Home Other Building Blocks 83928-76-1
83928-76-1,MFCD00868196
Catalog No.:AA00G5JA

83928-76-1 | 4,4-Dimethyl-1-(4-(4-(pyrimidin-2-yl)piperazin-1-yl)butyl)piperidine-2,6-dione

Pack Size
Purity
Availability
Price(USD)
Quantity
  
5mg
95%
1 week  
$127.00   $89.00
- +
10mg
95%
1 week  
$152.00   $107.00
- +
25mg
95%
1 week  
$220.00   $154.00
- +
50mg
95%
1 week  
$302.00   $212.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00G5JA
Chemical Name:
4,4-Dimethyl-1-(4-(4-(pyrimidin-2-yl)piperazin-1-yl)butyl)piperidine-2,6-dione
CAS Number:
83928-76-1
Molecular Formula:
C19H29N5O2
Molecular Weight:
359.4659
MDL Number:
MFCD00868196
SMILES:
O=C1CC(C)(C)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1
Properties
Computed Properties
 
Complexity:
476  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
26  
Hydrogen Bond Acceptor Count:
6  
Rotatable Bond Count:
6  
XLogP3:
1.8  

Literature

Title: The effect of gepirone-ER in the treatment of sexual dysfunction in depressed men.

Journal: The journal of sexual medicine 20120301

Title: Gepirone-ER treatment of low sexual desire associated with depression in women as measured by the DeRogatis Inventory of Sexual Function (DISF) fantasy/cognition (desire) domain--a post hoc analysis.

Journal: The journal of sexual medicine 20110901

Title: Prenatal Cocaine Disrupts Serotonin Signaling-Dependent Behaviors: Implications for Sex Differences, Early Stress and Prenatal SSRI Exposure.

Journal: Current neuropharmacology 20110901

Title: Raphe-Hippocampal Serotonin Neurotransmission In The Sex Related Differences of Adaptation to Stress: Focus on Serotonin-1A Receptor.

Journal: Current neuropharmacology 20110901

Title: Gepirone-ER treatment of hypoactive sexual desire disorder (HSDD) associated with depression in women.

Journal: The journal of sexual medicine 20110501

Title: Early postnatal protein-calorie malnutrition and cognition: a review of human and animal studies.

Journal: International journal of environmental research and public health 20110201

Title: Antidepressant potential of nitrogen-containing heterocyclic moieties: An updated review.

Journal: Journal of pharmacy & bioallied sciences 20110101

Title: Pharmacogenetics of antidepressants.

Journal: Frontiers in pharmacology 20110101

Title: Neurosteroid Binding Sites on the GABA(A) Receptor Complex as Novel Targets for Therapeutics to Reduce Alcohol Abuse and Dependence.

Journal: Advances in pharmacological sciences 20110101

Title: Cellular correlates of enhanced anxiety caused by acute treatment with the selective serotonin reuptake inhibitor fluoxetine in rats.

Journal: Frontiers in behavioral neuroscience 20110101

Title: Practical application of cure mixture model for long-term censored survivor data from a withdrawal clinical trial of patients with major depressive disorder.

Journal: BMC medical research methodology 20100101

Title: Physical binding pocket induction for affinity prediction.

Journal: Journal of medicinal chemistry 20091008

Title: Olanzapine and fluoxetine combination therapy for treatment-resistant depression: review of efficacy, safety, and study design issues.

Journal: Neuropsychiatric disease and treatment 20090101

Title: Emotional reactivity and cognitive performance in aversively motivated tasks: a comparison between four rat strains.

Journal: Behavioral and brain functions : BBF 20090101

Title: Assessing the neuronal serotonergic target-based antidepressant stratagem: impact of in vivo interaction studies and knockout models.

Journal: Current neuropharmacology 20080901

Title: Gepirone extended-release in the treatment of adult outpatients with major depressive disorder: a double-blind, randomized, placebo-controlled, parallel-group study.

Journal: The Journal of clinical psychiatry 20080401

Title: Differential response to gepirone but not to chlordiazepoxide in malnourished rats subjected to learned helplessness.

Journal: Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 20080101

Title: Acute and constitutive increases in central serotonin levels reduce social play behaviour in peri-adolescent rats.

Journal: Psychopharmacology 20071201

Title: An integrated in silico 3D model-driven discovery of a novel, potent, and selective amidosulfonamide 5-HT1A agonist (PRX-00023) for the treatment of anxiety and depression.

Journal: Journal of medicinal chemistry 20060601

Title: Early response and 8-week treatment outcome in GAD.

Journal: Depression and anxiety 20060101

Title: The 5-HT1A receptor and the stimulus effects of LSD in the rat.

