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84680-54-6,MFCD00941393
Catalog No.:AA003PUK

84680-54-6 | Enalaprilat dihydrate

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Purity
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1mg
97%
in stock  
$8.00   $6.00
- +
10mg
97%
in stock  
$27.00   $19.00
- +
50mg
97%
in stock  
$61.00   $43.00
- +
100mg
97%
in stock  
$106.00   $75.00
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250mg
97%
in stock  
$129.00   $90.00
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA003PUK
Chemical Name:
Enalaprilat dihydrate
CAS Number:
84680-54-6
Molecular Formula:
C18H28N2O7
Molecular Weight:
384.4241
MDL Number:
MFCD00941393
SMILES:
OC(=O)[C@@H](N[C@H](C(=O)N1CCC[C@H]1C(=O)O)C)CCc1ccccc1.O.O
Properties
Properties
 
BP:
601°C at 760 mmHg  
Form:
Solid  
MP:
134-136°C  
Storage:
Keep in dry area;2-8℃;  

Computed Properties
 
Complexity:
490  
Covalently-Bonded Unit Count:
3  
Defined Atom Stereocenter Count:
3  
Heavy Atom Count:
27  
Hydrogen Bond Acceptor Count:
8  
Hydrogen Bond Donor Count:
5  
Rotatable Bond Count:
8  

Downstream Synthesis Route

[1]CurrentPatentAssignee:MERCK&COINC-US5670655,1997,A

[2]CurrentPatentAssignee:MERCK&COINC-US5670655,1997,A

[1]CurrentPatentAssignee:UNIVERSITYOFSOUTHERNCALIFORNIA-US6232467,2001,B1

Literature

Title: Chronic infusion of enalaprilat into hypothalamic paraventricular nucleus attenuates angiotensin II-induced hypertension and cardiac hypertrophy by restoring neurotransmitters and cytokines.

Journal: Toxicology and applied pharmacology 20140201

Title: Enalaprilat increases PPARβ/δ expression, without influence on PPARα and PPARγ, and modulate cardiac function in sub-acute model of daunorubicin-induced cardiomyopathy.

Journal: European journal of pharmacology 20130815

Title: An in vitro reconstitution system to address the mechanism of the vascular expression of the bradykinin B₁ receptor in response to angiotensin converting enzyme inhibition.

Journal: Vascular pharmacology 20120819

Title: Quantitative determination of lisinopril in human plasma by high performance liquid chromatography-tandem mass spectrometry and its application in a pharmacokinetic study.

Journal: Biomedical chromatography : BMC 20120601

Title: Determination of enalapril and enalaprilat in small human serum quantities for pediatric trials by HPLC-tandem mass spectrometry.

Journal: Biomedical chromatography : BMC 20120601

Title: Inhibition of ACE activity contributes to the intestinal structural compensation in a massive intestinal resection rat model.

Journal: Pediatric surgery international 20120501

Title: The pharmacological mechanism of angiotensin-converting enzyme inhibition by green tea, Rooibos and enalaprilat - a study on enzyme kinetics.

Journal: Phytotherapy research : PTR 20120401

Title: Inhibitory effects of enalaprilat on rat cardiac fibroblast proliferation via ROS/P38MAPK/TGF-β1 signaling pathway.

Journal: Molecules (Basel, Switzerland) 20120306

Title: Rapid and sensitive liquid chromatography/tandem mass spectrometry method for simultaneous determination of enalapril and its major metabolite enalaprilat, in human plasma: application to a bioequivalence study.

Journal: Drug testing and analysis 20120201

Title: Myocardial autophagy after severe burn in rats.

Journal: PloS one 20120101

Title: Modulation of nitric oxide affects myocardial perfusion-contraction matching in anaesthetized dogs with recurrent no-flow ischaemia.

Journal: Experimental physiology 20111201

Title: Insignificant response of the fetal placental circulation to arterial hypotension in sheep.

Journal: Journal of applied physiology (Bethesda, Md. : 1985) 20111001

Title: Combining angiotensin II blockade and renin receptor inhibition results in enhanced antifibrotic effect in experimental nephritis.

Journal: American journal of physiology. Renal physiology 20111001

Title: Acute effects of the ACE inhibitor enalaprilat on the pulmonary, cerebral and systemic blood flow and resistance after the bidirectional cavopulmonary connection.

