Home Other Building Blocks 891494-63-6
891494-63-6,MFCD20922873
Catalog No.:AA00GU3N

891494-63-6 | MK-8776 (SCH 900776)

Pack Size
Purity
Availability
Price(USD)
Quantity
  
2mg
98+%
in stock  
$25.00   $18.00
- +
5mg
98+%
in stock  
$41.00   $29.00
- +
10mg
98+%
in stock  
$61.00   $43.00
- +
25mg
98+%
in stock  
$102.00   $71.00
- +
250mg
98+%
in stock  
$492.00   $344.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA00GU3N
Chemical Name:
MK-8776 (SCH 900776)
CAS Number:
891494-63-6
Molecular Formula:
C15H18BrN7
Molecular Weight:
376.2543
MDL Number:
MFCD20922873
SMILES:
Cn1ncc(c1)c1cnn2c1nc([C@@H]1CCCNC1)c(c2N)Br
Properties
Computed Properties
 
Complexity:
425  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
1  
Heavy Atom Count:
23  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
2  
XLogP3:
0.8  

Downstream Synthesis Route

[1]Patent:WO2011/119457,2011,A1.Locationinpatent:Page/Pagecolumn3

[2]TetrahedronLetters,2016,vol.57,p.2601-2603

[3]Patent:WO2013/39854,2013,A1.Locationinpatent:Page/Pagecolumn32;33

[4]Patent:WO2014/62454,2014,A1.Locationinpatent:Page/Pagecolumn36

[1]Patent:WO2013/39854,2013,A1

[2]Patent:WO2014/62454,2014,A1

[3]TetrahedronLetters,2016,vol.57,p.2601-2603

[4]TetrahedronLetters,2016,vol.57,p.2601-2603

[1]Patent:WO2013/39854,2013,A1

[2]Patent:WO2014/62454,2014,A1

[3]TetrahedronLetters,2016,vol.57,p.2601-2603

[4]TetrahedronLetters,2016,vol.57,p.2601-2603

[1]Patent:WO2013/39854,2013,A1

[2]Patent:WO2014/62454,2014,A1

[3]TetrahedronLetters,2016,vol.57,p.2601-2603

[4]TetrahedronLetters,2016,vol.57,p.2601-2603

[1]Patent:WO2013/39854,2013,A1

[2]Patent:WO2014/62454,2014,A1

[3]TetrahedronLetters,2016,vol.57,p.2601-2603

[4]TetrahedronLetters,2016,vol.57,p.2601-2603

Literature

Title: Cellular impedance assays for predictive preclinical drug screening of kinase inhibitor cardiovascular toxicity.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20131001

Title: Effects of selective checkpoint kinase 1 inhibition on cytarabine cytotoxicity in acute myelogenous leukemia cells in vitro.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20121001

Title: Decreased translation of p21waf1 mRNA causes attenuated p53 signaling in some p53 wild-type tumors.

Journal: Cell cycle (Georgetown, Tex.) 20120501

Title: Preclinical development of the novel Chk1 inhibitor SCH900776 in combination with DNA-damaging agents and antimetabolites.

Journal: Molecular cancer therapeutics 20120201

Title: Targeting the replication checkpoint using SCH 900776, a potent and functionally selective CHK1 inhibitor identified via high content screening.

Journal: Molecular cancer therapeutics 20110401

Title: Montano R, et al. Preclinical development of the novel Chk1 inhibitor SCH900776 in combination with DNA-damaging agents and antimetabolites. Mol Cancer Ther. 2012 Feb;11(2):427-38.

Title: Guzi TJ, et al. Targeting the replication checkpoint using SCH 900776, a potent and functionally selective CHK1 inhibitor identified via high content screening. Mol Cancer Ther. 2011 Apr;10(4):591-602.

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SDS
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Tags:891494-63-6 Molecular Formula|891494-63-6 MDL|891494-63-6 SMILES|891494-63-6 MK-8776 (SCH 900776)