Title: Thr302 is the site for the covalent modification of human cytochrome P450 2B6 leading to mechanism-based inactivation by tert-butylphenylacetylene.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20111201
Title: Structural analysis of mammalian cytochrome P450 2B4 covalently bound to the mechanism-based inactivator tert-butylphenylacetylene: insight into partial enzymatic activity.
Journal: Biochemistry 20110607
Title: Targeting of the highly conserved threonine 302 residue of cytochromes P450 2B family during mechanism-based inactivation by aryl acetylenes.
Journal: Archives of biochemistry and biophysics 20110301
Title: Covalent modification of Thr302 in cytochrome P450 2B1 by the mechanism-based inactivator 4-tert-butylphenylacetylene.
Journal: The Journal of pharmacology and experimental therapeutics 20100601
Title: Defining the structural consequences of mechanism-based inactivation of mammalian cytochrome P450 2B4 using resonance Raman spectroscopy.
Journal: Journal of the American Chemical Society 20100210
Title: Mechanism-based inactivation of CYP2B1 and its F-helix mutant by two tert-butyl acetylenic compounds: covalent modification of prosthetic heme versus apoprotein.
Journal: The Journal of pharmacology and experimental therapeutics 20091101
Title: tert-Butylphenylacetylene is a potent mechanism-based inactivator of cytochrome P450 2B4: inhibition of cytochrome P450 catalysis by steric hindrance.
Journal: Molecular pharmacology 20091101
