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81012-99-9,MFCD00044695
Catalog No.:AA003JHK

81012-99-9 | 3-Hydroxybenzylhydrazine DiHCl

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1g
≥98.0% (HPLC)
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5g
≥98.0% (HPLC)
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  • Technical Information
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  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA003JHK
Chemical Name:
3-Hydroxybenzylhydrazine DiHCl
CAS Number:
81012-99-9
Molecular Formula:
C7H12Cl2N2O
Molecular Weight:
211.0890
MDL Number:
MFCD00044695
SMILES:
NNCc1cccc(c1)O.Cl.Cl
Properties
Properties
 
Form:
Solid  
MP:
137-140°C  
Storage:
Keep in dry area;2-8℃;  

Computed Properties
 
Complexity:
97.6  
Covalently-Bonded Unit Count:
3  
Heavy Atom Count:
12  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
5  
Rotatable Bond Count:
2  

Literature

Title: Tyrosine depletion lowers in vivo DOPA synthesis in ventral hippocampus.

Journal: European journal of pharmacology 20121205

Title: Effects of neurotensin dipeptide analog dilept on dopamine metabolism and synthesis in the nucleus accumbens of Wistar rats.

Journal: Bulletin of experimental biology and medicine 20120901

Title: On the presence of serotonin in mammalian cardiomyocytes.

Journal: Molecular and cellular biochemistry 20120601

Title: An endogenous dopaminergic tone acting on dopamine D3 receptors may be involved in diurnal changes of tuberoinfundibular dopaminergic neuron activity and prolactin secretion in estrogen-primed ovariectomized rats.

Journal: Brain research bulletin 20120210

Title: Dichotomy of tyrosine hydroxylase and dopamine regulation between somatodendritic and terminal field areas of nigrostriatal and mesoaccumbens pathways.

Journal: PloS one 20120101

Title: Effect of chronic protein ingestion on tyrosine and tryptophan levels and catecholamine and serotonin synthesis in rat brain.

Journal: Nutritional neuroscience 20111101

Title: Functional reorganization of the presynaptic dopaminergic terminal in parkinsonism.

Journal: Neuroscience 20111013

Title: Cocaine supersensitivity and enhanced motivation for reward in mice lacking dopamine D2 autoreceptors.

Journal: Nature neuroscience 20110710

Title: 5-Hydroxytryptophan attenuates somatic signs of nicotine withdrawal.

Journal: Journal of pharmacological sciences 20110101

Title: Locomotor response to L-DOPA in reserpine-treated rats following central inhibition of aromatic L-amino acid decarboxylase: further evidence for non-dopaminergic actions of L-DOPA and its metabolites.

Journal: Neuroscience research 20100901

Title: Direct angiotensin II type 2 receptor stimulation decreases dopamine synthesis in the rat striatum.

Journal: Neuropharmacology 20100601

Title: [Neurochemical study of effects of the new anxiolytic drugs afobazol and ladasten on the synthesis and metabolism of monoamines and their metabolites in the brain structures of Wistar rat on the model of monoamine synthesis blockade induced by aromatic amino acid decarboxylase inhibitor NSD-1015].

Journal: Eksperimental'naia i klinicheskaia farmakologiia 20100301

Title: A role for serotonin in the antidepressant activity of NG-Nitro-L-arginine, in the rat forced swimming test.

Journal: Pharmacology, biochemistry, and behavior 20100201

Title: Detection of endogenous dopamine changes in Drosophila melanogaster using fast-scan cyclic voltammetry.

Journal: Analytical chemistry 20091115

Title: Lack of differential serotonin biosynthesis capacity in genetically selected low and high aggressive mice.

Journal: Physiology & behavior 20091019

Title: Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.

Journal: Nature chemical biology 20091001

Title: Amphetamine-evoked rotation requires newly synthesized dopamine at 14 days but not 1 day after intranigral 6-OHDA and is consistently dissociated from sensorimotor behavior.

Journal: Behavioural brain research 20090608

Title: Acoustic stimulation in vivo and corticotropin-releasing factor in vitro increase tryptophan hydroxylase activity in the rat caudal dorsal raphe nucleus.

Journal: Neuroscience letters 20090508

Title: Interplay between cytosolic dopamine, calcium, and alpha-synuclein causes selective death of substantia nigra neurons.

Journal: Neuron 20090430

Title: In vivo antagonism of the behavioral responses to L-3-,4-dihydroxyphenylalanine by L-3-,4-dihydroxyphenylalanine cyclohexyl ester in conscious rats.

Journal: European journal of pharmacology 20090301

Title: Evidence for serotonin synthesis-dependent regulation of in vitro neuronal firing rates in the midbrain raphe complex.

Journal: European journal of pharmacology 20080820

Title: Identification of small molecules rescuing fragile X syndrome phenotypes in Drosophila.