Journal: Heart (British Cardiac Society) 20110801

Title: Sublingual microcirculatory effects of enalaprilat in an ovine model of septic shock.

Journal: Shock (Augusta, Ga.) 20110601

Title: What's new in Shock, June 2011?

Journal: Shock (Augusta, Ga.) 20110601

Title: Gadolinium increases the vascular reactivity of rat aortic rings.

Journal: Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 20110501

Title: A novel pathway for receptor-mediated post-translational activation of inducible nitric oxide synthase.

Journal: Journal of cellular and molecular medicine 20110201

Title: Enalaprilat-mediated activation of kinin b(1) receptors and vasodilation in the rat isolated perfused kidney.

Journal: Pharmacology 20110101

Title: A ligand-based approach to investigate the expression and function of angiotensin converting enzyme in intact human umbilical vein endothelial cells.

Journal: Peptides 20100801

Title: Reduced systolic pressure load decreases cell-cycle activity in the fetal sheep heart.

Journal: American journal of physiology. Regulatory, integrative and comparative physiology 20100801

Title: Enalaprilat and enalapril maleate eyedrops lower intraocular pressure in rabbits.

Journal: Acta ophthalmologica 20100501

Title: Attenuation of renal excretory responses to ANG II during inhibition of superoxide dismutase in anesthetized rats.

Journal: American journal of physiology. Renal physiology 20100201

Title: Blood pressure, blood flow, and oxygenation in the clipped kidney of chronic 2-kidney, 1-clip rats: effects of tempol and Angiotensin blockade.

Journal: Hypertension (Dallas, Tex. : 1979) 20100201

Title: A high performance liquid chromatography-tandem mass spectrometry (LC-MS/MS) method using solid phase extraction for the simultaneous determination of plasma concentrations of enalapril and enalaprilate in hypertensive patients treated with different pharmaceutical formulations.

Journal: Therapeutic drug monitoring 20091201

Title: Abeta42-to-Abeta40- and angiotensin-converting activities in different domains of angiotensin-converting enzyme.

Journal: The Journal of biological chemistry 20091113

Title: [Influence of the angiotensin converting enzyme inhibition on the functional proteinuria in rats].

Journal: Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova 20091001

Title: Early effects of high glucose in retinal tissue cultures Renin-Angiotensin system-dependent and -independent signaling.

Journal: Neurobiology of disease 20090801

Title: [Effects of angiotensin (1-7) and enalaprilat on function of isolated rat heart perfused by burn serum].

Journal: Zhonghua shao shang za zhi = Zhonghua shaoshang zazhi = Chinese journal of burns 20090601

Title: Nanocomposites coated with xyloglucan for drug delivery: In vitro studies.

Journal: International journal of pharmaceutics 20090209

Title: Effect of hypotensive challenge on systemic hemodynamics and cerebral blood flow in persons with tetraplegia.

Journal: Clinical autonomic research : official journal of the Clinical Autonomic Research Society 20090201

Title: Simultaneous quantification of enalapril and enalaprilat in human plasma by high-performance liquid chromatography-tandem mass spectrometry and its application in a pharmacokinetic study.

Journal: Journal of pharmaceutical and biomedical analysis 20090115

Title: [The use of parenteral enalaprilat for the treatment of patients with hypertensive crisis and incipient acute disturbance of cerebral circulation].

Journal: Kardiologiia 20090101

Title: Myocardial protection with enalaprilat in patients unresponsive to ischemic preconditioning during percutaneous coronary intervention.

Journal: Canadian journal of physiology and pharmacology 20081201

Title: [Effects of single or combined administration of cedilanid and enalaprilat on visceral damages in early stage of severe scald in rats].

Journal: Zhonghua shao shang za zhi = Zhonghua shaoshang zazhi = Chinese journal of burns 20081201

Title: Protective effect of captopril and enalaprilat, angiotensin-converting enzyme inhibitors, on para-nonylphenol-induced *OH generation and dopamine efflux in rat striatum.

Journal: Toxicology 20080904

Title: Transanal delivery of angiotensin converting enzyme inhibitor prevents colonic fibrosis in a mouse colitis model: development of a unique mode of treatment.

Journal: Surgery 20080801

Title: [Protective effect of enalaprilat injection against early postburn organ damage in rats].

Journal: Zhonghua wai ke za zhi [Chinese journal of surgery] 20080701

Title: Perioperative hypertension management.

