole.

Journal: Xenobiotica; the fate of foreign compounds in biological systems 20010101

Title: Bicarbonate stimulatory action of nizatidine, a histamine H(2)-receptor antagonist, in rat duodenums.

Journal: Journal of physiology, Paris 20010101

Title: Effects of different antisecretory drugs on gastric potential difference in the rat: comparison with sucralfate.

Journal: Pharmacological research 19981201

Title: Nizatidine-induced delirium in a nonagenarian.

Journal: The Journal of clinical psychiatry 19970701

Title: Influence of H2-receptor- and proton pump inhibitors on some functions of the oxydative and conjugative drug metabolism.

Journal: Die Pharmazie 19960701

Title: Neurotoxic convulsions induced by histamine H2 receptor antagonists in mice.

Journal: Toxicology and applied pharmacology 19960201

Title: Effect of anti-ulcer drugs on DNA synthesis in adult normal human hepatocytes in culture.

Journal: Hepatology (Baltimore, Md.) 19950901

Title: Possible nizatidine-induced subfulminant hepatic failure.

Journal: Journal of clinical gastroenterology 19950301

Title: T M Lin, et al. Actions of nizatidine, a selective histamine H2-receptor antagonist, on gastric acid secretion in dogs, rats and frogs. J Pharmacol Exp Ther. 1986 Nov;239(2):406-10.

Title: Shen Li, et al. Abstract 4004: The H2 receptor antagonist nizatidine inhibits carcinogenesis in two rodent models of hepatocellular carcinoma. Tumor Biology. Cancer research.

Title: Ahmed S. Alazzouni, et al. Comparative histological and histochemical studies between ranitidine and nizatidine in treatment of peptic ulcer with evaluation of their adverse effects on male sex hormones. The Journal of Basic and Applied Zoology volume

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