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887148-69-8,MFCD19443706
Catalog No.:AA00H360

887148-69-8 | BenzaMide, N-[(1S)-1-cyano-2-[5-cyano-2-(trifluoroMethyl)phenoxy]-1-Methylethyl]-4-[(trifluoroMethyl)thio]-

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1mg
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1 week  
$225.00   $158.00
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5mg
99%
1 week  
$606.00   $424.00
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10mg
99%
1 week  
$844.00   $591.00
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25mg
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$1,638.00   $1,147.00
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50mg
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$2,431.00   $1,702.00
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00H360
Chemical Name:
BenzaMide, N-[(1S)-1-cyano-2-[5-cyano-2-(trifluoroMethyl)phenoxy]-1-Methylethyl]-4-[(trifluoroMethyl)thio]-
CAS Number:
887148-69-8
Molecular Formula:
C20H13F6N3O2S
Molecular Weight:
473.3915
MDL Number:
MFCD19443706
SMILES:
N#C[C@](NC(=O)c1ccc(cc1)SC(F)(F)F)(COc1cc(C#N)ccc1C(F)(F)F)C
Properties
Computed Properties
 
Complexity:
763  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
1  
Heavy Atom Count:
32  
Hydrogen Bond Acceptor Count:
11  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
6  
XLogP3:
5.2  

Literature

Title: Monepantel induces hepatic cytochromes p450 in sheep in vitro and in vivo.

Journal: Chemico-biological interactions 20150205

Title: A novel MDCKII in vitro model for assessing ABCG2-drug interactions and regulation of ABCG2 transport activity in the caprine mammary gland by environmental pollutants and pesticides.

Journal: Toxicology in vitro : an international journal published in association with BIBRA 20140401

Title: Efficacy of monepantel, derquantel and abamectin against adult stages of a multi-resistant Haemonchus contortus isolate.

Journal: Parasitology research 20121101

Title: The comparative efficacy of abamectin, monepantel and an abamectin/derquantel combination against fourth-stage larvae of a macrocyclic lactone-resistant Teladorsagia spp. isolate infecting sheep.

Journal: Veterinary parasitology 20120813

Title: Efficacy of monepantel and anthelmintic combinations against multiple-resistant Haemonchus contortus in sheep, including characterisation of the nematode isolate.

Journal: Veterinary parasitology 20120525

Title: The efficacy of monepantel against naturally acquired inhibited and developing fourth-stage larvae of Teladorsagia circumcincta in sheep in the United Kingdom.

Journal: Veterinary parasitology 20120525

Title: Modelling the benefits of a new class of anthelmintic in combination.

Journal: Veterinary parasitology 20120504

Title: Safety and efficacy against fourth-stage gastrointestinal nematode larvae, of monepantel in 6-week old lambs.

Journal: Veterinary parasitology 20120430

Title: Determination of the new anthelmintic monepantel and its sulfone metabolite in milk and muscle using a UHPLC-MS/MS and QuEChERS method.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20111201

Title: In vitro and in vivo efficacy of Monepantel (AAD 1566) against laboratory models of human intestinal nematode infections.

Journal: PLoS neglected tropical diseases 20111201

Title: Differences in efficacy of monepantel, derquantel and abamectin against multi-resistant nematodes of sheep.

Journal: Parasitology research 20110701

Title: Potential drug development candidates for human soil-transmitted helminthiases.

Journal: PLoS neglected tropical diseases 20110601

Title: Minimising the development of anthelmintic resistance, and optimising the use of the novel anthelmintic monepantel, for the sustainable control of nematode parasites in Australian sheep grazing systems.

Journal: Australian veterinary journal 20110501

Title: Activity of novel nicotinic anthelmintics in cut preparations of Caenorhabditis elegans.

Journal: International journal for parasitology 20110301

Title: [New drugs for horses and production animals in 2010].

Journal: Tierarztliche Praxis. Ausgabe G, Grosstiere/Nutztiere 20110101

Title: Assessment of risk of monepantel faecal residues to dung fauna.

Journal: Australian veterinary journal 20101201

Title: Monepantel allosterically activates DEG-3/DES-2 channels of the gastrointestinal nematode Haemonchus contortus.

Journal: Molecular pharmacology 20101101

Title: European field study of the efficacy and safety of the novel anthelmintic monepantel in sheep.

Journal: The Veterinary record 20101016

Title: Use of monepantel.

Journal: The Veterinary record 20101009

Title: Phylogenomics of ligand-gated ion channels predicts monepantel effect.

Journal: PLoS pathogens 20100901

Title: Quarantine treatment of sheep with monepantel--rapidity of fecal egg count reduction.

