Home Carboxes 882-09-7
882-09-7,MFCD00004192
Catalog No.:AA0032S0

882-09-7 | 2-(4-Chlorophenoxy)-2-methylpropanoic acid

Pack Size
Purity
Availability
Price(USD)
Quantity
  
5g
98%
in stock  
$15.00   $11.00
- +
25g
98%
in stock  
$22.00   $15.00
- +
100g
98%
in stock  
$62.00   $43.00
- +
  • Technical Information
  • Properties
  • Upstream Synthesis Route
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Upstream Synthesis Route
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA0032S0
Chemical Name:
2-(4-Chlorophenoxy)-2-methylpropanoic acid
CAS Number:
882-09-7
Molecular Formula:
C10H11ClO3
Molecular Weight:
214.6455
MDL Number:
MFCD00004192
SMILES:
OC(=O)C(Oc1ccc(cc1)Cl)(C)C
Properties
Properties
 
BP:
324.1 °C at 760 mmHg  
Form:
Solid  
MP:
120-122 °C(lit.)  
Refractive Index:
1.5220 (estimate)  
Storage:
Keep in dry area;Room Temperature;  

Computed Properties
 
Complexity:
207  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
14  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
3  
XLogP3:
2.6  

Upstream Synthesis Route

[1]Arzneimittel-Forschung/DrugResearch,1980,vol.30,#116,p.2045-2053

[1]JournalofMedicinalChemistry,2017,vol.60,#2,p.681-694

[2]Patent:WO2009/105509,2009,A1,.Locationinpatent:Page/Pagecolumn36-37

[3]JournalofPharmaceuticalSciences,1980,vol.69,#1,p.92-93

[4]Patent:WO2008/104994,2008,A2,.Locationinpatent:Page/Pagecolumn32-33

[5]Patent:US2009/197959,2009,A1,.Locationinpatent:Page/Pagecolumn18

[1]Patent:CN105503564,2016,A,.Locationinpatent:Paragraph0005;0013;0014

[1]Synthesis,2004,#12,p.1959-1962

[2]JournalofMedicinalChemistry,1994,vol.37,#11,p.1712-1719

[3]JournaloftheChineseChemicalSociety,2007,vol.54,#3,p.575-578

[4]JournaloftheAmericanChemicalSociety,2013,vol.135,#20,p.7567-7571

[1]SpectrochimicaActa-PartA:MolecularandBiomolecularSpectroscopy,2008,vol.70,#5,p.1231-1237

Downstream Synthesis Route

[1]IndianJournalofChemistry-SectionBOrganicandMedicinalChemistry,1986,vol.25,p.566-568

[1]EuropeanJournalofMedicinalChemistry,1985,vol.20,p.302-308

[1]IndianJournalofChemistry-SectionBOrganicandMedicinalChemistry,1994,vol.33,p.168-170

[2]CanadianJournalofChemistry,1989,vol.67,p.1472-1479

[1]JournalofMedicinalChemistry,1986,vol.29,p.1138-1152

[1]Arzneimittel-Forschung/DrugResearch,1980,vol.30,p.2045-2053

Literature

Title: Effects of clofibric acid alone and in combination with 17β-estradiol on mRNA abundance in primary hepatocytes isolated from rainbow trout.

Journal: Toxicology in vitro : an international journal published in association with BIBRA 20140901

Title: Tissue-specific 5' heterogeneity of PPARα transcripts and their differential regulation by leptin.

Journal: PloS one 20130101

Title: Transition metal modified and partially calcined inorganic-organic pillared clays for the adsorption of salicylic acid, clofibric acid, carbamazepine, and caffeine from water.

Journal: Journal of colloid and interface science 20121115

Title: The role of microbial adaptation and biodegradable dissolved organic carbon on the attenuation of trace organic chemicals during groundwater recharge.

Journal: The Science of the total environment 20121015

Title: Interactions of acidic pharmaceuticals with human serum albumin: insights into the molecular toxicity of emerging pollutants.

Journal: Amino acids 20121001

Title: Photochemical fate of a mixture of emerging pollutants in the presence of humic substances.

Journal: Water research 20121001

Title: Effects of effluent organic matter characteristics on the removal of bulk organic matter and selected pharmaceutically active compounds during managed aquifer recharge: Column study.

Journal: Journal of contaminant hydrology 20121001

Title: Impact of the auxin signaling inhibitor p-chlorophenoxyisobutyric acid on short-term Cd-induced hydrogen peroxide production and growth response in barley root tip.

Journal: Journal of plant physiology 20120915

Title: Photocatalytic decomposition of crotamiton over aqueous TiO(2) suspensions: determination of intermediates and the reaction pathway.

Journal: Chemosphere 20120901

Title: Hormonal and chemical regulation of paraoxonases in mice.

Journal: The Journal of pharmacology and experimental therapeutics 20120901

Title: Assessment of possible carcinogenicity of oxyfluorfen to humans using mode of action analysis of rodent liver effects.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20120801

Title: Evaluation of aquatic plants for removing polar microcontaminants: a microcosm experiment.

Journal: Chemosphere 20120801

Title: Batch versus continuous feeding strategies for pharmaceutical removal by subsurface flow constructed wetland.

Journal: Environmental pollution (Barking, Essex : 1987) 20120801

Title: Distribution and temporal evolution of pharmaceutically active compounds alongside sewage sludge treatment. Risk assessment of sludge application onto soils.

Journal: Journal of environmental management 20120715

Title: Effects of pharmaceuticals on the expression of genes involved in detoxification in a carp primary hepatocyte model.

Journal: Environmental science & technology 20120605

Title: Solar regeneration of powdered activated carbon impregnated with visible-light responsive photocatalyst: factors affecting performances and predictive model.

Journal: Water research 20120601

Title: Additive effects of clofibric acid and pyruvate dehydrogenase kinase isoenzyme 4 (PDK4) deficiency on hepatic steatosis in mice fed a high saturated fat diet.

Journal: The FEBS journal 20120501

Title: Pharmaceutical removal in tropical subsurface flow constructed wetlands at varying hydraulic loading rates.

Journal: Chemosphere 20120401

Title: The PPARα agonists fenofibrate and CP-778875 cause increased β-oxidation, leading to oxidative injury in skeletal and cardiac muscle in the rat.

Journal: Toxicologic pathology 20120401

Title: Adsorptive removal of naproxen and clofibric acid from water using metal-organic frameworks.

Journal: Journal of hazardous materials 20120330

Title: Suspended biofilm carrier and activated sludge removal of acidic pharmaceuticals.

Journal: Water research 20120315

Title: Uptake of organic emergent contaminants in spath and lettuce: an in vitro experiment.

Journal: Journal of agricultural and food chemistry 20120227

Title: Analysis of endocrine disrupting compounds, pharmaceuticals and personal care products in sewage sludge by gas chromatography-mass spectrometry.

Journal: Talanta 20120130

Title: Differential induction of stearoyl-CoA desaturase 1 and 2 genes by fibrates in the liver of rats.

Journal: Biological & pharmaceutical bulletin 20120101

Title: The effectiveness of sewage treatment processes to remove faecal pathogens and antibiotic residues.

Journal: Journal of environmental science and health. Part A, Toxic/hazardous substances & environmental engineering 20120101

Title: Malignant ovarian tumors with induced expression of carbonyl reductase show spontaneous regression.

Journal: Clinical Medicine Insights. Oncology 20120101

Title: Analysis of anti-inflammatory, analgesic, stimulant and antidepressant drugs in purified water from wastewater treatment plants using SPE-LC tandem mass spectrometry.

Journal: Journal of environmental science and health. Part A, Toxic/hazardous substances & environmental engineering 20120101

Title: PPARs: Interference with Warburg' Effect and Clinical Anticancer Trials.

Journal: PPAR research 20120101

Title: Impact of solid retention time and nitrification capacity on the ability of activated sludge to remove pharmaceuticals.

Journal: Environmental technology 20120101

Title: Removal of pharmaceuticals in biologically treated wastewater by chlorine dioxide or peracetic acid.

Journal: Environmental technology 20120101

Title: Induction of 1-acylglycerophosphocholine acyltransferase genes by fibrates in the liver of rats.

Journal: Biological & pharmaceutical bulletin 20120101

Title: Microextraction by packed sorbent for the analysis of pharmaceutical residues in environmental water samples by in situ derivatization-programmed temperature vaporizer-gas chromatography-mass spectrometry.

Journal: Journal of chromatography. A 20111230

Title: Adsorption of clofibric acid and ketoprofen onto powdered activated carbon: effect of natural organic matter.

Journal: Environmental technology 20111201

Title: Ecotoxicological impacts of clofibric acid and diclofenac in common carp (Cyprinus carpio) fingerlings: hematological, biochemical, ionoregulatory and enzymological responses.

Journal: Journal of hazardous materials 20111115

Title: Organically functionalized mesoporous SBA-15 as sorbents for removal of selected pharmaceuticals from water.

Journal: Journal of hazardous materials 20111015

Title: Can pharmaceuticals interfere with the synthesis of active androgens in male fish? An in vitro study.

Journal: Marine pollution bulletin 20111001

Title: Effects of clofibric acid on the biliary excretion of benoxaprofen glucuronide and taurine conjugate in rats.

Journal: Die Pharmazie 20111001

Title: Cork-based activated carbons as supported adsorbent materials for trace level analysis of ibuprofen and clofibric acid in environmental and biological matrices.

Journal: Journal of chromatography. A 20110916

Title: In situ aqueous derivatization and determination of non-steroidal anti-inflammatory drugs by salting-out-assisted liquid-liquid extraction and gas chromatography-mass spectrometry.

Journal: Journal of chromatography. A 20110916

Title: Benzothiazole-based N-(phenylsulfonyl)amides as a novel family of PPARα antagonists.

Journal: Bioorganic & medicinal chemistry letters 20110815

Title: Reactive tracer test to evaluate the fate of pharmaceuticals in rivers.

Journal: Environmental science & technology 20110801

Title: Fulvic acid affects proliferation and maturation phases in Abies cephalonica embryogenic cells.

Journal: Journal of plant physiology 20110715

Title: Monitoring of pharmaceutically active compounds on the Guadalquivir River basin (Spain): occurrence and risk assessment.

Journal: Journal of environmental monitoring : JEM 20110701

Title: UV and VUV photolysis vs. UV/H2O2 and VUV/H2O2, treatment for removal of clofibric acid from aqueous solution.

Journal: Environmental technology 20110701

Title: Simultaneous determination of 20 pharmacologically active substances in cow's milk, goat's milk, and human breast milk by gas chromatography-mass spectrometry.

Journal: Journal of agricultural and food chemistry 20110511

Title: Comparison of four extraction methods for the analysis of pharmaceuticals in wastewater.

Journal: Journal of chromatography. A 20110506

Title: Auxin: a major player in the shoot-to-root regulation of root Fe-stress physiological responses to Fe deficiency in cucumber plants.

Journal: Plant physiology and biochemistry : PPB 20110501

Title: Assessment of the occurrence and distribution of pharmaceuticals in a Mediterranean wetland (L'Albufera, Valencia, Spain) by LC-MS/MS.

Journal: Analytical and bioanalytical chemistry 20110501

Title: Nitrification activity and community structure of nitrite-oxidizing bacteria in the bioreactors operated with addition of pharmaceuticals.

Journal: Journal of hazardous materials 20110415

Title: Fate of organic micropollutants in the hyporheic zone of a eutrophic lowland stream: results of a preliminary field study.

Journal: The Science of the total environment 20110415

Title: Decrease of hepatic stellate cells in rats with enhanced sensitivity to clofibrate-induced hepatocarcinogenesis.

Journal: Cancer science 20110401

Title: Occurrence and behavior of non-steroidal anti-inflammatory drugs and lipid regulators in wastewater and urban river water of the Pearl River Delta, South China.

Journal: Journal of environmental monitoring : JEM 20110401

Title: Vibrational spectra and natural bond orbital analysis of the herbicidal molecule 2(4-chlorophenoxy)-2-methyl propionic acid.

Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20110201

Title: Toxicological evaluation of acyl glucuronides of nonsteroidal anti-inflammatory drugs using human embryonic kidney 293 cells stably expressing human UDP-glucuronosyltransferase and human hepatocytes.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20110101

Title: Clofibric acid increases the formation of oleic acid in endoplasmic reticulum of the liver of rats.

Journal: Journal of pharmacological sciences 20110101

Title: Transcription of DWARF4 plays a crucial role in auxin-regulated root elongation in addition to brassinosteroid homeostasis in Arabidopsis thaliana.

Journal: PloS one 20110101

Title: Exposure of the main italian river basin to pharmaceuticals.

Journal: Journal of toxicology 20110101

Title: Alert-QSAR. Implications for electrophilic theory of chemical carcinogenesis.

Journal: International journal of molecular sciences 20110101

Title: The value of repeating studies and multiple controls: replicated 28-day growth studies of rainbow trout exposed to clofibric acid.

Journal: Environmental toxicology and chemistry 20101201

Title: Triglycerides and gallstone formation.

Journal: Clinica chimica acta; international journal of clinical chemistry 20101111

Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Journal: Bioorganic & medicinal chemistry letters 20101101

Title: Human health risk assessment of pharmaceuticals in water: issues and challenges ahead.

Journal: International journal of environmental research and public health 20101101

Title: Identification of the UDP-glucuronosyltransferase responsible for bucolome N-glucuronide formation in rats.

Journal: Die Pharmazie 20101101

Title: Fibrates plus betaine: a winning combination?

Journal: The New Zealand medical journal 20101015

Title: Rapid resolution liquid chromatography-tandem mass spectrometry method for the determination of endocrine disrupting chemicals (EDCs), pharmaceuticals and personal care products (PPCPs) in wastewater irrigated soils.

Journal: Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes 20101001

Title: Case report. Hyperlipoproteinaemia(a): which is the optimal therapy? A case report.

Journal: Journal of clinical pharmacy and therapeutics 20101001

Title: Treating mixed hyperlipidemia and the atherogenic lipid phenotype for prevention of cardiovascular events.

Journal: The American journal of medicine 20101001

Title: Effects of fibrates on cardiovascular outcomes.

Journal: Lancet (London, England) 20100925

Title: Effects of fibrates on cardiovascular outcomes.

Journal: Lancet (London, England) 20100925

Title: Liverbeads: a practical and relevant in vitro model for gene induction investigations.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20100901

Title: Beyond statin therapy: a review of the management of residual risk in diabetes mellitus.

Journal: Journal of the Royal Society of Medicine 20100901

Title: Lipid-lowering agents and new onset diabetes mellitus.

Journal: Expert opinion on pharmacotherapy 20100801

Title: Management of hypertriglyceridemia in the diabetic patient.

Journal: Current diabetes reports 20100801

Title: PPARalpha: an emerging therapeutic target in diabetic microvascular damage.

Journal: Nature reviews. Endocrinology 20100801

Title: Assessment of plant-driven removal of emerging organic pollutants by duckweed.

Journal: Chemosphere 20100801

Title: Fibrates: no ACCORD on their use in the treatment of dyslipidaemia.

Journal: Current opinion in lipidology 20100801

Title: Physiological interactions of antiauxins with auxin in roots.

Journal: Journal of plant physiology 20100715

Title: Occurrence and risk assessment of acidic pharmaceuticals in the Yellow River, Hai River and Liao River of north China.

Journal: The Science of the total environment 20100715

Title: [On behalf and the extent of evidence].

Journal: Revue medicale suisse 20100609

Title: Multi-residue method for the analysis of pharmaceutical compounds in sewage sludge, compost and sediments by sonication-assisted extraction and LC determination.

Journal: Journal of separation science 20100601

Title: Fibrates consistently lower risk of cardiovascular events across high-risk groups.

Journal: Cardiovascular journal of Africa 20100601

Title: Occurrence and a screening-level risk assessment of human pharmaceuticals in the Pearl River system, South China.

Journal: Environmental toxicology and chemistry 20100601

Title: Effects of fibrates on cardiovascular outcomes: a systematic review and meta-analysis.

Journal: Lancet (London, England) 20100529

Title: Fibrates in CVD: a step towards personalised medicine.

Journal: Lancet (London, England) 20100529

Title: Fibrates in the prevention of cardiovascular disease in patients with type 2 diabetes mellitus--a pooled meta-analysis of randomized placebo-controlled clinical trials.

Journal: International journal of cardiology 20100528

Title: Conservative treatment of L-asparaginase-associated lipid abnormalities in children with acute lymphoblastic leukemia.

Journal: Pediatric blood & cancer 20100501

Title: Pharmacotherapy of mixed dyslipidemia in the metabolic syndrome.

Journal: Current clinical pharmacology 20100501

Title: The effect of structure and a secondary carbon source on the microbial degradation of chlorophenoxy acids.

Journal: Chemosphere 20100501

Title: Fibrates, glitazones, and peroxisome proliferator-activated receptors.