Journal: Vascular health and risk management 20080601

Title: [Protective effects of enalaprilat on the myocardial kinetics in rats at early stage of severe scald].

Journal: Zhonghua shao shang za zhi = Zhonghua shaoshang zazhi = Chinese journal of burns 20080601

Title: Lack of direct interaction between enalaprilat and the kinin B1 receptors.

Journal: Peptides 20080401

Title: 17Beta-estradiol increases basal but not bradykinin-stimulated release of active t-PA in young postmenopausal women.

Journal: Hypertension (Dallas, Tex. : 1979) 20080401

Title: Low nanomolar concentration of mercury chloride increases vascular reactivity to phenylephrine and local angiotensin production in rats.

Journal: Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 20080301

Title: Angiotensin II type 2 receptors and nitric oxide sustain oxygenation in the clipped kidney of early Goldblatt hypertensive rats.

Journal: Hypertension (Dallas, Tex. : 1979) 20080201

Title: Bradykinin type 2 receptor BE1 genotype influences bradykinin-dependent vasodilation during angiotensin-converting enzyme inhibition.

Journal: Hypertension (Dallas, Tex. : 1979) 20080201

Title: Expression of angiotensin I-converting enzymes and bradykinin B2 receptors in mouse inner medullary-collecting duct cells.

Journal: International immunopharmacology 20080201

Title: Enalaprilat induced acute parotitis.

Journal: The Journal of the Association of Physicians of India 20080201

Title: Angiotensin blockade and matrix synthesis by glomerular epithelial cells in high glucose: a further experimental insight into the pathophysiology of diabetic nephropathy.

Journal: La Clinica terapeutica 20080101

Title: [The in vitro cross-effects of inhibitors of renin-angiotensin and fibrinolytic systems on the key enzymes of these systems].

Journal: Bioorganicheskaia khimiia 20080101

Title: Effects of enalaprilat on acute necrotizing pancreatitis in rats.

Journal: Inflammation 20071201

Title: Structural characterization of photodegradation products of enalapril and its metabolite enalaprilat obtained under simulated environmental conditions by hybrid quadrupole-linear ion trap-MS and quadrupole-time-of-flight-MS.

Journal: Analytical chemistry 20071101

Title: Impairment of endothelium-dependent relaxation of rat aortas by homocysteine thiolactone and attenuation by captopril.

Journal: Journal of cardiovascular pharmacology 20070801

Title: Effects of intracoronary low-dose enalaprilat on ventricular repolarization dynamics after direct percutaneous intervention for acute myocardial infarction.

Journal: Pacing and clinical electrophysiology : PACE 20070501

Title: Effect of enalapril on the in vitro and in vivo peptidyl cleavage of a potent VLA-4 antagonist.

Journal: Xenobiotica; the fate of foreign compounds in biological systems 20070501

Title: Pretreatment with intracoronary enalaprilat protects human myocardium during percutaneous coronary angioplasty.

Journal: Journal of the American College of Cardiology 20070417

Title: Pharmacokinetics and pharmacodynamics of a nitric oxide-releasing derivative of enalapril in male beagles.

Journal: Clinical and experimental pharmacology & physiology 20070401

Title: Reduced severity of a mouse colitis model with angiotensin converting enzyme inhibition.

Journal: Digestive diseases and sciences 20070401

Title: Intracoronary enalaprilat during angioplasty for acute myocardial infarction: alleviation of postischaemic neurohumoral and inflammatory stress?

Journal: Journal of internal medicine 20070201

Title: Effects of 4 classes of cardiovascular drugs on ventricular function in dogs with mitral regurgitation.

Journal: Journal of veterinary internal medicine 20070101

Title: Angiotensin-(1-7) potentiates responses to bradykinin but does not change responses to angiotensin I.

Journal: Canadian journal of physiology and pharmacology 20061101

Title: Systemic effects of angiotensin III in conscious dogs during acute double blockade of the renin-angiotensin-aldosterone-system.

Journal: Acta physiologica (Oxford, England) 20061001

Title: Systemic and regional hemodynamic effects of enalaprilat infusion in experimental normotensive sepsis.

Journal: Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 20060901

Title: The effect of sublingual captopril versus intravenous enalaprilat on angiotensin II plasma levels.

Journal: Pharmacy world & science : PWS 20060601

Title: Effects of candesartan and enalaprilat on the organ-specific microvascular permeability during haemorrhagic shock in rats.

