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79-63-0,MFCD00021108
Catalog No.:AA003509

79-63-0 | (3β)-Lanosta-8,24-dien-3-ol

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Purity
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5g
60%
in stock  
$21.00   $15.00
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA003509
Chemical Name:
(3β)-Lanosta-8,24-dien-3-ol
CAS Number:
79-63-0
Molecular Formula:
C30H50O
Molecular Weight:
426.7174
MDL Number:
MFCD00021108
SMILES:
CC(=CCC[C@H]([C@H]1CC[C@@]2([C@]1(C)CCC1=C2CC[C@@H]2[C@]1(C)CC[C@@H](C2(C)C)O)C)C)C
NSC Number:
60677
Properties
Properties
 
BP:
498.9°C at 760 mmHg  
Form:
Solid  
MP:
117-122°C (dec.)  
Storage:
Inert atmosphere;-20 ℃;  

Computed Properties
 
Complexity:
767  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
7  
Heavy Atom Count:
31  
Hydrogen Bond Acceptor Count:
1  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
4  
XLogP3:
8.9  

Downstream Synthesis Route
79-63-0   
24,25-dihydrolanosterol 

[1]Jennings,GarethK.;Modi,Anuja;Elenewski,JustinE.;Ritchie,CarolineM.;Nguyen,Thuy;Ellis,KeithC.;Hackett,JohnC[JournalofInorganicBiochemistry,2014,vol.136,p.81-91]

[2]Dayal;Ertel;Rapole;Asgaonkar;Salen[Steroids,1997,vol.62,#5,p.451-454]

[3]McCreary,M.D.etal.[JournaloftheAmericanChemicalSociety,1974,vol.96,#4,p.1038-1054]

[4]Giera,Martin;Ploessl,Florian;Bracher,Franz[Steroids,2007,vol.72,#8,p.633-642]

[5]Kang,Taek;Kim,Youngchan;Lee,Donggun;Wang,Zhen;Chang,Sukbok[JournaloftheAmericanChemicalSociety,2014,vol.136,#11,p.4141-4144]

[1]Ator,MarkA.;Schmidt,StanleyJ.;Adams,JerryL.;Dolle,RolandE.;Kruse,LawrenceI.;Frey,CarrieL.;Barone,JaniceM.[JournalofMedicinalChemistry,1992,vol.35,#1,p.100-106]

[2]Manatt,S.L.[JournaloftheAmericanChemicalSociety,1966,vol.88,p.1323-1324]Jung,G.etal.[Steroids,1970,vol.15,p.275-281]

110-87-2    79-63-0   
3β-Tetrahydropyranyllanosterol 

[1]Locationinpatent:schemeortableHoward,AliciaL.;Liu,Jialin;Elmegeed,GamalA.;Collins,EmilyK.;Ganatra,KalgiS.;Nwogwugwu,ChizaramA.;Nes,W.David[ArchivesofBiochemistryandBiophysics,2012,vol.521,#1-2,p.43-50]

[2]Liu;Tao[Tetrahedron,1992,vol.48,#33,p.6793-6798]

2459-09-8    79-63-0   
Isonicotinicacid(3S,5R,10S,13R,14R,17R)-17-((R)-1,5-dimethyl-hex-4-enyl)-4,4,10,13,14-pentamethyl-2,3,4,5,6,7,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopentaaphenanthren-3-ylester 

[1]Meth-Cohn,Otto[JournaloftheChemicalSociety.Chemicalcommunications,1986,#9,p.695-697]

2,3-Oxidosqualene 
  79-63-0 

[1]Joubert;Buckner;Matsuda[Organicletters,2001,vol.3,#12,p.1957-1960]

[2]Hoshino;Williams;Chung;Scott[Tetrahedron,1991,vol.47,#31,p.5925-5932]

[3]Tani,Osamu;Akutsu,Yukie;Ito,Shinji;Suzuki,Takayuki;Tateishi,Yukihiro;Yamaguchi,Tomohiko;Niimi,Tatsuya;Namatame,Ichiji;Chiba,Yasunori;Sakashita,Hitoshi;Kubota,Tomomi;Yanagi,Tetsuo;Mizukami,Shusaku;Hirayama,Kenji;Furukawa,Koji;Yamasaki,Kazuhiko[JournalofMedicinalChemistry,2018,vol.61,#11,p.5047-5053]

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Journal: Infection and drug resistance 20110101

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Journal: Dermato-endocrinology 20110101

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Journal: PloS one 20110101

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Title: Characterization of the channel constriction allowing the access of the substrate to the active site of yeast oxidosqualene cyclase.

Journal: PloS one 20110101

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Journal: BMC cancer 20110101

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Journal: BMC systems biology 20110101

Title: The role of Candida albicans homologous recombination factors Rad54 and Rdh54 in DNA damage sensitivity.

Journal: BMC microbiology 20110101

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Title: Mechanism of resistance to dietary cholesterol.

Journal: Journal of lipids 20110101

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Journal: PloS one 20110101

Title: Mono-(2-ethylhexyl) phthalate directly alters the expression of Leydig cell genes and CYP17 lyase activity in cultured rat fetal testis.

Journal: PloS one 20110101

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Journal: Indian journal of dermatology 20110101

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Journal: PloS one 20110101

Title: Triterpenoid biosynthesis and engineering in plants.

Journal: Frontiers in plant science 20110101

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Journal: Journal of natural products 20101227

Title: Separation and determination of four ganoderic acids from dried fermentation mycelia powder of Ganoderma lucidum by capillary zone electrophoresis.

Journal: Journal of pharmaceutical and biomedical analysis 20101215

Title: Current progress in the study on biosynthesis and regulation of ganoderic acids.

Journal: Applied microbiology and biotechnology 20101201

Title: Impact of atorvastatin and omega-3 ethyl esters 90 on plasma plant sterol concentrations and cholesterol synthesis in type 2 diabetes: a randomised placebo controlled factorial trial.

Journal: Atherosclerosis 20101201

Title: Biochemical research elucidating metabolic pathways in Pneumocystis.

Journal: Parasite (Paris, France) 20101201

Title: Divergent interactions involving the oxidosqualene cyclase and the steroid-3-ketoreductase in the sterol biosynthetic pathway of mammals and yeasts.

Journal: Biochimica et biophysica acta 20101101

Title: Hair and skin sterols in normal mice and those with deficient dehydrosterol reductase (DHCR7), the enzyme associated with Smith-Lemli-Opitz syndrome.

Journal: The Journal of steroid biochemistry and molecular biology 20101101

Title: Significance of protein elicitor isolated from Tuber melanosporum on the production of ganoderic acid and Ganoderma polysaccharides during the fermentation of Ganoderma lucidum.

Journal: Bioprocess and biosystems engineering 20101001

Title: Inhibition of aldose reductase in vitro by constituents of Ganoderma lucidum.

Journal: Planta medica 20101001

Title: Cloning, mechanistic and functional analysis of a fungal sterol C24-methyltransferase implicated in brassicasterol biosynthesis.

Journal: Biochimica et biophysica acta 20101001

Title: Expression, purification, and characterization of Aspergillus fumigatus sterol 14-alpha demethylase (CYP51) isoenzymes A and B.

Journal: Antimicrobial agents and chemotherapy 20101001

Title: An unusual lanostane-type triterpenoid, spiroinonotsuoxodiol, and other triterpenoids from Inonotus obliquus.

Journal: Phytochemistry 20101001

Title: Targeting inflammatory pathways by triterpenoids for prevention and treatment of cancer.

Journal: Toxins 20101001

Title: Methyl jasmonate induces ganoderic acid biosynthesis in the basidiomycetous fungus Ganoderma lucidum.

Journal: Bioresource technology 20100901

Title: Observations on squalene accumulation in Saccharomyces cerevisiae due to the manipulation of HMG2 and ERG6.

Journal: FEMS yeast research 20100901

Title: Subcellular organelle lipidomics in TLR-4-activated macrophages.

Journal: Journal of lipid research 20100901

Title: Phytochemical investigation of the seeds of Althea officinalis L.

Journal: Natural product research 20100901

Title: Drug-induced regulation of target expression.

Journal: PLoS computational biology 20100901

Title: Azole drugs are imported by facilitated diffusion in Candida albicans and other pathogenic fungi.

Journal: PLoS pathogens 20100901

Title: Impact of oxygen level in gaseous phase on gene transcription and ganoderic acid biosynthesis in liquid static cultures of Ganoderma lucidum.

Journal: Bioprocess and biosystems engineering 20100801

Title: Adaptation of cholesterol synthesis to fasting and TNF-alpha: profiling cholesterol intermediates in the liver, brain, and testis.

Journal: The Journal of steroid biochemistry and molecular biology 20100801

Title: Alterations of cholesterol precursor levels in Alzheimer's disease.

Journal: Biochimica et biophysica acta 20100801

Title: A new ganoderic acid from Ganoderma lucidum mycelia.

Journal: Journal of Asian natural products research 20100801

Title: PKC signaling regulates drug resistance of the fungal pathogen Candida albicans via circuitry comprised of Mkc1, calcineurin, and Hsp90.

Journal: PLoS pathogens 20100801

Title: [Studies on the chemical constituents from the antithrombus activity extract of Radix Aerio Fici Microcarpae].

Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20100801

Title: Abiesatrines A-J: anti-inflammatory and antitumor triterpenoids from Abies georgei Orr.

Journal: Organic & biomolecular chemistry 20100607

Title: Effects of FoxO4 overexpression on cholesterol biosynthesis, triacylglycerol accumulation, and glucose uptake.

Journal: Journal of lipid research 20100601

Title: Gonadotropin-regulated expressions of lanosterol 14alpha-demethylase, sterol Delta14-reductase and C-4 sterol methyl oxidase contribute to the accumulation of meiosis-activating sterol in rabbit gonads.

Journal: Prostaglandins & other lipid mediators 20100601

Title: The sterol methyltransferases SMT1, SMT2, and SMT3 influence Arabidopsis development through nonbrassinosteroid products.

Journal: Plant physiology 20100601

Title: Biotechnological production and application of ganoderic acids.

Journal: Applied microbiology and biotechnology 20100601

Title: Requirement for ergosterol in V-ATPase function underlies antifungal activity of azole drugs.

Journal: PLoS pathogens 20100601

Title: Anticancer activity of subfractions containing pure compounds of Chaga mushroom (Inonotus obliquus) extract in human cancer cells and in Balbc/c mice bearing Sarcoma-180 cells.

Journal: Nutrition research and practice 20100601

Title: Antiplasmodial lanostanes from the Ganoderma lucidum mushroom.

Journal: Journal of natural products 20100528

Title: Second generation analogues of the cancer drug clinical candidate tipifarnib for anti-Chagas disease drug discovery.