Journal: Arteriosclerosis, thrombosis, and vascular biology 20100501

Title: Management of cardiovascular risk associated with insulin resistance, diabetes, and the metabolic syndrome.

Journal: Postgraduate medicine 20100501

Title: Determination of pharmaceuticals in soils and sediments by pressurized liquid extraction and liquid chromatography tandem mass spectrometry.

Journal: Journal of chromatography. A 20100416

Title: Investigating the mechanism of clofibric acid removal in Fe(0)/H2O systems.

Journal: Journal of hazardous materials 20100415

Title: Clofibric acid degradation in UV254/H2O2 process: effect of temperature.

Journal: Journal of hazardous materials 20100415

Title: Dynamics and attenuation of acidic pharmaceuticals along a river stretch.

Journal: Environmental science & technology 20100415

Title: [Global therapy of diabetic dyslipidemia: benefits and new therapeutic approaches].

Journal: Medicina clinica 20100403

Title: Removal of pharmaceuticals from water: using liquid-core microcapsules as a novel approach.

Journal: Water research 20100401

Title: Orthopaedic/radiology/pathology conference: Multiple nodular outgrowths in the hands and feet of a 60-year-old man.

Journal: Clinical orthopaedics and related research 20100201

Title: Bezafibrate induces myotoxicity in human rhabdomyosarcoma cells via peroxisome proliferator-activated receptor alpha signaling.

Journal: Toxicology in vitro : an international journal published in association with BIBRA 20100201

Title: Removal of pharmaceuticals in microcosm constructed wetlands using Typha spp. and LECA.

Journal: Bioresource technology 20100201

Title: [HDL and CETP in atherogenesis].

Journal: Deutsche medizinische Wochenschrift (1946) 20100201

Title: Fibrate/Statin initiation in warfarin users and gastrointestinal bleeding risk.

Journal: The American journal of medicine 20100201

Title: Ecotoxicity assessment of lipid regulators in water and biologically treated wastewater using three aquatic organisms.

Journal: Environmental science and pollution research international 20100101

Title: Application of the combination index (CI)-isobologram equation to study the toxicological interactions of lipid regulators in two aquatic bioluminescent organisms.

Journal: Water research 20100101

Title: Management of hypertriglyceridaemia caused by combination antiretroviral therapy in HIV-infected patients: role of omega-3 polyunsaturated fatty acids at different dosages, compared with fibrates.

Journal: International journal of STD & AIDS 20100101

Title: Oxidation of atenolol, propranolol, carbamazepine and clofibric acid by a biological Fenton-like system mediated by the white-rot fungus Trametes versicolor.

Journal: Water research 20100101

Title: Discussion by Reinhard Länge et al. on 'Degradation of the endocrine disrupting chemicals (EDCs) carbamazepine, clofibric acid, and iopromide by corona discharge over water' by Krause et al. [Chemosphere 75(2) (2009) 163-168].

Journal: Chemosphere 20100101

Title: Apolipoprotein B, diabetes and medical consensus.

Journal: Annals of clinical biochemistry 20100101

Title: Photocatalytic degradation of clofibric acid, carbamazepine and iomeprol using conglomerated TiO2 and activated carbon in aqueous suspension.

Journal: Water science and technology : a journal of the International Association on Water Pollution Research 20100101

Title: Antivascular therapy for epithelial ovarian cancer.

Journal: Journal of oncology 20100101

Title: Peroxisome proliferator-activated receptor alpha (PPARalpha) agonists induce constitutive androstane receptor (CAR) and cytochrome P450 2B in rat primary hepatocytes.

Journal: Drug metabolism and pharmacokinetics 20100101

Title: Liquid chromatography with post-column reagent addition of ammonia in methanol coupled to negative ion electrospray ionization tandem mass spectrometry for determination of phenoxyacid herbicides and their degradation products in surface water.

Journal: Analytical chemistry insights 20100101

Title: [Lipid therapy in patients with diabetes].

Journal: Wiener medizinische Wochenschrift (1946) 20100101

Title: PPARalpha: energy combustion, hypolipidemia, inflammation and cancer.

Journal: Nuclear receptor signaling 20100101

Title: Sex-different hepaticglycogen content and glucose output in rats.

Journal: BMC biochemistry 20100101

Title: Methods of chromatographic determination of medicines decreasing the level of cholesterol.

Journal: Acta poloniae pharmaceutica 20100101

Title: PRIC295, a Nuclear Receptor Coactivator, Identified from PPARα-Interacting Cofactor Complex.

Journal: PPAR research 20100101

Title: Peroxisome proliferator-activated receptor alpha target genes.

Journal: PPAR research 20100101

Title: Effects of the PPARα Agonist and Widely Used Antihyperlipidemic Drug Gemfibrozil on Hepatic Toxicity and Lipid Metabolism.

Journal: PPAR research 20100101

Title: Gene Expression Changes Induced by PPAR Gamma Agonists in Animal and Human Liver.

Journal: PPAR research 20100101

Title: Fate of selected pharmaceuticals and personal care products after secondary wastewater treatment processes in Taiwan.

Journal: Water science and technology : a journal of the International Association on Water Pollution Research 20100101

Title: Maternal influences on the transmission of leukocyte gene expression profiles in population samples from Brisbane, Australia.

Journal: PloS one 20100101

Title: Molecular Pharmacology of Kidney and Inner Ear CLC-K Chloride Channels.

Journal: Frontiers in pharmacology 20100101

Title: Glucose sensing neurons in the ventromedial hypothalamus.

Journal: Sensors (Basel, Switzerland) 20100101

Title: Identification of intermediates and assessment of ecotoxicity in the oxidation products generated during the ozonation of clofibric acid.

Journal: Journal of hazardous materials 20091230

Title: Effects of lipid-lowering pharmaceuticals bezafibrate and clofibric acid on lipid metabolism in fathead minnow (Pimephales promelas).

Journal: Environmental toxicology and chemistry 20091201

Title: Statins, fibrates, nicotinic acid, cholesterol absorption inhibitors, anion-exchange resins, omega-3 fatty acids: which drugs for which patients?

Journal: Fundamental & clinical pharmacology 20091201

Title: Functional role of neuroendocrine-specific protein-like 1 in membrane translocation of GLUT4.

Journal: Diabetes 20091201

Title: Combination therapy of statins and fibrates in the management of cardiovascular risk.

Journal: Current opinion in lipidology 20091201

Title: Novel targets that affect high-density lipoprotein metabolism: the next frontier.

Journal: The American journal of cardiology 20091116

Title: The characteristics of enriched nitrifier culture in the degradation of selected pharmaceutically active compounds.

Journal: Journal of hazardous materials 20091115

Title: Phenoxy herbicides and fibrates potently inhibit the human chemosensory receptor subunit T1R3.

Journal: Journal of medicinal chemistry 20091112

Title: Degradation and adsorption of selected pharmaceuticals and personal care products (PPCPs) in agricultural soils.

Journal: Chemosphere 20091101

Title: Lipid disorders.

Journal: JAAPA : official journal of the American Academy of Physician Assistants 20091101

Title: A reexamination of the PPAR-alpha activation mode of action as a basis for assessing human cancer risks of environmental contaminants.

Journal: Environmental health perspectives 20091101

Title: Application of dynamic liquid-phase microextraction and injection port derivatization combined with gas chromatography-mass spectrometry to the determination of acidic pharmaceutically active compounds in water samples.

Journal: Journal of chromatography. A 20091030

Title: Statins, fibrates and retinoic acid upregulate mitochondrial acylcarnitine carrier gene expression.

Journal: Biochemical and biophysical research communications 20091030

Title: New 2-aryloxy-3-phenyl-propanoic acids as peroxisome proliferator-activated receptors alpha/gamma dual agonists with improved potency and reduced adverse effects on skeletal muscle function.

Journal: Journal of medicinal chemistry 20091022

Title: Synthesis and biological evaluation of 2-heteroarylthioalkanoic acid analogues of clofibric acid as peroxisome proliferator-activated receptor alpha agonists.

Journal: Journal of medicinal chemistry 20091022

Title: Review article: nuclear receptors and liver disease--current understanding and new therapeutic implications.

Journal: Alimentary pharmacology & therapeutics 20091015

Title: Subacute exposure to N-ethyl perfluorooctanesulfonamidoethanol results in the formation of perfluorooctanesulfonate and alters superoxide dismutase activity in female rats.

Journal: Archives of toxicology 20091001

Title: Regulation of CYP4A expression by bezafibrate in primary culture of rat and human hepatocytes: interspecies difference and influence of N-acetylcysteine.

Journal: Toxicology in vitro : an international journal published in association with BIBRA 20091001

Title: Fibrates may cause an abnormal urinary betaine loss which is associated with elevations in plasma homocysteine.

Journal: Cardiovascular drugs and therapy 20091001

Title: Prevention of local lipotoxicity: a new renoprotective mechanism of peroxisome proliferator-activated receptor-alpha activation in hypertension and obesity?

Journal: Hypertension research : official journal of the Japanese Society of Hypertension 20091001

Title: Effect of fibrates on lipid profiles and cardiovascular outcomes: a systematic review.

Journal: The American journal of medicine 20091001

Title: Calcium-induced calcium release in skeletal muscle.

Journal: Physiological reviews 20091001

Title: Peroxisome proliferators attenuate free arachidonic acid pool in the kidney through inducing lysophospholipid acyltransferases.

Journal: Journal of pharmacological sciences 20091001

Title: A clinical puzzle: fibrates and homocysteine elevation: editorial to: 'fibrates may cause an abnormal urinary betaine loss which is associated with elevations in plasma homocysteine' by M. Lever et al.

Journal: Cardiovascular drugs and therapy 20091001

Title: [Place of fibrates for the treatment of patients with atherogenic dyslipidemia].

Journal: Revue medicale de Liege 20091001

Title: Ozonation of clofibric acid catalyzed by titanium dioxide.

Journal: Journal of hazardous materials 20090930

Title: Adsorptive removal of selected pharmaceuticals by mesoporous silica SBA-15.

Journal: Journal of hazardous materials 20090915

Title: Probing the fibrate binding specificity of rat liver fatty acid binding protein.

Journal: Journal of medicinal chemistry 20090910

Title: Leachability of some emerging contaminants in reclaimed municipal wastewater-irrigated turf grass fields.

Journal: Environmental toxicology and chemistry 20090901

Title: Dyslipidemia and cardiovascular risk: the importance of early prevention.

Journal: QJM : monthly journal of the Association of Physicians 20090901

Title: Enhancing cardiovascular disease risk reduction: raising high-density lipoprotein levels.

Journal: Current opinion in cardiology 20090901

Title: Factors modulating fibrates response: therapeutic implications and alternative strategies.

Journal: Endocrine, metabolic & immune disorders drug targets 20090901

Title: Myopathy with statin-fibrate combination therapy: clinical considerations.

Journal: Nature reviews. Endocrinology 20090901

Title: Fibrate therapy and renal function.

Journal: Current atherosclerosis reports 20090901

Title: The obesity, metabolic syndrome, and type 2 diabetes mellitus pandemic: II. Therapeutic management of atherogenic dyslipidemia.

Journal: Journal of clinical hypertension (Greenwich, Conn.) 20090901

Title: Differential regulation of the human versus the mouse apolipoprotein AV gene by PPARalpha. Implications for the study of pharmaceutical modifiers of hypertriglyceridemia in mice.

Journal: Biochimica et biophysica acta 20090801

Title: Co-medications that modulate liver injury and repair influence clinical outcome of acetaminophen-associated liver injury.

Journal: Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 20090801

Title: Occurrence of selected pharmaceuticals in an agricultural landscape, western Lake Erie basin.

Journal: Water research 20090801

Title: Advances in the medical treatment of diabetic retinopathy.

Journal: Diabetes care 20090801

Title: Single and combined toxicity of pharmaceuticals and personal care products (PPCPs) on the rainbow trout liver cell line RTL-W1.

Journal: Aquatic toxicology (Amsterdam, Netherlands) 20090726

Title: [HDL-cholesterol: from risk factor to therapeutic target].

Journal: Medicina clinica 20090711

Title: Iatrogenic severe depression of high-density lipoprotein cholesterol.

Journal: Journal of clinical pharmacology 20090701

Title: Fibrates in the treatment of cardiovascular risk and atherogenic dyslipidaemia.

Journal: Current opinion in cardiology 20090701

Title: Lipid-lowering drugs are associated with delayed onset and slower course of Parkinson's disease.

Journal: Pharmacological research 20090701

Title: Effects of WY-14643 on peroxisomal enzyme activity and hormone secretion in immortalized human trophoblast cells.

Journal: Biological & pharmaceutical bulletin 20090701

Title: [Efficacy and safety of etofibrate in patients with non-proliferative diabetic retinopathy].

Journal: Klinische Monatsblatter fur Augenheilkunde 20090701

Title: Analysis of selected pharmaceutical compounds and endocrine disruptors in municipal wastewater using solid-phase microextraction and gas chromatography.

Journal: Water environment research : a research publication of the Water Environment Federation 20090701

Title: Opposing roles of peroxisome proliferator-activated receptor alpha and growth hormone in the regulation of CYP4A11 expression in a transgenic mouse model.

Journal: The Journal of biological chemistry 20090612

Title: Lipids, lipid modifying agents and cardiovascular risk: a review of the evidence.

Journal: Clinical endocrinology 20090601

Title: Niacin and fibrate use among patients with high triglycerides and low high-density lipoprotein cholesterol.

Journal: Current medical research and opinion 20090601

Title: Comment on 'Oxidative degradation of organic compounds using zero-valent iron in the presence of natural organic matter serving as an electron shuttle'.

Journal: Environmental science & technology 20090515

Title: Analysis of differential gene expression in colorectal cancer and stroma using fluorescence-activated cell sorting purification.

Journal: British journal of cancer 20090505

Title: Antiplatelet actions of statins and fibrates are mediated by PPARs.

Journal: Arteriosclerosis, thrombosis, and vascular biology 20090501

Title: In vitro genotoxic assessment of xenobiotic diacylglycerols in an in vitro micronucleus assay.

Journal: Environmental and molecular mutagenesis 20090501

Title: Update on therapeutic strategies to increase adiponectin function and secretion in metabolic syndrome.

Journal: Diabetes, obesity & metabolism 20090501

Title: Statin islands and PPAR ligands in platelets.

Journal: Arteriosclerosis, thrombosis, and vascular biology 20090501

Title: [Diabetic dyslipoproteinemia: beyond LDL].

Journal: Deutsche medizinische Wochenschrift (1946) 20090501

Title: Anatase vs. rutile efficiency on the photocatalytic degradation of clofibric acid under near UV to visible irradiation.

Journal: Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology 20090501

Title: Fibrates in the chemical action of daunorubicin.

Journal: Current cancer drug targets 20090501

Title: Degradation of the endocrine disrupting chemicals (EDCs) carbamazepine, clofibric acid, and iopromide by corona discharge over water.

Journal: Chemosphere 20090401

Title: Occurrence and removal of pharmaceuticals in a municipal sewage treatment system in the south of Sweden.

Journal: The Science of the total environment 20090401

Title: Water quality improvement in a full-scale tertiary constructed wetland: effects on conventional and specific organic contaminants.

Journal: The Science of the total environment 20090401

Title: Rosiglitazone aggravates nonalcoholic Fatty pancreatic disease in C57BL/6 mice fed high-fat and high-sucrose diet.

Journal: Pancreas 20090401

Title: Automated potentiometric titrations in KCl/water-saturated octanol: method for quantifying factors influencing ion-pair partitioning.

Journal: Analytical chemistry 20090401

Title: Interpreting clinical trials of diabetic dyslipidaemia: new insights.

Journal: Diabetes, obesity & metabolism 20090301

Title: Differential regulation of peroxisome proliferator-activated receptor (PPAR)-alpha1 and truncated PPARalpha2 as an adaptive response to fasting in the control of hepatic peroxisomal fatty acid beta-oxidation in the hibernating mammal.

Journal: Endocrinology 20090301

Title: Lipid management in the geriatric patient.

Journal: Endocrinology and metabolism clinics of North America 20090301

Title: Activation of PPARalpha and PPARgamma reduces triacylglycerol synthesis in rat hepatoma cells by reduction of nuclear SREBP-1.

Journal: European journal of pharmacology 20090301

Title: Switching fibrate to statin in type 2 diabetic patients: consequences on lipid profile.

Journal: European journal of internal medicine 20090301

Title: The use of lipid-lowering drug therapy in children and adolescents.

Journal: Current opinion in investigational drugs (London, England : 2000) 20090301

Title: Free-radical-induced oxidative and reductive degradation of fibrate pharmaceuticals: kinetic studies and degradation mechanisms.

Journal: The journal of physical chemistry. A 20090219

Title: Properties of an oral preparation containing a chitosan salt.