Journal: Psychopharmacology 20051001

Title: Remission rates with 3 consecutive antidepressant trials: effectiveness for depressed outpatients.

Journal: The Journal of clinical psychiatry 20050601

Title: Novel, flexible, and conformationally defined analogs of gepirone: synthesis and 5-HT1A, 5-HT2A, and D2 receptor activity.

Journal: Bioorganic & medicinal chemistry 20050215

Title: Relapse prevention with gepirone ER in outpatients with major depression.

Journal: Journal of clinical psychopharmacology 20050201

Title: [Review of antidepressants from the TCAs to the third generation drugs].

Journal: Neuropsychopharmacologia Hungarica : a Magyar Pszichofarmakologiai Egyesulet lapja = official journal of the Hungarian Association of Psychopharmacology 20041201

Title: Gepirone extended-release treatment of anxious depression: evidence from a retrospective subgroup analysis in patients with major depressive disorder.

Journal: The Journal of clinical psychiatry 20040801

Title: Cellular consequences of stress and depression.

Journal: Dialogues in clinical neuroscience 20040601

Title: The design and preparation of metabolically protected new arylpiperazine 5-HT1A ligands.

Journal: Bioorganic & medicinal chemistry letters 20040405

Title: Use of physicochemical calculation of pKa and CLogP to predict phospholipidosis-inducing potential: a case study with structurally related piperazines.

Journal: Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie 20040301

Title: Metabolism of the newest antidepressants: comparisons with related predecessors.

Journal: IDrugs : the investigational drugs journal 20040201

Title: Sustained efficacy of gepirone-IR in major depressive disorder: a double-blind placebo substitution trial.

Journal: Journal of psychiatric research 20040101

Title: Differential effects of the 5-HT1A agonist gepirone on food intake in rats may depend on their motivation to eat.

Journal: Methods and findings in experimental and clinical pharmacology 20031101

Title: Pharmacokinetic evaluation of gepirone immediate-release capsules and gepirone extended-release tablets in healthy volunteers.

Journal: Journal of pharmaceutical sciences 20030901

Title: A review of the efficacy and tolerability of immediate-release and extended-release formulations of gepirone.

Journal: Clinical therapeutics 20030601

Title: Human cytochromes mediating gepirone biotransformation at low substrate concentrations.

Journal: Biopharmaceutics & drug disposition 20030301

Title: Gepirone extended-release: new evidence for efficacy in the treatment of major depressive disorder.

Journal: The Journal of clinical psychiatry 20030301

Title: Is there a role for 5-HT1A agonists in the treatment of depression?

Journal: Biological psychiatry 20030201

Title: Influence of housing conditions on the effects of serotonergic drugs on feeding behavior in non-deprived rats.

Journal: Neuropsychobiology 20030101

Title: Rigid analogues of buspirone and gepirone, 5-HT1A receptors partial agonists.

Journal: Farmaco (Societa chimica italiana : 1989) 20021101

Title: 5-HT1A receptor-mediated regulation of mitogen-activated protein kinase phosphorylation in rat brain.

Journal: European journal of pharmacology 20021004

Title: The clinical pharmacology of depressive states.

Journal: Dialogues in clinical neuroscience 20020301

Title: Effects of serotonergic compounds on aqueous humor dynamics in monkeys.

Journal: Current eye research 20010801

Title: Gepirone. Organon.

Journal: Current opinion in investigational drugs (London, England : 2000) 20010801

Title: 5-HT1A receptor agonists buspirone and gepirone attenuate apomorphine-induced aggressive behaviour in adult male Wistar rats.

Journal: Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20001201

Title: Involvement of 5-hydroxytryptamine(1A) receptors in nicotine-induced tail tremor in rats.

Journal: European journal of pharmacology 20001110

Title: Prenatal exposure to cocaine: effects on aggression in Sprague-Dawley rats.

Journal: Developmental psychobiology 19940501

Title: Effects of 5-HT1A agonists and 5-HT2 antagonists on haloperidol-induced dyskinesias in squirrel monkeys: no evidence for reciprocal 5-HT-dopamine interaction.

Journal: Psychopharmacology 19890101

Title: Strychnine seizure potentiation by azaspirodecanedione anxiolytics in rats.

Journal: European journal of pharmacology 19881018

Quotation Request
Company Name:
*
Contact Person:
*
Email:
*
Quantity Required:
*
Country:
Additional Info:
SDS
Tags:83928-76-1 Molecular Formula|83928-76-1 MDL|83928-76-1 SMILES|83928-76-1 4,4-Dimethyl-1-(4-(4-(pyrimidin-2-yl)piperazin-1-yl)butyl)piperidine-2,6-dione