Journal: British journal of anaesthesia 20060401

Title: The direct effects of the angiotensin-converting enzyme inhibitors, zofenoprilat and enalaprilat, on isolated human pancreatic islets.

Journal: European journal of endocrinology 20060201

Title: On call. I reread your articles on congestive heart failure when I was diagnosed with the condition last month. My breathing is back to normal, and I feel well. My doctor has prescribed all the medications you recommended, but he disagreed with one. He said that since I'm taking Vasotec, I should stop my aspirin. Do you agree?

Journal: Harvard men's health watch 20060201

Title: Assessment of drug-induced QT interval prolongation in conscious rabbits.

Journal: Journal of pharmacological and toxicological methods 20060101

Title: Interference of enalaprilat on glomerular permeability to macromolecules (IgG) in acute unilateral ureteral obstruction in rats.

Journal: International braz j urol : official journal of the Brazilian Society of Urology 20060101

Title: Angiotensin-converting enzyme inhibition increases basal vascular tissue plasminogen activator release in women but not in men.

Journal: Arteriosclerosis, thrombosis, and vascular biology 20051101

Title: Glomerular abundance of nephrin and podocin in experimental nephrotic syndrome: different effects of antiproteinuric therapies.

Journal: American journal of physiology. Renal physiology 20051001

Title: Effects of enalaprilat on the renin-angiotensin-aldosterone system and on renal function during CO2 pneumoperitoneum.

Journal: Journal of endourology 20051001

Title: Human vagal baroreflex sensitivity fluctuates widely and rhythmically at very low frequencies.

Journal: The Journal of physiology 20050915

Title: Pharmacokinetics and pharmacodynamics profiles of enalapril maleate in healthy volunteers following determination of enalapril and enalaprilat by two specific enzyme immunoassays.

Journal: Journal of clinical pharmacy and therapeutics 20050801

Title: The sensitivity of the cis/trans-isomerization of enalapril and enalaprilat to solvent conditions.

Journal: The Journal of pharmacy and pharmacology 20050701

Title: Role of PGI2 and effects of ACE inhibition on the bradykinin potentiation by angiotensin-(1-7) in resistance vessels of SHR.

Journal: Regulatory peptides 20050415

Title: Enalapril dosage in progressive chronic nephropathy: a randomised, controlled trial.

Journal: European journal of clinical pharmacology 20050401

Title: High-performance liquid chromatographic determination of enalapril in human plasma by enzyme kinetic analytical method.

Journal: Journal of pharmaceutical and biomedical analysis 20050401

Title: Partial angiotensin-converting enzyme inhibition during acute orthostatic stress in persons with tetraplegia.

Journal: The journal of spinal cord medicine 20050101

Title: Simultaneous determination of enalapril and enalaprilat in human plasma by liquid chromatography-tandem mass spectrometry.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20041225

Title: Effects of enalaprilat infusion on hemodynamics and renal function in patients undergoing cardiac surgery.

Journal: Anadolu kardiyoloji dergisi : AKD = the Anatolian journal of cardiology 20041201

Title: Brain angiotensin-converting enzyme activity and autonomic regulation in heart failure.

Journal: American journal of physiology. Heart and circulatory physiology 20041101

Title: Oxidant stress in kidneys of spontaneously hypertensive rats involves both oxidase overexpression and loss of extracellular superoxide dismutase.

Journal: American journal of physiology. Renal physiology 20041101

Title: Predominant postglomerular vascular resistance response to reflex renal sympathetic nerve activation during ANG II clamp in rabbits.

Journal: American journal of physiology. Regulatory, integrative and comparative physiology 20041001

Title: A calorimetric study of the binding of lisinopril, enalaprilat and captopril to angiotensin-converting enzyme.

Journal: Biophysical chemistry 20041001

Title: Intracellular and extracellular angiotensin II enhance the L-type calcium current in the failing heart.

Journal: Hypertension (Dallas, Tex. : 1979) 20040901

Title: Ouabain at nanomolar concentration promotes synthesis and release of angiotensin II from the endothelium of the tail vascular bed of spontaneously hypertensive rats.

Journal: Journal of cardiovascular pharmacology 20040901

Title: Structural details on the binding of antihypertensive drugs captopril and enalaprilat to human testicular angiotensin I-converting enzyme.

Journal: Biochemistry 20040713

Title: Role of brain and peripheral angiotensin II in hypertension and altered arterial baroreflex programmed during fetal life in rat.