Journal: Molecules (Basel, Switzerland) 20090213

Title: Toxicity and removal efficiency of pharmaceutical metabolite clofibric acid by Typha spp.--potential use for phytoremediation?

Journal: Bioresource technology 20090201

Title: Ability of white-rot fungi to remove selected pharmaceuticals and identification of degradation products of ibuprofen by Trametes versicolor.

Journal: Chemosphere 20090201

Title: Triglycerides and cardiovascular events in ACS: the need for combined lipid-altering therapies.

Journal: Nature clinical practice. Cardiovascular medicine 20090201

Title: Hyperlipidaemia and cardiovascular disease: nonlipid-lowering effects of omega-3 fatty acids, statins and fibrates.

Journal: Current opinion in lipidology 20090201

Title: Fibrates: where are we now?

Journal: Therapeutic advances in cardiovascular disease 20090201

Title: On the road to better dyslipidemia outcomes.

Journal: The Nurse practitioner 20090201

Title: Ten-year all-cause mortality in presumably healthy subjects on lipid-lowering drugs (from the Prospective Epidemiological Study of Myocardial Infarction [PRIME] prospective cohort).

Journal: The American journal of cardiology 20090201

Title: Meta-analysis of the relationship between non-high-density lipoprotein cholesterol reduction and coronary heart disease risk.

Journal: Journal of the American College of Cardiology 20090127

Title: A new respirometric endpoint-based biosensor to assess the relative toxicity of chemicals on immobilized human cells.

Journal: Ecotoxicology and environmental safety 20090101

Title: Determination of phenolic endocrine disrupting chemicals and acidic pharmaceuticals in surface water of the Pearl Rivers in South China by gas chromatography-negative chemical ionization-mass spectrometry.

Journal: The Science of the total environment 20090101

Title: Is there evidence-based hypolipidemic treatment with clinical benefit beyond statins?

Journal: Angiology 20090101

Title: HIV-1 infection and the PPARγ-dependent control of adipose tissue physiology.

Journal: PPAR research 20090101

Title: The effects of medications used for the management of dyslipidemia on postprandial lipemia.

Journal: Current medicinal chemistry 20090101

Title: Anti-inflammatory effects of fibrates: an overview.

Journal: Current medicinal chemistry 20090101

Title: Fibrates and microvascular complications in diabetes--insight from the FIELD study.

Journal: Current pharmaceutical design 20090101

Title: Fibrates but not statins increase plasma selenium in dyslipidemic aged patients--the EVA study.

Journal: Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) 20090101

Title: Thermodynamics of lipophilic drug binding to intestinal fatty acid binding protein and permeation across membranes.

Journal: Molecular pharmaceutics 20090101

Title: Impact of sample acquisition and linear amplification on gene expression profiling of lung adenocarcinoma: laser capture micro-dissection cell-sampling versus bulk tissue-sampling.

Journal: BMC medical genomics 20090101

Title: Etofibrate enhances 123I-LDL-binding in human liver.

Journal: Hellenic journal of nuclear medicine 20090101

Title: [Fibrate-induced deterioration of renal function].

Journal: Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia 20090101

Title: PPAR-γ agonists and their effects on IGF-I receptor signaling: Implications for cancer.

Journal: PPAR research 20090101

Title: Regulation of sulfotransferase and UDP-glucuronosyltransferase gene expression by the PPARs.

Journal: PPAR research 20090101

Title: Comparative analysis of gene regulation by the transcription factor PPARalpha between mouse and human.

Journal: PloS one 20090101

Title: Identifying patients with metabolic syndrome.

Journal: The Practitioner 20090101

Title: [Treatment of dyslipidemia in patients with metabolic syndrome and chronic kidney disease].

Journal: Vnitrni lekarstvi 20090101

Title: Thinking beyond low-density lipoprotein cholesterol: strategies to further reduce cardiovascular risk.

Journal: Vascular health and risk management 20090101

Title: Serum and erythrocyte membrane phospholipids fatty acid composition in hyperlipidemia: effects of dietary intervention and combined diet and fibrate therapy.

Journal: General physiology and biophysics 20090101

Title: Ciprofibrate increases cholesteryl ester transfer protein gene expression and the indirect reverse cholesterol transport to the liver.

Journal: Lipids in health and disease 20090101

Title: Photo-degradation of clofibric acid by ultraviolet light irradiation at 185 nm.

Journal: Water science and technology : a journal of the International Association on Water Pollution Research 20090101

Title: Prediction of pharmacological and xenobiotic responses to drugs based on time course gene expression profiles.

Journal: PloS one 20090101

Title: Combined bezafibrate and medroxyprogesterone acetate: potential novel therapy for acute myeloid leukaemia.

Journal: PloS one 20090101

Title: Crystal structure of the peroxisome proliferator-activated receptor gamma (PPARgamma) ligand binding domain complexed with a novel partial agonist: a new region of the hydrophobic pocket could be exploited for drug design.

Journal: Journal of medicinal chemistry 20081225

Title: A review of the current status of the management of mixed dyslipidemia associated with diabetes mellitus and metabolic syndrome.

Journal: The American journal of cardiology 20081222

Title: 2-Methyl-2-(4-nitro-phen-oxy)propanoic acid.

Journal: Acta crystallographica. Section E, Structure reports online 20081201

Title: Influence of pharmaceutical residues on the structure of activated sludge bacterial communities in wastewater treatment bioreactors.

Journal: Water research 20081101

Title: When high is low: raising low levels of high-density lipoprotein cholesterol.

Journal: Current cardiology reports 20081101

Title: The role of triglycerides in cardiovascular risk.

Journal: Current cardiology reports 20081101

Title: Targeting residual cardiovascular risk: raising high-density lipoprotein cholesterol levels.

Journal: Postgraduate medical journal 20081101

Title: Substituted tertiary phosphine Ru(II) organometallics: catalytic utility on the hydrolysis of etofibrate in pharmaceuticals.

Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20081001

Title: Behaviour and biomarkers of oxidative stress in Gambusia holbrooki after acute exposure to widely used pharmaceuticals and a detergent.

Journal: Ecotoxicology and environmental safety 20081001

Title: HDL therapy for cardiovascular diseases: the road to HDL mimetics.

Journal: Current atherosclerosis reports 20081001

Title: Selective determination of acidic pharmaceuticals in wastewater using molecularly imprinted solid-phase extraction.

Journal: Analytica chimica acta 20080926

Title: PPAR-alpha: therapeutic role in diabetes-related cardiovascular disease.

Journal: Diabetes, obesity & metabolism 20080901

Title: Fibrates and future PPARalpha agonists in the treatment of cardiovascular disease.

Journal: Nature clinical practice. Cardiovascular medicine 20080901

Title: CEPHEUS Trial.

Journal: Archives of cardiovascular diseases 20080901

Title: Assessment of lipid-lowering treatment in France--the CEPHEUS study.

Journal: Archives of cardiovascular diseases 20080901

Title: Simultaneous determination of pharmaceuticals, endocrine disrupting compounds and hormone in soils by gas chromatography-mass spectrometry.

Journal: Journal of chromatography. A 20080822

Title: Effects of fibrates, anti-inflammatory drugs and antidepressants in the fish hepatoma cell line PLHC-1: cytotoxicity and interactions with cytochrome P450 1A.

Journal: Toxicology in vitro : an international journal published in association with BIBRA 20080801

Title: Therapy and clinical trials: metabolic syndrome and cardiovascular risk management.

Journal: Current opinion in lipidology 20080801

Title: A case of rhabdomyolysis and thromboembolic event secondary to fibrate monotherapy.

Journal: Acta cardiologica 20080801

Title: [Clock genes regulate circadian rhythm of lipid metabolism and infarction].

Journal: [Rinsho ketsueki] The Japanese journal of clinical hematology 20080801

Title: Colchicine: serious interactions.

Journal: Prescrire international 20080801

Title: Simvastatin with or without ezetimibe in familial hypercholesterolemia.

Journal: The New England journal of medicine 20080731

Title: [New trends in lipidology: the increasing role of HDL-cholesterol].

Journal: Orvosi hetilap 20080727

Title: Treatment of hypercholesterolemia in patients with primary biliary cirrhosis might be more beneficial than indicated.

Journal: Swiss medical weekly 20080726

Title: [Effectiveness of cardiometabolic risk reduction in patients with type 1 diabetes mellitus].

Journal: Orvosi hetilap 20080706

Title: Species-specific kinetics and zonation of hepatic DNA synthesis induced by ligands of PPARalpha.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20080701

Title: Occurrence of steroid estrogens, endocrine-disrupting phenols, and acid pharmaceutical residues in urban riverine water of the Pearl River Delta, South China.

Journal: The Science of the total environment 20080701

Title: Bibliography. Current world literature. HDL cholesterol.

Journal: Current opinion in cardiology 20080701

Title: Managing dyslipidemia in chronic kidney disease.

Journal: Journal of the American College of Cardiology 20080624

Title: Efficacy of rosuvastatin (5 mg and 10 mg) twice a week in patients intolerant to daily statins.

Journal: The American journal of cardiology 20080615

Title: Role of the p50 subunit of NF-kappaB in vitamin E-induced changes in mice treated with the peroxisome proliferator, ciprofibrate.

Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20080601

Title: Administration of ciprofibrate to lactating mothers induces PPARalpha-signaling pathway in the liver and kidney of suckling rats.

Journal: Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie 20080601

Title: Targeting residual cardiovascular risk: raising high-density lipoprotein cholesterol levels.

Journal: Heart (British Cardiac Society) 20080601

Title: Using liquid chromatography-ion trap mass spectrometry to determine pharmaceutical residues in Taiwanese rivers and wastewaters.

Journal: Chemosphere 20080601

Title: Diabetic dyslipidemia: a practical guide to therapy.

Journal: The Journal of family practice 20080601

Title: Statin-fibrate combination therapy.

Journal: The American journal of cardiology 20080515

Title: Behaviour of pharmaceutical products and biodegradation intermediates in horizontal subsurface flow constructed wetland. A microcosm experiment.

Journal: The Science of the total environment 20080501

Title: Inhibiting wild-type and C299S mutant AKR1B10; a homologue of aldose reductase upregulated in cancers.

Journal: European journal of pharmacology 20080428

Title: Evidence to support aggressive management of high-density lipoprotein cholesterol: implications of recent imaging trials.

Journal: The American journal of cardiology 20080417

Title: Comprehensive lipid management versus aggressive low-density lipoprotein lowering to reduce cardiovascular risk.

Journal: The American journal of cardiology 20080417

Title: Nicotinic acid, alone and in combinations, for reduction of cardiovascular risk.

Journal: The American journal of cardiology 20080417

Title: Dual mechanisms for the fibrate-mediated repression of proprotein convertase subtilisin/kexin type 9.

Journal: The Journal of biological chemistry 20080411

Title: Differential effects of fibrates on the metabolic activation of 2-phenylpropionic acid in rats.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20080401

Title: Presence and some characteristics of peroxisomes in immortalized human trophoblast cells.

Journal: Biological & pharmaceutical bulletin 20080401

Title: Effects of modifying triglycerides and triglyceride-rich lipoproteins on cardiovascular outcomes.

Journal: Journal of cardiovascular pharmacology 20080401

Title: Cross-talk between statins and PPARalpha in cardiovascular diseases: clinical evidence and basic mechanisms.

Journal: Trends in cardiovascular medicine 20080401

Title: Belgian expert opinion: how to reduce the residual risk in atherogenic dyslipidaemic patients: place of fibrates.

Journal: Acta cardiologica 20080401

Title: [Dyslipidemia in visceral obesity: pathophysiological mechanisms, clinical implications and therapy].

Journal: Giornale italiano di cardiologia (2006) 20080401

Title: HDL-C in post-menopausal women: An important therapeutic target.

Journal: International journal of cardiology 20080314

Title: Stereospecific synthesis and bio-activity of novel beta(3)-adrenoceptor agonists and inverse agonists.

Journal: Bioorganic & medicinal chemistry 20080301

Title: Vascular and metabolic effects of treatment of combined hyperlipidemia: focus on statins and fibrates.

Journal: International journal of cardiology 20080227

Title: First-line therapies for lowering triglyceride levels.

Journal: American family physician 20080215

Title: Effects of pharmaceutically active compounds on a mixed microbial community originating from a municipal wastewater treatment plant.

Journal: Environmental science & technology 20080215

Title: Ciglitazone induces caspase-independent apoptosis via p38-dependent AIF nuclear translocation in renal epithelial cells.

Journal: Toxicology 20080203

Title: Organic micropollutant removal in a full-scale surface flow constructed wetland fed with secondary effluent.

Journal: Water research 20080201

Title: Individual and mixture effects of selected pharmaceuticals and personal care products on the marine phytoplankton species Dunaliella tertiolecta.

Journal: Archives of environmental contamination and toxicology 20080201

Title: The treatment of dyslipidemia--what's left in the pipeline?

Journal: ChemMedChem 20080201

Title: Quantitative analysis of auxin-regulated proteins from basal part of leaf sheaths in rice by two-dimensional difference gel electrophoresis.

Journal: Phytochemistry 20080201

Title: Multiple benign symmetric lipomatosis--a differential diagnosis of obesity: is there a rationale for fibrate treatment?

Journal: Obesity surgery 20080201

Title: Lipid levels and cardiovascular risk in elderly women: a general population study of the effects of hormonal treatment and lipid-lowering agents.

Journal: Climacteric : the journal of the International Menopause Society 20080201

Title: Drugs for lipids.

Journal: Treatment guidelines from the Medical Letter 20080201

Title: Management of mixed dyslipidemia in patients with or at risk for cardiovascular disease: a role for combination fibrate therapy.

Journal: Clinical therapeutics 20080201

Title: Synthesis of polymeric thiazolidinedione and fibrate conjugates.

Journal: Archives of pharmacal research 20080201

Title: Does the addition of fibrates to statin therapy have a favorable risk to benefit ratio?

Journal: Current atherosclerosis reports 20080201

Title: Is there a role for fibrates in the management of dyslipidemia in the metabolic syndrome?

Journal: Arteriosclerosis, thrombosis, and vascular biology 20080101

Title: A role for IAA in the infection of Arabidopsis thaliana by Orobanche aegyptiaca.

Journal: Annals of botany 20080101

Title: Peroxisome proliferator-activated receptor alpha agonists enhance cardiomyogenesis of mouse ES cells by utilization of a reactive oxygen species-dependent mechanism.

Journal: Stem cells (Dayton, Ohio) 20080101

Title: P-chlorophenoxyisobutyric acid impairs auxin response for gravity-regulated peg formation in cucumber (Cucumis sativus) seedlings.

Journal: Journal of plant research 20080101

Title: Tissue distribution, ontogeny, and regulation of aldehyde dehydrogenase (Aldh) enzymes mRNA by prototypical microsomal enzyme inducers in mice.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20080101

Title: Differential associations between lipid-lowering drugs, statins and fibrates, and venous thromboembolism: role of drug induced homocysteinemia?

Journal: Thrombosis research 20080101

Title: Chylomicronemia and the chylomicronemia syndrome: a practical approach to management.

Journal: The American journal of medicine 20080101

Title: Optimal management of combined dyslipidemia: what have we behind statins monotherapy?

Journal: Advances in cardiology 20080101

Title: Update on the treatment of diabetic retinopathy.

Journal: TheScientificWorldJournal 20080101

Title: Lipid-lowering therapy in patients with type 2 diabetes: the case for early intervention.

Journal: Diabetes/metabolism research and reviews 20080101

Title: Fibrate-associated adverse effects beyond muscle and liver toxicity.

Journal: Current pharmaceutical design 20080101

Title: Treatment of high-risk older persons with lipid-lowering drug therapy.

Journal: American journal of therapeutics 20080101

Title: Fibrate therapy: an update.

Journal: Cardiology in review 20080101

Title: Use of statins and the risk of Parkinson's disease: a retrospective case-control study in the UK.

Journal: Drug safety 20080101

Title: Pigment epithelium-derived factor is an angiogenesis and lipid regulator that activates peroxisome proliferator-activated receptor alpha.

Journal: Advances in experimental medicine and biology 20080101

Title: Plasma PCSK9 levels are significantly modified by statins and fibrates in humans.

Journal: Lipids in health and disease 20080101

Title: Ciprofibrate, clofibric acid and respective glycinate derivatives. Effects of a four-week treatment on male lean and obese Zucker rats.

Journal: Arzneimittel-Forschung 20080101

Title: The Role of PPAR Ligands in Controlling Growth-Related Gene Expression and their Interaction with Lipoperoxidation Products.

Journal: PPAR research 20080101

Title: Mitochondria, PPARs, and Cancer: Is Receptor-Independent Action of PPAR Agonists a Key?

