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78824-30-3,MFCD03700761
Catalog No.:AA00G39W

78824-30-3 | garcinol

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5mg
≥95%
in stock  
$82.00   $57.00
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10mg
≥95%
in stock  
$122.00   $85.00
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25mg
≥95%
in stock  
$276.00   $193.00
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50mg
≥95%
in stock  
$472.00   $330.00
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00G39W
Chemical Name:
garcinol
CAS Number:
78824-30-3
Molecular Formula:
C38H50O6
Molecular Weight:
602.8000
MDL Number:
MFCD03700761
SMILES:
CC(=CCC12C(=O)C(=C(c3ccc(c(c3)O)O)O)C(=O)C(C1=O)(CC(C(=C)C)CC=C(C)C)CC(C2(C)C)CC=C(C)C)C
Properties
Computed Properties
 
Complexity:
1300  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
4  
Defined Bond Stereocenter Count:
1  
Heavy Atom Count:
44  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
10  
XLogP3:
10.3  

Literature

Title: Inhibition of different histone acetyltransferases (HATs) uncovers transcription-dependent and -independent acetylation-mediated mechanisms in memory formation.

Journal: Learning & memory (Cold Spring Harbor, N.Y.) 20160201

Title: Acetylation of retinal histones in diabetes increases inflammatory proteins: effects of minocycline and manipulation of histone acetyltransferase (HAT) and histone deacetylase (HDAC).

Journal: The Journal of biological chemistry 20120727

Title: Hippocampal histone acetylation regulates object recognition and the estradiol-induced enhancement of object recognition.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20120215

Title: Inhibitory effects of garcinol and pterostilbene on cell proliferation and adipogenesis in 3T3-L1 cells.

Journal: Food & function 20120101

Title: Acetylation-mediated suppression of transcription-independent memory: bidirectional modulation of memory by acetylation.

Journal: PloS one 20120101

Title: Nicotinic acetylcholine receptor-based blockade: applications of molecular targets for cancer therapy.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20110601

Title: Garcinol promotes neurogenesis in rat cortical progenitor cells through the duration of extracellular signal-regulated kinase signaling.

Journal: Journal of agricultural and food chemistry 20110209

Title: Nicotine-induced human breast cancer cell proliferation attenuated by garcinol through down-regulation of the nicotinic receptor and cyclin D3 proteins.

Journal: Breast cancer research and treatment 20110101

Title: Garcinol inhibits cell proliferation and promotes apoptosis in pancreatic adenocarcinoma cells.

Journal: Nutrition and cancer 20110101

Title: Cambogin is preferentially cytotoxic to cells expressing PDGFR.

Journal: PloS one 20110101

Title: Ex vivo expansion of human hematopoietic stem cells by garcinol, a potent inhibitor of histone acetyltransferase.

Journal: PloS one 20110101

Title: Fluorinated 2'-hydroxychalcones as garcinol analogs with enhanced antioxidant and anticancer activities.

Journal: Bioorganic & medicinal chemistry letters 20101001

Title: Garcinol potentiates TRAIL-induced apoptosis through modulation of death receptors and antiapoptotic proteins.

Journal: Molecular cancer therapeutics 20100401

Title: Effects of garcinol and guttiferone K isolated from Garcinia cambogia on oxidative/nitrative modifications in blood platelets and plasma.

Journal: Platelets 20091101

Title: Chicken HS4 insulator significantly improves baculovirus-mediated foreign gene expression in insect cells by modifying the structure of neighbouring chromatin in virus minichromosome.

Journal: Journal of biotechnology 20090715

Title: Identification of 5-lipoxygenase and microsomal prostaglandin E2 synthase-1 as functional targets of the anti-inflammatory and anti-carcinogenic garcinol.

Journal: Biochemical pharmacology 20090501

Title: Emerging role of Garcinol, the antioxidant chalcone from Garcinia indica Choisy and its synthetic analogs.

Journal: Journal of hematology & oncology 20090101

Title: Liquid chromatography-tandem mass spectrometry method for identification and quantification of two biologically active polyisoprenylated benzophenones, isoxanthochymol and camboginol, in Garcinia species.

Journal: Biomedical chromatography : BMC 20071101

Title: Specific inhibition of p300-HAT alters global gene expression and represses HIV replication.

Journal: Chemistry & biology 20070601

Title: Inhibition of human lipoprotein oxidation by morelloflavone and camboginol from Garcinia dulcis.

Journal: Natural product research 20070601

Title: Effects of garcinol and its derivatives on intestinal cell growth: Inhibitory effects and autoxidation-dependent growth-stimulatory effects.

Journal: Free radical biology & medicine 20070415

Title: A rapid liquid chromatography-tandem mass spectrometry method for quantification of a biologically active molecule camboginol in the extract of Garcinia cambogia.

Journal: Biomedical chromatography : BMC 20070101

Title: Oblongifolins A-D, polyprenylated benzoylphloroglucinol derivatives from Garcinia oblongifolia.

Journal: Journal of natural products 20060501

Title: Modulation of arachidonic acid metabolism and nitric oxide synthesis by garcinol and its derivatives.

Journal: Carcinogenesis 20060201

Title: Garcinol modulates tyrosine phosphorylation of FAK and subsequently induces apoptosis through down-regulation of Src, ERK, and Akt survival signaling in human colon cancer cells.

Journal: Journal of cellular biochemistry 20050901

Title: Effects of garcinol on free radical generation and NO production in embryonic rat cortical neurons and astrocytes.

Journal: Biochemical and biophysical research communications 20050422

Title: Dietary garcinol inhibits 4-nitroquinoline 1-oxide-induced tongue carcinogenesis in rats.

Journal: Cancer letters 20050418

Title: A polyisoprenylated ketone from Calophyllum enervosum.

Journal: Phytochemistry 20050301

Title: Polyisoprenylated benzophenone, garcinol, a natural histone acetyltransferase inhibitor, represses chromatin transcription and alters global gene expression.

Journal: The Journal of biological chemistry 20040806

Title: The bactericidal effects of Lactobacillus acidophilus, garcinol and Protykin compared to clarithromycin, on Helicobacter pylori.

Journal: Molecular and cellular biochemistry 20030101

Title: Induction of apoptosis by garcinol and curcumin through cytochrome c release and activation of caspases in human leukemia HL-60 cells.

Journal: Journal of agricultural and food chemistry 20010301

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