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87205-99-0,MFCD03427684
Catalog No.:AA00GRRB

87205-99-0 | Dihydrotanshinone I

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5mg
98% by HPLC
in stock  
$125.00   $88.00
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10mg
98% by HPLC
in stock  
$168.00   $117.00
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100mg
98%
in stock  
$242.00   $170.00
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA00GRRB
Chemical Name:
Dihydrotanshinone I
CAS Number:
87205-99-0
Molecular Formula:
C18H14O3
Molecular Weight:
278.3020
MDL Number:
MFCD03427684
SMILES:
CC1COC2=C1C(=O)C(=O)c1c2ccc2c1cccc2C
Properties
Computed Properties
 
Complexity:
533  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
1  
Heavy Atom Count:
21  
Hydrogen Bond Acceptor Count:
3  
XLogP3:
3.2  

Downstream Synthesis Route

[1]TetrahedronLetters,1992,vol.33,p.1149-1152

Literature

Title: Inhibitory Effects of Danshen components on CYP2C8 and CYP2J2.

Journal: Chemico-biological interactions 20180601

Title: Dihydrotanshinone I, a natural product, ameliorates DSS-induced experimental ulcerative colitis in mice.

Journal: Toxicology and applied pharmacology 20180401

Title: Dihydrotanshinone I inhibits the translational expression of hypoxia-inducible factor-1α.

Journal: Chemico-biological interactions 20151005

Title: Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: the case of chelerythrine.

Journal: Bioorganic & medicinal chemistry 20121115

Title: Tanshinones as selective and slow-binding inhibitors for SARS-CoV cysteine proteases.

Journal: Bioorganic & medicinal chemistry 20121001

Title: Induction of cytochromes P450 1A1 and 1A2 by tanshinones in human HepG2 hepatoma cell line.

Journal: Toxicology and applied pharmacology 20110401

Title: Danshen extract 15,16-dihydrotanshinone I functions as a potential modulator against metabolic syndrome through multi-target pathways.

Journal: The Journal of steroid biochemistry and molecular biology 20100601

Title: Cytotoxic effects of tanshinones from Salvia miltiorrhiza on doxorubicin-resistant human liver cancer cells.

Journal: Journal of natural products 20100528

Title: Reactive oxygen species-mediated kinase activation by dihydrotanshinone in tanshinones-induced apoptosis in HepG2 cells.

Journal: Cancer letters 20091118

Title: Inhibition of prostaglandin and nitric oxide production in lipopolysaccharide-treated RAW 264.7 cells by tanshinones from the roots of Salvia miltiorrhiza bunge.

Journal: Archives of pharmacal research 20080601

Title: 15,16-dihydrotanshinone I, a major component from Salvia miltiorrhiza Bunge (Dansham), inhibits rabbit platelet aggregation by suppressing intracellular calcium mobilization.

Journal: Archives of pharmacal research 20080101

Title: Tanshinone congeners improve memory impairments induced by scopolamine on passive avoidance tasks in mice.

Journal: European journal of pharmacology 20071128

Title: Abietane diterpenes from Salvia miltiorrhiza inhibit the activation of hypoxia-inducible factor-1.

Journal: Journal of natural products 20070701

Title: Simultaneous determination of four tanshinones in Salvia miltiorrhiza by pressurized liquid extraction and capillary electrochromatography.

Journal: Journal of separation science 20070401

Title: Inhibition of osteoclast differentiation by tanshinones from the root of Salvia miltiorrhiza bunge.

Journal: Archives of pharmacal research 20050801

Title: Zhao W, et al. Dihydrotanshinone I Attenuates Atherosclerosis in ApoE-Deficient Mice: Role of NOX4/NF-κB Mediated Lectin-Like Oxidized LDL Receptor-1 (LOX-1) of the Endothelium. Front Pharmacol. 2016 Nov 8;7:418. eCollection 2016.

Title: Wei Y, et al. The cardioprotection of dihydrotanshinone I against myocardial ischemia-reperfusion injury via inhibition of arachidonic acid ω-hydroxylase. Can J Physiol Pharmacol. 2016 Dec;94(12):1267-1275. Epub 2016 Jun 24.

Title: Wang L, et al. Dihydrotanshinone I induced apoptosis and autophagy through caspase dependent pathway in colon cancer. Phytomedicine. 2015 Nov 15;22(12):1079-87

Title: Ji Yeun Kim, et al. Safe, High-Throughput Screening of Natural Compounds of MERS-CoV Entry Inhibitors Using a Pseudovirus Expressing MERS-CoV Spike Protein. Int J Antimicrob Agents. 2018 Nov;52(5):730-732.

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SDS
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