Journal: PPAR research 20080101

Title: Role of peroxisome proliferator-activated receptor alpha in the control of cyclooxygenase 2 and vascular endothelial growth factor: involvement in tumor growth.

Journal: PPAR research 20080101

Title: Therapeutic effects of fibrates in postprandial lipemia.

Journal: American journal of cardiovascular drugs : drugs, devices, and other interventions 20080101

Title: [Raising HDL cholesterol: which is the best strategy?].

Journal: Revista da Associacao Medica Brasileira (1992) 20080101

Title: Removal of selected pharmaceuticals by chlorination, coagulation-sedimentation and powdered activated carbon treatment.

Journal: Water science and technology : a journal of the International Association on Water Pollution Research 20080101

Title: Non invasive in vivo investigation of hepatobiliary structure and function in STII medaka (Oryzias latipes): methodology and applications.

Journal: Comparative hepatology 20080101

Title: Statins but not fibrates improve the atherogenic to anti-atherogenic lipoprotein particle ratio: a randomized crossover study.

Journal: BMC clinical pharmacology 20080101

Title: Determination of etofibrate, fenofibrate, and atorvastatin in pharmaceutical preparations and plasma using differential pulse polarographic and square wave voltammetric techniques.

Journal: Journal of AOAC International 20080101

Title: The importance of recognizing and treating low levels of high-density lipoprotein cholesterol: a new era in atherosclerosis management.

Journal: Reviews in cardiovascular medicine 20080101

Title: 2-Methyl-2-(4-nitro-phenyl-sulfanyl)-propanoic acid.

Journal: Acta crystallographica. Section E, Structure reports online 20080101

Title: High-density lipoprotein metabolism: potential therapeutic targets.

Journal: The American journal of cardiology 20071203

Title: Liver X receptors (LXRs). Part I: structure, function, regulation of activity, and role in lipid metabolism.

Journal: Postepy higieny i medycyny doswiadczalnej (Online) 20071203

Title: Fibrate therapy: safety considerations.

Journal: Current opinion in lipidology 20071201

Title: Effects of medication on cardiovascular events in the Japanese coronary artery disease (JCAD) study.

Journal: Circulation journal : official journal of the Japanese Circulation Society 20071201

Title: A comparison of the effectiveness of lipid-lowering therapy between HIV- and non-HIV-infected subjects with hyperlipidaemia.

Journal: International journal of STD & AIDS 20071201

Title: Atherosclerosis in type 2 diabetes: a role for fibrate therapy?

Journal: Diabetes & vascular disease research 20071201

Title: Bridging the gap in treatment options for patients with hypertriglyceridemia.

Journal: The Journal of family practice 20071201

Title: Behavior of selected priority organic pollutants in horizontal subsurface flow constructed wetlands: a preliminary screening.

Journal: Chemosphere 20071101

Title: Evaluation of UV irradiation for photolytic and oxidative degradation of pharmaceutical compounds in water.

Journal: Water research 20071101

Title: High incidence of reduced plasma HDL cholesterol in diabetic patients treated with rosiglitazone and fibrate.

Journal: Pharmacoepidemiology and drug safety 20071101

Title: Resequencing genomic DNA of patients with severe hypertriglyceridemia (MIM 144650).

Journal: Arteriosclerosis, thrombosis, and vascular biology 20071101

Title: Genetic characterization of mutants resistant to the antiauxin p-chlorophenoxyisobutyric acid reveals that AAR3, a gene encoding a DCN1-like protein, regulates responses to the synthetic auxin 2,4-dichlorophenoxyacetic acid in Arabidopsis roots.

Journal: Plant physiology 20071101

Title: The role of fibrates in the prevention of cardiovascular disease--a pooled meta-analysis of long-term randomized placebo-controlled clinical trials.

Journal: American heart journal 20071101

Title: Measuring biomarkers to assess the therapeutic effects of PPAR agonists?

Journal: Pharmacogenomics 20071101

Title: [Adverse effects of lipid-lowering medications].

Journal: Nihon rinsho. Japanese journal of clinical medicine 20071028

Title: [Drug-induced myopathies].

Journal: Nihon rinsho. Japanese journal of clinical medicine 20071028

Title: Peroxisome proliferator-activated receptor alpha and gamma ligands inhibit the growth of human ovarian cancer.

Journal: Oncology reports 20071001

Title: Carboxylic acid drug-induced DNA nicking in HEK293 cells expressing human UDP-glucuronosyltransferases: role of acyl glucuronide metabolites and glycation pathways.

Journal: Chemical research in toxicology 20071001

Title: Efficacy and safety of pioglitazone in treatment of a patient with an atypical partial lipodystrophy syndrome.

Journal: Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists 20071001

Title: FPIN's clinical inquiries. Best alternatives to statins for treating hyperlipidemia.

Journal: American family physician 20071001

Title: Atherosclerosis and cardiovascular risk reduction with PPAR agonists.

Journal: Current atherosclerosis reports 20071001

Title: Mitochondrial impairment by PPAR agonists and statins identified via immunocaptured OXPHOS complex activities and respiration.

Journal: Toxicology and applied pharmacology 20070915

Title: Treating hypertriglyceridemia.

Journal: CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne 20070911

Title: Treating hypertriglyceridemia.

Journal: CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne 20070911

Title: Treating hypertriglyceridemia.

Journal: CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne 20070911

Title: Is it time to stop treating dyslipidaemia with fibrates?

Journal: The New Zealand medical journal 20070907

Title: Clinical practice. Hypertriglyceridemia.

Journal: The New England journal of medicine 20070906

Title: The mode of action of thidiazuron: auxins, indoleamines, and ion channels in the regeneration of Echinacea purpurea L.

Journal: Plant cell reports 20070901

Title: Characterization of 1-aminocyclopropane-1-carboxylate (ACC) deaminase containing Methylobacterium oryzae and interactions with auxins and ACC regulation of ethylene in canola (Brassica campestris).

Journal: Planta 20070901

Title: Diethylnitrosamine initiation does not alter clofibric acid-induced hepatocarcinogenesis in the rat.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20070901

Title: Preliminary studies into the effects of the human pharmaceutical Clofibric acid on sperm parameters in adult Fathead minnow.

Journal: Aquatic toxicology (Amsterdam, Netherlands) 20070815

Title: Liquid chromatography-(tandem) mass spectrometry for the follow-up of the elimination of persistent pharmaceuticals during wastewater treatment applying biological wastewater treatment and advanced oxidation.

Journal: Journal of chromatography. A 20070810

Title: The acyl-CoA thioesterase I is regulated by PPARalpha and HNF4alpha via a distal response element in the promoter.

Journal: Journal of lipid research 20070801

Title: Influence of HDL-cholesterol-elevating drugs on the in vitro activity of the HDL receptor SR-BI.

Journal: Journal of lipid research 20070801

Title: CEC enantioseparations on chiral monolithic columns: a study of the stereoselective degradation of (R/S)-dichlorprop [2-(2,4-dichlorophenoxy)propionic acid] in soil.

Journal: Electrophoresis 20070801

Title: Statin and statin-fibrate use was significantly associated with increased myositis risk in a managed care population.

Journal: Journal of clinical epidemiology 20070801

Title: Strategies for reducing cardiovascular risk in patients with hypertriglyceridemia.

Journal: The Journal of family practice 20070801

Title: [Intervention for hypertriglyceridemia].

Journal: Nihon rinsho. Japanese journal of clinical medicine 20070728

Title: [Intervention study for elevating high density lipoprotein cholesterol level].

Journal: Nihon rinsho. Japanese journal of clinical medicine 20070728

Title: [Role of fibrate in cardiovascular disease prevention].

Journal: Nihon rinsho. Japanese journal of clinical medicine 20070728

Title: Selection of a support matrix for the removal of some phenoxyacetic compounds in constructed wetlands systems.

Journal: The Science of the total environment 20070715

Title: Mitochondria, ciglitazone and liver: a neglected interaction in biochemical pharmacology.

Journal: European journal of pharmacology 20070712

Title: Expression and characterization of cytochrome P450 2X1 in channel catfish (Ictalurus punctatus).

Journal: Biochimica et biophysica acta 20070701

Title: Effect of chrysin and natural coumarins on UGT1A1 and 1A6 activities in rat and human hepatocytes in primary culture.

Journal: Planta medica 20070701

Title: Analytical development for analysis of pharmaceuticals in water samples by SPE and GC-MS.

Journal: Analytical and bioanalytical chemistry 20070601

Title: [Metabolically designed treatments: from biochemistry to the vessel lining].

Journal: La Revue de medecine interne 20070601

Title: Elimination of selected acidic pharmaceuticals from municipal wastewater by an activated sludge system and membrane bioreactors.

Journal: Environmental science & technology 20070515

Title: Studies on the metabolism of tolmetin to the chemically reactive acyl-coenzyme A thioester intermediate in rats.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20070501

Title: Management of hypertriglyceridemia.

Journal: American family physician 20070501

Title: The clinical significance of the size of low-density-lipoproteins and the modulation of subclasses by fibrates.

Journal: Current medical research and opinion 20070501

Title: Determination of anti-inflammatory drugs and estrogens in water by HPLC with UV detection.

Journal: Journal of separation science 20070501

Title: Hypertriglyceridemia and cardiovascular risk reduction.

Journal: Clinical therapeutics 20070501

Title: Hypertriglyceridemia: its etiology, effects and treatment.

Journal: CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne 20070410

Title: P450 CYP2C epoxygenase and CYP4A omega-hydroxylase mediate ciprofibrate-induced PPARalpha-dependent peroxisomal proliferation.

Journal: Journal of lipid research 20070401

Title: Stearoyl-CoA desaturase activity is elevated by the suppression of its degradation by clofibric acid in the liver of rats.

Journal: Journal of pharmacological sciences 20070401

Title: The role of PPAR-alpha agonists in the prevention of CVD in diabetes.

Journal: Current diabetes reports 20070401

Title: Clofibric acid, a peroxisome proliferator-activated receptor alpha ligand, inhibits growth of human ovarian cancer.

Journal: Molecular cancer therapeutics 20070401

Title: [IV Brazilian Guideline for Dyslipidemia and Atherosclerosis prevention: Department of Atherosclerosis of Brazilian Society of Cardiology].

Journal: Arquivos brasileiros de cardiologia 20070401

Title: Aqueous in situ derivatization of carboxylic acids by an ionic carbodiimide and 2,2,2-trifluoroethylamine for electron-capture detection.

Journal: Journal of chromatography. A 20070323

Title: Expert commentary: the safety of fibrates in lipid-lowering therapy.

Journal: The American journal of cardiology 20070319

Title: Safety considerations with fibrate therapy.

Journal: The American journal of cardiology 20070319

Title: Statins and the risk of pneumonia: a population-based, nested case-control study.

Journal: Pharmacotherapy 20070301

Title: Fibrates: what have we learned in the past 40 years?

Journal: Pharmacotherapy 20070301

Title: Fibrates upregulate TRB3 in lymphocytes independent of PPAR alpha by augmenting CCAAT/enhancer-binding protein beta (C/EBP beta) expression.

Journal: Molecular immunology 20070201

Title: LC-MS analysis and environmental risk of lipid regulators.

Journal: Analytical and bioanalytical chemistry 20070201

Title: Analysis of pharmaceuticals in wastewater and removal using a membrane bioreactor.

Journal: Analytical and bioanalytical chemistry 20070201

Title: Removal of pharmaceutical residues in a pilot wastewater treatment plant.

Journal: Analytical and bioanalytical chemistry 20070201

Title: Ultrastructural effects of pharmaceuticals (carbamazepine, clofibric acid, metoprolol, diclofenac) in rainbow trout (Oncorhynchus mykiss) and common carp (Cyprinus carpio).

Journal: Analytical and bioanalytical chemistry 20070201

Title: Human pharmaceuticals, antioxidants, and plasticizers in wastewater treatment plant and water reclamation plant effluents.

Journal: Water environment research : a research publication of the Water Environment Federation 20070201

Title: High performance liquid chromatographic determination of etofibrate and its hydrolysis products.

Journal: Journal of pharmaceutical and biomedical analysis 20070104

Title: Simultaneous quantification of polycyclic aromatic hydrocarbons (PAHs), polychlorinated biphenyls (PCBs), and pharmaceuticals and personal care products (PPCPs) in Mississippi river water, in New Orleans, Louisiana, USA.

Journal: Chemosphere 20070101

Title: Degradation of clofibric acid in acidic aqueous medium by electro-Fenton and photoelectro-Fenton.

Journal: Chemosphere 20070101

Title: Paradoxical HDL-C reduction during rosiglitazone and fibrate treatment.

Journal: Diabetic medicine : a journal of the British Diabetic Association 20070101

Title: A light- and electron-microscope study of hepatocytes of rats fed different diets.

Journal: Comptes rendus biologies 20070101

Title: Dual PPAR alpha/gamma agonists: promises and pitfalls in type 2 diabetes.

Journal: American journal of therapeutics 20070101

Title: Management of dyslipidemia in the metabolic syndrome: recommendations of the Spanish HDL-Forum.

Journal: American journal of cardiovascular drugs : drugs, devices, and other interventions 20070101

Title: Advances in swine transcriptomics.

Journal: International journal of biological sciences 20070101

Title: Ciprofibrate treatment decreases non-high density lipoprotein cholesterol and triglycerides and increases high density lipoprotein cholesterol in patients with Frederickson type IV dyslipidemia phenotype.

Journal: American journal of therapeutics 20070101

Title: [Molecular pharmacology and medicinal chemistry of fibrate].

Journal: Pharmazie in unserer Zeit 20070101

Title: [Fibrate in lipid metabolism disorders].

Journal: Pharmazie in unserer Zeit 20070101

Title: Clofibrate treatment in pigs: effects on parameters critical with respect to peroxisome proliferator-induced hepatocarcinogenesis in rodents.

Journal: BMC pharmacology 20070101

Title: [Fibrates and markers of inflammation].

Journal: Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego 20070101

Title: [Influence of combined, hypolipemic therapy on lipids and non-lipid atherosclerosis risk factors].

Journal: Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego 20070101

Title: [Pleiotropic effects of fibric acid derivatives (Lipanthyl-200) among patients with metabolic syndrome].

Journal: Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology 20070101

Title: Dyslipidemia as a risk factor for erectile dysfunction.

Journal: Current medicinal chemistry 20070101

Title: Pharmacoenvironmentology--a component of pharmacovigilance.

Journal: Environmental health : a global access science source 20070101

Title: Effects of statins, fibrates, rosuvastatin, and ezetimibe beyond cholesterol: the modulation of LDL size and subclasses in high-risk patients.

Journal: Advances in therapy 20070101

Title: Lipid-modifying therapy and attainment of cholesterol goals in Hungary: the return on expenditure achieved for lipid therapy (REALITY) study.

Journal: Clinical drug investigation 20070101

Title: An investigation of the effects of lipid-lowering medications: genome-wide linkage analysis of lipids in the HyperGEN study.

Journal: BMC genetics 20070101

Title: [When should an association of lipid-lowering drugs be proposed in a patient failing to reach therapeutic targets under monotherapy? Guidelines of the New French Society of Atherosclerosis].

Journal: Archives des maladies du coeur et des vaisseaux 20070101

Title: Treatment of dyslipidemia to reduce cardiovascular risk in patients with multiple risk factors.

Journal: Clinical cornerstone 20070101

Title: Targeting high-density lipoprotein cholesterol in the management of cardiovascular disease.

Journal: The American heart hospital journal 20070101

Title: Effectiveness and tolerability of oral administration of low-dose salmon oil to HIV patients with HAART-associated dyslipidemia.

Journal: HIV clinical trials 20070101

Title: [Therapy of dyslipidemia in post-infarction: state of the art].

Journal: La Clinica terapeutica 20070101

Title: Activating effect of benzbromarone, a uricosuric drug, on peroxisome proliferator-activated receptors.

Journal: PPAR research 20070101

Title: [Analysis of dietary habits and dietary intake in hypertensive smokers].

Journal: Przeglad lekarski 20070101

Title: Type 2 diabetes mellitus is associated with multiple cardiometabolic risk factors.

Journal: Clinical cornerstone 20070101

Title: Hypertriglyceridemia and cardiovascular disease management.

Journal: Journal of the American Academy of Nurse Practitioners 20070101

Title: [Fibrate and its perspective as a drug for metabolic syndrome].

Journal: Nihon rinsho. Japanese journal of clinical medicine 20061228

Title: Aryloxoalcanoic compounds induce resistance to antibiotic therapy in urinary tract infection caused by Escherichia coli.

Journal: FEMS immunology and medical microbiology 20061201

Title: Regulation of hepatic cholesterol synthesis by a novel protein (SPF) that accelerates cholesterol biosynthesis.

Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20061201

Title: [Favorable effects of decreasing lipids in patients with diabetes mellitus].