Journal: Pediatric research 20040601

Title: Gender differences in angiotensin-converting enzyme (ACE) activity and inhibition by enalaprilat in healthy volunteers.

Journal: Journal of cardiovascular pharmacology 20040501

Title: Losartan but not enalaprilat acutely reduces reperfusion ventricular tachyarrhythmias in hypertrophied rat hearts after low-flow ischaemia.

Journal: The Journal of pharmacy and pharmacology 20040401

Title: Experimental design optimization of a capillary zone electrophoresis method for the screening of several diuretics and ACE inhibitors.

Journal: Journal of chromatographic science 20040201

Title: Oxidant stress leads to impaired regulation of renal cortical oxygen consumption by nitric oxide in the aging kidney.

Journal: Journal of the American Society of Nephrology : JASN 20040101

Title: Determination of the cis-trans isomerization barrier of enalaprilat by dynamic capillary electrophoresis and computer simulation.

Journal: Electrophoresis 20040101

Title: Characterization of the pharmacokinetic and pharmacodynamic properties of the angiotensin-converting enzyme inhibitor, enalapril, in horses.

Journal: Journal of veterinary internal medicine 20040101

Title: Evaluation of the efficacy, safety and tolerability of intravenous enalaprilat in the treatment of grade III essential hypertension in Indian patients.

Journal: Indian heart journal 20040101

Title: Endogenous angiotensin II in the regulation of hypoxic pulmonary vasoconstriction in anaesthetized dogs.

Journal: Critical care (London, England) 20040101

Title: Effect of angiotensin II type 2 receptor blockade on activation of mitogen-activated protein kinases after ischemia-reperfusion in isolated working rat hearts.

Journal: Journal of cardiovascular pharmacology and therapeutics 20031201

Title: Omapatrilat increases renal endothelin in deoxycorticosterone acetate-salt hypertensive rats.

Journal: Vascular pharmacology 20031201

Title: A novel activation process of protein kinase C in the remote, non-ischemic area of an infarcted heart is mediated by angiotensin-AT1 receptors.

Journal: Journal of molecular and cellular cardiology 20031101

Title: Relative bioavailability study of 20-mg enalapril tablets in healthy male volunteers.

Journal: Journal of the Medical Association of Thailand = Chotmaihet thangphaet 20031001

Title: NAD(P)H oxidase-generated superoxide anion accounts for reduced control of myocardial O2 consumption by NO in old Fischer 344 rats.

Journal: American journal of physiology. Heart and circulatory physiology 20030901

Title: Further studies on the effect of intracellular angiotensins on heart cell communication: on the role of endogenous angiotensin II.

Journal: Regulatory peptides 20030815

Title: Differentiation between acute cyclosporine nephrotoxicity and acute tubular necrosis using enalaprilat renal scintigraphy in rats.

Journal: Investigative radiology 20030801

Title: Do angiotensin-converting enzyme inhibitors directly stimulate the kinin B1 receptor?

Journal: American journal of physiology. Heart and circulatory physiology 20030701

Title: Regional norepinephrine spillover in response to angiotensin-converting enzyme inhibition in healthy subjects.

Journal: Journal of hypertension 20030701

Title: Effects of enalaprilat on venoconstriction to norepinephrine: role of prostaglandins.

Journal: Cardiovascular research 20030701

Title: Effect of enalaprilat on postoperative hypertension after surgical repair of coarctation of the aorta.

Journal: Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies 20030701

Title: Angiotensin II-induced modulation of endothelium-dependent relaxation in rabbit mesenteric resistance arteries.

Journal: The Journal of physiology 20030501

Title: Enalaprilat, losartan and LU 135252 in coronary blood flow regulation.

Journal: European journal of clinical investigation 20030501

Title: Beneficial hemodynamic and renal effects of intravenous enalaprilat following coronary artery bypass surgery complicated by left ventricular dysfunction.

Journal: Critical care medicine 20030501

Title: Is there an 'ACE' in the hole for postcoronary artery bypass graft myocardial dysfunction?

Journal: Critical care medicine 20030501

Title: Bioequivalence study of two brands of enalapril tablets after single oral administration to healthy volunteers.

Journal: International journal of clinical pharmacology and therapeutics 20030501

Title: RP-HPLC and NMR study of cis-trans isomerization of enalaprilat.