Journal: Journal of medicinal chemistry 20100527

Title: Identification of testosterone-dependent volatile compounds and proteins in the preputial gland of rat Rattus norvegicus.

Journal: General and comparative endocrinology 20100515

Title: Enhanced biosynthetic gene expressions and production of ganoderic acids in static liquid culture of Ganoderma lucidum under phenobarbital induction.

Journal: Applied microbiology and biotechnology 20100501

Title: Structure-based rational design, synthesis and antifungal activity of oxime-containing azole derivatives.

Journal: Bioorganic & medicinal chemistry letters 20100501

Title: Antifungal drug resistance: not all azoles are equal.

Journal: Expert review of anti-infective therapy 20100501

Title: Lipid metabolism and HCV infection.

Journal: Viruses 20100501

Title: Cloning and characterization of the lanosterol 14alpha-demethylase gene from Antrodia cinnamomea.

Journal: Journal of agricultural and food chemistry 20100428

Title: Lipotoxicity in obese pregnancy and its potential role in adverse pregnancy outcome and obesity in the offspring.

Journal: Clinical science (London, England : 1979) 20100428

Title: Structural elucidation of cisoid and transoid cyclization pathways of a sesquiterpene synthase using 2-fluorofarnesyl diphosphates.

Journal: ACS chemical biology 20100416

Title: Screening for amino acid substitutions in the Candida albicans Erg11 protein of azole-susceptible and azole-resistant clinical isolates: new substitutions and a review of the literature.

Journal: Diagnostic microbiology and infectious disease 20100401

Title: Structural characterization of CYP51 from Trypanosoma cruzi and Trypanosoma brucei bound to the antifungal drugs posaconazole and fluconazole.

Journal: PLoS neglected tropical diseases 20100401

Title: [RP-HPLC simultaneous determination of five triterpenoid acids in different parts of Poria cocos by UV wavelengths switch].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20100401

Title: Relationship between antifungal resistance of fluconazole resistant Candida albicans and mutations in ERG11 gene.

Journal: Chinese medical journal 20100305

Title: Improved model of lanosterol 14alpha-demethylase by ligand-supported homology modeling: validation by virtual screening and azole optimization.

Journal: ChemMedChem 20100301

Title: Lanostane triterpenes from the fruiting bodies of Ganoderma lucidum and their inhibitory effects on adipocyte differentiation in 3T3-L1 Cells.

Journal: Journal of natural products 20100226

Title: Effects of lanosterol on in vitro maturation of porcine oocytes.

Journal: Animal reproduction science 20100201

Title: Topical anti-inflammatory effect of tirucallol, a triterpene isolated from Euphorbia lactea latex.

Journal: Phytomedicine : international journal of phytotherapy and phytopharmacology 20100201

Title: Antibacterial compounds from mushrooms I: a lanostane-type triterpene and prenylphenol derivatives from Jahnoporus hirtus and Albatrellus flettii and their activities against Bacillus cereus and Enterococcus faecalis.

Journal: Planta medica 20100201

Title: Ganoderic acids from Ganoderma lucidum: inhibitory activity of osteoclastic differentiation and structural criteria.

Journal: Planta medica 20100201

Title: Interactions of oxidosqualene cyclase (Erg7p) with 3-keto reductase (Erg27p) and other enzymes of sterol biosynthesis in yeast.

Journal: Biochimica et biophysica acta 20100201

Title: Reverse genetics in Candida albicans predicts ARF cycling is essential for drug resistance and virulence.

Journal: PLoS pathogens 20100201

Title: Phytochemical characteristics and hypoglycaemic activity of fraction from mushroom Inonotus obliquus.

Journal: Journal of the science of food and agriculture 20100130

Title: Production of individual ganoderic acids and expression of biosynthetic genes in liquid static and shaking cultures of Ganoderma lucidum.

Journal: Applied microbiology and biotechnology 20100101

Title: Cholesterol, non-cholesterol sterols and bile acids in paediatric gallstones.

Journal: Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 20100101

Title: Evolution of ergosterol biosynthesis inhibitors as fungicidal against Candida.

Journal: Microbial pathogenesis 20100101

Title: Changes in cholesterol biosynthetic and transport pathways after excitotoxicity.

Journal: Journal of neurochemistry 20100101

Title: Functional characterization and localization of Pneumocystis carinii lanosterol synthase.

Journal: Eukaryotic cell 20100101

Title: Protostadienol synthase from Aspergillus fumigatus: functional conversion into lanosterol synthase.

Journal: Biochemical and biophysical research communications 20100101

Title: Vitamin d levels and lipid response to atorvastatin.

Journal: International journal of endocrinology 20100101

Title: Functional characterization of the Chlamydomonas reinhardtii ERG3 ortholog, a gene involved in the biosynthesis of ergosterol.

Journal: PloS one 20100101

Title: Origin of the cell nucleus, mitosis and sex: roles of intracellular coevolution.

Journal: Biology direct 20100101

Title: Chemogenomic and transcriptome analysis identifies mode of action of the chemosensitizing agent CTBT (7-chlorotetrazolo[5,1-c]benzo[1,2,4]triazine).

Journal: BMC genomics 20100101

Title: Identification and analysis of unitary pseudogenes: historic and contemporary gene losses in humans and other primates.

Journal: Genome biology 20100101

Title: Metabolomic analyses of plasma reveals new insights into asphyxia and resuscitation in pigs.

Journal: PloS one 20100101

Title: Anti-inflammatory effects of Inonotus obliquus in colitis induced by dextran sodium sulfate.

Journal: Journal of biomedicine & biotechnology 20100101

Title: Downregulation of genes with a function in axon outgrowth and synapse formation in motor neurones of the VEGFdelta/delta mouse model of amyotrophic lateral sclerosis.

Journal: BMC genomics 20100101

Title: Ganoderic acid T inhibits tumor invasion in vitro and in vivo through inhibition of MMP expression.

Journal: Pharmacological reports : PR 20100101

Title: Development of azole resistance in Aspergillus fumigatus during azole therapy associated with change in virulence.

Journal: PloS one 20100101

Title: De novo sequencing and analysis of the American ginseng root transcriptome using a GS FLX Titanium platform to discover putative genes involved in ginsenoside biosynthesis.

Journal: BMC genomics 20100101

Title: Clinical utility of voriconazole eye drops in ophthalmic fungal keratitis.

Journal: Clinical ophthalmology (Auckland, N.Z.) 20100101

Title: Cellular cholesterol delivery, intracellular processing and utilization for biosynthesis of steroid hormones.

Journal: Nutrition & metabolism 20100101

Title: Phylogenetic distribution of fungal sterols.

Journal: PloS one 20100101

Title: Chemical combinations elucidate pathway interactions and regulation relevant to Hepatitis C replication.

Journal: Molecular systems biology 20100101

Title: Structural and functional study of YER067W, a new protein involved in yeast metabolism control and drug resistance.

Journal: PloS one 20100101

Title: Cholesterol induces specific spatial and orientational order in cholesterol/phospholipid membranes.

Journal: PloS one 20100101

Title: Antagonistic changes in sensitivity to antifungal drugs by mutations of an important ABC transporter gene in a fungal pathogen.

Journal: PloS one 20100101

Title: Liposomal amphotericin B and leishmaniasis: dose and response.

Journal: Journal of global infectious diseases 20100101

Title: Inhibition of iron uptake is responsible for differential sensitivity to V-ATPase inhibitors in several cancer cell lines.

Journal: PloS one 20100101

Title: Candida albicans virulence and drug-resistance requires the O-acyltransferase Gup1p.

Journal: BMC microbiology 20100101

Title: Lipid mediators in acne.

Journal: Mediators of inflammation 20100101

Title: Surface lipids as multifunctional mediators of skin responses to environmental stimuli.

Journal: Mediators of inflammation 20100101

Title: Identification and developmental expression of the full complement of Cytochrome P450 genes in Zebrafish.

Journal: BMC genomics 20100101

Title: Development, clinical utility, and place in therapy of posaconazole for prevention and treatment of invasive fungal infections.

Journal: Drug design, development and therapy 20100101

Title: Direct electrochemical analyses of human cytochromes b5 with a mutated heme pocket showed a good correlation between their midpoint and half wave potentials.

Journal: Journal of biomedical science 20100101

Title: Clearance in vivo of instilled [h]cholesterol from the rat lung.

Journal: Biochemistry research international 20100101

Title: Tumor and reproductive traits are linked by RNA metabolism genes in the mouse ovary: a transcriptome-phenotype association analysis.

Journal: BMC genomics 20100101

Title: Deciphering the nuclear bile acid receptor FXR paradigm.

Journal: Nuclear receptor signaling 20100101

Title: Management of tinea capitis in childhood.

Journal: Clinical, cosmetic and investigational dermatology 20100101

Title: Amelioration of lead-induced hepatotoxicity by Allium sativum extracts in Swiss albino mice.

Journal: The Libyan journal of medicine 20100101

Title: Role of posaconazole in the treatment of oropharyngeal candidiasis.

Journal: Infection and drug resistance 20100101

Title: Optimal management of oropharyngeal and esophageal candidiasis in patients living with HIV infection.

Journal: HIV/AIDS (Auckland, N.Z.) 20100101

Title: Phytopharmacology of Ficus religiosa.

Journal: Pharmacognosy reviews 20100101

Title: Lanostanes from Phellinus igniarius and their iNOS inhibitory activities.

Journal: Planta medica 20091201

Title: 13C nuclear magnetic resonance data of lanosterol derivatives--profiling the steric topology of the steroid skeleton via substituent effects on its 13C NMR.

Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20091201

Title: Design, synthesis, and antifungal activity of novel conformationally restricted triazole derivatives.

Journal: Archiv der Pharmazie 20091201

Title: Development of a new method for improved identification and relative quantification of unknown metabolites in complex samples: determination of a triterpenoid metabolic fingerprint for the in situ characterization of Ganoderma bioactive compounds.

Journal: Journal of separation science 20091201

Title: 4beta-hydroxycholesterol as a marker of CYP3A4 inhibition in vivo - effects of itraconazole in man.

Journal: International journal of clinical pharmacology and therapeutics 20091201

Title: Steroidal triterpenes: design of substrate-based inhibitors of ergosterol and sitosterol synthesis.

Journal: Molecules (Basel, Switzerland) 20091118

Title: Inhibition of nucleoside transport and synergistic potentiation of methotrexate cytotoxicity by cimicifugoside, a triterpenoid from Cimicifuga simplex.

Journal: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20091105

Title: Reducing CYP51 inhibits follicle-stimulating hormone induced resumption of mouse oocyte meiosis in vitro.

Journal: Journal of lipid research 20091101

Title: Initiation of steroidogenesis precedes expression of cholesterologenic enzymes in the fetal mouse testes.

