Home Deuterated Building Blocks 771-99-3
771-99-3,MFCD00006002
Catalog No.:AA003LWP

771-99-3 | 4-phenylpiperidine

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250mg
97%
in stock  
$7.00   $5.00
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1g
97%
in stock  
$11.00   $8.00
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5g
97%
in stock  
$21.00   $15.00
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10g
97%
in stock  
$36.00   $25.00
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25g
97%
in stock  
$87.00   $61.00
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100g
97%
in stock  
$341.00   $239.00
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA003LWP
Chemical Name:
4-phenylpiperidine
CAS Number:
771-99-3
Molecular Formula:
C11H15N
Molecular Weight:
161.2435
MDL Number:
MFCD00006002
SMILES:
N1CCC(CC1)c1ccccc1
NSC Number:
89743
Properties
Properties
 
BP:
257.0°C  
Form:
Solid  
MP:
57-63 °C  
Refractive Index:
n20/D 1.588(lit.)  
Storage:
Light sensitive;Inert atmosphere;Room Temperature;  

Computed Properties
 
Complexity:
121  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
12  
Hydrogen Bond Acceptor Count:
1  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
1  
XLogP3:
2  

Literature

Title: Radical-mediated nitrile translocation as the key step in the stereoselective transformation of 2-(4-chloro-2-cyanobutyl)aziridines to methyl cis-(1-arylmethyl-4-phenylpiperidin-2-yl)acetates.

Journal: Organic & biomolecular chemistry 20120428

Title: Pyrrolovesamicols--synthesis, structure and VAChT binding of two 4-fluorobenzoyl regioisomers.

Journal: Bioorganic & medicinal chemistry letters 20120315

Title: Influence of cocaine history on the behavioral effects of Dopamine D(3) receptor-selective compounds in monkeys.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20110401

Title: Evaluation of role of noradrenergic system in the antidepressant activity of tramadol using tail suspension test in Albino mice.

Journal: Journal of pharmacology & pharmacotherapeutics 20110101

Title: Design, synthesis, and pharmacological evaluation of haloperidol derivatives as novel potent calcium channel blockers with vasodilator activity.

Journal: PloS one 20110101

Title: Oxidation of fluoroquinolone antibiotics and structurally related amines by chlorine dioxide: Reaction kinetics, product and pathway evaluation.

Journal: Water research 20101201

Title: Synthesis and evaluation of a set of 4-phenylpiperidines and 4-phenylpiperazines as D2 receptor ligands and the discovery of the dopaminergic stabilizer 4-[3-(methylsulfonyl)phenyl]-1-propylpiperidine (huntexil, pridopidine, ACR16).

Journal: Journal of medicinal chemistry 20100325

Title: Discovery of N-{[1-(propylsulfonyl)-4-pyridin-2-ylpiperidin-4-yl]methyl}benzamides as novel, selective and potent GlyT1 inhibitors.

Journal: Bioorganic & medicinal chemistry letters 20090301

Title: A strategy for isotope containment during radiosynthesis--devolatilisation of bromobenzene by fluorous-tagging-Ir-catalysed borylation en route to the 4-phenylpiperidine pharmacophore.

Journal: Organic & biomolecular chemistry 20081121

Title: First CoMFA characterization of vesamicol analogs as ligands for the vesicular acetylcholine transporter.

Journal: Journal of medicinal chemistry 20080410

Title: Phenylpiperidine-benzoxazinones as urotensin-II receptor antagonists: synthesis, SAR, and in vivo assessment.

Journal: Bioorganic & medicinal chemistry letters 20071201

Title: The prediction of (1)H chemical shifts in amines: a semiempirical and ab initio investigation.

Journal: Magnetic resonance in chemistry : MRC 20070901

Title: Synthesis and biological evaluation of 1,3,3,4-tetrasubstituted pyrrolidine CCR5 receptor antagonists. Discovery of a potent and orally bioavailable anti-HIV agent.

Journal: ChemMedChem 20070201

Title: The enantiomers of tramadol and its major metabolite inhibit peristalsis in the guinea pig small intestine via differential mechanisms.

Journal: BMC pharmacology 20070101

Title: Synthesis and binding affinities of methylvesamicol analogs for the acetylcholine transporter and sigma receptor.

Journal: Bioorganic & medicinal chemistry 20060415

Title: QSAR study of 4-phenylpiperidine derivatives as mu opioid agonists by neural network method.

Journal: European journal of medicinal chemistry 20060201

Title: Absolute oral bioavailability of traxoprodil in cytochrome P450 2D6 extensive and poor metabolisers.

Journal: Clinical pharmacokinetics 20060101

Title: Synthesis and structure-activity relationship of the first nonpeptidergic inverse agonists for the human cytomegalovirus encoded chemokine receptor US28.

Journal: Journal of medicinal chemistry 20051006

Title: Oxidative transformation of fluoroquinolone antibacterial agents and structurally related amines by manganese oxide.

Journal: Environmental science & technology 20050615

Title: In vitro characterization of radioiodinated (+)-2-[4-(4-iodophenyl) piperidino]cyclohexanol [(+)-pIV] as a sigma-1 receptor ligand.

Journal: Bioorganic & medicinal chemistry 20050215

Title: Design and synthesis of 4-phenyl piperidine compounds targeting the mu receptor.

Journal: Bioorganic & medicinal chemistry letters 20041101

Title: Na+ modulation, inverse agonism, and anorectic potency of 4-phenylpiperidine opioid antagonists.

Journal: European journal of pharmacology 20040628

Title: Quantitative structure-activity relationship study of novel alpha1a-selective adrenoceptor antagonists.

Journal: Journal of enzyme inhibition 20011001

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