Journal: Deutsche medizinische Wochenschrift (1946) 20061201

Title: Fibrates after the FIELD study: Some answers, more questions.

Journal: Diabetes & vascular disease research 20061201

Title: Management of hyperlipidemia with statins in the older patient.

Journal: Clinical interventions in aging 20061201

Title: [New indications and therapeutic objectives for dyslipidemia].

Journal: Atencion primaria 20061130

Title: 9-cis beta-carotene-rich powder of the alga Dunaliella bardawil increases plasma HDL-cholesterol in fibrate-treated patients.

Journal: Atherosclerosis 20061101

Title: Human UDP-glucuronosyltransferase (UGT)1A3 enzyme conjugates chenodeoxycholic acid in the liver.

Journal: Hepatology (Baltimore, Md.) 20061101

Title: 20-HETE and salt-sensitivity of blood pressure a novel emerging concept.

Journal: American journal of hypertension 20061101

Title: Activation of peroxisome proliferator-activated receptor-gamma (PPARgamma) induces cell death through MAPK-dependent mechanism in osteoblastic cells.

Journal: Toxicology and applied pharmacology 20060901

Title: Nucleophilic group transfer reactivity for fibric acid derived drug molecules.

Journal: Journal of pharmaceutical sciences 20060901

Title: Fibrate therapy in patients with metabolic syndrome and diabetes mellitus.

Journal: Current atherosclerosis reports 20060901

Title: A critical role for peroxisomal proliferator-activated receptor-alpha nuclear receptors in the development of cardiomyocyte degeneration and necrosis.

Journal: The American journal of pathology 20060901

Title: Seasonality effects on pharmaceuticals and s-triazine herbicides in wastewater effluent and surface water from the Canadian side of the upper Detroit River.

Journal: Environmental toxicology and chemistry 20060901

Title: The interference of pharmaceuticals with endogenous and xenobiotic metabolizing enzymes in carp liver: an in-vitro study.

Journal: Environmental science & technology 20060815

Title: Cloning, tissue expression, and regulation of beagle dog CYP4A genes.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20060801

Title: Fibric acid derivatives in cardiovascular disease prevention: results from the large clinical trials.

Journal: Current opinion in lipidology 20060801

Title: Decrease in triglyceride level by bezafibrate is related to reduction of recurrent coronary events: a Bezafibrate Infarction Prevention substudy.

Journal: Coronary artery disease 20060801

Title: Clofibrate treatment promotes branched-chain amino acid catabolism and decreases the phosphorylation state of mTOR, eIF4E-BP1, and S6K1 in rat liver.

Journal: Life sciences 20060717

Title: Effects of ciprofibrate on testicular and adrenal steroidogenic enzymes in the rat.

Journal: Reproductive toxicology (Elmsford, N.Y.) 20060701

Title: Trace-level determination of pharmaceutical residues by LC-MS/MS in natural and treated waters. A pilot-survey study.

Journal: Analytical and bioanalytical chemistry 20060701

Title: Peroxisome proliferator-activated receptors in vascular biology-molecular mechanisms and clinical implications.

Journal: Vascular pharmacology 20060701

Title: Dyslipidaemia, hypercoagulability and the metabolic syndrome.

Journal: Current vascular pharmacology 20060701

Title: Is it necessary to add fibrate to statin therapy in the management of dyslipidemia of metabolic syndrome?

Journal: International journal of cardiology 20060616

Title: N-3 fatty acid supplementation decreases plasma homocysteine in diabetic dyslipidemia treated with statin-fibrate combination.

Journal: The Journal of nutritional biochemistry 20060601

Title: Cytochrome P450 gene induction in rats ex vivo assessed by quantitative real-time reverse transcriptase-polymerase chain reaction (TaqMan).

Journal: Drug metabolism and disposition: the biological fate of chemicals 20060601

Title: Metabolomic study of cisplatin-induced nephrotoxicity.

Journal: Kidney international 20060601

Title: Ciprofibrate increases paraoxonase activity in patients with metabolic syndrome.

Journal: British journal of clinical pharmacology 20060601

Title: [Nuclear receptors PPARalpha].

Journal: Vnitrni lekarstvi 20060601

Title: PRIC320, a transcription coactivator, isolated from peroxisome proliferator-binding protein complex.

Journal: Biochemical and biophysical research communications 20060505

Title: Separation of fibrate-type antihyperlipidemic drugs by capillary electrophoresis and their quantitation in pharmaceuticals.

Journal: Journal of pharmaceutical and biomedical analysis 20060503

Title: Lipid-lowering drugs.

Journal: Cellular and molecular life sciences : CMLS 20060501

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Title: Apolipoproteins AI and B as therapeutic targets.

Journal: Journal of internal medicine 20060501

Title: Field of confusion: future prospects for fibrate therapy in cardiovascular disease.

Journal: Current atherosclerosis reports 20060501

Title: Bioactivation of carboxylic acid compounds by UDP-Glucuronosyltransferases to DNA-damaging intermediates: role of glycoxidation and oxidative stress in genotoxicity.

Journal: Chemical research in toxicology 20060501

Title: [Intensive cholesterol lowering therapy to reduce cardiovascular risk].

Journal: Revista medica de Chile 20060501

Title: Is atorvastatin superior to other statins? Analysis of the clinical trials with atorvastatin having cardiovascular endpoints.

Journal: Reviews on recent clinical trials 20060501

Title: Statin safety: a systematic review.

Journal: The American journal of cardiology 20060417

Title: [Diabetic dyslipoproteinemia].

Journal: MMW Fortschritte der Medizin 20060406

Title: HDL: the 'new' target of cardiovascular medicine.

Journal: International journal of cardiology 20060404

Title: Early diet-induced non-alcoholic steatohepatitis in APOE2 knock-in mice and its prevention by fibrates.

Journal: Journal of hepatology 20060401

Title: Fish oil increases bile acid synthesis in male patients with hypertriglyceridemia.

Journal: The Journal of nutrition 20060401

Title: [The fibrate-activated PPARalpha/p16INK4A pathway inhibits vascular smooth muscle cell proliferation and vascular occlusion].

Journal: Medecine sciences : M/S 20060401

Title: [Hyperlipidemia].

Journal: Nihon rinsho. Japanese journal of clinical medicine 20060401

Title: [Treatment of dyslipidemia: how and when to combine lipid lowering drugs].

Journal: Arquivos brasileiros de endocrinologia e metabologia 20060401

Title: Cardioprotective properties of fibrates: which fibrate, which patients, what mechanism?

Journal: Circulation 20060328

Title: [Treatment of dyslipidemia in clinical practice].

Journal: Orvosi hetilap 20060305

Title: The occurrence of selected pharmaceuticals in wastewater effluent and surface waters of the lower Tyne catchment.

Journal: The Science of the total environment 20060301

Title: Enantiomeric separation of some demethylated analogues of clofibric acid by capillary zone electrophoresis and nano-liquid chromatography.

Journal: Electrophoresis 20060301

Title: [Changes in serum lipids, plasma fibrinogen and other haemostatic parameters induced by ciprofibrate action in hyperlipidemic patients with and without coronary artery disease].

Journal: Investigacion clinica 20060301

Title: Fibrates in the prevention of cardiovascular disease in patients with type 2 diabetes mellitus: meta-analysis of randomised controlled trials.

Journal: Current medical research and opinion 20060301

Title: [Fibrates, nicotinic acid preparations and muscular pain].

Journal: Lakartidningen 20060301

Title: Is there evidence for the evidence-based guidelines for cardiovascular disease prevention in women?

Journal: Gender medicine 20060301

Title: Strategies for management and treatment of dyslipidemia in HIV/AIDS.

Journal: AIDS care 20060201

Title: Preliminary risk assessment of the lipid-regulating pharmaceutical clofibric acid, for three estuarine species.

Journal: Environmental research 20060201

Title: Management of hyperlipidemia: new LDL-C targets for persons at high-risk for cardiovascular events.

Journal: Medical science monitor : international medical journal of experimental and clinical research 20060201

Title: 'Anti-inflammatory' drugs and their effects on type 2 diabetes.

Journal: Diabetes technology & therapeutics 20060201

Title: Effects of widely used pharmaceuticals and a detergent on oxidative stress biomarkers of the crustacean Artemia parthenogenetica.

Journal: Chemosphere 20060101

Title: Anti-atherogenic properties of fibrates may be largely due to their anti-inflammatory effects.

Journal: Medical hypotheses 20060101

Title: Lipid testing and lipid-lowering therapy in hospitalized ischemic stroke and transient ischemic attack patients: results from a statewide stroke registry.

Journal: Stroke 20060101

Title: Assessment of compliance with lipid guidelines in an academic medical center.

Journal: The Annals of pharmacotherapy 20060101

Title: Statin/fibrate combination in patients with metabolic syndrome or diabetes: evaluating the risks of pharmacokinetic drug interactions.

Journal: Expert opinion on drug safety 20060101

Title: Low-density lipoprotein size and cardiovascular risk assessment.

Journal: QJM : monthly journal of the Association of Physicians 20060101

Title: Fibrates in combination with statins in the management of dyslipidemia.

Journal: Journal of clinical hypertension (Greenwich, Conn.) 20060101

Title: The metabolic syndrome--what is it and how should it be managed?

Journal: Journal of clinical hypertension (Greenwich, Conn.) 20060101

Title: Diabetes mellitus-associated atherosclerosis: mechanisms involved and potential for pharmacological invention.

Journal: American journal of cardiovascular drugs : drugs, devices, and other interventions 20060101

Title: Flow cytometric assessment of peroxisome proliferation from frozen liver of fibrate-treated monkeys.

Journal: International journal of toxicology 20060101

Title: Mode of action of fibrates in the regulation of triglyceride and HDL-cholesterol metabolism.

Journal: Drugs of today (Barcelona, Spain : 1998) 20060101

Title: Regulatory effects of synthetic liver X receptor- and peroxisome-proliferator activated receptor agonists on sterol transport pathways in polarized cerebrovascular endothelial cells.

Journal: The international journal of biochemistry & cell biology 20060101

Title: Biologically relevant effects of mRNA amplification on gene expression profiles.

Journal: BMC bioinformatics 20060101

Title: Potential of fibrates in the treatment of fatty acid oxidation disorders: revival of classical drugs?

Journal: Journal of inherited metabolic disease 20060101

Title: 2-{3-[2-(4-chlorophenyl)ethoxy]phenylthio}-2-methylpropanoic acid: a fibrate-like compound with hypolipidemic and antidiabetic activity.

Journal: ChemMedChem 20060101

Title: Gene expression profiles in rat liver slices exposed to hepatocarcinogenic enzyme inducers, peroxisome proliferators, and 17alpha-ethinylestradiol.

Journal: International journal of toxicology 20060101

Title: Effect of clofibric acid on desmin and vimentin contents in rat myocardiocytes.

Journal: International journal of toxicology 20060101

Title: Atherogenic dyslipidemia in metabolic syndrome and type 2 diabetes: therapeutic options beyond statins.

Journal: Cardiovascular diabetology 20060101

Title: [Clinical trials of statins and fibrates --a meta-analysis].

Journal: Medicinski pregled 20060101

Title: Comparison of effects of fibrates in patients with hypertriglyceridemia.

Journal: Advances in therapy 20060101

Title: [Cardiovascular risk and possibilities of lowering it in patients with metabolic syndrome and type II diabetes mellitus. The role of fibrates].

Journal: Kardiologiia 20060101

Title: Examination of Ligand-Dependent Coactivator Recruitment by Peroxisome Proliferator-Activated Receptor-alpha (PPARalpha).

Journal: PPAR research 20060101

Title: Cardiovascular disease: strategies for risk assessment and modification.

Journal: The Journal of cardiovascular nursing 20060101

Title: Prolonged statin administration does not act on the cell-mediated immunity of HIV-infected dyslipidemic patients treated with a steady and effective highly active antiretroviral therapy. A two-year prospective study of statin versus fibrate administration.

Journal: Journal of biological regulators and homeostatic agents 20060101

Title: [Synthesis and physico-chemical characterisation of some new derivatives of rutoside and clofibric acid].

Journal: Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi 20060101

Title: [Continuing care of patients with cardiovascular risk in general practice: patients with dyslipidemia and their care].

Journal: Orvosi hetilap 20051225

Title: [New studies of high dosage statins and fibrates. How is lipid lowering therapy changing? (interview by Dr. med. Dirk Einecke)].

Journal: MMW Fortschritte der Medizin 20051208

Title: Ciprofibrate stimulates the gastrin-producing cell by acting luminally on antral PPAR-alpha.

Journal: American journal of physiology. Gastrointestinal and liver physiology 20051201

Title: Role for fibrate therapy in diabetes: evidence before FIELD.

Journal: Current opinion in lipidology 20051201

Title: Fibrate prevents cisplatin-induced proximal tubule cell death.

Journal: Kidney international 20051201

Title: Household disposal of pharmaceuticals as a pathway for aquatic contamination in the United kingdom.

Journal: Environmental health perspectives 20051201

Title: Optimal lipid modification: the rationale for combination therapy.

Journal: Vascular health and risk management 20051201

Title: Fibrates inhibit aldose reductase activity in the forward and reverse reactions.

Journal: Biochemical pharmacology 20051125

Title: Phytol directly activates peroxisome proliferator-activated receptor alpha (PPARalpha) and regulates gene expression involved in lipid metabolism in PPARalpha-expressing HepG2 hepatocytes.

Journal: Biochemical and biophysical research communications 20051118

Title: Modifying plasma low-density lipoprotein and high-density lipoprotein cholesterol: what combinations are available in the future?

Journal: The American journal of cardiology 20051107

Title: Pharmacokinetic interactions between statins and fibrates.

Journal: The American journal of cardiology 20051107

Title: Severe rhabdomyolysis during a hypersensitivity reaction to abacavir in a patient treated with ciprofibrate.

Journal: AIDS (London, England) 20051104

Title: Gene expression profiling of the PPAR-alpha agonist ciprofibrate in the cynomolgus monkey liver.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20051101

Title: Beneficial vascular and metabolic effects of peroxisome proliferator-activated receptor-alpha activators.

Journal: Hypertension (Dallas, Tex. : 1979) 20051101

Title: Hypertriglyceridemia-why, when and how should it be treated?

Journal: Zeitschrift fur Kardiologie 20051101

Title: Differential associations of statin and fibrate treatment with carotid arterial remodeling.

Journal: American journal of hypertension 20051101

Title: Therapeutical effects of PPAR agonists assessed by biomarker modulation.

Journal: Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals 20051101

Title: Orthogonal array designs for the optimization of liquid-liquid-liquid microextraction of nonsteroidal anti-inflammatory drugs combined with high-performance liquid chromatography-ultraviolet detection.

Journal: Journal of chromatography. A 20051028

Title: Statins and fibrates for preventing melanoma.

Journal: The Cochrane database of systematic reviews 20051019

Title: Fibrates and coronary risk reduction.

Journal: Atherosclerosis 20051001

Title: Effects of pharmaceuticals on Daphnia survival, growth, and reproduction.

Journal: Chemosphere 20051001

Title: High-density lipoprotein cholesterol: ready for prime time?

Journal: Singapore medical journal 20051001

Title: Patients with low levels of high-density lipoprotein cholesterol: to treat or not to treat?

Journal: Singapore medical journal 20051001

Title: Lipoprotein-associated phospholipase A2 as a biomarker for coronary disease and stroke.

Journal: Nature clinical practice. Cardiovascular medicine 20051001

Title: [Drug combinations: statins and fibrates].

Journal: Arquivos brasileiros de cardiologia 20051001

Title: Clinical practice. Low HDL cholesterol levels.

Journal: The New England journal of medicine 20050922

Title: Synthesis and antiplatelet activity of thioaryloxyacids analogues of clofibric acid.

Journal: European journal of medicinal chemistry 20050901

Title: Pleiotropic effects of fibrates.

Journal: Current atherosclerosis reports 20050901

Title: Monocyte release of tumor necrosis factor-alpha and interleukin-1beta in primary type IIa and IIb dyslipidemic patients treated with statins or fibrates.

Journal: Journal of cardiovascular pharmacology 20050901

Title: Differential antiatherogenic effects of PPARalpha versus PPARgamma agonists: should we be surprised?

Journal: Arteriosclerosis, thrombosis, and vascular biology 20050901

Title: Current perspective. Diabetic vascular disease: from endothelial dysfunction to atherosclerosis.

Journal: Italian heart journal : official journal of the Italian Federation of Cardiology 20050901

Title: Synthesis, biological evaluation, and molecular modeling investigation of new chiral fibrates with PPARalpha and PPARgamma agonist activity.

Journal: Journal of medicinal chemistry 20050825

Title: Management of dyslipidemia in patients with complicated metabolic syndrome.

Journal: The American journal of cardiology 20050822

Title: Anti-inflammatory effect of fibrate protects from cisplatin-induced ARF.

