Home Other Building Blocks 888216-25-9
888216-25-9,MFCD22420818
Catalog No.:AA00GU0Q

888216-25-9 | Ganetespib

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
98%
in stock  
$15.00   $11.00
- +
100mg
95%
in stock  
$358.00   $251.00
- +
250mg
98%
in stock  
$390.00   $273.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA00GU0Q
Chemical Name:
Ganetespib
CAS Number:
888216-25-9
Molecular Formula:
C20H20N4O3
Molecular Weight:
364.3978
MDL Number:
MFCD22420818
SMILES:
Oc1cc(O)c(cc1c1n[nH]c(=O)n1c1ccc2c(c1)ccn2C)C(C)C
Properties
Computed Properties
 
Complexity:
610  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
27  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
3  
XLogP3:
3.1  

Downstream Synthesis Route

[1]Liu,Zilei;Li,Jie;Li,Suhua;Li,Gencheng;Sharpless,K.Barry;Wu,Peng[JournaloftheAmericanChemicalSociety,2018,vol.140,#8,p.2919-2925]

[1]CurrentPatentAssignee:SOUTHEASTUNIVERSITY-CN107163029,2017,ALocationinpatent:Paragraph0049;0081;0082;0083;0084;0085

[1]CurrentPatentAssignee:SOUTHEASTUNIVERSITY-CN107163029,2017,A

29906-67-0   
5-2,4-dihydroxy-5-(1-methylethyl)phenyl-2,4-dihydro-4-(1-methyl-1H-indol-5-yl)-3H-1,2,4-triazole-3-one 

[1]Patent:CN107163029,2017,A

102308-97-4   
5-2,4-dihydroxy-5-(1-methylethyl)phenyl-2,4-dihydro-4-(1-methyl-1H-indol-5-yl)-3H-1,2,4-triazole-3-one 

[1]Patent:CN107163029,2017,A

Literature

Title: Therapeutic targeting of BET bromodomain protein, Brd4, delays cyst growth in ADPKD.

Journal: Human molecular genetics 20150715

Title: Shimamura T, et al. Ganetespib (STA-9090), a Non-Geldanamycin HSP90 Inhibitor, has Potent Antitumor Activity in In Vitro and In Vivo Models of Non-Small Cell Lung Cancer. Clin Cancer Res. 2012 Jul 17.

Title: Ying W, et al. Ganetespib, a unique triazolone-containing Hsp90 inhibitor, exhibits potent antitumor activity and a superior safety profile for cancer therapy. Mol Cancer Ther. 2012 Feb;11(2):475-84.

Title: London CA, et al. Phase I evaluation of STA-1474, a prodrug of the novel HSP90 inhibitor ganetespib, in dogs with spontaneous cancer.PLoS One. 2011;6(11):e27018.

Title: Proia DA, et al. Multifaceted intervention by the Hsp90 inhibitor ganetespib (STA-9090) in cancer cells with activated JAK/STAT signaling. PLoS One. 2011 Apr 14;6(4):e18552.

Title: Stewart E, et al. Identification of Therapeutic Targets in Rhabdomyosarcoma through Integrated Genomic, Epigenomic, and Proteomic Analyses. Cancer Cell. 2018 Sep 10;34(3):411-426.e19.

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SDS
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