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78033-08-6,MFCD00211081
Catalog No.:AA003JJ6

78033-08-6 | 8-Methoxymethyl-isobutyryl-1-methylxanthine

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Purity
Availability
Price(USD)
Quantity
  
1mg
≥98%
in stock  
$66.00   $46.00
- +
5mg
≥98%
in stock  
$263.00   $184.00
- +
10mg
≥98%
in stock  
$428.00   $299.00
- +
  • Technical Information
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA003JJ6
Chemical Name:
8-Methoxymethyl-isobutyryl-1-methylxanthine
CAS Number:
78033-08-6
Molecular Formula:
C12H18N4O3
Molecular Weight:
266.2963
MDL Number:
MFCD00211081
SMILES:
COCc1[nH]c2c(n1)n(CC(C)C)c(=O)n(c2=O)C
Properties
Properties
 
Form:
Solid  
MP:
194-200°C  
Storage:
Keep in dry area;2-8℃;  

Computed Properties
 
Complexity:
374  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
19  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
4  
XLogP3:
1.6  

Literature

Title: New perspectives for the treatment of pulmonary hypertension.

Journal: British journal of pharmacology 20110501

Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Journal: Bioorganic & medicinal chemistry letters 20101101

Title: Gq-mediated Ca2+ signals inhibit adenylyl cyclases 5/6 in vascular smooth muscle cells.

Journal: American journal of physiology. Cell physiology 20100201

Title: Phosphodiesterases do not limit beta1-adrenoceptor-mediated sinoatrial tachycardia: evidence with PDE3 and PDE4 in rabbits and PDE1-5 in rats.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20091101

Title: Genistein stimulates electrogenic Cl- secretion via phosphodiesterase modulation in the mouse jejunum.

Journal: American journal of physiology. Cell physiology 20090901

Title: Regulation of renovascular adenosine 3',5'-cyclic monophosphate in spontaneously hypertensive rats.

Journal: Hypertension (Dallas, Tex. : 1979) 20090801

Title: Discovery and structure-activity study of a novel benzoxaborole anti-inflammatory agent (AN2728) for the potential topical treatment of psoriasis and atopic dermatitis.

Journal: Bioorganic & medicinal chemistry letters 20090415

Title: Kinetic properties of Ca2+/calmodulin-dependent phosphodiesterase isoforms dictate intracellular cAMP dynamics in response to elevation of cytosolic Ca2+.

Journal: Cellular signalling 20080201

Title: Characterization of inhibitors of phosphodiesterase 1C on a human cellular system.

Journal: The FEBS journal 20070901

Title: Phosphodiesterase 1 upregulation in pulmonary arterial hypertension: target for reverse-remodeling therapy.

Journal: Circulation 20070501

Title: The effect of oxidative stress on macrophages and lung epithelial cells: the role of phosphodiesterases 1 and 4.

Journal: Toxicology letters 20070110

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Title: Ca(2+)/calmodulin-dependent cyclic nucleotide phosphodiesterase in cGMP metabolism in rabbit parotid acinar cells.

Journal: Biomedical research (Tokyo, Japan) 20060201

Title: The phosphodiesterase 3 inhibitor cilostamide enhances inotropic responses to glucagon but not to dobutamine in rat ventricular myocardium.

Journal: European journal of pharmacology 20050411

Title: Characterization of forskolin-induced Ca2+ signals in rat olfactory receptor neurons.

Journal: Journal of pharmacological sciences 20050401

Title: Lung vasodilatory response to inhaled iloprost in experimental pulmonary hypertension: amplification by different type phosphodiesterase inhibitors.

Journal: Respiratory research 20050101

Title: Comparative actions of diazepam and other phosphodiesterase inhibitors on the effects of noradrenaline in rat myocardium.

Journal: Pharmacology & toxicology 20030701

Title: Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells.

Journal: The Journal of biological chemistry 20020419

Title: Immunopharmacological potential of selective phosphodiesterase inhibition. I. Differential regulation of lipopolysaccharide-mediated proinflammatory cytokine (interleukin-6 and tumor necrosis factor-alpha) biosynthesis in alveolar epithelial cells.

Journal: The Journal of pharmacology and experimental therapeutics 20020201

Title: Immunopharmacological potential of selective phosphodiesterase inhibition. II. Evidence for the involvement of an inhibitory-kappaB/nuclear factor-kappaB-sensitive pathway in alveolar epithelial cells.

Journal: The Journal of pharmacology and experimental therapeutics 20020201

Title: Regulatory roles of adenylate cyclase and cyclic nucleotide phosphodiesterases 1 and 4 in interleukin-13 production by activated human T cells.

Journal: Biochemical pharmacology 20010815

Title: The role of cGMP hydrolysing phosphodiesterases 1 and 5 in cerebral artery dilatation.

Journal: European journal of pharmacology 20010518

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