Journal: Anatomia, histologia, embryologia 20091101

Title: Dehydroeburicoic acid induces calcium- and calpain-dependent necrosis in human U87MG glioblastomas.

Journal: Chemical research in toxicology 20091101

Title: 24-Ethyl,24-methyl-29-nor-lanostanes from leaves of Freycinetia formosana.

Journal: Chemical & pharmaceutical bulletin 20091101

Title: Quantitative determination of steroids in the fruiting bodies and submerged-cultured mycelia of Inonotus obliquus.

Journal: Se pu = Chinese journal of chromatography 20091101

Title: Discovery of potent and reversible monoacylglycerol lipase inhibitors.

Journal: Chemistry & biology 20091030

Title: Discovery of highly potent novel antifungal azoles by structure-based rational design.

Journal: Bioorganic & medicinal chemistry letters 20091015

Title: Plasma levels of 24S-hydroxycholesterol reflect brain volumes in patients without objective cognitive impairment but not in those with Alzheimer's disease.

Journal: Neuroscience letters 20091002

Title: New azoles with potent antifungal activity: design, synthesis and molecular docking.

Journal: European journal of medicinal chemistry 20091001

Title: Anti-tumor-promoting effects of 25-methoxyporicoic acid A and other triterpene acids from Poria cocos.

Journal: Journal of natural products 20091001

Title: Acquisition of aneuploidy provides increased fitness during the evolution of antifungal drug resistance.

Journal: PLoS genetics 20091001

Title: Inhibition of cholesterol biosynthesis disrupts lipid raft/caveolae and affects insulin receptor activation in 3T3-L1 preadipocytes.

Journal: Biochimica et biophysica acta 20090901

Title: A comparison of the packing behavior of egg phosphatidylcholine with cholesterol and biogenically related sterols in Langmuir monolayer films.

Journal: Chemistry and physics of lipids 20090901

Title: Effects of triterpenoids from Poria cocos Wolf on the serotonin type 3A receptor-mediated ion current in Xenopus oocytes.

Journal: European journal of pharmacology 20090801

Title: Hsp90 orchestrates stress response signaling governing fungal drug resistance.

Journal: PLoS pathogens 20090801

Title: Exploring the effects of sterols in model lipid membranes using single-molecule orientations.

Journal: The journal of physical chemistry. B 20090730

Title: Combined gas chromatographic/mass spectrometric analysis of cholesterol precursors and plant sterols in cultured cells.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20090715

Title: Metabolism and pharmacokinetics in rats of ganoderiol F, a highly cytotoxic and antitumor triterpene from Ganoderma lucidum.

Journal: Journal of natural medicines 20090701

Title: Genomic analysis of the basal lineage fungus Rhizopus oryzae reveals a whole-genome duplication.

Journal: PLoS genetics 20090701

Title: Frequency and evolution of Azole resistance in Aspergillus fumigatus associated with treatment failure.

Journal: Emerging infectious diseases 20090701

Title: Hsp90 governs echinocandin resistance in the pathogenic yeast Candida albicans via calcineurin.

Journal: PLoS pathogens 20090701

Title: A new triterpene from the fruiting bodies of Ganoderma lucidum.

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20090701

Title: Structurally simple inhibitors of lanosterol 14alpha-demethylase are efficacious in a rodent model of acute Chagas disease.

Journal: Journal of medicinal chemistry 20090625

Title: Molecular oxygen activation and proton transfer mechanisms in lanosterol 14alpha-demethylase catalysis.

Journal: The journal of physical chemistry. B 20090611

Title: Polyporenic acid C induces caspase-8-mediated apoptosis in human lung cancer A549 cells.

Journal: Molecular carcinogenesis 20090601

Title: Age-dependent increase in desmosterol restores DRM formation and membrane-related functions in cholesterol-free DHCR24-/- mice.

Journal: Neurochemical research 20090601

Title: Sterol content analysis suggests altered eburicol 14alpha-demethylase (CYP51) activity in isolates of Mycosphaerella graminicola adapted to azole fungicides.

Journal: FEMS microbiology letters 20090601

Title: Cyclodextrin-modified capillary electrophoresis for achiral and chiral separation of ergostane and lanostane compounds extracted from the fruiting body of Antrodia camphorata.

Journal: Electrophoresis 20090601

Title: Lanosterol metabolic product(s) is involved in primordial folliculogenesis and establishment of primordial follicle pool in mouse fetal ovary.

Journal: Molecular reproduction and development 20090501

Title: Antiplasmodial and other constituents from four Indonesian Garcinia spp.

Journal: Phytochemistry 20090501

Title: Cytolethal distending toxin-induced cell cycle arrest of lymphocytes is dependent upon recognition and binding to cholesterol.

Journal: The Journal of biological chemistry 20090417

Title: The construction and characterization of self-sufficient lanosterol 14-demethylase fusion proteins consisting of yeast CYP51 and its reductase.

Journal: Biological & pharmaceutical bulletin 20090401

Title: Compound MMH01 possesses toxicity against human leukemia and pancreatic cancer cells.

Journal: Toxicology in vitro : an international journal published in association with BIBRA 20090401

Title: Performance analyses of a pH-shift and DOT-shift integrated fed-batch fermentation process for the production of ganoderic acid and Ganoderma polysaccharides by medicinal mushroom Ganoderma lucidum.

Journal: Bioresource technology 20090301

Title: Modified oxidosqualene cyclases in the formation of bioactive secondary metabolites: biosynthesis of the antitumor clavaric acid.

Journal: Fungal genetics and biology : FG & B 20090301

Title: Drug interaction potential of 2-((3,4-dichlorophenethyl)(propyl)amino)-1-(pyridin-3-yl)ethanol (LK-935), the novel nonstatin-type cholesterol-lowering agent.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20090201

Title: Trypanosoma cruzi CYP51 inhibitor derived from a Mycobacterium tuberculosis screen hit.

Journal: PLoS neglected tropical diseases 20090201

Title: Sterol 24-C-methyltransferase: an enzymatic target for the disruption of ergosterol biosynthesis and homeostasis in Cryptococcus neoformans.

Journal: Archives of biochemistry and biophysics 20090115

Title: The effect of plagiochin E alone and in combination with fluconazole on the ergosterol biosynthesis of Candida albicans.

Journal: Biological & pharmaceutical bulletin 20090101

Title: Characterization of sterol lipids in Kluyveromyces lactis strain M-16 accumulating a high amount of steryl glucoside.

Journal: Journal of oleo science 20090101

Title: Transcriptional profiling of the effects of 25-hydroxycholesterol on human hepatocyte metabolism and the antiviral state it conveys against the hepatitis C virus.

Journal: BMC chemical biology 20090101

Title: Revision of the absolute configuration at C(23) of lanostanoids and isolation of secondary metabolites from formosan soft coral Nephthea erecta.

Journal: Chemistry & biodiversity 20090101

Title: Sequential metabolism of 7-dehydrocholesterol to steroidal 5,7-dienes in adrenal glands and its biological implication in the skin.

Journal: PloS one 20090101

Title: Regulation of clock-controlled genes in mammals.

Journal: PloS one 20090101

Title: Influence of the cystic fibrosis transmembrane conductance regulator on expression of lipid metabolism-related genes in dendritic cells.

Journal: Respiratory research 20090101

Title: Growth inhibition and ultrastructural alterations induced by Delta24(25)-sterol methyltransferase inhibitors in Candida spp. isolates, including non-albicans organisms.

Journal: BMC microbiology 20090101

Title: Sterol metabolism in the oomycete Aphanomyces euteiches, a legume root pathogen.

Journal: The New phytologist 20090101

Title: LeishCyc: a biochemical pathways database for Leishmania major.

Journal: BMC systems biology 20090101

Title: Targeted suppression of heme oxygenase-1 by small interference RNAs inhibits the production of bilirubin in neonatal rat with hyperbilirubinemia.

Journal: BMC molecular biology 20090101

Title: Progressive obesity leads to altered ovarian gene expression in the Lethal Yellow mouse: a microarray study.

Journal: Journal of ovarian research 20090101

Title: Early development of Moniliophthora perniciosa basidiomata and developmentally regulated genes.

Journal: BMC microbiology 20090101

Title: Sterol Biosynthesis Pathway as Target for Anti-trypanosomatid Drugs.

Journal: Interdisciplinary perspectives on infectious diseases 20090101

Title: Rapid detection of ERG11 gene mutations in clinical Candida albicans isolates with reduced susceptibility to fluconazole by rolling circle amplification and DNA sequencing.

Journal: BMC microbiology 20090101

Title: Management of invasive aspergillosis in patients with COPD: rational use of voriconazole.

Journal: International journal of chronic obstructive pulmonary disease 20090101

Title: Gene array analysis of adrenal glands in broiler chickens following ACTH treatment.

Journal: BMC genomics 20090101

Title: Transcriptional profiling of rats subjected to gestational undernourishment: implications for the developmental variations in metabolic traits.

Journal: PloS one 20090101

Title: Fixed drug eruption resulting from fluconazole use: a case report.

Journal: Journal of medical case reports 20090101

Title: Transcriptome analysis of differentiating trypanosomes reveals the existence of multiple post-transcriptional regulons.

Journal: BMC genomics 20090101

Title: Investigating the effects of statins on cellular lipid metabolism using a yeast expression system.

Journal: PloS one 20090101

Title: Phylogenomics of sterol synthesis: insights into the origin, evolution, and diversity of a key eukaryotic feature.

Journal: Genome biology and evolution 20090101

Title: Simultaneous HPLC determination of butenafine hydrochloride and betamethasone in a cream formulation.

Journal: Indian journal of pharmaceutical sciences 20090101

Title: Economic considerations in the treatment of invasive aspergillosis: a review of voriconazole pharmacoeconomic studies.

Journal: ClinicoEconomics and outcomes research : CEOR 20090101

Title: Elevated cholesterol precursors other than cholestanol can also be a hallmark for CTX.

Journal: Journal of inherited metabolic disease 20081201

Title: Lanostane-type triterpenes from the mushroom Astraeus pteridis with antituberculosis activity.

Journal: Journal of natural products 20081201

Title: Two novel A-seco-rearranged lanostane triterpenoids from Abies sachalinensis.

Journal: Archives of pharmacal research 20081201

Title: Loss of gamma-secretase function impairs endocytosis of lipoprotein particles and membrane cholesterol homeostasis.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20081112

Title: Importance of Saccharomyces cerevisiae oxidosqualene-lanosterol cyclase tyrosine 707 residue for chair-boat bicyclic ring formation and deprotonation reactions.

Journal: Organic letters 20081106

Title: Antifungal activity of 25-azalanosterol against Candida species.

