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88149-94-4,MFCD02684527
Catalog No.:AA004D0K

88149-94-4 | Thiophene,5-bromo-2-(4-fluorophenyl)-3-[4-(methylsulfonyl)phenyl]-

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5mg
≥98%
in stock  
$158.00   $110.00
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10mg
≥98%
in stock  
$250.00   $175.00
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25mg
≥98%
in stock  
$582.00   $407.00
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50mg
≥98%
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$1,082.00   $757.00
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  • Technical Information
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA004D0K
Chemical Name:
Thiophene,5-bromo-2-(4-fluorophenyl)-3-[4-(methylsulfonyl)phenyl]-
CAS Number:
88149-94-4
Molecular Formula:
C17H12BrFO2S2
Molecular Weight:
411.3084
MDL Number:
MFCD02684527
SMILES:
Fc1ccc(cc1)c1sc(cc1c1ccc(cc1)S(=O)(=O)C)Br
Properties
Computed Properties
 
Complexity:
491  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
23  
Hydrogen Bond Acceptor Count:
4  
Rotatable Bond Count:
3  
XLogP3:
5.3  

Literature

Title: Inhibition of microsomal PGE synthase-1 reduces human vascular tone by increasing PGI(2) : a safer alternative to COX-2 inhibition.

Journal: British journal of pharmacology 20171101

Title: Anti-inflammatory effects of 7-hydroxyl-1-methylindole-3-acetonitrile, a synthetic arvelexin derivative, on the macrophages through destabilizing mPGES-1 mRNA and suppressing NF-κB activation.

Journal: Chemico-biological interactions 20141205

Title: Synthesis and biological evaluation of isoxazolo[4,5-d]pyridazin-4-(5H)-one analogues as potent anti-inflammatory agents.

Journal: Bioorganic & medicinal chemistry 20120501

Title: Contact sensitizers modulate the arachidonic acid metabolism of PMA-differentiated U-937 monocytic cells activated by LPS.

Journal: Toxicology and applied pharmacology 20111001

Title: Human prostaglandin H synthase (hPHS)-1 and hPHS-2 in amphetamine analog bioactivation, DNA oxidation, and cytotoxicity.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20110301

Title: Guinea pig ileum motility stimulation elicited by N-formyl-Met-Leu-Phe (fMLF) involves neurotransmitters and prostanoids.

Journal: Peptides 20110201

Title: Synthesis and PGE(2) production inhibition of 1H-furan-2,5-dione and 1H-pyrrole-2,5-dione derivatives.

Journal: Bioorganic & medicinal chemistry letters 20100115

Title: Both B1R and B2R act as intermediate signaling molecules in high glucose-induced stimulation of glutamate uptake in ARPE cells.

Journal: Journal of cellular physiology 20091201

Title: Altered reactivity to norepinephrine through COX-2 induction by vascular injury in hypercholesterolemic rabbits.

Journal: American journal of physiology. Heart and circulatory physiology 20091101

Title: Increased cyclooxygenase activity impairs apoptosis of inflammatory neutrophils in mice lacking gelatinase B/matrix metalloproteinase-9.

Journal: Immunology 20090901

Title: Identification and optimisation of a novel series of pyrimidine based cyclooxygenase-2 (COX-2) inhibitors. Utilisation of a biotransformation approach.

Journal: Bioorganic & medicinal chemistry letters 20090801

Title: Prostaglandin E2 released from activated microglia enhances astrocyte proliferation in vitro.

Journal: Toxicology and applied pharmacology 20090701

Title: Inhibition of angiogenic tubule formation and induction of apoptosis in human endothelial cells by the selective cyclooxygenase-2 inhibitor 5-bromo-2-(4-fluorophenyl)-3-(methylsulfonyl) thiophene (DuP-697).

Journal: European journal of pharmacology 20071114

Title: Mechanisms involved in the anti-inflammatory action of inhaled tea tree oil in mice.

Journal: Experimental biology and medicine (Maywood, N.J.) 20070301

Title: Differential expression of cyclooxygenase 1 and cyclooxygenase 2 in the bovine oviduct.

Journal: The Journal of endocrinology 20061001

Title: Anti-angiogenic activity of basic-type, selective cyclooxygenase (COX)-1 inhibitors.

Journal: Bioorganic & medicinal chemistry letters 20060601

Title: Growth stimulation of COX-2-negative pancreatic cancer by a selective COX-2 inhibitor.

Journal: Cancer research 20050201

Title: Death receptor regulation and celecoxib-induced apoptosis in human lung cancer cells.

Journal: Journal of the National Cancer Institute 20041201

Title: Detergents profoundly affect inhibitor potencies against both cyclo-oxygenase isoforms.

Journal: The Biochemical journal 20040201

Title: Role of unbalanced growth of gram-negative bacteria in ileal ulcer formation in rats treated with a nonsteroidal anti-inflammatory drug.

Journal: The journal of medical investigation : JMI 20040201

Title: Acute effects of cyclooxygenase-2 inhibition on renal function in heterozygous ren-2-transgenic rats on normal or low sodium intake.

Journal: Kidney & blood pressure research 20040101

Title: Prenatal effects of DuP-697-the irreversible, highly selective cyclooxygenase-2 inhibitor.

Journal: Reproductive toxicology (Elmsford, N.Y.) 20030101

Title: On the interaction of specific prostaglandin H synthase-2 inhibitors with prostaglandin H synthase-1.

Journal: European journal of pharmacology 20021025

Title: Diesel exhaust particle extracts and associated polycyclic aromatic hydrocarbons inhibit Cox-2-dependent prostaglandin synthesis in murine macrophages and fibroblasts.

Journal: The Journal of biological chemistry 20021018

Title: Paracrine regulation of fat cell formation in bone marrow cultures via adiponectin and prostaglandins.

Journal: The Journal of clinical investigation 20020515

Title: The role of spinal neuropeptides and prostaglandins in opioid physical dependence.

Journal: British journal of pharmacology 20020501

Title: The COX-2 inhibitor NS-398 causes T-cell developmental disruptions independent of COX-2 enzyme inhibition.

Journal: Cellular immunology 20011215

Title: Three-dimensional quantitative structure-activity relationships of cyclo-oxygenase-2 (COX-2) inhibitors: a comparative molecular field analysis.

Journal: Journal of medicinal chemistry 20010927

Title: Prostaglandin H synthase-2 inhibitors interfere with prostaglandin H synthase-1 inhibition by nonsteroidal anti-inflammatory drugs.

Journal: European journal of pharmacology 20010119

Title: Apoptosis signaling pathways mediated by cyclooxygenase-2 inhibitors in prostate cancer cells.

Journal: Advances in enzyme regulation 20010101

Title: Structure-based design of COX-2 selectivity into flurbiprofen.

Journal: Bioorganic & medicinal chemistry letters 19990208

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Tags:88149-94-4 Molecular Formula|88149-94-4 MDL|88149-94-4 SMILES|88149-94-4 Thiophene,5-bromo-2-(4-fluorophenyl)-3-[4-(methylsulfonyl)phenyl]-