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851983-85-2,MFCD16660907
Catalog No.:AA00G3NH

851983-85-2 | Galaterone

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1mg
≥98%
in stock  
$36.00   $25.00
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5mg
98%(HPLC)
in stock  
$88.00   $62.00
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25mg
98%(HPLC)
in stock  
$262.00   $184.00
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100mg
98%(HPLC)
in stock  
$786.00   $550.00
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00G3NH
Chemical Name:
Galaterone
CAS Number:
851983-85-2
Molecular Formula:
C26H32N2O
Molecular Weight:
388.5451
MDL Number:
MFCD16660907
SMILES:
O[C@H]1CC[C@]2(C(=CC[C@@H]3[C@@H]2CC[C@]2([C@H]3CC=C2n2cnc3c2cccc3)C)C1)C
Properties
Computed Properties
 
Complexity:
743  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
6  
Heavy Atom Count:
29  
Hydrogen Bond Acceptor Count:
2  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
1  
XLogP3:
5.2  

Literature

Title: Changing paradigms in management of metastatic Castration Resistant Prostate Cancer (mCRPC).

Journal: BMC urology 20140101

Title: The evolving paradigm of second-line hormonal therapy options for castration-resistant prostate cancer.

Journal: Current opinion in oncology 20120501

Title: Direct regulation of androgen receptor activity by potent CYP17 inhibitors in prostate cancer cells.

Journal: The Journal of biological chemistry 20120203

Title: Structures of cytochrome P450 17A1 with prostate cancer drugs abiraterone and TOK-001.

Journal: Nature 20120202

Title: Synthesis and biological evaluations of putative metabolically stable analogs of VN/124-1 (TOK-001): head to head anti-tumor efficacy evaluation of VN/124-1 (TOK-001) and abiraterone in LAPC-4 human prostate cancer xenograft model.

Journal: Steroids 20111101

Title: CYP17 inhibitors for prostate cancer therapy.

Journal: The Journal of steroid biochemistry and molecular biology 20110501

Title: Prolonging hormone sensitivity in prostate cancer xenografts through dual inhibition of AR and mTOR.

Journal: British journal of cancer 20100928

Title: CYP17 inhibition as a hormonal strategy for prostate cancer.

Journal: Nature clinical practice. Urology 20081101

Title: 17alpha-Hydroxylase/17,20 lyase inhibitor VN/124-1 inhibits growth of androgen-independent prostate cancer cells via induction of the endoplasmic reticulum stress response.

Journal: Molecular cancer therapeutics 20080901

Title: Androgen receptor inactivation contributes to antitumor efficacy of 17{alpha}-hydroxylase/17,20-lyase inhibitor 3beta-hydroxy-17-(1H-benzimidazole-1-yl)androsta-5,16-diene in prostate cancer.

Journal: Molecular cancer therapeutics 20080801

Title: Synergistic effect of a novel antiandrogen, VN/124-1, and signal transduction inhibitors in prostate cancer progression to hormone independence in vitro.

Journal: Molecular cancer therapeutics 20080101

Title: Novel C-17-heteroaryl steroidal CYP17 inhibitors/antiandrogens: synthesis, in vitro biological activity, pharmacokinetics, and antitumor activity in the LAPC4 human prostate cancer xenograft model.

Journal: Journal of medicinal chemistry 20050421

Title: Bruno RD, et al. Synthesis and biological evaluations of putative metabolically stable analogs of VN/124-1 (TOK-001): head to head anti-tumor efficacy evaluation of VN/124-1 (TOK-001) and abiraterone in LAPC-4 human prostate cancer xenograft model.Steroid

Title: DeVore NM, et al. Structures of cytochrome P450 17A1 with prostate cancer drugs abiraterone and TOK-001.Nature. 2012 Jan 22;482(7383):116-9.

Title: Soifer HS, et al. Direct regulation of androgen receptor activity by potent CYP17 inhibitors in prostate cancer cells.J Biol Chem. 2012 Feb 3;287(6):3777-87. Epub 2011 Dec 15.

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