Journal: European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology 20081101

Title: A sterol-regulatory element binding protein is required for cell polarity, hypoxia adaptation, azole drug resistance, and virulence in Aspergillus fumigatus.

Journal: PLoS pathogens 20081101

Title: Overexpression of human ABCG1 does not affect atherosclerosis in fat-fed ApoE-deficient mice.

Journal: Arteriosclerosis, thrombosis, and vascular biology 20081001

Title: Gas chromatographic-mass spectrometric analyses of cholesterol and its precursors in rat plasma as tert-butyldimethylsilyl derivatives.

Journal: Clinica chimica acta; international journal of clinical chemistry 20081001

Title: Differential azole antifungal efficacies contrasted using a Saccharomyces cerevisiae strain humanized for sterol 14 alpha-demethylase at the homologous locus.

Journal: Antimicrobial agents and chemotherapy 20081001

Title: Disruption of the gene encoding 3beta-hydroxysterol Delta-reductase (Tm7sf2) in mice does not impair cholesterol biosynthesis.

Journal: The FEBS journal 20081001

Title: Cytotoxic and anti-oxidant activities of lanostane-type triterpenes isolated from Poria cocos.

Journal: Chemical & pharmaceutical bulletin 20081001

Title: Regulation of cholesterologenesis by the oxysterol receptor, LXRalpha.

Journal: The Journal of biological chemistry 20080926

Title: Interfacial behavior of cholesterol, ergosterol, and lanosterol in mixtures with DPPC and DMPC.

Journal: Biophysical journal 20080901

Title: Multiple effects of a novel compound from Burkholderia cepacia against Candida albicans.

Journal: FEMS microbiology letters 20080801

Title: Posaconazole in the management of refractory invasive fungal infections.

Journal: Therapeutics and clinical risk management 20080801

Title: Spheciosterol sulfates, PKCzeta inhibitors from a philippine sponge Spheciospongia sp.

Journal: Journal of natural products 20080725

Title: Expression of microsomal lanosterol 14alpha-demethylase (CYP51) in an engineered soluble monomeric form.

Journal: Biochemical and biophysical research communications 20080711

Title: Nonenzymic polycyclization of analogues of oxidosqualene with a preformed C-ring.

Journal: Organic & biomolecular chemistry 20080607

Title: Cholesterol, lanosterol, and ergosterol attenuate the membrane association of LL-37(W27F) and temporin L.

Journal: Biochimica et biophysica acta 20080601

Title: Lanostane-type triterpenoids from the roots of Kadsura coccinea.

Journal: Journal of natural products 20080601

Title: Silencing of mouse hepatic lanosterol 14-alpha demethylase down-regulated plasma low-density lipoprotein cholesterol levels by short-term treatment of siRNA.

Journal: Biological & pharmaceutical bulletin 20080601

Title: Anti-HIV-1 protease activity of lanostane triterpenes from the vietnamese mushroom Ganoderma colossum.

Journal: Journal of natural products 20080601

Title: Characteristics of biofilm formation by Candida tropicalis and antifungal resistance.

Journal: FEMS yeast research 20080501

Title: Ganoderic acids suppress growth and invasive behavior of breast cancer cells by modulating AP-1 and NF-kappaB signaling.

Journal: International journal of molecular medicine 20080501

Title: ATP-binding cassette transporters G1 and G4 mediate cholesterol and desmosterol efflux to HDL and regulate sterol accumulation in the brain.

Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20080401

Title: Kadsuracoccinic acids A-C, ring-A seco-lanostane triterpenes from Kadsura coccinea and their effects on embryonic cell division of Xenopus laevis.

Journal: Journal of natural products 20080401

Title: Novel lanostane and rearranged lanostane-type triterpenoids from Abies sachalinensis - II -.

Journal: Chemical & pharmaceutical bulletin 20080401

Title: Oxysterols: novel biologic roles for the 21st century.

Journal: Steroids 20080201

Title: Effectors of rapid homeostatic responses of endoplasmic reticulum cholesterol and 3-hydroxy-3-methylglutaryl-CoA reductase.

Journal: The Journal of biological chemistry 20080118

Title: Moderately elevated plant sterol levels are associated with reduced cardiovascular risk--the LASA study.

Journal: Atherosclerosis 20080101

Title: Novel cholesterol biosynthesis inhibitors targeting human lanosterol 14alpha-demethylase (CYP51).

Journal: Bioorganic & medicinal chemistry 20080101

Title: Metabolic model integration of the bibliome, genome, metabolome and reactome of Aspergillus niger.

Journal: Molecular systems biology 20080101

Title: Novel role for SLPI in MOG-induced EAE revealed by spinal cord expression analysis.

Journal: Journal of neuroinflammation 20080101

Title: [Chemical constituents of the spores of Ganoderma lucidum].

Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20080101

Title: Preservation of genes involved in sterol metabolism in cholesterol auxotrophs: facts and hypotheses.

Journal: PloS one 20080101

Title: Metabolic innovations towards the human lineage.

Journal: BMC evolutionary biology 20080101

Title: Altered bile acid metabolism in patients with constipation-predominant irritable bowel syndrome and functional constipation.

Journal: Scandinavian journal of gastroenterology 20080101

Title: Breast cancer proteomics reveals correlation between estrogen receptor status and differential phosphorylation of PGRMC1.

Journal: Breast cancer research : BCR 20080101

Title: Histone deacetylase inhibitors: a new mode for inhibition of cholesterol metabolism.

Journal: BMC genomics 20080101

Title: Expression and regulation of lanosterol 14alpha-demethylase in mouse embryo and uterus during the peri-implantation period.

Journal: Reproduction, fertility, and development 20080101

Title: Insulin-like growth factor-1 coordinately induces the expression of fatty acid and cholesterol biosynthetic genes in murine C2C12 myoblasts.

Journal: BMC genomics 20080101

Title: Dynamical modeling of the cholesterol regulatory pathway with Boolean networks.

Journal: BMC systems biology 20080101

Title: Inotodiol, a lanostane triterpenoid, from Inonotus obliquus inhibits cell proliferation through caspase-3-dependent apoptosis.

Journal: Anticancer research 20080101

Title: Monocytes of patients with familial hypercholesterolemia show alterations in cholesterol metabolism.

Journal: BMC medical genomics 20080101

Title: A novel three-stage light irradiation strategy in the submerged fermentation of medicinal mushroom Ganoderma lucidum for the efficient production of ganoderic acid and Ganoderma polysaccharides.

Journal: Biotechnology progress 20080101

Title: Antifungals: need to search for a new molecular target.

Journal: Indian journal of pharmaceutical sciences 20080101

Title: Hypolipidemia: a word of caution.

Journal: The Libyan journal of medicine 20080101

Title: Histone deacetylase 3 down-regulates cholesterol synthesis through repression of lanosterol synthase gene expression.

Journal: The Journal of biological chemistry 20071207

Title: cis-Acting elements within the Candida albicans ERG11 promoter mediate the azole response through transcription factor Upc2p.

Journal: Eukaryotic cell 20071201

Title: A squalene epoxidase is involved in biosynthesis of both the antitumor compound clavaric acid and sterols in the basidiomycete H. sublateritium.

Journal: Chemistry & biology 20071201

Title: Biosynthesis of phytosterol esters: identification of a sterol o-acyltransferase in Arabidopsis.

Journal: Plant physiology 20071101

Title: Synthesis and antifungal activities of novel 2-aminotetralin derivatives.

Journal: Journal of medicinal chemistry 20071101

Title: [Application of binding spectra in DMIs fungicide screening].

Journal: Sheng wu gong cheng xue bao = Chinese journal of biotechnology 20071101

Title: [Study on chemical constituents from rhizomes of Actaea asiatica].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20071101

Title: Progressive dysfunction of the cholesterol biosynthesis pathway in the R6/2 mouse model of Huntington's disease.

Journal: Neurobiology of disease 20071001

Title: Sterol biosynthesis by a prokaryote: first in vitro identification of the genes encoding squalene epoxidase and lanosterol synthase from Methylococcus capsulatus.

Journal: Bioscience, biotechnology, and biochemistry 20071001

Title: Hypoxia stimulates degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase through accumulation of lanosterol and hypoxia-inducible factor-mediated induction of insigs.

Journal: The Journal of biological chemistry 20070914

Title: The farnesoid X receptor FXRalpha/NR1H4 acquired ligand specificity for bile salts late in vertebrate evolution.

Journal: American journal of physiology. Regulatory, integrative and comparative physiology 20070901

Title: Structure elucidation and complete NMR spectral assignments of three new lanostanoid triterpenes with unprecedented Delta(16, 17) double bond from Ganoderma lucidum.

Journal: Magnetic resonance in chemistry : MRC 20070901

Title: Atorvastatin in patients with primary biliary cirrhosis and incomplete biochemical response to ursodeoxycholic acid.

Journal: Hepatology (Baltimore, Md.) 20070901

Title: 4-Methyl sterols regulate fission yeast SREBP-Scap under low oxygen and cell stress.

Journal: The Journal of biological chemistry 20070817

Title: Conformational dynamics in the F/G segment of CYP51 from Mycobacterium tuberculosis monitored by FRET.

Journal: Archives of biochemistry and biophysics 20070815

Title: Lanosterol biosynthesis in the prokaryote Methylococcus capsulatus: insight into the evolution of sterol biosynthesis.

Journal: Molecular biology and evolution 20070801

Title: Role of posaconazole in the management of oropharyngeal and esophageal candidiasis.

Journal: Therapeutics and clinical risk management 20070801

Title: Design, synthesis, and antifungal activities of novel 1H-triazole derivatives based on the structure of the active site of fungal lanosterol 14 alpha-demethylase (CYP51).

Journal: Chemistry & biodiversity 20070701

Title: Sterol composition in field-grown and cultured mycelia of Inonotus obliquus.

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20070701

Title: [Studies on the chemical constituents from herba anoectochili].

Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20070701

Title: Regulation of hepatic Insig-2 by the farnesoid X receptor.

Journal: Molecular endocrinology (Baltimore, Md.) 20070601

Title: Enhancement of IL-2 and IFN-gamma expression and NK cells activity involved in the anti-tumor effect of ganoderic acid Me in vivo.

Journal: International immunopharmacology 20070601

Title: Electrochemical reduction of sterol-14alpha-demethylase from Mycobacterium tuberculosis (CYP51b1).

Journal: Biochemistry. Biokhimiia 20070601

Title: Diterpenoids and triterpenoids from Euphorbia guyoniana.

Journal: Phytochemistry 20070501

Title: Hepatic cytochrome P450 reductase-null mice reveal a second microsomal reductase for squalene monooxygenase.