Journal: American journal of physiology. Renal physiology 20050801

Title: Modulation of hepatic canalicular or basolateral transport proteins alters hepatobiliary disposition of a model organic anion in the isolated perfused rat liver.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20050801

Title: Fate and mobility of pharmaceuticals in solid matrices.

Journal: Chemosphere 20050801

Title: Therapeutic roles of peroxisome proliferator-activated receptor agonists.

Journal: Diabetes 20050801

Title: Demystifying triglycerides: a practical approach for the clinician.

Journal: Cleveland Clinic journal of medicine 20050801

Title: Electrochemical determination of pharmaceuticals in spiked water samples.

Journal: Journal of hazardous materials 20050715

Title: Environmental fate of pharmaceuticals in water/sediment systems.

Journal: Environmental science & technology 20050715

Title: Behavior of selected pharmaceuticals in subsurface flow constructed wetlands: a pilot-scale study.

Journal: Environmental science & technology 20050715

Title: Expression and induction potential of cytochromes P450 in human cryopreserved hepatocytes.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20050701

Title: Adiponectin receptor gene expression in human skeletal muscle cells is not regulated by fibrates and thiazolidinediones.

Journal: International journal of obesity (2005) 20050701

Title: Acute toxicity of widely used pharmaceuticals in aquatic species: Gambusia holbrooki, Artemia parthenogenetica and Tetraselmis chuii.

Journal: Ecotoxicology and environmental safety 20050701

Title: Pharmacologic augmentation of high-density lipoproteins: mechanisms of currently available and emerging therapies.

Journal: Current opinion in cardiology 20050701

Title: Effects of fibrates on human organic anion-transporting polypeptide 1B1-, multidrug resistance protein 2- and P-glycoprotein-mediated transport.

Journal: Xenobiotica; the fate of foreign compounds in biological systems 20050701

Title: Induction of overlapping genes by fasting and a peroxisome proliferator in pigs: evidence of functional PPARalpha in nonproliferating species.

Journal: American journal of physiology. Regulatory, integrative and comparative physiology 20050601

Title: Hepatic beta-oxidation and carnitine palmitoyltransferase I in neonatal pigs after dietary treatments of clofibric acid, isoproterenol, and medium-chain triglycerides.

Journal: American journal of physiology. Regulatory, integrative and comparative physiology 20050601

Title: Induction of pancreatic acinar cell proliferation by thyroid hormone.

Journal: The Journal of endocrinology 20050601

Title: Expression of cytochrome P450 enzymes in hepatic organoid reconstructed by rat small hepatocytes.

Journal: Journal of gastroenterology and hepatology 20050601

Title: [Significance of HDL cholesterol increase for the risk reduction. Methods of intervention. recommendations of experts].

Journal: Kardiologia polska 20050601

Title: [Treatment of lipid disorders in metabolic syndrome and type 2 diabetes. The place for fibrates].

Journal: Kardiologia polska 20050601

Title: [Influence of ACE inhibitors and fibrates on endothelial function].

Journal: Kardiologia polska 20050601

Title: [Pleiotropic action of ACE-I and fibrates].

Journal: Kardiologia polska 20050601

Title: [Combination pharmacotherapy therapy in the management of atherogenic dyslipidemia].

Journal: Kardiologia polska 20050601

Title: PPAR-alpha activators suppress STAT1 inflammatory signaling in lipopolysaccharide-activated rat glia.

Journal: Neuroreport 20050531

Title: Differences in cell proliferation in rodent and human hepatic derived cell lines exposed to ciprofibrate.

Journal: Cancer letters 20050526

Title: The benefit of fibrates in the treatment of 'bad HDL-C responders to statins'.

Journal: International journal of cardiology 20050525

Title: APOE genotype, cholesterol level, lipid-lowering treatment, and dementia: the Three-City Study.

Journal: Neurology 20050510

Title: Occurrence of several acidic drugs in sewage treatment plants in Switzerland and risk assessment.

Journal: Water research 20050501

Title: The potential use of PPARalpha agonists as immunosuppressive agents.

Journal: Current opinion in investigational drugs (London, England : 2000) 20050501

Title: Regulation of palmitoyl-CoA chain elongation by clofibric acid in the liver of Zucker fa/fa rats.

Journal: Lipids 20050501

Title: Effect of different antilipidemic agents and diets on mortality: a systematic review.

Journal: Archives of internal medicine 20050411

Title: Regulation of human hepatic hydroxysteroid sulfotransferase gene expression by the peroxisome proliferator-activated receptor alpha transcription factor.

Journal: Molecular pharmacology 20050401

Title: Characterization of an acute molecular marker of nongenotoxic rodent hepatocarcinogenesis by gene expression profiling in a long term clofibric acid study.

Journal: Chemical research in toxicology 20050401

Title: Automorphosis of etiolated pea seedlings in space is simulated by a three-dimensional clinostat and the application of inhibitors of auxin polar transport.

Journal: Physiologia plantarum 20050401

Title: Rhabdomyolysis and lipid-lowering drugs.

Journal: JAMA 20050323

Title: Operational options to reduce matrix effects in liquid chromatography-electrospray ionization-mass spectrometry analysis of aqueous environmental samples.

Journal: Journal of chromatography. A 20050304

Title: Effect of lipid-lowering drug therapy on small-dense low-density lipoprotein.

Journal: The Annals of pharmacotherapy 20050301

Title: Drugs for lipids.

Journal: Treatment guidelines from the Medical Letter 20050301

Title: Cross-flow microfiltration with periodical back-washing for photocatalytic degradation of pharmaceutical and diagnostic residues-evaluation of the long-term stability of the photocatalytic activity of TiO2.

Journal: Water research 20050301

Title: Management of dyslipidemia in women in the post-hormone therapy era.

Journal: Journal of general internal medicine 20050301

Title: Beyond the statins: new therapeutic perspectives in cardiovascular disease prevention.

Journal: Cardiovascular drugs and therapy 20050301

Title: Help for your cholesterol when statins won't do. If you are one of the many, but also one of the few..

Journal: Harvard men's health watch 20050301

Title: Determination of pharmaceutical residues in waters by solid-phase extraction and large-volume on-line derivatization with gas chromatography-mass spectrometry.

Journal: Journal of chromatography. A 20050218

Title: Pretranslational upregulation of microsomal CYP4A in rat liver by intake of a high-sucrose, lipid-devoid diet containing orotic acid.

Journal: Biochemical pharmacology 20050215

Title: [Myopathies under therapy with lipid-lowering agents].

Journal: Der Nervenarzt 20050201

Title: Hypolipidemic drugs affect monocyte IL-1beta gene expression and release in patients with IIa and IIb dyslipidemia.

Journal: Journal of cardiovascular pharmacology 20050201

Title: Rationale for combination therapy with statin drugs in the treatment of dyslipidemia.

Journal: Current atherosclerosis reports 20050201

Title: [Dyslipidemia management in patients with impaired glucose tolerance].

Journal: Nihon rinsho. Japanese journal of clinical medicine 20050201

Title: Have we forgotten the pivotal role of high-density lipoprotein cholesterol in atherosclerosis prevention?

Journal: Current medical research and opinion 20050201

Title: Dissociation of branched-chain alpha-keto acid dehydrogenase kinase (BDK) from branched-chain alpha-keto acid dehydrogenase complex (BCKDC) by BDK inhibitors.

Journal: Journal of nutritional science and vitaminology 20050201

Title: Efficacy and safety of high-density lipoprotein cholesterol-increasing compounds: a meta-analysis of randomized controlled trials.

Journal: Journal of the American College of Cardiology 20050118

Title: Photocatalytic degradation of carbamazepine, clofibric acid and iomeprol with P25 and Hombikat UV100 in the presence of natural organic matter (NOM) and other organic water constituents.

Journal: Water research 20050101

Title: Management of diabetic dyslipidemia: need for reappraisal of the goals.

Journal: American journal of cardiovascular drugs : drugs, devices, and other interventions 20050101

Title: Comparative effects of fibrates on drug metabolizing enzymes in human hepatocytes.

Journal: Pharmaceutical research 20050101

Title: [Cardiovascular system drugs. 9/12. Antilipemics--II. Fibrates and colestyramine].

Journal: Soins; la revue de reference infirmiere 20050101

Title: AhR and PPARalpha: antagonistic effects on CYP2B and CYP3A, and additive inhibitory effects on CYP2C11.

Journal: Xenobiotica; the fate of foreign compounds in biological systems 20050101

Title: Diabetic dyslipidaemia: insights for optimizing patient management.

Journal: Current medical research and opinion 20050101

Title: Outcome studies in type 2 diabetes.

Journal: Current medical research and opinion 20050101

Title: Study of the liquid chromatography retention of some fibrate-type antihyperlipidemic drugs on C18 and CN columns: application for quantitation in pharmaceutical formulations.

Journal: Journal of AOAC International 20050101

Title: A two-dimensional electrophoresis preliminary approach to human hepatocarcinoma differentiation induced by PPAR-agonists.

Journal: Journal of cellular and molecular medicine 20050101

Title: [Dyslipidaemia and diabetes mellitus].

Journal: Revue medicale de Liege 20050101

Title: Mechanisms of calcium release from the sarcoplasmic reticulum in skeletal muscle.

Journal: Advances in experimental medicine and biology 20050101

Title: The effect of ciprofibrate on flow-mediated dilation and inflammatory markers in patients with combined hyperlipidemia.

Journal: Endothelium : journal of endothelial cell research 20050101

Title: Enzymatic examination of potential interaction between statins or fibrates and consumed Tricholoma equestre.

Journal: Przeglad lekarski 20050101

Title: Macrodissection versus microdissection of rectal carcinoma: minor influence of stroma cells to tumor cell gene expression profiles.

Journal: BMC genomics 20050101

Title: Single and chronic administration of ciprofibrate or of ciprofibrate-glycinate in male Fischer 344 rats: comparison of the effects on morphological and biochemical parameters in liver and blood.

Journal: European journal of drug metabolism and pharmacokinetics 20050101

Title: Evaluation of the carcinogenic potential of clofibrate in the neonatal mouse.

Journal: International journal of toxicology 20050101

Title: Peroxisome proliferator-activated receptor-gamma and its agonists in hypertension and atherosclerosis : mechanisms and clinical implications.

Journal: American journal of cardiovascular drugs : drugs, devices, and other interventions 20050101

Title: Hypertriglyceridemia, the coronary heart disease risk marker 'solved'.

Journal: Acta physiologica Hungarica 20050101

Title: [Variability in primary care drug prescription in 2003 in Castile-la Mancha, Spain].

Journal: Revista espanola de salud publica 20050101

Title: [Fibrate-induced increase in serum creatinine levels: two cases].

Journal: Therapie 20050101

Title: Suitability of hollow fibre liquid-phase microextraction for the determination of acidic pharmaceuticals in wastewater by liquid chromatography-electrospray tandem mass spectrometry without matrix effects.

Journal: Journal of chromatography. A 20041217

Title: Acute and chronic effects of clofibrate and clofibric acid on the enzymes acetylcholinesterase, lactate dehydrogenase and catalase of the mosquitofish, Gambusia holbrooki.

Journal: Chemosphere 20041201

Title: Lipid lowering drugs prescription and the risk of peripheral neuropathy: an exploratory case-control study using automated databases.

Journal: Journal of epidemiology and community health 20041201

Title: Incidence of hospitalized rhabdomyolysis in patients treated with lipid-lowering drugs.

Journal: JAMA 20041201

Title: Induction of phytohormones and differential gene expression in citrus flowers infected by the fungus Colletotrichum acutatum.

Journal: Molecular plant-microbe interactions : MPMI 20041201

Title: Therapeutic approaches to raising plasma HDL-cholesterol levels.

Journal: Nature clinical practice. Cardiovascular medicine 20041201

Title: [Low HDL-cholesterol, high triglycerides--well known but often ignored].

Journal: Praxis 20041110

Title: Lipid lowering effects of statins and fibrates in the management of HIV dyslipidemias associated with antiretroviral therapy in HIV clinical practice.

Journal: The Journal of infection 20041101

Title: Clofibric and ethacrynic acids prevent experimental pyelonephritis by Escherichia coli in mice.

Journal: FEMS immunology and medical microbiology 20041101

Title: Statin and fibrate treatment of combined hyperlipidemia: the effects on some novel risk factors.

Journal: Thrombosis and haemostasis 20041101

Title: Down regulation of hepatic PPARalpha function by AhR ligand.

Journal: The Journal of veterinary medical science 20041101

Title: Peroxisome proliferator-activated receptors as regulators of lipid metabolism; tissue differential expression in adipose tissues during cold acclimatization and hibernation of jerboa (Jaculus orientalis).

Journal: Biochimie 20041101

Title: Pharmaceuticals and personal care products (PPCPs) and endocrine disrupting chemicals (EDCs) in stormwater canals and Bayou St. John in New Orleans, Louisiana, USA.

Journal: The Science of the total environment 20041015

Title: Activation of peroxisome proliferator-activated receptor alpha in rat spinal cord after peripheral noxious stimulation.

Journal: Neuroscience letters 20041007

Title: The effect of statins and fibrates on interferon-gamma and interleukin-2 release in patients with primary type II dyslipidemia.

Journal: Atherosclerosis 20041001

Title: Raising high-density lipoprotein cholesterol with inhibitors of cholesteryl ester transfer protein - a new approach to coronary artery disease.

Journal: Expert opinion on investigational drugs 20041001

Title: Determination of some acidic drugs in surface and sewage treatment plant waters by capillary electrophoresis-electrospray ionization-mass spectrometry.

Journal: Electrophoresis 20041001

Title: Management of dyslipidaemia in HIV-infected patients receiving antiretroviral therapy.

Journal: Antiviral therapy 20041001

Title: Co-induction of methyltransferase Rv0560c by naphthoquinones and fibric acids suggests attenuation of isoprenoid quinone action in Mycobacterium tuberculosis.

Journal: Canadian journal of microbiology 20041001

Title: PPARalpha-dependent modulation of hepatic CYP1A by clofibric acid in rats.

Journal: Archives of toxicology 20040901

Title: Fibrates induce hepatic peroxisome and mitochondrial proliferation without overt evidence of cellular proliferation and oxidative stress in cynomolgus monkeys.

Journal: Carcinogenesis 20040901

Title: Therapeutic approaches in the prevention of cardiovascular disease in metabolic syndrome and in patients with type 2 diabetes.

Journal: Current opinion in cardiology 20040901

Title: Diabetes mellitus and unstable coronary artery disease: improved clinical outcome of coronary artery stenting in an era of glycoprotein IIb/IIIa inhibitors and lipid-lowering therapy.

Journal: Coronary artery disease 20040901

Title: Utility of currently available modes of therapy in reaching lipid goals.

Journal: The Journal of the American Osteopathic Association 20040901

Title: Coadministration of multidrug therapy to achieve lipid goals.

Journal: The Journal of the American Osteopathic Association 20040901

Title: Peroxisome proliferator-activated receptor (PPAR)-alpha: a pharmacological target with a promising future.

Journal: Pharmaceutical research 20040901

Title: PPARalpha agonists stimulate progastrin production in human colorectal carcinoma cells.

Journal: Regulatory peptides 20040815

Title: Effects of vitamin E on the NF-kappaB pathway in rats treated with the peroxisome proliferator, ciprofibrate.

Journal: Toxicology and applied pharmacology 20040815

Title: Analysis by liquid chromatography-electrospray ionization tandem mass spectrometry and acute toxicity evaluation for beta-blockers and lipid-regulating agents in wastewater samples.

Journal: Journal of chromatography. A 20040813

Title: Statins but not fibrates are associated with a reduced risk of venous thromboembolism: a hospital-based case-control study.

Journal: Fundamental & clinical pharmacology 20040801

Title: Protective behavior survey, West Nile virus, British Columbia.

Journal: Emerging infectious diseases 20040801

Title: Leaching behaviour of pharmaceuticals in soil-testing-systems: a part of an environmental risk assessment for groundwater protection.

Journal: The Science of the total environment 20040726

Title: PPARalpha agonists clofibrate and gemfibrozil inhibit cell growth, down-regulate hCG and up-regulate progesterone secretions in immortalized human trophoblast cells.

Journal: Biochemical pharmacology 20040715

Title: Effects of peroxisome proliferator-activated receptor alpha activation on pathways contributing to cholesterol homeostasis in rat hepatocytes.

Journal: Biochimica et biophysica acta 20040705

Title: Gastrointestinally distributed UDP-glucuronosyltransferase 1A10, which metabolizes estrogens and nonsteroidal anti-inflammatory drugs, depends upon phosphorylation.