Journal: Journal of pharmaceutical and biomedical analysis 20030326

Title: Myocardial uptake and biochemical and hemodynamic effects of ACE inhibitors in humans.

Journal: Hypertension (Dallas, Tex. : 1979) 20030301

Title: Role of angiotensin II in the neural control of renal function.

Journal: Hypertension (Dallas, Tex. : 1979) 20030301

Title: Angiotensin-converting enzyme inhibition increases human vascular tissue-type plasminogen activator release through endogenous bradykinin.

Journal: Circulation 20030204

Title: Current medical treatment for the exacerbation of chronic heart failure resulting in hospitalization.

Journal: American heart journal 20030201

Title: Simultaneous quantitation of enalapril and enalaprilat in human plasma by 96-well solid-phase extraction and liquid chromatography/tandem mass spectrometry.

Journal: Rapid communications in mass spectrometry : RCM 20030101

Title: Angiotensin II blockade augments renal cortical microvascular pO2 indicating a novel, potentially renoprotective action.

Journal: Nephron. Physiology 20030101

Title: Effects of an angiotensin II receptor antagonist and angiotensin-converting enzyme inhibitors on burst forming units-erythroid in chronic hemodialysis patients.

Journal: American journal of nephrology 20030101

Title: Captopril and enalaprilat decrease antioxidant defences in human endothelial cells and are unable to protect against apoptosis.

Journal: Cell biology international 20030101

Title: Angiotensin-converting enzyme inhibition modulates high-glucose-induced extracellular matrix changes in mouse glomerular epithelial cells.

Journal: Nephron. Experimental nephrology 20030101

Title: Prejunctional AT(1) receptor subtype-dependent modification of neurotransmitter releases in canine isolated splenic arteries.

Journal: Autonomic & autacoid pharmacology 20030101

Title: Influence of propranolol, enalaprilat, verapamil, and caffeine on adenosine A(2A)-receptor-mediated coronary vasodilation.

Journal: Journal of the American College of Cardiology 20021106

Title: Angiotensin II contributes to arterial compliance in congestive heart failure.

Journal: American journal of physiology. Heart and circulatory physiology 20021001

Title: Haemodynamic effects of an angiotensin-converting enzyme inhibitor and angiotensin receptor antagonist during hypovolaemia in the anaesthetized pig.

Journal: British journal of anaesthesia 20021001

Title: Captopril and quinapril reduce reactive oxygen species.

Journal: European journal of clinical investigation 20021001

Title: Renal interstitial fluid angiotensin I and angiotensin II concentrations during local angiotensin-converting enzyme inhibition.

Journal: Journal of the American Society of Nephrology : JASN 20020901

Title: Angiotensin inhibition and coronary autoregulation in a canine model of LV hypertrophy.

Journal: Basic research in cardiology 20020901

Title: Impaired regulation of renal oxygen consumption in spontaneously hypertensive rats.

Journal: Journal of the American Society of Nephrology : JASN 20020701

Title: Icatibant blocks but does not reverse ACE inhibitor renal effect in Goldblatt rabbit.

Journal: Clinical and experimental hypertension (New York, N.Y. : 1993) 20020701

Title: Angiotensin-converting enzyme inhibitors improve coronary flow reserve in dilated cardiomyopathy by a bradykinin-mediated, nitric oxide-dependent mechanism.

Journal: Circulation 20020611

Title: Investigation of polymeric nanoparticles as carriers of enalaprilat for oral administration.

Journal: International journal of pharmaceutics 20020604

Title: Renal nerve stimulation augments effect of intraluminal angiotensin II on proximal tubule transport.

Journal: American journal of physiology. Renal physiology 20020601

Title: Biochemical basis of angioedema associated with recombinant tissue plasminogen activator treatment: an in vitro experimental approach.

Journal: Stroke 20020601

Title: Determination of enalapril and enalaprilat by enzyme linked immunosorbent assays: application to pharmacokinetic and pharmacodynamic analysis.

Journal: Fundamental & clinical pharmacology 20020601

Title: Novel mode of action of angiotensin I converting enzyme inhibitors: direct activation of bradykinin B1 receptor.

Journal: The Journal of biological chemistry 20020510

Title: AT(1) and AT(2) receptor expression and blockade after acute ischemia-reperfusion in isolated working rat hearts.

Journal: American journal of physiology. Heart and circulatory physiology 20020401

Title: Enalaprilat improves systemic cardiovascular parameters and mesenteric blood flow during hypotensive resuscitation from hemorrhagic shock in dogs.