Journal: Veterinary parasitology 20100624

Title: The control of inhibited fourth-stage larvae of Haemonchus contortus and Teladorsagia spp. in sheep in Australia with monepantel.

Journal: Veterinary parasitology 20100511

Title: Effect of route of administration on the efficacy and pharmacokinetics of an experimental formulation of the amino-acetonitrile derivative monepantel in sheep.

Journal: The Veterinary record 20100417

Title: Use of monepantel.

Journal: The Veterinary record 20100410

Title: A pooled analysis of the efficacy of monepantel, an amino-acetonitrile derivative against gastrointestinal nematodes of sheep.

Journal: Parasitology research 20100101

Title: The effect of sheep breed, age, and gender on the pharmacokinetics and efficacy of monepantel, an amino-acetonitrile derivative.

Journal: Parasitology research 20100101

Title: The efficacy of monepantel, an amino-acetonitrile derivative, against gastrointestinal nematodes of sheep in three countries of southern Latin America.

Journal: Parasitology research 20091201

Title: Clinical field study to evaluate the efficacy and safety of the amino-acetonitrile derivative, monepantel, compared with registered anthelmintics against gastrointestinal nematodes of sheep in Australia.

Journal: Australian veterinary journal 20091101

Title: Pharmacokinetics of monepantel and its sulfone metabolite, monepantel sulfone, after intravenous and oral administration in sheep.

Journal: Journal of veterinary pharmacology and therapeutics 20090801

Title: Safety of an amino-acetonitrile derivative (AAD), monepantel, in ewes and their offspring following repeated oral administration.

Journal: New Zealand veterinary journal 20090801

Title: Effect of fasting sheep for a short period on the efficacy and safety of monepantel.

Journal: The Veterinary record 20090711

Title: Haemonchus contortus acetylcholine receptors of the DEG-3 subfamily and their role in sensitivity to monepantel.

Journal: PLoS pathogens 20090401

Title: Dose confirmation studies for monepantel, an amino-acetonitrile derivative, against fourth stage gastro-intestinal nematode larvae infecting sheep.

Journal: Veterinary parasitology 20090323

Title: Determination of the effective dose rate for monepantel (AAD 1566) against adult gastro-intestinal nematodes in sheep.

Journal: International journal for parasitology 20090301

Title: A large-scale clinical field study to evaluate the efficacy and safety of an oral formulation of the amino-acetonitrile derivative ( AAD ), monepantel , in sheep in New Zealand.

Journal: New Zealand veterinary journal 20090201

Title: Safety of an amino-acetonitrile derivative ( AAD ), monepantel, in weaned lambs following repeated oral administration.

Journal: New Zealand veterinary journal 20090201

Title: Reproductive safety of an amino-acetonitrile derivative (AAD), monepantel, in rams following repeated oral administration.

Journal: New Zealand veterinary journal 20090201

Title: Efficacy of the amino-acetonitrile derivative, monepantel, against experimental and natural adult stage gastro-intestinal nematode infections in sheep.

Journal: Veterinary parasitology 20090122

Title: Dose determination studies for monepantel, an amino-acetonitrile derivative, against fourth stage gastro-intestinal nematode larvae infecting sheep.

Journal: Veterinary parasitology 20081020

Title: Discovery of amino-acetonitrile derivatives, a new class of synthetic anthelmintic compounds.

Journal: Bioorganic & medicinal chemistry letters 20080501

Title: Hess J, et al. Assessment of the nematocidal activity of metallocenyl analogues of monepantel. Dalton Trans. 2016 Nov 28;45(44):17662-17671.

Title: Bahrami F, et al. Monepantel induces autophagy in human ovarian cancer cells through disruption of the mTOR/p70S6K signalling pathway. Am J Cancer Res. 2014 Sep 6;4(5):558-71.

Title: Raza A, et al. Increased expression of ATP binding cassette transporter genes following exposure of Haemonchus contortus larvae to a high concentration of monepantel in vitro. Parasit Vectors. 2016 Sep 29;9(1):522.

Title: Stuchlikova, et al. Monepantel induces hepatic cytochromes p450 in sheep in vitro and in vivo. Chem Biol Interact. 2015 Feb 5;227:63-8. 

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Tags:887148-69-8 Molecular Formula|887148-69-8 MDL|887148-69-8 SMILES|887148-69-8 BenzaMide, N-[(1S)-1-cyano-2-[5-cyano-2-(trifluoroMethyl)phenoxy]-1-Methylethyl]-4-[(trifluoroMethyl)thio]-