Journal: Nature chemical biology 20080401

Title: Effect of the beta3 adrenoceptor agonist CL 316243 on hypothalamic 5-HT synthesis and suppression of REM sleep in the rat.

Journal: Journal of psychopharmacology (Oxford, England) 20070801

Title: Dopaminergic toxicity of the herbicide atrazine in rat striatal slices.

Journal: Toxicology 20070322

Title: L-DOPA inhibits depolarization-induced [3H]GABA release in the dopamine-denervated globus pallidus of the rat: the effect is dopamine independent and mediated by D2-like receptors.

Journal: Journal of neural transmission (Vienna, Austria : 1996) 20061201

Title: Validation studies on the 5-hydroxy-L-[beta-11C]-tryptophan/PET method for probing the decarboxylase step in serotonin synthesis.

Journal: Synapse (New York, N.Y.) 20060615

Title: L-3,4-dihydroxyphenylalanine-induced c-Fos expression in the CNS under inhibition of central aromatic L-amino acid decarboxylase.

Journal: Neuropharmacology 20060601

Title: Neuropeptide Y induced attenuation of catecholamine synthesis in the rat mesenteric arterial bed.

Journal: Journal of cardiovascular pharmacology 20060601

Title: Synthesis, thermodynamics stability constant and relaxation properties of neutral Gd(III) complex with derivative from diethylene triamine pentaacetic acid and p-hydroxybenzoyl hydrazine.

Journal: Chemical & pharmaceutical bulletin 20060301

Title: Effects of a partial D2-like receptor agonist on striatal dopamine autoreceptor functioning in preweanling rats.

Journal: Brain research 20060216

Title: Ethanol desensitizes cannabinoid CB1 receptors modulating monoamine synthesis in the rat brain in vivo.

Journal: Neuroscience letters 20060109

Title: Dopaminergic mechanisms involved in prolactin release after mifepristone and naloxone treatment during late pregnancy in the rat.

Journal: Neuroendocrinology 20060101

Title: Possibility of autocrine beta-adrenergic signaling in C2C12 myotubes.

Journal: Experimental biology and medicine (Maywood, N.J.) 20051201

Title: Effects of manganese on extracellular levels of dopamine in rat striatum: an analysis in vivo by brain microdialysis.

Journal: Neurochemical research 20050901

Title: Tyrosine administration does not affect desipramine-induced dopamine levels as measured in vivo in prefrontal cortex.

Journal: Brain research 20050830

Title: Permanent deficits in serotonergic functioning of olfactory bulbectomized rats: an in vivo microdialysis study.

Journal: Biological psychiatry 20050501

Title: Influence of polychlorinated biphenyls and turning preference on striatal dopamine metabolism.

Journal: Journal of toxicology and environmental health. Part A 20050213

Title: Long-term prenatal hypoxia alters maturation of brain catecholaminergic systems and motor behavior in rats.

Journal: Synapse (New York, N.Y.) 20041101

Title: Serotonergic and dopaminergic influence of the duration of embryogenesis and intracapsular locomotion of Lymnaea stagnalis L.

Journal: Acta biologica Hungarica 20040101

Title: Effects of acute, repeated and chronic variable stress on in vivo tyrosine hydroxylase activity and on alpha(2)-adrenoceptor sensitivity in the rat brain.

Journal: Stress (Amsterdam, Netherlands) 20031201

Title: Commonly used L-amino acid decarboxylase inhibitors block monoamine oxidase activity in the rat.

Journal: Journal of neural transmission (Vienna, Austria : 1996) 20030301

Title: Evidence for involvement of 5-hydroxytryptamine(1B) autoreceptors in the enhancement of serotonin turnover in the mouse brain following repeated treatment with fluoxetine.

Journal: Life sciences 20021101

Title: Chronic hypercortisolemia inhibits dopamine synthesis and turnover in the nucleus accumbens: an in vivo microdialysis study.

Journal: Neuroendocrinology 20020901

Title: Dopamine autoreceptor regulation of release and uptake in mouse brain slices in the absence of D(3) receptors.

Journal: Neuroscience 20020101

Title: The role of dopamine in methylene blue-mediated inhibition of estradiol benzoate-induced anterior pituitary hyperplasia in rats.

Journal: Neuroscience letters 20010525

Title: Stress-induced increase in extracellular dopamine in striatum: role of glutamatergic action via N-methyl-D-aspartate receptors in substantia nigra.

Journal: Brain research 20010518

Title: Endogenously released DOPA is a causal factor for glutamate release and resultant delayed neuronal cell death by transient ischemia in rat striata.

Journal: Journal of neurochemistry 20010201

Title: The central aromatic amino acid DOPA decarboxylase inhibitor, NSD-1015, does not inhibit L-DOPA-induced circling in unilateral 6-OHDA-lesioned-rats.

Journal: The European journal of neuroscience 20010101

Title: Mechanisms of the effects of exogenous levodopa on the dopamine-denervated striatum.

Journal: Neuroscience 20010101

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