Home Pyridines 890842-28-1
890842-28-1,MFCD12828779
Catalog No.:AA00405P

890842-28-1 | 2-Cyclopentyl-4-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)benzoic acid

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
98%
in stock  
$45.00   $32.00
- +
5mg
98%
in stock  
$111.00   $78.00
- +
10mg
98%
in stock  
$144.00   $101.00
- +
100mg
98
in stock  
$1,270.00   $889.00
- +
500mg
98
in stock  
$3,958.00   $2,771.00
- +
1000mg
98
in stock  
$6,295.00   $4,407.00
- +
  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00405P
Chemical Name:
2-Cyclopentyl-4-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)benzoic acid
CAS Number:
890842-28-1
Molecular Formula:
C25H22N2O2
Molecular Weight:
382.4544
MDL Number:
MFCD12828779
SMILES:
OC(=O)c1ccc(cc1C1CCCC1)c1c[nH]c2c1cc(cn2)c1ccccc1
Properties
Properties
 
Form:
Solid  
Storage:
Keep in dry area;Room Temperature;  

Computed Properties
 
Complexity:
569  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
29  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
4  
XLogP3:
6.1  

Literature

Title: Convergent Signaling Pathways Regulate Parathyroid Hormone and Fibroblast Growth Factor-23 Action on NPT2A-mediated Phosphate Transport.

Journal: The Journal of biological chemistry 20160902

Title: Identification of a novel serum and glucocorticoid regulated kinase-1 (SGK1) ligand from virtual screening.

Journal: Bioorganic & medicinal chemistry letters 20120901

Title: Epithelial sodium channel regulation by cell surface-associated serum- and glucocorticoid-regulated kinase 1.

Journal: The Journal of biological chemistry 20110916

Title: Selectivity of kinase inhibitor fragments.

Journal: Journal of medicinal chemistry 20110728

Title: Effects of nominally selective inhibitors of the kinases PI3K, SGK1 and PKB on the insulin-dependent control of epithelial Na+ absorption.

Journal: British journal of pharmacology 20101001

Title: Design and synthesis of orally bioavailable serum and glucocorticoid-regulated kinase 1 (SGK1) inhibitors.

Journal: Bioorganic & medicinal chemistry letters 20090801

Title: Development of a small-molecule serum- and glucocorticoid-regulated kinase-1 antagonist and its evaluation as a prostate cancer therapeutic.

Journal: Cancer research 20080915

Title: Sherk AB, et al. Development of a small-molecule serum- and glucocorticoid-regulated kinase-1 antagonist and its evaluation as a prostate cancer therapeutic. Cancer Res. 2008 Sep 15;68(18):7475-83.

Title: Mansley MK, et al. Effects of nominally selective inhibitors of the kinases PI3K, SGK1 and PKB on the insulin-dependent control of epithelial Na+ absorption. Br J Pharmacol. 2010 Oct;161(3):571-88.

Title: Peng HY, et al. Spinal SGK1/GRASP-1/Rab4 is involved in complete Freund's adjuvant-induced inflammatory pain via regulating dorsal horn GluR1-containing AMPA receptor trafficking in rats. Pain. 2012 Dec;153(12):2380-92.

Title: Peng HY, et al. Spinal serum-inducible and glucocorticoid-inducible kinase 1 mediates neuropathic pain via kalirin and downstream PSD-95-dependent NR2B phosphorylation in rats. J Neurosci. 2013 Mar 20;33(12):5227-40.

Title: Alamares-Sapuay JG, et al. Serum- and glucocorticoid-regulated kinase 1 is required for nuclear export of the ribonucleoprotein of influenza A virus. J Virol. 2013 May;87(10):6020-6.

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Tags:890842-28-1 Molecular Formula|890842-28-1 MDL|890842-28-1 SMILES|890842-28-1 2-Cyclopentyl-4-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)benzoic acid