Title: In vitro metabolism of N'-Nitrosonornicotine catalyzed by cytochrome P450 2A13 and its inhibition by nicotine, N'-Nitrosoanatabine and N'-Nitrosoanabasine.
Journal: Chemico-biological interactions 20161225
Title: In vitro exposure of tobacco specific nitrosamines decreases the rat lung phospholipids by enhanced phospholipase A2 activity.
Journal: Toxicology in vitro : an international journal published in association with BIBRA 20140901
Title: Analysis of N'-nitrosonornicotine and its metabolites in rabbit blood with liquid chromatography/tandem mass spectrometric method.
Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20120615
Title: Major tobacco companies have technology to reduce carcinogen levels but do not apply it to popular smokeless tobacco products.
Journal: Tobacco control 20111101
Title: Urinary levels of the tobacco-specific carcinogen N'-nitrosonornicotine and its glucuronide are strongly associated with esophageal cancer risk in smokers.
Journal: Carcinogenesis 20110901
Title: Environmental mutagens may be implicated in the emergence of drug-resistant microorganisms.
Journal: FEMS microbiology letters 20110401
Title: Enhanced phospholipase B activity and alteration of phospholipids and neutral lipids in Saccharomyces cerevisiae exposed to N-nitrosonornicotine.
Journal: Antonie van Leeuwenhoek 20110301
Title: Three nicotine demethylase genes mediate nornicotine biosynthesis in Nicotiana tabacum L.: functional characterization of the CYP82E10 gene.
Journal: Phytochemistry 20101201
Title: Adsorption of nitrosamines by mesoporous zeolite.
Journal: Journal of colloid and interface science 20100815
Title: [Determination of four carcinogens in mainstream cigarette smoke by liquid chromatography-tandem mass spectrometry].
Journal: Se pu = Chinese journal of chromatography 20100801
Title: Determination of tobacco-specific N-nitrosamines in urine of smokers and non-smokers.
Journal: Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals 20091201
Title: Incremental lifetime cancer risks computed for benzo[a]pyrene and two tobacco-specific N-nitrosamines in mainstream cigarette smoke compared with lung cancer risks derived from epidemiologic data.
Journal: Regulatory toxicology and pharmacology : RTP 20091101
Title: Presence of the carcinogen N'-nitrosonornicotine in the urine of some users of oral nicotine replacement therapy products.
Journal: Cancer research 20091101
Title: The influence of repair pathways on the cytotoxicity and mutagenicity induced by the pyridyloxobutylation pathway of tobacco-specific nitrosamines.
Journal: Chemical research in toxicology 20090817
Title: Quantitation of pyridyloxobutyl DNA adducts in nasal and oral mucosa of rats treated chronically with enantiomers of N'-nitrosonornicotine.
Journal: Chemical research in toxicology 20090501
Title: Effect of CYP2A13 active site mutation N297A on metabolism of coumarin and tobacco-specific nitrosamines.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20090301
Title: Evaluation of the mutagenic effects of myosmine in human lymphocytes using the HPRT gene mutation assay.
Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20090101
Title: Evidence for endogenous formation of N'-nitrosonornicotine in some long-term nicotine patch users.
Journal: Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco 20090101
Title: CYP2A6 polymorphisms and risk for tobacco-related cancers.
Journal: Pharmacogenomics 20081101
Title: Mouse model of diethylnitrosamine-induced gastric cancer.
Journal: The Journal of surgical research 20080801
Title: Glucuronidation of tobacco-specific nitrosamines by UGT2B10.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20080501
Title: RNA interference (RNAi)-induced suppression of nicotine demethylase activity reduces levels of a key carcinogen in cured tobacco leaves.
Journal: Plant biotechnology journal 20080501
Title: A susceptibility locus for lung cancer maps to nicotinic acetylcholine receptor subunit genes on 15q25.
Journal: Nature 20080403
Title: Detection and quantitation of N'-nitrosonornicotine in human toenails by liquid chromatography-electrospray ionization-tandem mass spectrometry.
Journal: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20080401
Title: Basic and clinical aspects of non-neuronal acetylcholine: biological and clinical significance of non-canonical ligands of epithelial nicotinic acetylcholine receptors.
Journal: Journal of pharmacological sciences 20080201
Title: Functional characterization of CYP2A13 polymorphisms.
Journal: Xenobiotica; the fate of foreign compounds in biological systems 20071201
Title: Endogenous formation of N'-nitrosonornicotine in F344 rats in the presence of some antioxidants and grape seed extract.
Journal: Journal of agricultural and food chemistry 20070822
Title: SLURP-1 and -2 in normal, immortalized and malignant oral keratinocytes.
Journal: Life sciences 20070530
Title: Nitrosamines as nicotinic receptor ligands.
Journal: Life sciences 20070530
Title: A new method for estimating the retention of selected smoke constituents in the respiratory tract of smokers during cigarette smoking.
Journal: Inhalation toxicology 20070201
Title: Analysis of pyridyloxobutyl DNA adducts in F344 rats chronically treated with (R)- and (S)-N'-nitrosonornicotine.
Journal: Chemical research in toxicology 20070201
Title: Development of a commercial cigarette 'market map' comparison methodology for evaluating new or non-conventional cigarettes.