Journal: The Journal of biological chemistry 20040702

Title: The peroxisome proliferator-activated receptor alpha (PPARalpha) agonist ciprofibrate inhibits apolipoprotein B mRNA editing in low density lipoprotein receptor-deficient mice: effects on plasma lipoproteins and the development of atherosclerotic lesions.

Journal: The Journal of biological chemistry 20040702

Title: Mitochondrial respiratory chain dysfunction, a non-receptor-mediated effect of synthetic PPAR-ligands: biochemical and pharmacological implications.

Journal: Biochemical and biophysical research communications 20040702

Title: Adiponectin in peritoneal dialysis patients: a comparison with hemodialysis patients and subjects with normal renal function.

Journal: American journal of kidney diseases : the official journal of the National Kidney Foundation 20040601

Title: Statin and fibrate associated myopathy: study of eight patients.

Journal: Arquivos de neuro-psiquiatria 20040601

Title: Sexually dimorphic metabolism of branched-chain lipids in C57BL/6J mice.

Journal: Journal of lipid research 20040501

Title: Environmental risk assessment of six human pharmaceuticals: are the current environmental risk assessment procedures sufficient for the protection of the aquatic environment?

Journal: Environmental toxicology and chemistry 20040501

Title: Highlights from the 74th Congress of the European Atherosclerosis Society.

Journal: Timely topics in medicine. Cardiovascular diseases 20040501

Title: Characterization of the species-specificity of peroxisome proliferators in rat and human hepatocytes.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20040401

Title: Regulation of apoptosis by peroxisome proliferators.

Journal: Toxicology letters 20040401

Title: Properties of an alginate gel bead containing a chitosan-drug salt.

Journal: Biological & pharmaceutical bulletin 20040301

Title: Liquid chromatography with triple-quadrupole or quadrupole-time of flight mass spectrometry for screening and confirmation of residues of pharmaceuticals in water.

Journal: Analytical and bioanalytical chemistry 20040201

Title: Evaluation of the dermal subchronic toxicity of phenoxyethyl isobutyrate in the rat.

Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20040201

Title: Kinetic study of photocatalytic degradation of carbamazepine, clofibric acid, iomeprol and iopromide assisted by different TiO2 materials--determination of intermediates and reaction pathways.

Journal: Water research 20040201

Title: Two-step liquid-liquid-liquid microextraction of nonsteroidal antiinflammatory drugs in wastewater.

Journal: Analytical chemistry 20040101

Title: In vitro reactivity of carboxylic acid-CoA thioesters with glutathione.

Journal: Chemical research in toxicology 20040101

Title: Miniaturized fluorescent RNA dot blot method for rapid quantitation of gene expression.

Journal: BMC biotechnology 20040101

Title: Application of UV-derivative spectra for determination of four antihyperlipidaemic drugs in pharmaceutical formulations.

Journal: Acta poloniae pharmaceutica 20040101

Title: Role of fibric acid derivatives in the management of risk factors for coronary heart disease.

Journal: Drugs 20040101

Title: Transport of pharmaceutically active compounds in saturated laboratory columns.

Journal: Ground water 20040101

Title: Effects of advanced oxidation processes (AOPs) on the toxicity of a mixture of pharmaceuticals.

Journal: Water science and technology : a journal of the International Association on Water Pollution Research 20040101

Title: Toxic effect of pharmaceuticals on methanogenesis.

Journal: Water science and technology : a journal of the International Association on Water Pollution Research 20040101

Title: Comparative effects of lipid-lowering therapies.

Journal: Progress in cardiovascular diseases 20040101

Title: Overexpression of SR-BI by adenoviral vector reverses the fibrateinduced hypercholesterolemia of apolipoprotein E-deficient mice.

Journal: The Journal of biological chemistry 20031226

Title: Determination of acidic pharmaceuticals, antibiotics and ivermectin in river sediment using liquid chromatography-tandem mass spectrometry.

Journal: Journal of chromatography. A 20031222

Title: Cardiovascular disease with diabetes or the metabolic syndrome: should statins or fibrates be first line lipid therapy?

Journal: Current opinion in lipidology 20031201

Title: Liver gene expression profiles of rats treated with clofibric acid: comparison of whole liver and laser capture microdissected liver.

Journal: The American journal of pathology 20031201

Title: Occurrence of neutral and acidic drugs in the effluents of Canadian sewage treatment plants.

Journal: Environmental toxicology and chemistry 20031201

Title: Distribution of acidic and neutral drugs in surface waters near sewage treatment plants in the lower Great Lakes, Canada.

Journal: Environmental toxicology and chemistry 20031201

Title: p-Chlorophenoxyisobutyric acid impairs auxin response in Arabidopsis root.

Journal: Plant physiology 20031101

Title: Ozonation and H2O2/UV treatment of clofibric acid in water: a kinetic investigation.

Journal: Journal of hazardous materials 20031031

Title: Determination of selected human pharmaceutical compounds in effluent and surface water samples by high-performance liquid chromatography-electrospray tandem mass spectrometry.

Journal: Journal of chromatography. A 20031010

Title: Cell proliferation and apoptosis are altered in mice deficient in the NF-kappaB p50 subunit after treatment with the peroxisome proliferator ciprofibrate.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20031001

Title: Pharmaceutical and personal care products in sewage treatment works.

Journal: Journal of environmental monitoring : JEM 20031001

Title: Hypertriglyceridemia increases mitochondrial resting respiration and susceptibility to permeability transition.

Journal: Journal of bioenergetics and biomembranes 20031001

Title: Liver gene expression in rats in response to the peroxisome proliferator-activated receptor-alpha agonist ciprofibrate.

Journal: Physiological genomics 20030929

Title: Simultaneous determination of clofibrate and its active metabolite clofibric acid in human plasma by reversed-phase high-performance liquid chromatography with ultraviolet absorbance detection.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20030905

Title: Fate of pharmaceuticals--photodegradation by simulated solar UV-light.

Journal: Chemosphere 20030901

Title: Effects of clofibric acid on mRNA expression profiles in primary cultures of rat, mouse and human hepatocytes.

Journal: Toxicology and applied pharmacology 20030901

Title: Ethylene promotes the induction by auxin of the cortical microtubule randomization required for low-pH-induced root hair initiation in lettuce (Lactuca sativa L.) seedlings.

Journal: Plant & cell physiology 20030901

Title: Influence of etofibrate on LDL-subtype distribution in patients with diabetic dyslipoproteinemia.

Journal: Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 20030901

Title: The peroxisome-proliferator-activated receptor alpha agonist ciprofibrate severely aggravates hypercholesterolaemia and accelerates the development of atherosclerosis in mice lacking apolipoprotein E.

Journal: The Biochemical journal 20030801

Title: Chromatin sphingomyelin changes in cell proliferation and/or apoptosis induced by ciprofibrate.

Journal: Journal of cellular physiology 20030801

Title: Action of ciprofibrate in type IIb hyperlipoproteinemia: modulation of the atherogenic lipoprotein phenotype and stimulation of high-density lipoprotein-mediated cellular cholesterol efflux.

Journal: The Journal of clinical endocrinology and metabolism 20030801

Title: [Long-term hypolipidemic treatment of mixed hyperlipidemia with a combination of statins and fibrates].

Journal: Casopis lekaru ceskych 20030801

Title: Reshaping the dyslipidemia management paradigm.

Journal: Postgraduate medicine 20030801

Title: CHD risk equivalents and the metabolic syndrome. Trial evidence supports aggressive management.

Journal: Postgraduate medicine 20030801

Title: Pharmaceuticals and personal care products (PPCPs) in surface and treated waters of Louisiana, USA and Ontario, Canada.

Journal: The Science of the total environment 20030720

Title: Ecotoxicological impact of pharmaceuticals found in treated wastewaters: study of carbamazepine, clofibric acid, and diclofenac.

Journal: Ecotoxicology and environmental safety 20030701

Title: Fibrates and renal function.

Journal: Clinical nephrology 20030701

Title: LDL-cholesterol, HDL-cholesterol or triglycerides--which is the culprit?

Journal: Diabetes research and clinical practice 20030701

Title: Short-term tests with a pilot sewage plant and biofilm reactors for the biological degradation of the pharmaceutical compounds clofibric acid, ibuprofen, and diclofenac.

Journal: The Science of the total environment 20030620

Title: Peroxisome proliferator-activated receptor ligands affect growth-related gene expression in human leukemic cells.

Journal: The Journal of pharmacology and experimental therapeutics 20030601

Title: Serum lipid comparison in patients treated by statins or fibrates: existence of bad HDL-C responders to statins.

Journal: Acta cardiologica 20030601

Title: [Ciprofibrate-induced acute cholestatic hepatitis].

Journal: Annales d'endocrinologie 20030601

Title: UDP-glucuronosyltransferase-dependent bioactivation of clofibric acid to a DNA-damaging intermediate in mouse hepatocytes.

Journal: Chemico-biological interactions 20030506

Title: Identification of coenzyme A-related tolmetin metabolites in rats: relationship with reactive drug metabolites.

Journal: Xenobiotica; the fate of foreign compounds in biological systems 20030501

Title: Molecular profiling of hepatocellular carcinomas developing spontaneously in acyl-CoA oxidase deficient mice: comparison with liver tumors induced in wild-type mice by a peroxisome proliferator and a genotoxic carcinogen.

Journal: Carcinogenesis 20030501

Title: Regulation by carbohydrate and clofibric acid of palmitoyl-CoA chain elongation in the liver of rats.

Journal: Lipids 20030501

Title: Determination of polar pharmaceuticals in sewage water of Greece by gas chromatography-mass spectrometry.

Journal: Chemosphere 20030401

Title: Occurrence and fate of carbamazepine, clofibric acid, diclofenac, ibuprofen, ketoprofen, and naproxen in surface waters.

Journal: Environmental science & technology 20030315

Title: Pharmaceuticals in STP effluents and their solar photodegradation in aquatic environment.

Journal: Chemosphere 20030301

Title: Cell-specific toxicity of fibrates in human embryonal rhabdomyosarcoma cells.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20030301

Title: Fibrates and medroxyprogesterone acetate induce apoptosis of primary Burkitt's lymphoma cells and cell lines: potential for applying old drugs to a new disease.

Journal: Leukemia 20030301

Title: Antral G cells in rats during dosing with a PPAR alpha agonist: a morphometric and immunocytochemical study.

Journal: Medical electron microscopy : official journal of the Clinical Electron Microscopy Society of Japan 20030301

Title: What future for combination therapies?

Journal: International journal of clinical practice. Supplement 20030301

Title: Peroxisome proliferator-activated receptor alpha (PPARalpha)-mediated regulation of multidrug resistance 2 (Mdr2) expression and function in mice.

Journal: The Biochemical journal 20030201

Title: Peroxisome proliferator ameliorates endothelial dysfunction in a murine model of hyperhomocysteinemia.

Journal: American journal of physiology. Lung cellular and molecular physiology 20030201

Title: Fibrates and C-reactive protein.

Journal: Clinica chimica acta; international journal of clinical chemistry 20030201

Title: Inhibition of TNF-alpha-induced RANTES expression in human hepatocyte-derived cells by fibrates, the hypolipidemic drugs.

Journal: International immunopharmacology 20030201

Title: Fibrates down-regulate IL-1-stimulated C-reactive protein gene expression in hepatocytes by reducing nuclear p50-NFkappa B-C/EBP-beta complex formation.

Journal: Blood 20030115

Title: Induction of hepatic ABC transporter expression is part of the PPARalpha-mediated fasting response in the mouse.

Journal: Gastroenterology 20030101

Title: Different effects of the liver mitogens triiodo-thyronine and ciprofibrate on the development of rat hepatocellular carcinoma.

Journal: Toxicologic pathology 20030101

Title: [Conjugation reactions of ciprofibrate with human and laboratory animals].

Journal: Arzneimittel-Forschung 20030101

Title: Evidence of cytochrome P450-catalyzed cleavage of the ether bond of phenoxybutyrate herbicides in Rhodococcus erythropolis K2-3.

Journal: Biodegradation 20030101

Title: A comprehensive description of muscle symptoms associated with lipid-lowering drugs.

Journal: Cardiovascular drugs and therapy 20030101

Title: Clofibric acid stimulates branched-chain amino acid catabolism by three mechanisms.

Journal: Archives of biochemistry and biophysics 20021115

Title: Effects of various fibrates on serum alkaline phosphatase activity.

Journal: Atherosclerosis 20021101

Title: In vivo and in vitro induction of cytochrome P450 enzymes in beagle dogs.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20021101

Title: Dysbetalipoproteinaemia--clinical and pathophysiological features.

Journal: South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde 20021101

Title: Peroxisome proliferators compete and ameliorate Hcy-mediated endocardial endothelial cell activation.

Journal: American journal of physiology. Cell physiology 20021001

Title: Effect of ciprofibrate on lipoproteins, fibrinogen, renal function, and hepatic enzymes.

Journal: Journal of cardiovascular pharmacology and therapeutics 20021001

Title: PPAR alpha stimulates the rat gastrin-producing cell.

Journal: Molecular and cellular endocrinology 20020930

Title: Differentiated properties of hepatocytes induced from pancreatic cells.

Journal: Hepatology (Baltimore, Md.) 20020901

Title: Removal of pharmaceuticals during drinking water treatment.

Journal: Environmental science & technology 20020901

Title: Current drug treatments for lipid management.

Journal: Managed care (Langhorne, Pa.) 20020901

Title: Drugs and personal care products as ubiquitous pollutants: occurrence and distribution of clofibric acid, caffeine and DEET in the North Sea.

Journal: The Science of the total environment 20020805

Title: HMG-CoA reductase inhibition and PPAR- alpha activation both inhibit cyclosporin A induced endothelin-1 secretion in cultured endothelial cells.

Journal: Clinical science (London, England : 1979) 20020801

Title: Ciglitazone inhibits plasmin-induced proinflammatory monocyte activation via modulation of p38 MAP kinase activity.

Journal: Thrombosis and haemostasis 20020801

Title: Fibrates suppress chenodeoxycholic acid-induced RANTES expression through inhibition of NF-kappaB activation.

Journal: European journal of pharmacology 20020712

Title: Peroxisome proliferator-activated receptor agonists, hyperlipidaemia, and atherosclerosis.

Journal: Pharmacology & therapeutics 20020701

Title: Detection of pharmaceutical contaminations of river, pond, and tap water from Cologne (Germany) and surroundings.

Journal: International journal of hygiene and environmental health 20020701

Title: Molecular modelling of the peroxisome proliferator-activated receptor alpha (PPAR alpha) from human, rat and mouse, based on homology with the human PPAR gamma crystal structure.

Journal: Toxicology in vitro : an international journal published in association with BIBRA 20020601

Title: PPARalpha suppresses insulin secretion and induces UCP2 in insulinoma cells.

Journal: Journal of lipid research 20020601

Title: Occurrence, fate, and removal of pharmaceutical residues in the aquatic environment: a review of recent research data.

Journal: Toxicology letters 20020510

Title: Mechanism of constrictive vascular remodeling by homocysteine: role of PPAR.

Journal: American journal of physiology. Cell physiology 20020501

Title: Analysis of acidic drugs in the effluents of sewage treatment plants using liquid chromatography-electrospray ionization tandem mass spectrometry.

Journal: Journal of chromatography. A 20020405

Title: The peroxisome proliferator-activated receptor alpha-selective activator ciprofibrate upregulates expression of genes encoding fatty acid oxidation and ketogenesis enzymes in rat brain.

Journal: Neuropharmacology 20020401

Title: Cytochemical and biochemical demonstration of an ATPase in membranes of human peroxisomes.

Journal: The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 20020301

Title: Analysis of serious adverse events. Lipid-lowering therapy revisited.

Journal: Canadian family physician Medecin de famille canadien 20020301

Title: Tolerability of statin-fibrate and statin-niacin combination therapy in dyslipidemic patients at high risk for cardiovascular events.

Journal: The American journal of cardiology 20020215

Title: Synergistic effect of 4-hydroxynonenal and PPAR ligands in controlling human leukemic cell growth and differentiation.

Journal: Free radical biology & medicine 20020201

Title: Atorvastatin versus four statin-fibrate combinations in patients with familial combined hyperlipidaemia.

Journal: Journal of cardiovascular risk 20020201

Title: Lipids in type 2 diabetes.

Journal: Seminars in vascular medicine 20020201

Title: Clofibric acid down-regulation of metallothionein IIA in HepG2 human hepatoma cells.

Journal: Biochemical pharmacology 20020115

Title: Fibrate and statin synergistically increase the transcriptional activities of PPARalpha/RXRalpha and decrease the transactivation of NFkappaB.

Journal: Biochemical and biophysical research communications 20020111

Title: Studies on the reactivity of clofibryl-S-acyl-CoA thioester with glutathione in vitro.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20020101

Title: Organ distribution of multidrug resistance proteins 1, 2, and 3 (Mrp1, 2, and 3) mRNA and hepatic induction of Mrp3 by constitutive androstane receptor activators in rats.