Journal: Archives of biochemistry and biophysics 20070501

Title: Electrochemical properties of cytochroms P450 using nanostructured electrodes: direct electron transfer and electro catalysis.

Journal: Journal of inorganic biochemistry 20070501

Title: Rapid birth-death evolution specific to xenobiotic cytochrome P450 genes in vertebrates.

Journal: PLoS genetics 20070501

Title: Inhibition of angiogenesis by the antifungal drug itraconazole.

Journal: ACS chemical biology 20070424

Title: Structure of mixed micelles formed in PEG-lipid/lipid dispersions.

Journal: Langmuir : the ACS journal of surfaces and colloids 20070410

Title: Separation and determination of diversiform phytosterols in food materials using supercritical carbon dioxide extraction and ultraperformance liquid chromatography-atmospheric pressure chemical ionization-mass spectrometry.

Journal: Analytica chimica acta 20070404

Title: Cholesterol starvation induces differentiation of human leukemia HL-60 cells.

Journal: Cancer research 20070401

Title: [Study on chemical constituents of Euphorbia hylonoma hand. -Mazz].

Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20070401

Title: Three-dimensional quantitative structure-activity relationship analysis of human CYP51 inhibitors.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20070301

Title: Differential effects of cholesterol, ergosterol and lanosterol on a dipalmitoyl phosphatidylcholine membrane: a molecular dynamics simulation study.

Journal: The journal of physical chemistry. B 20070222

Title: Syntheses of ring C oxysterols: inhibitors of sterol biosynthesis.

Journal: Lipids 20070201

Title: Structure determination of inonotsuoxides A and B and in vivo anti-tumor promoting activity of inotodiol from the sclerotia of Inonotus obliquus.

Journal: Bioorganic & medicinal chemistry 20070101

Title: Amaranth oil application for coronary heart disease and hypertension.

Journal: Lipids in health and disease 20070101

Title: Preparative isolation of cyclolanostane-type saponins from Astragalus membranaceus bge. var. mongholicus (Bge.) Hsiao by TLC-MS/MS guided high-speed counter-current chromatography.

Journal: Journal of separation science 20070101

Title: The Interleukin-6 inflammation pathway from cholesterol to aging--role of statins, bisphosphonates and plant polyphenols in aging and age-related diseases.

Journal: Immunity & ageing : I & A 20070101

Title: Synthesis of the oxysterol, 24(S), 25-epoxycholesterol, parallels cholesterol production and may protect against cellular accumulation of newly-synthesized cholesterol.

Journal: Lipids in health and disease 20070101

Title: The transcriptome analysis of early morphogenesis in Paracoccidioides brasiliensis mycelium reveals novel and induced genes potentially associated to the dimorphic process.

Journal: BMC microbiology 20070101

Title: Transcriptome of Pneumocystis carinii during fulminate infection: carbohydrate metabolism and the concept of a compatible parasite.

Journal: PloS one 20070101

Title: Genomic analysis of the secretion stress response in the enzyme-producing cell factory Aspergillus niger.

Journal: BMC genomics 20070101

Title: Gene expression profiles in testis of pigs with extreme high and low levels of androstenone.

Journal: BMC genomics 20070101

Title: Coordinate up-regulation of TMEM97 and cholesterol biosynthesis genes in normal ovarian surface epithelial cells treated with progesterone: implications for pathogenesis of ovarian cancer.

Journal: BMC cancer 20070101

Title: Photosensitivity in Smith-Lemli-Opitz syndrome: a flux balance analysis of altered metabolism.

Journal: Bioinformation 20070101

Title: Trametes versatillis, a fungus highly producing eburicoic acid.

Journal: Zeitschrift fur Naturforschung. C, Journal of biosciences 20070101

Title: Separation of free sterols by high temperature liquid chromatography.

Journal: Journal of chromatography. A 20061229

Title: Ganoderic acid T from Ganoderma lucidum mycelia induces mitochondria mediated apoptosis in lung cancer cells.

Journal: Life sciences 20061223

Title: Comparison of lanosterol-14 alpha-demethylase (CYP51) of human and Candida albicans for inhibition by different antifungal azoles.

Journal: Toxicology 20061110

Title: Comparative calorimetric and spectroscopic studies of the effects of lanosterol and cholesterol on the thermotropic phase behavior and organization of dipalmitoylphosphatidylcholine bilayer membranes.

Journal: Biophysical journal 20061101

Title: Cloning of chicken lanosterol 14alpha-demethylase (CYP51) cDNA: discovery of a testis-specific CYP51 transcript.

Journal: Comparative biochemistry and physiology. Part A, Molecular & integrative physiology 20061101

Title: Design, synthesis, and antifungal activities in vitro of novel tetrahydroisoquinoline compounds based on the structure of lanosterol 14alpha-demethylase (CYP51) of fungi.

Journal: Bioorganic & medicinal chemistry letters 20061015

Title: Domain-formation in DOPC/SM bilayers studied by pfg-NMR: effect of sterol structure.

Journal: Biophysical journal 20061001

Title: Steroid structural requirements for interaction of ostreolysin, a lipid-raft binding cytolysin, with lipid monolayers and bilayers.

Journal: Biochimica et biophysica acta 20061001

Title: Inhibition of oxidative stress-induced invasiveness of cancer cells by Ganoderma lucidum is mediated through the suppression of interleukin-8 secretion.

Journal: International journal of molecular medicine 20061001

Title: Lanosterol 14alpha-demethylase expression in the mouse ovary and its participation in cumulus-enclosed oocyte spontaneous meiotic maturation in vitro.

Journal: Theriogenology 20060915

Title: New ganoderic acids, bioactive triterpenoid metabolites from the mushroom Ganoderma lucidum.

Journal: Natural product research 20060901

Title: Cholesterol precursors stabilize ordinary and ceramide-rich ordered lipid domains (lipid rafts) to different degrees. Implications for the Bloch hypothesis and sterol biosynthesis disorders.

Journal: The Journal of biological chemistry 20060804

Title: Synthetic studies toward highly functionalized 5beta-lanosterol derivatives: a versatile approach utilizing anionic cycloaddition.

Journal: The Journal of organic chemistry 20060804

Title: Cloning and characterization of CYP51 from Mycobacterium avium.

Journal: American journal of respiratory cell and molecular biology 20060801

Title: Phytosterol biosynthesis pathway in Mortierella alpina.

Journal: Phytochemistry 20060801

Title: Lanostane triterpenoids from the Sri Lankan basidiomycete Ganoderma applanatum.

Journal: Journal of natural products 20060801

Title: Cholesterol synthesis rate in human hippocampus declines with aging.

Journal: Neuroscience letters 20060731

Title: Sterol dependent regulation of human TM7SF2 gene expression: role of the encoded 3beta-hydroxysterol Delta14-reductase in human cholesterol biosynthesis.

Journal: Biochimica et biophysica acta 20060701

Title: Classical QSAR study on chromene derivatives as lanosterol 14alpha- demethylase inhibitor: a non azole antifungal target.

Journal: Medicinal chemistry (Shariqah (United Arab Emirates)) 20060701

Title: Triadimefon causes branchial arch malformations in Xenopus laevis embryos.

Journal: Environmental science and pollution research international 20060701

Title: Puerarin decreases serum total cholesterol and enhances thoracic aorta endothelial nitric oxide synthase expression in diet-induced hypercholesterolemic rats.

Journal: Life sciences 20060620

Title: Influence of thermodynamic parameter in Lanosterol 14alpha-demethylase inhibitory activity as antifungal agents: a QSAR approach.

Journal: Biological & pharmaceutical bulletin 20060601

Title: Host-specific response to HCV infection in the chimeric SCID-beige/Alb-uPA mouse model: role of the innate antiviral immune response.

Journal: PLoS pathogens 20060601

Title: Voriconazole in the management of nosocomial invasive fungal infections.

Journal: Therapeutics and clinical risk management 20060601

Title: Site-saturated mutagenesis of histidine 234 of Saccharomyces cerevisiae oxidosqualene-lanosterol cyclase demonstrates dual functions in cyclization and rearrangement reactions.

Journal: Journal of the American Chemical Society 20060517

Title: Phase behavior of lipid monolayers containing DPPC and cholesterol analogs.

Journal: Biophysical journal 20060501

Title: Plant lanosterol synthase: divergence of the sterol and triterpene biosynthetic pathways in eukaryotes.

Journal: Plant & cell physiology 20060501

Title: Lanosterol synthase in dicotyledonous plants.

Journal: Plant & cell physiology 20060501

Title: [Studies on constituents from roots of Euphorbia hylonoma].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20060501

Title: Meiosis activating sterol (MAS) regulate FSH-induced meiotic resumption of cumulus cell-enclosed porcine oocytes via PKC pathway.

Journal: Molecular and cellular endocrinology 20060425

Title: Follicular sterol composition in gonadotrophin stimulated women with polycystic ovarian syndrome.

Journal: Molecular and cellular endocrinology 20060425

Title: Cimicifuga species identification by high performance liquid chromatography-photodiode array/mass spectrometric/evaporative light scattering detection for quality control of black cohosh products.

Journal: Journal of chromatography. A 20060421

Title: Structure-based optimization of azole antifungal agents by CoMFA, CoMSIA, and molecular docking.

Journal: Journal of medicinal chemistry 20060420

Title: Tryptophan 232 within oxidosqualene-lanosterol cyclase from Saccharomyces cerevisiae influences rearrangement and deprotonation but not cyclization reactions.

Journal: Organic letters 20060330

Title: Modulation of cholesterol metabolism by the green tea polyphenol (-)-epigallocatechin gallate in cultured human liver (HepG2) cells.

Journal: Journal of agricultural and food chemistry 20060308

Title: Universal behavior of membranes with sterols.

Journal: Biophysical journal 20060301

Title: Lanosterol biosynthesis in plants.

Journal: Archives of biochemistry and biophysics 20060301

Title: cDNA cloning, genomic structure and expression analysis of the bovine lanosterol 14alpha-demethylase (CYP51) in gonads.

Journal: Biological & pharmaceutical bulletin 20060301

Title: Mechanistic insights into triterpene synthesis from quantum mechanical calculations. Detection of systematic errors in B3LYP cyclization energies.

Journal: Organic & biomolecular chemistry 20060207

Title: Effect of geraniol on fatty-acid and mevalonate metabolism in the human hepatoma cell line Hep G2.

Journal: Biochemistry and cell biology = Biochimie et biologie cellulaire 20060201

Title: Cytotoxicity of cycloartane triterpenoids from aerial part of Cimicifuga foetida.

Journal: Fitoterapia 20060101

Title: Investigation of de novo cholesterol synthetic capacity in the gonads of goldfish (Carassius auratus) exposed to the phytosterol beta-sitosterol.