Journal: Regulatory toxicology and pharmacology : RTP 20061201
Title: The nicotinic receptor antagonists abolish pathobiologic effects of tobacco-derived nitrosamines on BEP2D cells.
Journal: Journal of cancer research and clinical oncology 20061001
Title: Nicotinic receptors mediate tumorigenic action of tobacco-derived nitrosamines on immortalized oral epithelial cells.
Journal: Cancer biology & therapy 20060501
Title: Acute and subacute effects of tobacco alkaloids, tobacco-specific nitrosamines and phenethyl isothiocyanate on N'-nitrosonornicotine metabolism in rats.
Journal: Toxicology 20051115
Title: Tobacco-specific nitrosamines in smokeless tobacco products marketed in India.
Journal: International journal of cancer 20050810
Title: Nicotine 5'-oxidation and methyl oxidation by P450 2A enzymes.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20050801
Title: Duodenal acidity may increase the risk of pancreatic cancer in the course of chronic pancreatitis: an etiopathogenetic hypothesis.
Journal: JOP : Journal of the pancreas 20050310
Title: Effect of N'-nitrosonornicotine (NNN) on murine palatal fusion in vitro.
Journal: Toxicology 20050227
Title: Inhibition by N'-nitrosonornicotine of the catalytic activity of glutamate dehydrogenase in alpha-ketoglutarate amination.
Journal: Journal of enzyme inhibition and medicinal chemistry 20050201
Title: Cytochrome P450 2A-catalyzed metabolic activation of structurally similar carcinogenic nitrosamines: N'-nitrosonornicotine enantiomers, N-nitrosopiperidine, and N-nitrosopyrrolidine.
Journal: Chemical research in toxicology 20050101
Title: Tobacco-related-compound-induced nitrosative stress injury in the hamster cheek pouch.
Journal: Journal of dental research 20041201
Title: Identification of O2-substituted pyrimidine adducts formed in reactions of 4-(acetoxymethylnitrosamino)- 1-(3-pyridyl)-1-butanone and 4-(acetoxymethylnitros- amino)-1-(3-pyridyl)-1-butanol with DNA.
Journal: Chemical research in toxicology 20040501
Title: Effect of ethanol on lipid metabolism and epithelial permeability barrier of skin and oral mucosa in the rat.
Journal: Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology 20031101
Title: The permeability of oral leukoplakia.
Journal: European journal of oral sciences 20030801
Title: Nucleophilic reactions between thiols and a tobacco specific nitrosamine metabolite, 4-hydroxy-1-(3-pyridyl)-1-butanone.
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Title: [Cancer from snuff?].
Journal: HNO 20030301
Title: Nicotine exposure and bronchial epithelial cell nicotinic acetylcholine receptor expression in the pathogenesis of lung cancer.
Journal: The Journal of clinical investigation 20030101
Title: Metabolism and pharmacokinetics of N'-nitrosonornicotine in the patas monkey.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20021001
Title: Nitrosation of dietary myosmine as risk factor of human cancer.
Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20020801
Title: Role of human cytochrome P450 (CYP) in the metabolic activation of nitrosamine derivatives: application of genetically engineered Salmonella expressing human CYP.
Journal: Drug metabolism reviews 20020801
Title: Analysis of tobacco-specific nitrosamines in Moldovan cigarette tobacco.
Journal: Journal of agricultural and food chemistry 20020508
Title: Bacterial mutagenicity of some tobacco aromatic nitrogen bases and their mixtures.
Journal: Mutation research 20010531
Title: Preparation of pyridine-N-glucuronides of tobacco-specific nitrosamines.
Journal: Chemical research in toxicology 20010501
Title: Tobacco industry must not dump its high nitrosamine tobacco on poor countries.
Journal: BMJ (Clinical research ed.) 20010303
Title: Mutagenesis induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and N-nitrosonornicotine in lacZ upper aerodigestive tissue and liver and inhibition by green tea.
Journal: Carcinogenesis 20010101
Title: Predicting the mutagenicity of tobacco-related N-nitrosamines in humans using 11 strains of Salmonella typhimurium YG7108, each coexpressing a form of human cytochrome P450 along with NADPH-cytochrome P450 reductase.
Journal: Environmental and molecular mutagenesis 20010101
Title: Smoke yields of tobacco-specific nitrosamines in relation to FTC tar level and cigarette manufacturer: analysis of the Massachusetts Benchmark Study.
Journal: Public health reports (Washington, D.C. : 1974) 20010101
Title: Comparative metabolism of the tobacco-related carcinogens benzo[a]pyrene, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol, and N'- nitrosonornicotine in human hepatic microsomes.
Journal: Drug metabolism and disposition: the biological fate of chemicals 19970201
Title: A tobacco smoke-derived nitrosamine, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, is activated by multiple human cytochrome P450s including the polymorphic human cytochrome P4502D6.
Journal: Carcinogenesis 19910701
Title: Comparative carcinogenicity in F344 rats of the tobacco-specific nitrosamines, N'-nitrosonornicotine and 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone.
Journal: Cancer research 19800201
Title: Carcinogenicity of N'-nitrosonornicotine in Sprague-Dawley rats.
Journal: Journal of the National Cancer Institute 19761201