Journal: The Journal of pharmacology and experimental therapeutics 20020101

Title: Effect of ciprofibrate on C-reactive protein and fibrinogen levels.

Journal: Angiology 20020101

Title: Prevention/reversal of choline deficiency-induced steatohepatitis by a peroxisome proliferator-activated receptor alpha ligand in rats.

Journal: In vivo (Athens, Greece) 20020101

Title: Combined treatment with fibrates and small doses of atorvastatin in patients with mixed hyperlipidemia.

Journal: Current medical research and opinion 20020101

Title: Use of dominant negative nuclear receptors to study xenobiotic-inducible gene expression in primary cultured hepatocytes.

Journal: Journal of pharmacological and toxicological methods 20020101

Title: Nafenopin-, ciprofibroyl-, and palmitoyl-CoA conjugation in vitro: kinetic and molecular characterization of marmoset liver microsomes and expressed MLCL1.

Journal: Archives of biochemistry and biophysics 20011201

Title: Effects of fibrates on plasma prothrombotic activity in patients with type IIb dyslipidemia.

Journal: International journal of clinical pharmacology and therapeutics 20011201

Title: Occurrence of pharmaceutical contaminants and screening of treatment alternatives for southeastern Louisiana.

Journal: Annals of the New York Academy of Sciences 20011201

Title: Ciprofibrate increases plasma concentration of platelet-derived growth factor AB in patients with advanced atherosclerosis and hyperlipidemia independently of its hypolipidemic effects.

Journal: Journal of cardiovascular pharmacology 20011101

Title: Differential induction of peroxisomal beta-oxidation enzymes by clofibric acid and aspirin in piglet tissues.

Journal: American journal of physiology. Regulatory, integrative and comparative physiology 20011101

Title: Fibrates suppress bile acid synthesis via peroxisome proliferator-activated receptor-alpha-mediated downregulation of cholesterol 7alpha-hydroxylase and sterol 27-hydroxylase expression.

Journal: Arteriosclerosis, thrombosis, and vascular biology 20011101

Title: Ciprofibrate versus gemfibrozil in the treatment of mixed hyperlipidemias: an open-label, multicenter study.

Journal: Metabolism: clinical and experimental 20011101

Title: Metabolic alterations by clofibric acid in the formation of molecular species of phosphatidylcholine in rat liver.

Journal: Biochemical pharmacology 20011001

Title: Properties of Ca(2+) release induced by clofibric acid from the sarcoplasmic reticulum of mouse skeletal muscle fibres.

Journal: British journal of pharmacology 20011001

Title: Effects of dantrolene and its derivatives on Ca(2+) release from the sarcoplasmic reticulum of mouse skeletal muscle fibres.

Journal: British journal of pharmacology 20011001

Title: Carboxylic acids and skeletal muscle chloride channel conductance: effects on the biological activity induced by the introduction of an aryloxyalkyl group alpha to the carboxylic function of 4-chloro-phenoxyacetic acid.

Journal: Farmaco (Societa chimica italiana : 1989) 20011001

Title: Selective degradation of ibuprofen and clofibric acid in two model river biofilm systems.

Journal: Water research 20010901

Title: Drastic reduction of the slow gate of human muscle chloride channel (ClC-1) by mutation C277S.

Journal: The Journal of physiology 20010801

Title: Activation of the activator protein-1 by the peroxisome proliferator clofibric acid in rat H4IIEC3 hepatoma cells.

Journal: Toxicology and applied pharmacology 20010801

Title: Interaction of gamma-glutamyltranspeptidase with clofibryl-S-acyl-glutathione in vitro and in vivo in rat.

Journal: Chemical research in toxicology 20010801

Title: Fibrate-induced increase in blood urea and creatinine.

Journal: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20010701

Title: Fibrate treatment can increase serum creatinine levels.

Journal: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20010601

Title: Ciprofibrate versus gemfibrozil in the treatment of mixed hyperlipidemias: an open-label, multicenter study.

Journal: Metabolism: clinical and experimental 20010601

Title: Suppression of hepatocyte nuclear factor-4alpha by acyl-CoA thioesters of hypolipidemic peroxisome proliferators.

Journal: Biochemical pharmacology 20010501

Title: [Effect of ciprofibrate on the endothelial dysfunction of patients with combined dyslipidemia].

Journal: Orvosi hetilap 20010415

Title: Impressive lipid changes following hypolipidaemic drug administration can unveil subclinical hyperthyroidism.

Journal: Diabetes, obesity & metabolism 20010401

Title: Reversible binding of the novel anti-tumour agent 5,6-dimethylxanthenone-4-acetic acid to plasma proteins and its distribution into blood cells in various species.

Journal: The Journal of pharmacy and pharmacology 20010401

Title: Homocysteine elevation with fibrates: is it a class effect?

Journal: The Israel Medical Association journal : IMAJ 20010401

Title: Simultaneous quantification of neutral and acidic pharmaceuticals and pesticides at the low-ng/l level in surface and waste water.

Journal: Journal of chromatography. A 20010316

Title: Assessment of P450 induction in the marmoset monkey using targeted anti-peptide antibodies.

Journal: Biochimica et biophysica acta 20010309

Title: Statin-fibrate combinations in patients with combined hyperlipedemia.

Journal: Atherosclerosis 20010301

Title: Carboxylic acids and skeletal muscle chloride channel conductance: effects on the biological activity induced by the introduction of methyl groups on the aromatic ring of chiral alpha-(4-chloro-phenoxy)alkanoic acids.

Journal: Farmaco (Societa chimica italiana : 1989) 20010301

Title: Determination of drug residues in water by the combination of liquid chromatography or capillary electrophoresis with electrospray mass spectrometry.

Journal: Journal of chromatography. A 20010223

Title: Effects of etofibrate upon the metabolism of chylomicron-like emulsions in patients with coronary artery disease.

Journal: Atherosclerosis 20010201

Title: Differential induction of stearoyl-CoA desaturase and acyl-CoA oxidase genes by fibrates in HepG2 cells.

Journal: Biochemical pharmacology 20010201

Title: Etofibrate but not controlled-release niacin decreases LDL cholesterol and lipoprotein (a) in type IIb dyslipidemic subjects.

Journal: Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 20010201

Title: Diabetes: statins, fibrates, or both?

Journal: Current atherosclerosis reports 20010101

Title: The role of fibric acids in atherosclerosis.

Journal: Current atherosclerosis reports 20010101

Title: Treatment of dyslipoproteinemia in the metabolic syndrome.

Journal: Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 20010101

Title: Statin-fibrate combination therapy.

Journal: The Annals of pharmacotherapy 20010101

Title: Hypertriglyceridemia: associated risks and effect of drug treatment.

Journal: American journal of cardiovascular drugs : drugs, devices, and other interventions 20010101

Title: Drug treatment of combined hyperlipidemia.

Journal: American journal of cardiovascular drugs : drugs, devices, and other interventions 20010101

Title: Fibrate-induced increase in blood urea and creatinine: is gemfibrozil the only innocuous agent?

Journal: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20001201

Title: CYP2A5/CYP2A6 expression in mouse and human hepatocytes treated with various in vivo inducers.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20001101

Title: Pharmacological characterization of chloride channels belonging to the ClC family by the use of chiral clofibric acid derivatives.

Journal: Molecular pharmacology 20000901

Title: Detection of chemical-induced differential expression of rat hepatic cytochrome P450 mRNA transcripts using branched DNA signal amplification technology.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20000501

Title: Differential induction of hepatic drug-metabolizing enzymes by fenvaleric acid in male rats.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 19991201

Title: Fibrates, dyslipoproteinaemia and cardiovascular disease.

Journal: Current opinion in lipidology 19991201

Title: A ureido-thioisobutyric acid (GW9578) is a subtype-selective PPARalpha agonist with potent lipid-lowering activity.

Journal: Journal of medicinal chemistry 19990923

Title: Effects of fibrate compounds on expression of plasminogen activator inhibitor-1 by cultured endothelial cells.

Journal: Arteriosclerosis, thrombosis, and vascular biology 19990601

Title: Statin + fibrate combination therapy fluvastatin with bezafibrate or ciprofibrate in high risk patients with vascular disease.

Journal: International journal of cardiology 19990601

Title: Insulin differentially affects xenobiotic-enhanced, cytochrome P-450 (CYP)2E1, CYP2B, CYP3A, and CYP4A expression in primary cultured rat hepatocytes.

Journal: The Journal of pharmacology and experimental therapeutics 19990501

Title: Fibrates suppress fibrinogen gene expression in rodents via activation of the peroxisome proliferator-activated receptor-alpha.

Journal: Blood 19990501

Title: Fibrate-modulated expression of fibrinogen, plasminogen activator inhibitor-1 and apolipoprotein A-I in cultured cynomolgus monkey hepatocytes -- role of the peroxisome proliferator-activated receptor-alpha.

Journal: Thrombosis and haemostasis 19981201

Title: Mechanisms of peroxisome proliferation by perfluorooctanoic acid and endogenous fatty acids.

Journal: General pharmacology 19980801

Title: Clinical pharmacokinetics of fibric acid derivatives (fibrates).

Journal: Clinical pharmacokinetics 19980201

Title: The role of phosphatidylethanolamine methylation in the secretion of very low density lipoproteins by cultured rat hepatocytes: rapid inhibition of phosphatidylethanolamine methylation by bezafibrate increases the density of apolipoprotein B48-containing lipoproteins.

Journal: Biochimica et biophysica acta 19961111

Title: Growth regulation by peroxisome proliferators: opposing activities in early and late G1.

Journal: Cancer research 19960715

Title: Oltipraz-mediated changes in aflatoxin B(1) biotransformation in rat liver: implications for human chemointervention.

Journal: Cancer research 19960515

Title: Flow cytometric analysis of neoplastic nodules and hepatocellular carcinomas induced by ciprofibrate in the rat.

Journal: British journal of cancer 19960101

Title: [Rhabdomyolysis and unexplained malaise. Role of combination of ciprofibrate and norfloxacin].

Journal: La Revue de medecine interne 19960101

Title: Hypolipidemic activity of select fibrates correlates to changes in hepatic apolipoprotein C-III expression: a potential physiologic basis for their mode of action.

Journal: Journal of lipid research 19951201

Title: Currently available hypolipidaemic drugs and future therapeutic developments.

Journal: Bailliere's clinical endocrinology and metabolism 19951001

Title: The effects of diquat and ciprofibrate on mRNA expression and catalytic activities of hepatic xenobiotic metabolizing and antioxidant enzymes in rat liver.

Journal: Toxicology and applied pharmacology 19950901

Title: Xenobiotic-enhanced expression of cytochrome P450 2E1 and 2B1/2B2 in primary cultured rat hepatocytes.

Journal: Drug metabolism and disposition: the biological fate of chemicals 19950701

Title: The herbicide dicamba (2-methoxy-3,6-dichlorobenzoic acid) is a peroxisome proliferator in rats.

Journal: Fundamental and applied toxicology : official journal of the Society of Toxicology 19950601

Title: Effect of the peroxisome proliferators ciprofibrate and perfluorodecanoic acid on hepatic cell proliferation and toxicity in Sprague-Dawley rats.

Journal: Carcinogenesis 19941201

Title: The effects of clofibrate and bezafibrate on cholesterol metabolism in the liver of the male rat.

Journal: Lipids 19941101

Title: Antihyperlipidaemic agents. Drug interactions of clinical significance.

Journal: Drug safety 19941101

Title: A recombinant phenobarbital-inducible rat liver UDP-glucuronosyltransferase (UDP-glucuronosyltransferase 2B1) stably expressed in V79 cells catalyzes the glucuronidation of morphine, phenols, and carboxylic acids.

Journal: Molecular pharmacology 19940101

Title: Further studies on the involvement of selenium in peroxisome proliferation in rat liver. Comparison of effects with clofibric acid and perfluorooctanoic acid and the pharmacokinetics of [14C]clofibrate.

Journal: Biochemical pharmacology 19931117

Title: Coordinate induction of acyl-CoA binding protein, fatty acid binding protein and peroxisomal beta-oxidation by peroxisome proliferators.

Journal: Biochimica et biophysica acta 19930606

Title: Reinduction of the hypnotic effects of thiopental with NSAIDs by decreasing thiopental plasma protein binding in humans.

Journal: Acta anaesthesiologica Scandinavica 19930401

Title: Lack of peroxisomal enzyme inducibility in rat hepatic preneoplastic lesions induced by mutagenic carcinogens: contrasted expression of glutathione S-transferase P form and enoyl CoA hydratase.

Journal: Carcinogenesis 19930301

Title: Complementary deoxyribonucleic acid cloning and expression of a human liver uridine diphosphate-glucuronosyltransferase glucuronidating carboxylic acid-containing drugs.

Journal: The Journal of pharmacology and experimental therapeutics 19930101

Title: Analysis of activated protooncogenes in B6C3F1 mouse liver tumors induced by ciprofibrate, a potent peroxisome proliferator.

Journal: Carcinogenesis 19930101

Title: Mechanism of action of fibrates.

Journal: Postgraduate medical journal 19930101

Title: Convergence of 9-cis retinoic acid and peroxisome proliferator signalling pathways through heterodimer formation of their receptors.

Journal: Nature 19920827

Title: Regulation of HMG-CoA reductase, apoprotein-B and LDL receptor gene expression by the hypocholesterolemic drugs simvastatin and ciprofibrate in Hep G2, human and rat hepatocytes.

Journal: Biochimica et biophysica acta 19920709

Title: Plasma levels of HGF in rats treated with tumor promoters.

Journal: Carcinogenesis 19920101

Title: Peroxisome proliferation in neoplastic nodules and hepatocellular carcinomas induced by ciprofibrate in the rat.

Journal: Experimental pathology 19910101

Title: On the mechanism of the hepatocarcinogenicity of peroxisome proliferators.

Journal: Chemico-biological interactions 19910101

Title: Effects of gemfibrozil and other fibric acid derivatives on blood lipids and lipoproteins.

Journal: Journal of clinical pharmacology 19910101

Title: Characterization of the hepatic responses to the short-term administration of ciprofibrate in several rat strain. Co-induction of microsomal cytochrome P-450 IVA1 and peroxisome proliferation.

Journal: Biochemical pharmacology 19900901

Title: Peroxisome proliferator-induced alterations in the expression and modification of rat hepatocyte plasma membrane proteins.

Journal: Cancer research 19900201

Title: Studies with etofibrate in the rat. Part I: Effects on glycerol, free fatty acid and triacylglycerol metabolism.

Journal: Biochimica et biophysica acta 19881104

Title: Lack of expression of glutathione-S-transferase P, gamma-glutamyl transpeptidase, and alpha-fetoprotein messenger RNAs in liver tumors induced by peroxisome proliferators.

Journal: Cancer research 19880901

Title: Interactions of inhibitors of carnitine palmitoyltransferase I and fibrates in cultured hepatocytes.

Journal: The Biochemical journal 19880701

Title: Absence of gamma-glutamyltranspeptidase activity in lung metastasis in rats with hepatocellular carcinomas induced by ciprofibrate, a peroxisome proliferator.

Journal: Cancer letters 19871201

Title: Peroxisome proliferator-induced hepatocarcinogenesis: levels of activating and detoxifying enzymes in hepatocellular carcinomas induced by ciprofibrate.

Journal: Carcinogenesis 19870101

Title: Mitochondrial myopathy--a result of clofibrate/etofibrate treatment? Case report.

Journal: Acta neuropathologica 19850101

Title: Effect of bezafibrate on plasma lipids, lipoproteins, apolipoproteins AI, AII and B and LCAT activity in hyperlipidemic, non-insulin-dependent diabetics.

Journal: Atherosclerosis 19820601

Title: [Clofibrate therapy--current status from a gerontological viewpoint].

Journal: Zeitschrift fur Alternsforschung 19820101

Title: Forman BM, et, al. Hypolipidemic drugs, polyunsaturated fatty acids, and eicosanoids are ligands for peroxisome proliferator-activated receptors alpha and delta. Proc Natl Acad Sci U S A. 1997 Apr 29;94(9):4312-7.

Title: Salgado R, et, al. Biodegradation of clofibric acid and identification of its metabolites. J Hazard Mater. 2012 Nov 30;241-242:182-9.

Title: Kawashima Y, et, al. Increased activity of stearoyl-CoA desaturation in liver from rat fed clofibric acid. Biochim Biophys Acta. 1982 Dec 13;713(3):622-8.

Quotation Request
Company Name:
*
Contact Person:
*
Email:
*
Quantity Required:
*
Country:
Additional Info:
SDS
Tags:882-09-7 Molecular Formula|882-09-7 MDL|882-09-7 SMILES|882-09-7 2-(4-Chlorophenoxy)-2-methylpropanoic acid |Organic_Building_Blocks