Journal: Reproductive biology and endocrinology : RB&E 20060101

Title: [Nanoelectrochemistry of cytochrome P450s: direct electron transfer and electrocatalysis].

Journal: Biomeditsinskaia khimiia 20060101

Title: Bilayer thickness and thermal response of dimyristoylphosphatidylcholine unilamellar vesicles containing cholesterol, ergosterol and lanosterol: a small-angle neutron scattering study.

Journal: Biochimica et biophysica acta 20051230

Title: Cholesterogenic lanosterol 14alpha-demethylase (CYP51) is an immediate early response gene.

Journal: Endocrinology 20051201

Title: A new cytotoxic lanostane triterpenoid from the basidiomycete Hebeloma versipelle.

Journal: The Journal of antibiotics 20051201

Title: Sterol profiling of amniotic fluid: a routine method for the detection of distal cholesterol synthesis deficit.

Journal: Prenatal diagnosis 20051101

Title: Enzyme redesign: two mutations cooperate to convert cycloartenol synthase into an accurate lanosterol synthase.

Journal: Journal of the American Chemical Society 20051019

Title: A molecular mechanics force field for biologically important sterols.

Journal: Journal of computational chemistry 20051001

Title: Diffusion of cholesterol and its precursors in lipid membranes studied by 1H pulsed field gradient magic angle spinning NMR.

Journal: Biophysical journal 20051001

Title: Lipid signaling in plants. Cloning and expression analysis of the obtusifoliol 14alpha-demethylase from Solanum chacoense Bitt., a pollination- and fertilization-induced gene with both obtusifoliol and lanosterol demethylase activity.

Journal: Plant physiology 20051001

Title: Reductions in cholesterol and synaptic markers in association cortex in mood disorders.

Journal: Bipolar disorders 20051001

Title: Sterol structure determines miscibility versus melting transitions in lipid vesicles.

Journal: Biophysical journal 20050901

Title: The protein farnesyltransferase inhibitor Tipifarnib as a new lead for the development of drugs against Chagas disease.

Journal: Journal of medicinal chemistry 20050825

Title: Fluconazole upregulates sconC expression and inhibits sulphur metabolism in Microsporum canis.

Journal: Fungal genetics and biology : FG & B 20050801

Title: A prospective, randomized, double-blind, placebo-controlled study of the platelet and global hemostatic effects of Ganoderma lucidum (Ling-Zhi) in healthy volunteers.

Journal: Anesthesia and analgesia 20050801

Title: In vitro antifungal activity of ZJ-522, a new triazole restructured from fluconazole and butenafine, against clinically important fungi in comparison with fluconazole and butenafine.

Journal: Biological & pharmaceutical bulletin 20050801

Title: Friedolanostanes and lanostanes from the leaves of Garcinia hombroniana.

Journal: Journal of natural products 20050801

Title: Norlanostane triterpenoidal saponins from the marine sponge melophlussarassinorum.

Journal: Journal of natural products 20050801

Title: [Studies on chemical constitutes of green alga Chaetomorpha basiretorsa and their bioactivity].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20050801

Title: Flux of sterol intermediates in a yeast strain deleted of the lanosterol C-14 demethylase Erg11p.

Journal: Biochimica et biophysica acta 20050715

Title: Cytochrome P450 17alpha hydroxylase/17,20 lyase (CYP17) function in cholesterol biosynthesis: identification of squalene monooxygenase (epoxidase) activity associated with CYP17 in Leydig cells.

Journal: Molecular endocrinology (Baltimore, Md.) 20050701

Title: Ganoderic acid Sz, a new lanostanoid from the mushroom Ganoderma lucidum.

Journal: Natural product research 20050701

Title: Lord of the rings--the mechanism for oxidosqualene:lanosterol cyclase becomes crystal clear.

Journal: Trends in pharmacological sciences 20050701

Title: Synthetic lanostane-type triterpenoids as inhibitors of DNA topoisomerase II.

Journal: Bioorganic & medicinal chemistry letters 20050615

Title: Ganoderic acid X, a lanostanoid triterpene, inhibits topoisomerases and induces apoptosis of cancer cells.

Journal: Life sciences 20050603

Title: N-Phenethylhexadecanamide from the edible mushroom Laetiporus sulphureus.

Journal: Natural product research 20050601

Title: Cytotoxic constituents of the fruit body of Daedalea dickisii.

Journal: Journal of natural products 20050601

Title: Sterol stringency of proliferation and cell cycle progression in human cells.

Journal: Biochimica et biophysica acta 20050515

Title: Differences in the modulation of collective membrane motions by ergosterol, lanosterol, and cholesterol: a dynamic light scattering study.

Journal: Biophysical journal 20050501

Title: Pre-cholesterol precursors in gametogenesis.

Journal: Molecular and cellular endocrinology 20050429

Title: The imidazoline-like drug S23515 affects lipid metabolism in hepatocyte by inhibiting the oxidosqualene: lanosterol cyclase activity.

Journal: Biochemical pharmacology 20050401

Title: Determination of sterols in biological samples by SPME with on-fiber derivatization and GC/FID.

Journal: Analytical and bioanalytical chemistry 20050401

Title: Oxygenated lanostane-type triterpenoids from the fungus ganodermalucidum.

Journal: Journal of natural products 20050401

Title: How low can you go?

Journal: Science of aging knowledge environment : SAGE KE 20050316

Title: Desmosterol may replace cholesterol in lipid membranes.

Journal: Biophysical journal 20050301

Title: Dual-action hypoglycemic and hypocholesterolemic agents that inhibit glycogen phosphorylase and lanosterol demethylase.

Journal: Journal of lipid research 20050301

Title: Isotopomer spectral analysis of intermediates of cholesterol synthesis in patients with cerebrotendinous xanthomatosis.

Journal: Metabolism: clinical and experimental 20050301

Title: Insig-mediated degradation of HMG CoA reductase stimulated by lanosterol, an intermediate in the synthesis of cholesterol.

Journal: Cell metabolism 20050301

Title: Cancer preventive agents. Part 1: chemopreventive potential of cimigenol, cimigenol-3,15-dione, and related compounds.

Journal: Bioorganic & medicinal chemistry 20050215

Title: Antiproliferative synergism of azasterols and antifolates against Toxoplasma gondii.

Journal: International journal of antimicrobial agents 20050201

Title: The combination effects of phenolic compounds and fluconazole on the formation of ergosterol in Candida albicans determined by high-performance liquid chromatography/tandem mass spectrometry.

Journal: Analytical biochemistry 20050101

Title: Multidrug resistance in yeast Candida.

Journal: International review of cytology 20050101

Title: Aspergillus oryzae produces compounds inhibiting cholesterol biosynthesis downstream of dihydrolanosterol.

Journal: FEMS microbiology letters 20050101

Title: Lanostane triterpenoids and triterpene glycosides from the fruit body of Fomitopsis pinicola and their inhibitory activity against COX-1 and COX-2.

Journal: Journal of natural products 20050101

Title: MT FdR: a ferredoxin reductase from M. tuberculosis that couples to MT CYP51.

Journal: Biochimica et biophysica acta 20050101

Title: Exploring hepatic hormone actions using a compilation of gene expression profiles.

Journal: BMC physiology 20050101

Title: Genome-wide structural and evolutionary analysis of the P450 monooxygenase genes (P450ome) in the white rot fungus Phanerochaete chrysosporium: evidence for gene duplications and extensive gene clustering.

Journal: BMC genomics 20050101

Title: Vesicle fluctuation analysis of the effects of sterols on membrane bending rigidity.

Journal: European biophysics journal : EBJ 20041201

Title: Meiosis-activating sterol synthesis in rat preovulatory follicle: is it involved in resumption of meiosis?

Journal: Biology of reproduction 20041201

Title: Lead nitrate-induced development of hypercholesterolemia in rats: sterol-independent gene regulation of hepatic enzymes responsible for cholesterol homeostasis.

Journal: Toxicology letters 20041201

Title: Lanostanoid triterpenes from Laetiporus sulphureus and apoptosis induction on HL-60 human myeloid leukemia cells.

Journal: Journal of natural products 20041201

Title: Bioactive friedolanostanes and 11(10-->8)-abeolanostanes from the bark of Garcinia speciosa.

Journal: Journal of natural products 20041201

Title: 27-norlanostane glycosides from the bulbs of Muscari paradoxum.

Journal: Journal of natural products 20041201

Title: Studies on the expression levels of sterol-metabolizing enzymes in the obese model SHR/NDmcr-cp rats.

Journal: Clinical and experimental pharmacology & physiology 20041201

Title: Biochemical characterization of terbinafine-resistant Trichophyton rubrum isolates.

Journal: Medical mycology 20041201

Title: Molecular mechanisms of vitamin E transport.

Journal: Annals of the New York Academy of Sciences 20041201

Title: Cloning and characterization of the lanosterol 14alpha-demethylase (ERG11) gene in Cryptococcus neoformans.

Journal: Biochemical and biophysical research communications 20041112

Title: Insight into steroid scaffold formation from the structure of human oxidosqualene cyclase.

Journal: Nature 20041104

Title: Agrobacterium tumefaciens-mediated transformation of the antitumor clavaric acid-producing basidiomycete Hypholoma sublateritium.

Journal: Current genetics 20041101

Title: New lanostane-type triterpenes from Fomes officinalis.

Journal: Chemical & pharmaceutical bulletin 20041101

Title: Anti-inflammatory and anti-hyaluronate lyase activities of lanostanoids from Piptoporus betulinus.

Journal: The Journal of antibiotics 20041101

Title: What's so special about cholesterol?

Journal: Lipids 20041101

Title: Cholesterol is essential for mitosis progression and its deficiency induces polyploid cell formation.

Journal: Experimental cell research 20041015

Title: Geranylgeraniol regulates negatively caspase-1 autoprocessing: implication in the Th1 response against Mycobacterium tuberculosis.

Journal: Journal of immunology (Baltimore, Md. : 1950) 20041015

Title: Oxysteroids: a new class of steroids with autocrine and paracrine functions.

Journal: Trends in endocrinology and metabolism: TEM 20041001

Title: Abnormal steroidogenesis in three patients with Antley-Bixler syndrome: apparent decreased activity of 17alpha-hydroxylase, 17,20-lyase and 21-hydroxylase.

Journal: Pediatrics international : official journal of the Japan Pediatric Society 20041001

Title: Low concentrations of the non-ionic detergent Nonidet P-40 interfere with sterol biogenesis and viability of the yeast Saccharomyces cerevisiae.

Journal: FEMS microbiology letters 20040901

Title: A low-toxicity method for the separation of lanosterol and dihydrolanosterol from commercial mixtures.

Journal: Steroids 20040901

Title: CYP51 from Trypanosoma brucei is obtusifoliol-specific.