Journal: Shock (Augusta, Ga.) 20020301

Title: Studies on the angiotensin-converting enzyme and the kinin B2 receptor in the rabbit jugular vein: modulation of contractile response to bradykinin.

Journal: Canadian journal of physiology and pharmacology 20020201

Title: Effect of angiotensin-converting enzyme inhibitors on liver regeneration in rats.

Journal: Hepato-gastroenterology 20020101

Title: Effects of intracoronary low-dose enalaprilat as an adjunct to primary percutaneous transluminal coronary angiography in acute myocardial infarction.

Journal: The American journal of cardiology 20011215

Title: High serum enalaprilat in chronic renal failure.

Journal: Journal of the renin-angiotensin-aldosterone system : JRAAS 20011201

Title: Enalaprilat blunts reflexive increases in cardiac interstitial norepinephrine in conscious rats.

Journal: Journal of hypertension 20011101

Title: The pharmacokinetics of enalapril in children and infants with hypertension.

Journal: Journal of clinical pharmacology 20011001

Title: Inhibition of serum angiotensin-converting enzyme in rabbits after intravenous administration of enalaprilat-loaded intact erythrocytes.

Journal: The Journal of pharmacy and pharmacology 20010901

Title: Pathophysiological roles of endogenous endothelin-1 in dogs with chronic heart failure produced by rapid right ventricular pacing.

Journal: The Journal of pharmacology and experimental therapeutics 20010801

Title: Cardiac nitric oxide production due to angiotensin-converting enzyme inhibition decreases beta-adrenergic myocardial contractility in patients with dilated cardiomyopathy.

Journal: Journal of the American College of Cardiology 20010801

Title: High tissue affinity angiotensin-converting enzyme inhibitors improve endothelial function and reduce infarct size.

Journal: The Annals of thoracic surgery 20010801

Title: Effects of enalaprilat on cardiorespiratory, hemodynamic, and hematologic variables in exercising horses.

Journal: American journal of veterinary research 20010701

Title: Effect of column temperature on the behaviour of some angiotensin converting enzyme inhibitors during high-performance liquid chromatographic analysis.

Journal: Journal of chromatography. B, Biomedical sciences and applications 20010505

Title: The bladder angiotensin system in female rats: response to infusions of angiotensin I and the angiotensin converting enzyme inhibitor enalaprilat.

Journal: The Journal of urology 20010501

Title: Influence of Ca(2+)-activated K(+) channels on rat renal arteriolar responses to depolarizing agonists.

Journal: American journal of physiology. Renal physiology 20010401

Title: Angiotensin converting enzyme (ACE) and non-ACE dependent angiotensin II generation in resistance arteries from patients with heart failure and coronary heart disease.

Journal: Journal of the American College of Cardiology 20010315

Title: The renal nerve is required for regulation of proximal tubule transport by intraluminally produced ANG II.

Journal: American journal of physiology. Renal physiology 20010301

Title: The pancreatic islets in spontaneously hypertensive rats: islet blood flow and insulin production.

Journal: European journal of endocrinology 20010201

Title: Tyrosine kinase involvement in renal arteriolar constrictor responses to angiotensin II.

Journal: Hypertension (Dallas, Tex. : 1979) 20010201

Title: A simple HPLC method for quantitation of enalaprilat.

Journal: Journal of pharmaceutical and biomedical analysis 20010201

Title: Haemodynamic and renal effects of intravenous enalaprilat during coronary artery bypass graft surgery in patients with ischaemic heart dysfunction.

Journal: British journal of anaesthesia 20010201

Title: Treatment of chronic hypertension with intravenous enalaprilat and transdermal clonidine.

Journal: Pediatric nephrology (Berlin, Germany) 20010101

Title: Effects of digoxin, furosemide, enalaprilat and metoprolol on endothelial function in young normotensive subjects.

Journal: Clinical and experimental pharmacology & physiology 20010101

Title: Enalaprilat attenuates ischemic rises in intracellular sodium in the isolated rat heart via the bradykinin receptor.

Journal: Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance 20010101

Title: Comparative study of effects of angiotensin II receptor antagonist, KD3-671, and angiotensin converting enzyme inhibitor, enalaprilat, on cough reflex in guinea pig.

