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Title: Synthesis and biological evaluation of isoxazolo[4,5-d]pyridazin-4-(5H)-one analogues as potent anti-inflammatory agents.
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Title: Contact sensitizers modulate the arachidonic acid metabolism of PMA-differentiated U-937 monocytic cells activated by LPS.
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Title: Human prostaglandin H synthase (hPHS)-1 and hPHS-2 in amphetamine analog bioactivation, DNA oxidation, and cytotoxicity.
Journal: Toxicological sciences : an official journal of the Society of Toxicology 20110301
Title: Guinea pig ileum motility stimulation elicited by N-formyl-Met-Leu-Phe (fMLF) involves neurotransmitters and prostanoids.
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Title: Synthesis and PGE(2) production inhibition of 1H-furan-2,5-dione and 1H-pyrrole-2,5-dione derivatives.
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Title: Both B1R and B2R act as intermediate signaling molecules in high glucose-induced stimulation of glutamate uptake in ARPE cells.
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Title: Altered reactivity to norepinephrine through COX-2 induction by vascular injury in hypercholesterolemic rabbits.
Journal: American journal of physiology. Heart and circulatory physiology 20091101
Title: Increased cyclooxygenase activity impairs apoptosis of inflammatory neutrophils in mice lacking gelatinase B/matrix metalloproteinase-9.
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Title: Identification and optimisation of a novel series of pyrimidine based cyclooxygenase-2 (COX-2) inhibitors. Utilisation of a biotransformation approach.
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Title: Prostaglandin E2 released from activated microglia enhances astrocyte proliferation in vitro.
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Title: Inhibition of angiogenic tubule formation and induction of apoptosis in human endothelial cells by the selective cyclooxygenase-2 inhibitor 5-bromo-2-(4-fluorophenyl)-3-(methylsulfonyl) thiophene (DuP-697).
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Title: Mechanisms involved in the anti-inflammatory action of inhaled tea tree oil in mice.
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Title: Differential expression of cyclooxygenase 1 and cyclooxygenase 2 in the bovine oviduct.
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Title: Anti-angiogenic activity of basic-type, selective cyclooxygenase (COX)-1 inhibitors.
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Title: Growth stimulation of COX-2-negative pancreatic cancer by a selective COX-2 inhibitor.
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Title: Death receptor regulation and celecoxib-induced apoptosis in human lung cancer cells.
Journal: Journal of the National Cancer Institute 20041201
Title: Detergents profoundly affect inhibitor potencies against both cyclo-oxygenase isoforms.
Journal: The Biochemical journal 20040201
Title: Role of unbalanced growth of gram-negative bacteria in ileal ulcer formation in rats treated with a nonsteroidal anti-inflammatory drug.
Journal: The journal of medical investigation : JMI 20040201
Title: Acute effects of cyclooxygenase-2 inhibition on renal function in heterozygous ren-2-transgenic rats on normal or low sodium intake.
Journal: Kidney & blood pressure research 20040101
Title: Prenatal effects of DuP-697-the irreversible, highly selective cyclooxygenase-2 inhibitor.
Journal: Reproductive toxicology (Elmsford, N.Y.) 20030101
Title: On the interaction of specific prostaglandin H synthase-2 inhibitors with prostaglandin H synthase-1.
Journal: European journal of pharmacology 20021025
Title: Diesel exhaust particle extracts and associated polycyclic aromatic hydrocarbons inhibit Cox-2-dependent prostaglandin synthesis in murine macrophages and fibroblasts.
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Title: Paracrine regulation of fat cell formation in bone marrow cultures via adiponectin and prostaglandins.
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Title: The role of spinal neuropeptides and prostaglandins in opioid physical dependence.
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Title: The COX-2 inhibitor NS-398 causes T-cell developmental disruptions independent of COX-2 enzyme inhibition.
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Title: Three-dimensional quantitative structure-activity relationships of cyclo-oxygenase-2 (COX-2) inhibitors: a comparative molecular field analysis.
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Title: Prostaglandin H synthase-2 inhibitors interfere with prostaglandin H synthase-1 inhibition by nonsteroidal anti-inflammatory drugs.
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Title: Apoptosis signaling pathways mediated by cyclooxygenase-2 inhibitors in prostate cancer cells.
Journal: Advances in enzyme regulation 20010101
Title: Structure-based design of COX-2 selectivity into flurbiprofen.
Journal: Bioorganic & medicinal chemistry letters 19990208