Journal: Biochemistry 20040824

Title: Undetectable maternal serum uE3 and postnatal abnormal sterol and steroid metabolism in Antley-Bixler syndrome.

Journal: American journal of medical genetics. Part A 20040815

Title: Genome-wide expression profiling reveals genes associated with amphotericin B and fluconazole resistance in experimentally induced antifungal resistant isolates of Candida albicans.

Journal: The Journal of antimicrobial chemotherapy 20040801

Title: Homology modeling of lanosterol 14alpha-demethylase of Candida albicans and Aspergillus fumigatus and insights into the enzyme-substrate Interactions.

Journal: Journal of biomolecular structure & dynamics 20040801

Title: Compound heterozygous mutations of cytochrome P450 oxidoreductase gene (POR) in two patients with Antley-Bixler syndrome.

Journal: American journal of medical genetics. Part A 20040801

Title: Quantitation of lanosterol and its major metabolite FF-MAS in an inhibition assay of CYP51 by azoles with atmospheric pressure photoionization based LC-MS/MS.

Journal: Journal of the American Society for Mass Spectrometry 20040801

Title: Sterol metabolism in the opportunistic pathogen Pneumocystis: advances and new insights.

Journal: Lipids 20040801

Title: New lanostane-type triterpenoids from Ganoderma applanatum.

Journal: Journal of natural products 20040701

Title: New aspects on lanosterol 14alpha-demethylase and cytochrome P450 evolution: lanosterol/cycloartenol diversification and lateral transfer.

Journal: Journal of molecular evolution 20040701

Title: Selective anti-Toxoplasma gondii activities of azasterols.

Journal: International journal of antimicrobial agents 20040601

Title: Phytoestrogen cimicifugoside-mediated inhibition of catecholamine secretion by blocking nicotinic acetylcholine receptor in bovine adrenal chromaffin cells.

Journal: The Journal of pharmacology and experimental therapeutics 20040501

Title: The role of cholesterol in the activity of pneumolysin, a bacterial protein toxin.

Journal: Biophysical journal 20040501

Title: Ananosic acids B and C, two new 18(13-->12)-abeo-lanostane triterpenoids from Kadsura ananosma.

Journal: Journal of natural products 20040501

Title: Eucosterol-type nortriterpenoids from Merwilla natalensis.

Journal: Journal of natural products 20040501

Title: Roles of gonadotropins and meiosis-activating sterols in meiotic resumption of cultured follicle-enclosed mouse oocytes.

Journal: Molecular and cellular endocrinology 20040415

Title: Efficient routes to epimerically-pure side-chain derivatives of lanosterol.

Journal: Steroids 20040401

Title: Enzymatic cyclization of 22,23-dihydro-2,3-oxidosqualene into euph-7-en-3beta-ol and bacchar-12-en-3beta-ol by recombinant beta-amyrin synthase.

Journal: Journal of the American Chemical Society 20040324

Title: The monotopic membrane protein human oxidosqualene cyclase is active as monomer.

Journal: Biochemical and biophysical research communications 20040305

Title: A functional cytochrome P450 lanosterol 14 alpha-demethylase CYP51 enzyme in the acrosome: transport through the Golgi and synthesis of meiosis-activating sterols.

Journal: Endocrinology 20040301

Title: Two new cyclolanostanol glycosides from the aerial parts of Cimicifuga foetida.

Journal: Journal of Asian natural products research 20040301

Title: Characterization of a human Sec14-like protein cDNA SEC14L3 highly homologous to human SPF/TAP.

Journal: Molecular biology reports 20040301

Title: Impact of 10 dietary sterols on growth and reproduction of Daphnia galeata.

Journal: Journal of chemical ecology 20040301

Title: CYP51--the omnipotent P450.

Journal: Molecular and cellular endocrinology 20040227

Title: Lanosterol and cholesterol-induced variations in bilayer elasticity probed by 2H NMR relaxation.

Journal: Langmuir : the ACS journal of surfaces and colloids 20040217

Title: Cholesterol-lowering properties of Ganoderma lucidum in vitro, ex vivo, and in hamsters and minipigs.

Journal: Lipids in health and disease 20040101

Title: Modeling lipid-sterol bilayers: applications to structural evolution, lateral diffusion, and rafts.

Journal: Methods in enzymology 20040101

Title: Fungal biofilms and drug resistance.

Journal: Emerging infectious diseases 20040101

Title: Cloning and analysis of Trypanosoma cruzi lanosterol 14alpha-demethylase.

Journal: Molecular and biochemical parasitology 20031201

Title: Novel sterols synthesized via the CYP27A1 metabolic pathway.

Journal: Archives of biochemistry and biophysics 20031201

Title: Lanosterol and tetranorlanosterol glycosides from the bulbs of Muscari paradoxum.

Journal: Phytochemistry 20031201

Title: Changes in cholesterol and its precursors during the first days after major trauma.

Journal: Wiener klinische Wochenschrift 20031128

Title: Combined overexpression of genes of the ergosterol biosynthetic pathway leads to accumulation of sterols in Saccharomyces cerevisiae.

Journal: FEMS yeast research 20031001

Title: Localization of mammalian NAD(P)H steroid dehydrogenase-like protein on lipid droplets.

Journal: The Journal of biological chemistry 20030919

Title: Conservation in the CYP51 family. Role of the B' helix/BC loop and helices F and G in enzymatic function.

Journal: Biochemistry 20030805

Title: Characterization of a lanosterol 14 alpha-demethylase from Pneumocystis carinii.

Journal: American journal of respiratory cell and molecular biology 20030801

Title: Anti-inflammatory lanostane-type triterpene acids from Piptoporus betulinus.

Journal: Journal of natural products 20030801

Title: In yeast sterol biosynthesis the 3-keto reductase protein (Erg27p) is required for oxidosqualene cyclase (Erg7p) activity.

Journal: Biochimica et biophysica acta 20030704

Title: Revision and confirmation of the regiochemistry of isoxazoles derived from methyl oleanonate and lanost-8-en-3-one. Synthesis of a new lanostane triterpenoid with a cyano-enone functionality in ring A.

Journal: The Journal of organic chemistry 20030613

Title: Lanosterol metabolism and sterol regulatory element binding protein (SREBP) expression in male germ cell maturation.

Journal: The Journal of steroid biochemistry and molecular biology 20030601

Title: Phylogeny of choanozoa, apusozoa, and other protozoa and early eukaryote megaevolution.

Journal: Journal of molecular evolution 20030501

Title: Mechanistic insights into oxidosqualene cyclizations through homology modeling.

Journal: Journal of computational chemistry 20030430

Title: Production of progesterone from de novo-synthesized cholesterol in cumulus cells and its physiological role during meiotic resumption of porcine oocytes.

Journal: Biology of reproduction 20030401

Title: Saccharomyces cerevisiae Dap1p, a novel DNA damage response protein related to the mammalian membrane-associated progesterone receptor.

Journal: Eukaryotic cell 20030401

Title: Antitumor agents 220. Antitumor-promoting effects of cimigenol and related compounds on Epstein-Barr virus activation and two-stage mouse skin carcinogenesis.

Journal: Bioorganic & medicinal chemistry 20030320

Title: Human serum paraoxonase 1 decreases macrophage cholesterol biosynthesis: possible role for its phospholipase-A2-like activity and lysophosphatidylcholine formation.

Journal: Arteriosclerosis, thrombosis, and vascular biology 20030301

Title: Drug induced proteome changes in Candida albicans: comparison of the effect of beta(1,3) glucan synthase inhibitors and two triazoles, fluconazole and itraconazole.

Journal: Proteomics 20030301

Title: [Studies on the new triterpenoid saponin of the aerial part of Cimicifuga foetida].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20030301

Title: Structure-based de novo design, synthesis, and biological evaluation of non-azole inhibitors specific for lanosterol 14alpha-demethylase of fungi.

Journal: Journal of medicinal chemistry 20030213

Title: Conservation and cloning of CYP51: a sterol 14 alpha-demethylase from Mycobacterium smegmatis.

Journal: Biochemical and biophysical research communications 20030207

Title: Identification of farnesoid X receptor beta as a novel mammalian nuclear receptor sensing lanosterol.

Journal: Molecular and cellular biology 20030201

Title: Triterpenoids from the orchids Agrostophyllum brevipes and Agrostophyllum callosum.

Journal: Phytochemistry 20030201

Title: [Serum markers in relation to cognitive functioning in an aging population: results of the Maastricht Aging Study (MAAS)].

Journal: Tijdschrift voor gerontologie en geriatrie 20030201

Title: [Studies on new trierpenoid constituents from the Rhizoma of Cimicifuga foetida].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20030201

Title: Formation of the C ring in the lanosterol biosynthesis from squalene.

Journal: Organic letters 20030123

Title: Many facets of mammalian lanosterol 14alpha-demethylase from the evolutionarily conserved cytochrome P450 family CYP51.

Journal: Archives of biochemistry and biophysics 20030101

Title: Serum cholesterol, precursors and metabolites and cognitive performance in an aging population.

Journal: Neurobiology of aging 20030101

Title: Supernatant protein factor and tocopherol-associated protein: an unexpected link between cholesterol synthesis and vitamin E (review).

Journal: The Journal of nutritional biochemistry 20030101

Title: Protein prenyltransferases.

Journal: Genome biology 20030101

Title: Two new 24-isopropenyl-lanostanoids from Tillandsia brachycaulos.

Journal: Zeitschrift fur Naturforschung. C, Journal of biosciences 20030101

Title: Scale-up of a liquid static culture process for hyperproduction of ganoderic acid by the medicinal mushroom Ganoderma lucidum.

Journal: Biotechnology progress 20030101

Title: Identification of two proteins induced by exposure of the pathogenic fungus Candida glabrata to fluconazole.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20021225

Title: Creating new supramolecular materials by architecture of three-dimensional nanocrystal fiber networks.

Journal: Journal of the American Chemical Society 20021218

Title: Desmosterolosis presenting with multiple congenital anomalies and profound developmental delay.

Journal: American journal of medical genetics 20021215

Title: Directed evolution experiments reveal mutations at cycloartenol synthase residue His477 that dramatically alter catalysis.

Journal: Organic letters 20021212

Title: A novel sterol 14alpha-demethylase/ferredoxin fusion protein (MCCYP51FX) from Methylococcus capsulatus represents a new class of the cytochrome P450 superfamily.

Journal: The Journal of biological chemistry 20021206

Title: Nuclear receptor agonists stimulate release of arachidonic acid from rat liver cells.

Journal: Prostaglandins, leukotrienes, and essential fatty acids 20021201

Title: Sterol biosynthesis in Pneumocystis: unique steps that define unique targets.