Journal: European journal of drug metabolism and pharmacokinetics 20010101

Title: In vitro characterization of human intact erythrocytes loaded by enalaprilat.

Journal: Drug delivery 20010101

Title: Effects of indomethacin on hemodynamic parameters after intravenous administration of propranolol and enalaprilat in rabbits.

Journal: Polish journal of pharmacology 20010101

Title: A comparative study between a calcium channel blocker (Nicardipine) and a combined alpha-beta-blocker (Labetalol) for the control of emergence hypertension during craniotomy for tumor surgery.

Journal: Anesthesia and analgesia 20001001

Title: Protective effect of imidaprilat, an angiotensin-converting enzyme inhibitor on *OH generation in rat myocardium.

Journal: Biochimica et biophysica acta 19991018

Title: Effects of renin-angiotensin blockade on sympathetic reactivity and beta-adrenergic pathway in the spontaneously hypertensive rat.

Journal: Hypertension (Dallas, Tex. : 1979) 19970801

Title: [Enalaprilat in the prevention of left ventricular hypertrophy induced by isoproterenol].

Journal: Arquivos brasileiros de cardiologia 19970701

Title: [Effect of enalaprilat on cardiotoxicity induced by doxorubicin].

Journal: Arquivos brasileiros de cardiologia 19961001

Title: Endogenous vasopressin and renin-angiotensin systems support blood pressure after epidural block in humans.

Journal: Anesthesiology 19940501

Title: Replacement of L-Lys by D-Lys(NH2) in peptide Ala-Arg-Pro-Ala-Lys (peptide 6A) increases its coronary blood flow-promoting properties.

Journal: Journal of cardiovascular pharmacology 19940101

Title: Compared properties of trandolapril, enalapril, and their diacid metabolites.

Journal: Journal of cardiovascular pharmacology 19940101

Title: No relation of the suppressive effect on the sympathetic nervous system to the acute hypotension caused by imidapril and enalapril.

Journal: Japanese journal of pharmacology 19931101

Title: Influence of converting enzyme inhibition on isoflurane-induced hypotension for cerebral aneurysm surgery.

Journal: Anaesthesia 19920301

Title: Microvascular effects of cocaine; interaction with nitrendipine and enalaprilat.

Journal: Journal of toxicology. Clinical toxicology 19910101

Title: Angiotensin-converting enzyme inhibitors. Mercaptan, carboxyalkyl dipeptide, and phosphinic acid inhibitors incorporating 4-substituted prolines.

Journal: Journal of medicinal chemistry 19880601

Title: The acute haemodynamic effects of intravenous enalaprilic acid (MK422) in patients with left ventricular dysfunction.

Journal: British journal of clinical pharmacology 19870101

Title: Enalapril and the kidney: renal vasodilation and natriuresis due to the inhibition of angiotensin II formation.

Journal: Journal of cardiovascular pharmacology 19860101

Title: Angiotensin-converting enzyme inhibitors potentiate the analgesic activity of [Met]-enkephalin-Arg6-Phe7 by inhibiting its degradation in mouse brain.

Journal: Molecular pharmacology 19851201

Title: Proteolytic conversion of [Met]enkephalin-Arg6-Gly7-Leu8 by brain synaptic membranes. Characterization of formed peptides and mechanism of proteolysis.

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Title: An overview of the clinical pharmacology of enalapril.

Journal: British journal of clinical pharmacology 19840101

Title: Enalapril maleate (MK-421), a potent, nonsulfhydryl angiotensin-converting enzyme inhibitor: absorption, disposition, and metabolism in man.

Journal: Drug metabolism reviews 19830101

Title: Ceconi C, et, al. Angiotensin-converting enzyme (ACE) inhibitors have different selectivity for bradykinin binding sites of human somatic ACE. Eur J Pharmacol. 2007 Dec 22;577(1-3):1-6.

Title: Eickels M, et, al. Angiotensin-converting enzyme (ACE) inhibition attenuates insulin-like growth factor-I (IGF-I) induced cardiac fibroblast proliferation. Br J Pharmacol. 2000 Dec;131(8):1592-6.

Title: Loftsson T, et, al. Enalaprilat and enalapril maleate eyedrops lower intraocular pressure in rabbits. Acta Ophthalmol. 2010 May;88(3):337-41.

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Tags:84680-54-6 Molecular Formula|84680-54-6 MDL|84680-54-6 SMILES|84680-54-6 Enalaprilat dihydrate