Home Amines 83435-67-0
83435-67-0,MFCD00884619
Catalog No.:AA00ID81

83435-67-0 | 2-[(2S)-N-(2,3-dihydro-1H-inden-2-yl)-2-{[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino}propanamido]acetic acid hydrochloride

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1mg
97%
in stock  
$6.00   $4.00
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5mg
97%
in stock  
$7.00   $5.00
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10mg
97%
in stock  
$9.00   $7.00
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25mg
97%
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$14.00   $10.00
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50mg
97%
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$25.00   $18.00
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250mg
97%
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$120.00   $84.00
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500mg
95%
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$196.00   $137.00
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1g
97%
in stock  
$216.00   $152.00
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5g
97%
in stock  
$847.00   $593.00
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
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Technical Information
Catalog Number:
AA00ID81
Chemical Name:
2-[(2S)-N-(2,3-dihydro-1H-inden-2-yl)-2-{[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino}propanamido]acetic acid hydrochloride
CAS Number:
83435-67-0
Molecular Formula:
C26H33ClN2O5
Molecular Weight:
489.0036
MDL Number:
MFCD00884619
SMILES:
CCOC(=O)[C@@H](N[C@H](C(=O)N(C1Cc2c(C1)cccc2)CC(=O)O)C)CCc1ccccc1.Cl
Properties
Computed Properties
 
Complexity:
649  
Covalently-Bonded Unit Count:
2  
Defined Atom Stereocenter Count:
2  
Heavy Atom Count:
34  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
12  

Literature

Title: Effects of manidipine and delapril in hypertensive patients with type 2 diabetes mellitus: the delapril and manidipine for nephroprotection in diabetes (DEMAND) randomized clinical trial.

Journal: Hypertension (Dallas, Tex. : 1979) 20111101

Title: Optimal treatment strategies for patients with hypertension and diabetes: are effects on metabolism important?

Journal: Hypertension (Dallas, Tex. : 1979) 20111101

Title: Combination delapril/manidipine as antihypertensive therapy in high-risk patients.

Journal: Clinical drug investigation 20110101

Title: Delapril and manidipine measurements by liquid chromatography-tandem mass spectrometry in a pharmaceutical formulation.

Journal: European journal of mass spectrometry (Chichester, England) 20110101

Title: Fixed-dose manidipine/delapril versus losartan/hydrochlorothiazide in hypertensive patients with type 2 diabetes and microalbuminuria.

Journal: Advances in therapy 20090301

Title: Efficacy of manidipine/delapril versus losartan/hydrochlorothiazide fixed combinations in patients with hypertension and diabetes.

Journal: Journal of hypertension 20080401

Title: Effect of delapril/manidipine vs olmesartan/ hydrochlorothiazide combination on insulin sensitivity and fibrinogen in obese hypertensive patients.

Journal: Internal medicine (Tokyo, Japan) 20080101

Title: Effects of manidipine/delapril versus olmesartan/hydrochlorothiazide combination therapy in elderly hypertensive patients with type 2 diabetes mellitus.

Journal: Hypertension research : official journal of the Japanese Society of Hypertension 20080101

Title: Manidipine-delapril combination in the management of hypertension.

Journal: Vascular health and risk management 20070601

Title: Manidipine plus delapril in patients with Type 2 diabetes and hypertension: reducing cardiovascular risk and end-organ damage.

Journal: Expert review of cardiovascular therapy 20070301

Title: Effect on the development of ankle edema of adding delapril to manidipine in patients with mild to moderate essential hypertension: a three-way crossover study.

Journal: Clinical therapeutics 20070301

Title: Delapril plus indapamide: a review of the combination in the treatment of hypertension.

Journal: Clinical drug investigation 20070101

Title: Effects of angiotensin converting enzyme inhibitor and angiotensin II receptor blocker on ventricular defibrillation threshold.

Journal: Pacing and clinical electrophysiology : PACE 20060701

Title: Delapril/manidipine.

Journal: Drugs 20060101

Title: Delapril/manidipine: viewpoints.

Journal: Drugs 20060101

Title: Fixed combination of manidipine and delapril in the treatment of mild to moderate essential hypertension: evaluation by 24-hour ambulatory blood pressure monitoring.

Journal: Blood pressure. Supplement 20050701

Title: Effect of delapril-manidipine combination vs irbesartan-hydrochlorothiazide combination on fibrinolytic function in hypertensive patients with type II diabetes mellitus.

Journal: Journal of human hypertension 20041001

Title: Efficacy and safety of delapril plus manidipine compared with enalapril plus hydrochlorothiazide in mild to moderate essential hypertension: results of a randomized trial.

Journal: Clinical therapeutics 20040901

Title: Different effects of losartan and delapril on plasma PAI-1 levels in patients with mild to moderate hypertension.

Journal: International journal of cardiology 20031201

Title: Beneficial effects of angiotensin-converting enzyme inhibitor and nitrate association on left ventricular remodeling in patients with large acute myocardial infarction: the Delapril Remodeling after Acute Myocardial Infarction (DRAMI) trial.

Journal: American heart journal 20030701

Title: Effect of an ACE inhibitor and an AT1 receptor antagonist on cardiac hypertrophy.

Journal: Molecular and cellular biochemistry 20030601

Title: Evaluation of the efficacy and tolerability of the combination delapril plus indapamide in the treatment of mild to moderate essential hypertension: a randomised, multicentre, controlled study.

Journal: Journal of human hypertension 20030201

Title: Pharmacokinetics and tolerability of a new manidipine and delapril fixed oral combination in young and elderly subjects.

Journal: Arzneimittel-Forschung 20030101

Title: Single oral dose pharmacokinetic interaction study of manidipine and delapril in healthy volunteers.

Journal: Arzneimittel-Forschung 20030101

Title: Dose-dependent prevention of fibrosis in aorta of salt-loaded stroke-prone spontaneously hypertensive rats by combined delapril and indapamide treatment.

Journal: Journal of cardiovascular pharmacology 20020901

Title: Fixed combinations of delapril plus indapamide vs fosinopril plus hydrochlorothiazide in mild to moderate essential hypertension.

Journal: Advances in therapy 20020101

Title: Temporary treatment of prepubescent rats with angiotensin inhibitors suppresses the development of hypertensive nephrosclerosis.

Journal: Journal of the American Society of Nephrology : JASN 20010401

Title: Effects on urinary albumin excretion and renal function changes by delapril and manidipine in normotensive type 2 diabetic patients with microalbuminuria.

Journal: Journal of the Medical Association of Thailand = Chotmaihet thangphaet 20010201

Title: Hydrolytic profile for ester- or amide-linkage by carboxylesterases pI 5.3 and 4.5 from human liver.

Journal: Biological & pharmaceutical bulletin 19970801

Title: Metabolic alkalosis and myoclonus from antacid ingestion.

Journal: Internal medicine (Tokyo, Japan) 19960601

Title: Razzetti R, et al. Pharmacokinetic and pharmacologic properties of delapril, a lipophilic nonsulfhydryl angiotensin-converting enzyme inhibitor. Am J Cardiol. 1995 Jun 16;75(18):7F-12F.

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SDS
Tags:83435-67-0 Molecular Formula|83435-67-0 MDL|83435-67-0 SMILES|83435-67-0 2-[(2S)-N-(2,3-dihydro-1H-inden-2-yl)-2-{[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino}propanamido]acetic acid hydrochloride