Journal: Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy 20021201

Title: Novel hydroquinone as a matrix metallo-proteinase inhibitor from the mushroom, Piptoporus betulinus.

Journal: Bioscience, biotechnology, and biochemistry 20021201

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Journal: Lipids 20021201

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Journal: Lipids 20021201

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Journal: Steroids 20021101

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Journal: Journal of natural products 20021101

Title: Anisotropic motion and molecular dynamics of cholesterol, lanosterol, and ergosterol in lecithin bilayers studied by quasi-elastic neutron scattering.

Journal: Biochemistry 20021029

Title: Complete characterisation of lanolin steryl esters by sub-ambient pressure gas chromatography-mass spectrometry in the electron impact and chemical ionisation modes.

Journal: Journal of chromatography. A 20020913

Title: Concomitant C-ring Expansion and D-ring formation in lanosterol biosynthesis from squalene without violation of Markovnikov's rule.

Journal: Journal of the American Chemical Society 20020904

Title: A cAMP-responsive element binding site is essential for sterol regulation of the human lanosterol 14alpha-demethylase gene (CYP51).

Journal: Molecular endocrinology (Baltimore, Md.) 20020801

Title: Conversion of a plant oxidosqualene-cycloartenol synthase to an oxidosqualene-lanosterol cyclase by random mutagenesis.

Journal: Biochemistry 20020702

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Journal: The Journal of laboratory and clinical medicine 20020701

Title: Profile of cholesterol-related sterols in aged amyloid precursor protein transgenic mouse brain.

Journal: Journal of lipid research 20020701

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Journal: Journal of lipid research 20020701

Title: Altered gene expression of hepatic lanosterol 14alpha-demethylase (CYP51) in lead nitrate-treated rats.

Journal: Archives of toxicology 20020701

Title: Abnormal sterol metabolism in a patient with Antley-Bixler syndrome and ambiguous genitalia.

Journal: American journal of medical genetics 20020615

Title: Sterol 14alpha-demethylase activity in Streptomyces coelicolor A3(2) is associated with an unusual member of the CYP51 gene family.

Journal: The Biochemical journal 20020601

Title: The Salmonella-containing vacuole is a major site of intracellular cholesterol accumulation and recruits the GPI-anchored protein CD55.

Journal: Cellular microbiology 20020601

Title: Polyene substrates with unusual methylation patterns to probe the active sites of three catalytic antibodies.

Journal: Bioorganic & medicinal chemistry 20020501

Title: The Pneumocystis carinii drug target S-adenosyl-L-methionine:sterol C-24 methyl transferase has a unique substrate preference.

Journal: Molecular microbiology 20020501

Title: Membrane-bound enzymes of cholesterol synthesis from lanosterol.

Journal: Biochemical and biophysical research communications 20020419

Title: My years with Konrad, a memoir.

Journal: Biochemical and biophysical research communications 20020419

Title: Directed evolution to generate cycloartenol synthase mutants that produce lanosterol.

Journal: Organic letters 20020418

Title: Inhibition of tumor-promoting effects by poricoic acids G and H and other lanostane-type triterpenes and cytotoxic activity of poricoic acids A and G from Poria cocos.

Journal: Journal of natural products 20020401

Title: New lanostanoids, elfvingic acids A-H, from the fruit body of Elfvingia applanata.

Journal: Journal of natural products 20020401

Title: Modeling of binding modes and inhibition mechanism of some natural ligands of farnesyl transferase using molecular docking.

Journal: Journal of medicinal chemistry 20020328

Title: Elution behavior of unsaponifiable lipids with various capillary electrochromatographic stationary phases.

Journal: Journal of chromatography. A 20020308

Title: From lanosterol to cholesterol: structural evolution and differential effects on lipid bilayers.

Journal: Biophysical journal 20020301

Title: Differential effects of ergosterol and cholesterol on Cdk1 activation and SRE-driven transcription.

Journal: European journal of biochemistry 20020301

Title: New lanostanoids from the fungus Ganoderma concinna.

Journal: Journal of natural products 20020301

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Journal: Journal of mass spectrometry : JMS 20020301

Title: Lanosterol 14alpha-demethylase and MAS sterols in mammalian gametogenesis.

Journal: Molecular and cellular endocrinology 20020222

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Journal: Molecular and cellular endocrinology 20020222

Title: Molecular basis of resistance to azole antifungals.

Journal: Trends in molecular medicine 20020201

Title: Yeast oxidosqualene cyclase (Erg7p) is a major component of lipid particles.

Journal: The Journal of biological chemistry 20020125

Title: Cloning and expression of sterol Delta 14-reductase from bovine liver.

Journal: European journal of biochemistry 20020101

Title: New lanostanoids from the mushroom Ganoderma lucidum.

Journal: Journal of natural products 20020101

Title: Lanostanoids of Amentotaxus formosana.

Journal: Journal of natural products 20020101

Title: Two-stage culture process for improved production of ganoderic acid by liquid fermentation of higher fungus Ganoderma lucidum.

Journal: Biotechnology progress 20020101

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Journal: The Journal of eukaryotic microbiology 20020101

Title: Chemopreventive effect of farnesol and lanosterol on colon carcinogenesis.

Journal: Cancer detection and prevention 20020101

Title: Substrate recognition sites in 14alpha-sterol demethylase from comparative analysis of amino acid sequences and X-ray structure of Mycobacterium tuberculosis CYP51.

Journal: Journal of inorganic biochemistry 20011215

Title: Gonadotropin-induced accumulation of 4,4-dimethylsterols in mouse ovaries and its temporal relation to meiosis.

Journal: Biology of reproduction 20011201

Title: Anticomplement activity of terpenoids from the spores of Ganoderma lucidum.

Journal: Planta medica 20011201

Title: Regulation of hepatic lanosterol 14 alpha-demethylase gene expression by dietary cholesterol and cholesterol-lowering agents.

Journal: Archives of biochemistry and biophysics 20011115

Title: Steryl and stanyl esters of fatty acids by solvent-free esterification and transesterification in vacuo using lipases from Rhizomucor miehei, Candida antarctica, and Carica papaya.

Journal: Journal of agricultural and food chemistry 20011101

Title: Blocking protein geranylgeranylation is essential for lovastatin-induced apoptosis of human acute myeloid leukemia cells.

Journal: Leukemia 20010901

Title: New pentanorlanostane derivatives, cladosporide B-D, as characteristic antifungal agents against Aspergillus fumigatus, isolated from Cladosporium sp.

Journal: The Journal of antibiotics 20010901

Title: Identification of a novel mutation in 3beta-hydroxysteroid-Delta8-Delta7-isomerase in a case of Conradi-Hünermann-Happle syndrome.

Journal: Experimental dermatology 20010801

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Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20010801

Title: Obtusifoliol 14alpha-demethylase (CYP51) antisense Arabidopsis shows slow growth and long life.

Journal: Biochemical and biophysical research communications 20010706

Title: The interactions of amphotericin B with various sterols in relation to its possible use in anticancer therapy.

Journal: Biophysical chemistry 20010702

Title: Neutral sterols of rat epididymis. High concentrations of dehydrocholesterols in rat caput epididymidis.

Journal: Journal of lipid research 20010701

Title: Content of meiosis activating sterols in equine follicular fluids: correlation to follicular size and dominance.

Journal: Theriogenology 20010701

Title: Trypanosome and animal lanosterol synthases use different catalytic motifs.

Journal: Organic letters 20010614

Title: Mammalian exocrine secretions XVI. Constitutents of secretion of supplementary sacculi of dwarf hamster, Phodopus sungorus sungorus.

Journal: Journal of chemical ecology 20010601

Title: Cholesterol biosynthesis from lanosterol. A concerted role for Sp1 and NF-Y-binding sites for sterol-mediated regulation of rat 7-dehydrocholesterol reductase gene expression.

Journal: The Journal of biological chemistry 20010525

Title: Molecular dynamics simulation of the structure of dimyristoylphosphatidylcholine bilayers with cholesterol, ergosterol, and lanosterol.

Journal: Biophysical journal 20010401

Title: Anaerobiosis induces complex changes in sterol esterification pattern in the yeast Saccharomyces cerevisiae.

Journal: FEMS microbiology letters 20010401

Title: Ergosterol biosynthesis in novel melanized fungi from hypersaline environments.

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Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20010301

Title: LDL downregulates CYP51 in porcine vascular endothelial cells and in the arterial wall through a sterol regulatory element binding protein-2-dependent mechanism.

Journal: Circulation research 20010216

Title: Cholesterol biosynthesis from lanosterol: molecular cloning, chromosomal localization, functional expression and liver-specific gene regulation of rat sterol delta8-isomerase, a cholesterogenic enzyme with multiple functions.

Journal: The Biochemical journal 20010201

Title: Meiosis-activating sterol and the maturation of isolated mouse oocytes.

Journal: Biology of reproduction 20010101

Title: Role of meiosis-activating sterols in rat oocyte maturation: effects of specific inhibitors and changes in the expression of lanosterol 14alpha-demethylase during the preovulatory period.

Journal: Biology of reproduction 20010101

Title: Quantification of plasma membrane ergosterol of Saccharomyces cerevisiae by direct-injection atmospheric pressure chemical ionization/tandem mass spectrometry.

Journal: Analytical biochemistry 20010101

Title: Molecular cloning and expression in yeast of 2,3-oxidosqualene-triterpenoid cyclases from Arabidopsis thaliana.

Journal: Plant molecular biology 20010101

Title: Localisation of lanosterol 14alpha-demethylase in round and elongated spermatids of the mouse testis: an immunoelectron microscopic and stereological study.

Journal: Pflugers Archiv : European journal of physiology 20010101

Title: Inhibitors of sterol biosynthesis and amphotericin B reduce the viability of pneumocystis carinii f. sp. carinii.

Journal: Antimicrobial agents and chemotherapy 20000601

Title: Synthesis of 25-aminosterols, new antifungal agents.

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Title: Selective inhibition of mammalian lanosterol 14 alpha-demethylase by RS-21607 in vitro and in vivo.

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Journal: Biochimica et biophysica acta 19920423

Title: Synthesis, specificity, and antifungal activity of inhibitors of the Candida albicans delta 24-sterol methyltransferase.

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Title: Effects of environmentally encountered epoxides on mouse liver epoxide-metabolizing enzymes.

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Title: Upadhyay A, et al. Lanosterol Suppresses the Aggregation and Cytotoxicity of Misfolded Proteins Linked with Neurodegenerative Diseases. Mol Neurobiol. 2018;55(2):1169-1182.

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Tags:79-63-0 Molecular Formula|79-63-0 MDL|79-63-0 SMILES|79-63-0 (3β)-Lanosta-8,24-dien-3-ol